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UniProtKB - P29089 (AGTRB_RAT)
Protein
Type-1B angiotensin II receptor
Gene
Agtr1b
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- angiotensin type II receptor activity Source: InterPro
- angiotensin type I receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- angiotensin-activated signaling pathway Source: BHF-UCL
- blood vessel development Source: RGD
- cellular response to dexamethasone stimulus Source: UniProtKB
- drinking behavior Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- inflammatory response Source: RGD
- kidney development Source: RGD
- multicellular organism aging Source: RGD
- positive regulation of blood pressure Source: BHF-UCL
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of blood pressure Source: RGD
- regulation of renal output by angiotensin Source: RGD
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: RGD
- regulation of vasoconstriction Source: InterPro
- renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure Source: RGD
- response to angiotensin Source: RGD
- response to estrogen Source: RGD
- response to hypoxia Source: RGD
- response to immobilization stress Source: RGD
- response to nicotine Source: RGD
- response to nutrient Source: RGD
- response to salt stress Source: RGD
- response to xenobiotic stimulus Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Type-1B angiotensin II receptorAlternative name(s): AT3 Angiotensin II type-1B receptor Short name: AT1B |
Gene namesi | Name:Agtr1b Synonyms:Agtr1, At1b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2071, Agtr1b |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 52 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 53 – 64 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 65 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 88 – 102 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 103 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 125 – 142 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 143 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 163 – 192 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 193 – 214 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 215 – 240 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 241 – 262 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 263 – 275 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 276 – 296 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 359 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069161 | 1 – 359 | Type-1B angiotensin II receptorAdd BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 101 ↔ 180 | PROSITE-ProRule annotation | ||
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
C-terminal Ser or Thr residues may be phosphorylated.
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P29089 |
PTM databases
GlyGeni | P29089, 3 sites |
iPTMneti | P29089 |
PhosphoSitePlusi | P29089 |
Expressioni
Tissue specificityi
Is expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, and vascular smooth muscle cell. Expressed most abundantly in the adrenal gland.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000010640, Expressed in kidney and 11 other tissues |
Genevisiblei | P29089, RN |
Interactioni
Subunit structurei
Interacts with MAS1 (By similarity).
Interacts with ARRB1 (By similarity).
Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014175 |
Chemistry databases
BindingDBi | P29089 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 339 – 359 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 339 – 353 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P29089 |
OMAi | WVPHQIL |
OrthoDBi | 810397at2759 |
PhylomeDBi | P29089 |
TreeFami | TF330024 |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P29089-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLNSSTEDG IKRIQDDCPK AGRHNYIFVM IPTLYSIIFV VGIFGNSLVV
60 70 80 90 100
IVIYFYMKLK TVASVFLLNL ALADLCFLLT LPLWAVYTAM EYRWPFGNHL
110 120 130 140 150
CKIASASVSF NLYASVFLLT CLSIDRYLAI VHPMKSRLRR TMLVAKVTCI
160 170 180 190 200
IIWLMAGLAS LPAVIYRNVY FIENTNITVC AFHYESQNST LPIGLGLTKN
210 220 230 240 250
ILGFVFPFLI ILTSYTLIWK ALKKAYKIQK NTPRNDDIFR IIMAIVLFFF
260 270 280 290 300
FSWVPHQIFT FLDVLIQLGI IRDCEIADIV DTAMPITICI AYFNNCLNPL
310 320 330 340 350
FYGFLGKKFK KYFLQLLKYI PPTAKSHAGL STKMSTLSYR PSDNMSSSAK
KSASFFEVE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | T → I (PubMed:1567388).Curated | 1 | |
Sequence conflicti | 2 | T → I (PubMed:1575725).Curated | 1 | |
Sequence conflicti | 40 | V → M (PubMed:1567388).Curated | 1 | |
Sequence conflicti | 40 | V → M (PubMed:1575725).Curated | 1 | |
Sequence conflicti | 75 | L → Y (PubMed:1575725).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87003 mRNA Translation: AAA40739.1 X64052 mRNA Translation: CAA45410.1 M90065 mRNA Translation: AAA40704.1 S37461 mRNA Translation: AAB22267.1 |
PIRi | A42656 JQ1516 |
RefSeqi | NP_112271.2, NM_031009.2 XP_006232249.1, XM_006232187.2 XP_008759101.1, XM_008760879.2 |
Genome annotation databases
Ensembli | ENSRNOT00000014178; ENSRNOP00000014175; ENSRNOG00000010640 |
GeneIDi | 81638 |
KEGGi | rno:81638 |
UCSCi | RGD:2071, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87003 mRNA Translation: AAA40739.1 X64052 mRNA Translation: CAA45410.1 M90065 mRNA Translation: AAA40704.1 S37461 mRNA Translation: AAB22267.1 |
PIRi | A42656 JQ1516 |
RefSeqi | NP_112271.2, NM_031009.2 XP_006232249.1, XM_006232187.2 XP_008759101.1, XM_008760879.2 |
3D structure databases
AlphaFoldDBi | P29089 |
SMRi | P29089 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014175 |
Chemistry databases
BindingDBi | P29089 |
ChEMBLi | CHEMBL263 |
DrugCentrali | P29089 |
GuidetoPHARMACOLOGYi | 34 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P29089, 3 sites |
iPTMneti | P29089 |
PhosphoSitePlusi | P29089 |
Proteomic databases
PaxDbi | P29089 |
Genome annotation databases
Ensembli | ENSRNOT00000014178; ENSRNOP00000014175; ENSRNOG00000010640 |
GeneIDi | 81638 |
KEGGi | rno:81638 |
UCSCi | RGD:2071, rat |
Organism-specific databases
CTDi | 11608 |
RGDi | 2071, Agtr1b |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234534 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P29089 |
OMAi | WVPHQIL |
OrthoDBi | 810397at2759 |
PhylomeDBi | P29089 |
TreeFami | TF330024 |
Miscellaneous databases
PROi | PR:P29089 |
Gene expression databases
Bgeei | ENSRNOG00000010640, Expressed in kidney and 11 other tissues |
Genevisiblei | P29089, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000190, ATII_AT1_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00635, ANGIOTENSN1R PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGTRB_RAT | |
Accessioni | P29089Primary (citable) accession number: P29089 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families