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Entry version 129 (16 Oct 2019)
Sequence version 2 (07 Jun 2005)
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Protein

Chitin synthase 1

Gene

chs-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in cell wall biogenesis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT2 Glycosyltransferase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitin synthase 1 (EC:2.4.1.16)
Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase 1
Class-III chitin synthase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chs-1
ORF Names:B11H24.170, NCU03611
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri367110 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001805 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2, Linkage Group V

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:NCU03611

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 570ExtracellularSequence analysisAdd BLAST570
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei571 – 591HelicalSequence analysisAdd BLAST21
Topological domaini592 – 629CytoplasmicSequence analysisAdd BLAST38
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Topological domaini651 – 664ExtracellularSequence analysisAdd BLAST14
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21
Topological domaini686 – 716CytoplasmicSequence analysisAdd BLAST31
Transmembranei717 – 737HelicalSequence analysisAdd BLAST21
Topological domaini738 – 744ExtracellularSequence analysis7
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Topological domaini766 – 843CytoplasmicSequence analysisAdd BLAST78
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Topological domaini865 – 884ExtracellularSequence analysisAdd BLAST20
Transmembranei885 – 905HelicalSequence analysisAdd BLAST21
Topological domaini906 – 917CytoplasmicSequence analysisAdd BLAST12

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5625

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937011 – 917Chitin synthase 1Add BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi544N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162144

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29070

KEGG Orthology (KO)

More...
KOi
K00698

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWIFSNA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR22914 PTHR22914, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29070-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYHGRGDGY DGHQLQDLPG GHNQGDQHDD AQAPFLSENP MPYDNDRLGT
60 70 80 90 100
DTPPVRPVSA YSLTESYAPG AGTTRAGVAV NPTPPPHGGY GGGGVSSGVD
110 120 130 140 150
QGYNYGGDYA TDPAYRMSAI DEDDSWLRRQ QPNAAPTGGL KRYATRKVKL
160 170 180 190 200
VQGSVLSLDY PVPSAIRNAV QPKYRDEEGN NEEFFKMRYT AATCDPNDFT
210 220 230 240 250
LKNGYDLRPR MYNRHTELLI AITYYNEDKV LLSRTLHSVM TNIRDIVNLK
260 270 280 290 300
KSSFWNRGGP AWQKIVVCLV FDGLDKTDKN VLDVLATIGV YQDGVIKKDV
310 320 330 340 350
DGKETVAHIF EYTSQLSVTP NQALIRPVDD GPQTLPPVQF IFCLKQKNTK
360 370 380 390 400
KINSHRWLFN AFGRILNPEV CILLDAGTKP SPRSLLALWE GFYNDKDLGG
410 420 430 440 450
ACGEIHAMLG KGGKKLLNPL VAVQNFEYKI SNILDKPLES AFGYVSVLPG
460 470 480 490 500
AFSAYRFRAI MGRPLEQYFH GDHTLSKLLG KKGIEGMNIF KKNMFLAEDR
510 520 530 540 550
ILCFELVAKA GQKWHLSYIK AAKGETDVPE GAPEFISQRR RWLNGSFAAS
560 570 580 590 600
LYSLMHFGRM YKSGHNIVRM FFFHVQLIYN IANVIFTWFS LASYWLTTTV
610 620 630 640 650
IMDLVGTPVT ASSSSAEHHG WPFGDTVTPF FNAVLKYIYL AFVILQFILA
660 670 680 690 700
LGNRPKGSKW TYITSFFVFS LIQSYILVLS GYLVARAFSV PLDQQLQLDN
710 720 730 740 750
AKDAMASLFG GSGSAGVILV ALVTIYGLYF LASFMYLDPW HMFHSFPYYM
760 770 780 790 800
LLMSTYINIL MIYAFNNWHD VSWGTKGSDK AEALPSANVS KGEKDEAVVE
810 820 830 840 850
EIEKPQEDID QQFEATVRRA LAPYKEDETP EPKDLEDSYK SFRTMLVVSW
860 870 880 890 900
LFSNCLLAVV ITSDNFNTFG IGQTASARTA WFFKFLLFAT GALSVIRFIG
910
FCWFLGRTGI MCCFARR
Length:917
Mass (Da):102,692
Last modified:June 7, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i903EBBF6BD95A69A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA33568 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33A → R in AAA33568 (PubMed:1836444).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M73437 Genomic DNA Translation: AAA33568.1 Frameshift.
AL670005 Genomic DNA Translation: CAD21286.1
CM002240 Genomic DNA Translation: EAA32102.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A41638

NCBI Reference Sequences

More...
RefSeqi
XP_961338.2, XM_956245.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAA32102; EAA32102; NCU03611

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3877520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ncr:NCU03611

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73437 Genomic DNA Translation: AAA33568.1 Frameshift.
AL670005 Genomic DNA Translation: CAD21286.1
CM002240 Genomic DNA Translation: EAA32102.2
PIRiA41638
RefSeqiXP_961338.2, XM_956245.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Chemistry databases

ChEMBLiCHEMBL5625

Protein family/group databases

CAZyiGT2 Glycosyltransferase Family 2

Genome annotation databases

EnsemblFungiiEAA32102; EAA32102; NCU03611
GeneIDi3877520
KEGGincr:NCU03611

Organism-specific databases

EuPathDBiFungiDB:NCU03611

Phylogenomic databases

HOGENOMiHOG000162144
InParanoidiP29070
KOiK00698
OMAiFWIFSNA

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P29070

Family and domain databases

InterProiView protein in InterPro
IPR004835 Chitin_synth
IPR004834 Chitin_synth_fun
IPR013616 Chitin_synth_N
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR22914 PTHR22914, 1 hit
PfamiView protein in Pfam
PF01644 Chitin_synth_1, 1 hit
PF08407 Chitin_synth_1N, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHS1_NEUCR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29070
Secondary accession number(s): Q7RVD4, Q8X0I7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: June 7, 2005
Last modified: October 16, 2019
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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