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Protein

Tyrosine-protein phosphatase non-receptor type 4

Gene

PTPN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act at junctions between the membrane and the cytoskeleton.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei820SubstrateBy similarity1
Active sitei852Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei896SubstrateBy similarity1

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • non-membrane spanning protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • cellular response to cytokine stimulus Source: Reactome
  • protein dephosphorylation Source: ProtInc

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-9008059 Interleukin-37 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 4 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase MEG1
Short name:
MEG
Short name:
PTPase-MEG1
Gene namesi
Name:PTPN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000088179.8
HGNCiHGNC:9656 PTPN4
MIMi176878 gene
neXtProtiNX_P29074

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5775
OpenTargetsiENSG00000088179
PharmGKBiPA34000

Chemistry databases

ChEMBLiCHEMBL3165
DrugBankiDB00630 Alendronic acid

Polymorphism and mutation databases

BioMutaiPTPN4
DMDMi131531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194341 – 926Tyrosine-protein phosphatase non-receptor type 4Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei474PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP29074
PaxDbiP29074
PeptideAtlasiP29074
PRIDEiP29074
ProteomicsDBi54516

PTM databases

DEPODiP29074
iPTMnetiP29074
PhosphoSitePlusiP29074

Miscellaneous databases

PMAP-CutDBiP29074

Expressioni

Gene expression databases

BgeeiENSG00000088179
CleanExiHS_PTPN4
ExpressionAtlasiP29074 baseline and differential
GenevisibleiP29074 HS

Organism-specific databases

HPAiHPA019351

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111741, 33 interactors
DIPiDIP-34634N
IntActiP29074, 27 interactors
MINTiP29074
STRINGi9606.ENSP00000263708

Chemistry databases

BindingDBiP29074

Structurei

Secondary structure

1926
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi516 – 520Combined sources5
Beta strandi524 – 526Combined sources3
Beta strandi530 – 535Combined sources6
Helixi536 – 538Combined sources3
Beta strandi540 – 547Combined sources8
Beta strandi549 – 551Combined sources3
Helixi552 – 555Combined sources4
Beta strandi556 – 558Combined sources3
Beta strandi565 – 569Combined sources5
Helixi579 – 587Combined sources9
Helixi589 – 591Combined sources3
Beta strandi596 – 602Combined sources7
Beta strandi605 – 609Combined sources5
Helixi639 – 651Combined sources13
Helixi654 – 661Combined sources8
Turni677 – 679Combined sources3
Helixi680 – 682Combined sources3
Helixi692 – 694Combined sources3
Beta strandi695 – 697Combined sources3
Beta strandi704 – 713Combined sources10
Beta strandi720 – 726Combined sources7
Helixi731 – 733Combined sources3
Helixi734 – 743Combined sources10
Beta strandi748 – 751Combined sources4
Beta strandi755 – 757Combined sources3
Beta strandi773 – 776Combined sources4
Beta strandi779 – 783Combined sources5
Beta strandi790 – 801Combined sources12
Turni802 – 805Combined sources4
Beta strandi806 – 815Combined sources10
Beta strandi820 – 823Combined sources4
Helixi828 – 841Combined sources14
Beta strandi848 – 851Combined sources4
Beta strandi853 – 857Combined sources5
Helixi858 – 873Combined sources16
Helixi880 – 888Combined sources9
Helixi898 – 911Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CS5NMR-A507-612[»]
2I75X-ray2.45A611-926[»]
2VPHX-ray1.90A/B513-606[»]
3NFKX-ray1.43A/B499-604[»]
3NFLX-ray1.91A/B/C/D499-604[»]
5EYZX-ray2.09A/B/C/D499-604[»]
5EZ0X-ray2.35A/B/C/D499-604[»]
ProteinModelPortaliP29074
SMRiP29074
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29074

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 312FERMPROSITE-ProRule annotationAdd BLAST284
Domaini517 – 589PDZPROSITE-ProRule annotationAdd BLAST73
Domaini655 – 911Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni852 – 858Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000007048
HOVERGENiHBG008322
InParanoidiP29074
KOiK18037
OMAiHTCTDFW
OrthoDBiEOG091G016K
PhylomeDBiP29074
TreeFamiTF315900

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P29074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRFRLPAG RTYNVRASEL ARDRQHTEVV CNILLLDNTV QAFKVNKHDQ
60 70 80 90 100
GQVLLDVVFK HLDLTEQDYF GLQLADDSTD NPRWLDPNKP IRKQLKRGSP
110 120 130 140 150
YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI KQDILTGRLP CPSNTAALLA
160 170 180 190 200
SFAVQSELGD YDQSENLSGY LSDYSFIPNQ PQDFEKEIAK LHQQHIGLSP
210 220 230 240 250
AEAEFNYLNT ARTLELYGVE FHYARDQSNN EIMIGVMSGG ILIYKNRVRM
260 270 280 290 300
NTFPWLKIVK ISFKCKQFFI QLRKELHESR ETLLGFNMVN YRACKNLWKA
310 320 330 340 350
CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK FRYCGRTEVQ SVQYGKEKAN
360 370 380 390 400
KDRVFARSPS KPLARKLMDW EVVSRNSISD DRLETQSLPS RSPPGTPNHR
410 420 430 440 450
NSTFTQEGTR LRPSSVGHLV DHMVHTSPSE VFVNQRSPSS TQANSIVLES
460 470 480 490 500
SPSQETPGDG KPPALPPKQS KKNSWNQIHY SHSQQDLESH INETFDIPSS
510 520 530 540 550
PEKPTPNGGI PHDNLVLIRM KPDENGRFGF NVKGGYDQKM PVIVSRVAPG
560 570 580 590 600
TPADLCVPRL NEGDQVVLIN GRDIAEHTHD QVVLFIKASC ERHSGELMLL
610 620 630 640 650
VRPNAVYDVV EEKLENEPDF QYIPEKAPLD SVHQDDHSLR ESMIQLAEGL
660 670 680 690 700
ITGTVLTQFD QLYRKKPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG
710 720 730 740 750
NEDYINANYI NMEIPSSSII NQYIACQGPL PHTCTDFWQM TWEQGSSMVV
760 770 780 790 800
MLTTQVERGR VKCHQYWPEP TGSSSYGCYQ VTCHSEEGNT AYIFRKMTLF
810 820 830 840 850
NQEKNESRPL TQIQYIAWPD HGVPDDSSDF LDFVCHVRNK RAGKEEPVVV
860 870 880 890 900
HCSAGIGRTG VLITMETAMC LIECNQPVYP LDIVRTMRDQ RAMMIQTPSQ
910 920
YRFVCEAILK VYEEGFVKPL TTSTNK
Length:926
Mass (Da):105,911
Last modified:December 1, 1992 - v1
Checksum:i4DAC6A87A675CFB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131K → E in BAG37355 (PubMed:14702039).Curated1
Sequence conflicti772G → K no nucleotide entry (PubMed:8483328).Curated1
Sequence conflicti863I → V in BAG37355 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061033924T → S. Corresponds to variant dbSNP:rs3189128Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68941 mRNA Translation: AAA36530.1
AK314836 mRNA Translation: BAG37355.1
BC010674 mRNA Translation: AAH10674.1
CCDSiCCDS2129.1
PIRiA41105
RefSeqiNP_002821.1, NM_002830.3
XP_016860089.1, XM_017004600.1
UniGeneiHs.469809

Genome annotation databases

EnsembliENST00000263708; ENSP00000263708; ENSG00000088179
GeneIDi5775
KEGGihsa:5775
UCSCiuc002tmf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTN4_HUMAN
AccessioniPrimary (citable) accession number: P29074
Secondary accession number(s): B2RBV8, Q9UDA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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