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Protein

Protein S100-A2

Gene

S100A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.2 Publications

Miscellaneous

This protein binds two calcium ions.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 341; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi64 – 752; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • transition metal ion binding Source: InterPro

GO - Biological processi

  • endothelial cell migration Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A2
Alternative name(s):
CAN19
Protein S-100L
S100 calcium-binding protein A2
Gene namesi
Name:S100A2
Synonyms:S100L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196754.10
HGNCiHGNC:10492 S100A2
MIMi176993 gene
neXtProtiNX_P29034

Pathology & Biotechi

Organism-specific databases

DisGeNETi6273
PharmGKBiPA34904

Chemistry databases

DrugBankiDB00768 Olopatadine

Polymorphism and mutation databases

BioMutaiS100A2
DMDMi114152869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439711 – 98Protein S100-A2Add BLAST98

Proteomic databases

EPDiP29034
MaxQBiP29034
PaxDbiP29034
PeptideAtlasiP29034
PRIDEiP29034
ProteomicsDBi54515

PTM databases

iPTMnetiP29034
PhosphoSitePlusiP29034

Expressioni

Tissue specificityi

A subset of epithelial cells including normal human mammary epithelial cells and keratinocytes.1 Publication

Developmental stagei

Preferentially expressed in normal human mammary epithelial cells as opposed to tumor-derived ones. The level of S100L was shown to correlate inversely with tumor progression.1 Publication

Inductioni

By growth factors in early G1 phase and probably by cell-cycle regulation in S phase. DNA methylation probably plays a direct negative role in suppressing S100L gene expression in tumor cells.2 Publications

Gene expression databases

BgeeiENSG00000196754 Expressed in 139 organ(s), highest expression level in hair follicle
CleanExiHS_S100A2
ExpressionAtlasiP29034 baseline and differential
GenevisibleiP29034 HS

Organism-specific databases

HPAiCAB002600
CAB047340
HPA062451

Interactioni

Subunit structurei

Homodimer. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112181, 13 interactors
IntActiP29034, 15 interactors
MINTiP29034
STRINGi9606.ENSP00000357697

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29034
SMRiP29034
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29034

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYI7 Eukaryota
ENOG41115QW LUCA
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP29034
OrthoDBiEOG091G10JX
PhylomeDBiP29034
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P29034-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KELPSFVGEK
60 70 80 90
VDEEGLKKLM GSLDENSDQQ VDFQEYAVFL ALITVMCNDF FQGCPDRP
Length:98
Mass (Da):11,117
Last modified:September 5, 2006 - v3
Checksum:i56D09548450142A9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GN49R4GN49_HUMAN
Protein S100-A2
S100A2
64Annotation score:
Q5RHS7Q5RHS7_HUMAN
Protein S100-A2
S100A2
95Annotation score:

Sequence cautioni

The sequence CAA69033 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62S → N in M87068 (PubMed:1372446).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87068 mRNA No translation available.
Y07755 Genomic DNA Translation: CAA69033.1 Different initiation.
BX470102 Genomic DNA No translation available.
BC002829 mRNA Translation: AAH02829.3
BC105787 mRNA Translation: AAI05788.1
PIRiA41988
RefSeqiNP_005969.1, NM_005978.3
UniGeneiHs.516484

Genome annotation databases

EnsembliENST00000368708; ENSP00000357697; ENSG00000196754
ENST00000368709; ENSP00000357698; ENSG00000196754
ENST00000368710; ENSP00000357699; ENSG00000196754
ENST00000487430; ENSP00000473260; ENSG00000196754
GeneIDi6273
KEGGihsa:6273
UCSCiuc001fcb.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87068 mRNA No translation available.
Y07755 Genomic DNA Translation: CAA69033.1 Different initiation.
BX470102 Genomic DNA No translation available.
BC002829 mRNA Translation: AAH02829.3
BC105787 mRNA Translation: AAI05788.1
PIRiA41988
RefSeqiNP_005969.1, NM_005978.3
UniGeneiHs.516484

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RGIX-ray1.60A/B1-98[»]
4DUQX-ray1.30A/B1-98[»]
ProteinModelPortaliP29034
SMRiP29034
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112181, 13 interactors
IntActiP29034, 15 interactors
MINTiP29034
STRINGi9606.ENSP00000357697

Chemistry databases

DrugBankiDB00768 Olopatadine

PTM databases

iPTMnetiP29034
PhosphoSitePlusiP29034

Polymorphism and mutation databases

BioMutaiS100A2
DMDMi114152869

Proteomic databases

EPDiP29034
MaxQBiP29034
PaxDbiP29034
PeptideAtlasiP29034
PRIDEiP29034
ProteomicsDBi54515

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368708; ENSP00000357697; ENSG00000196754
ENST00000368709; ENSP00000357698; ENSG00000196754
ENST00000368710; ENSP00000357699; ENSG00000196754
ENST00000487430; ENSP00000473260; ENSG00000196754
GeneIDi6273
KEGGihsa:6273
UCSCiuc001fcb.4 human

Organism-specific databases

CTDi6273
DisGeNETi6273
EuPathDBiHostDB:ENSG00000196754.10
GeneCardsiS100A2
H-InvDBiHIX0001083
HGNCiHGNC:10492 S100A2
HPAiCAB002600
CAB047340
HPA062451
MIMi176993 gene
neXtProtiNX_P29034
PharmGKBiPA34904
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYI7 Eukaryota
ENOG41115QW LUCA
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP29034
OrthoDBiEOG091G10JX
PhylomeDBiP29034
TreeFamiTF332727

Miscellaneous databases

ChiTaRSiS100A2 human
EvolutionaryTraceiP29034
GeneWikiiS100A2
GenomeRNAii6273
PROiPR:P29034
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196754 Expressed in 139 organ(s), highest expression level in hair follicle
CleanExiHS_S100A2
ExpressionAtlasiP29034 baseline and differential
GenevisibleiP29034 HS

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A2_HUMAN
AccessioniPrimary (citable) accession number: P29034
Secondary accession number(s): O00266
, Q3KRB9, Q5RHS8, Q9BU83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 167 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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