UniProtKB - P29034 (S10A2_HUMAN)
Protein S100-A2
S100A2
Functioni
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
2 PublicationsMiscellaneous
Caution
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 21 – 34 | 1; low affinityPROSITE-ProRule annotationAdd BLAST | 14 | |
Calcium bindingi | 64 – 75 | 2; high affinityPROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- calcium ion binding Source: GO_Central
- identical protein binding Source: IntAct
- transition metal ion binding Source: InterPro
GO - Biological processi
- endothelial cell migration Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P29034 |
SignaLinki | P29034 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A2Alternative name(s): CAN19 Protein S-100L S100 calcium-binding protein A2 |
Gene namesi | Name:S100A2 Synonyms:S100L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10492, S100A2 |
MIMi | 176993, gene |
neXtProti | NX_P29034 |
VEuPathDBi | HostDB:ENSG00000196754 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6273 |
OpenTargetsi | ENSG00000196754 |
PharmGKBi | PA34904 |
Miscellaneous databases
Pharosi | P29034, Tbio |
Chemistry databases
DrugBanki | DB01373, Calcium DB09130, Copper DB00768, Olopatadine DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | S100A2 |
DMDMi | 114152869 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143971 | 1 – 98 | Protein S100-A2Add BLAST | 98 |
Proteomic databases
CPTACi | CPTAC-1453 |
EPDi | P29034 |
jPOSTi | P29034 |
MassIVEi | P29034 |
MaxQBi | P29034 |
PaxDbi | P29034 |
PeptideAtlasi | P29034 |
PRIDEi | P29034 |
ProteomicsDBi | 54515 |
PTM databases
iPTMneti | P29034 |
PhosphoSitePlusi | P29034 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000196754, Expressed in hair follicle and 162 other tissues |
ExpressionAtlasi | P29034, baseline and differential |
Genevisiblei | P29034, HS |
Organism-specific databases
HPAi | ENSG00000196754, Tissue enhanced (esophagus, urinary bladder) |
Interactioni
Subunit structurei
Homodimer.
Interacts with FKBP4.
Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
Interacts with TPPP; this interaction inhibits TPPP dimerization (PubMed:33831707).
4 PublicationsBinary interactionsi
P29034
GO - Molecular functioni
- calcium-dependent protein binding Source: GO_Central
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 112181, 346 interactors |
IntActi | P29034, 30 interactors |
MINTi | P29034 |
STRINGi | 9606.ENSP00000357697 |
Miscellaneous databases
RNActi | P29034, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P29034 |
SMRi | P29034 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29034 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 48 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 51 – 86 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S4AU, Eukaryota |
GeneTreei | ENSGT00940000163114 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P29034 |
OMAi | ITVMCNE |
OrthoDBi | 1560865at2759 |
PhylomeDBi | P29034 |
TreeFami | TF332727 |
Family and domain databases
CDDi | cd00213, S-100, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034325, S-100_dom IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MMCSSLEQAL AVLVTTFHKY SCQEGDKFKL SKGEMKELLH KELPSFVGEK
60 70 80 90
VDEEGLKKLM GSLDENSDQQ VDFQEYAVFL ALITVMCNDF FQGCPDRP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketR4GN49 | R4GN49_HUMAN | Protein S100-A2 | S100A2 | 64 | Annotation score: | ||
Q5RHS7 | Q5RHS7_HUMAN | Protein S100-A2 | S100A2 | 96 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | S → N in M87068 (PubMed:1372446).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87068 mRNA No translation available. Y07755 Genomic DNA Translation: CAA69033.1 Different initiation. BX470102 Genomic DNA No translation available. BC002829 mRNA Translation: AAH02829.3 BC105787 mRNA Translation: AAI05788.1 |
CCDSi | CCDS1044.1 |
PIRi | A41988 |
RefSeqi | NP_005969.1, NM_005978.3 |
Genome annotation databases
Ensembli | ENST00000368708; ENSP00000357697; ENSG00000196754 ENST00000368709; ENSP00000357698; ENSG00000196754 ENST00000368710; ENSP00000357699; ENSG00000196754 ENST00000487430; ENSP00000473260; ENSG00000196754 |
GeneIDi | 6273 |
KEGGi | hsa:6273 |
MANE-Selecti | ENST00000368708.9; ENSP00000357697.4; NM_005978.4; NP_005969.2 |
UCSCi | uc001fcb.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M87068 mRNA No translation available. Y07755 Genomic DNA Translation: CAA69033.1 Different initiation. BX470102 Genomic DNA No translation available. BC002829 mRNA Translation: AAH02829.3 BC105787 mRNA Translation: AAI05788.1 |
CCDSi | CCDS1044.1 |
PIRi | A41988 |
RefSeqi | NP_005969.1, NM_005978.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2RGI | X-ray | 1.60 | A/B | 1-98 | [»] | |
4DUQ | X-ray | 1.30 | A/B | 1-98 | [»] | |
BMRBi | P29034 | |||||
SMRi | P29034 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112181, 346 interactors |
IntActi | P29034, 30 interactors |
MINTi | P29034 |
STRINGi | 9606.ENSP00000357697 |
Chemistry databases
DrugBanki | DB01373, Calcium DB09130, Copper DB00768, Olopatadine DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
PTM databases
iPTMneti | P29034 |
PhosphoSitePlusi | P29034 |
Genetic variation databases
BioMutai | S100A2 |
DMDMi | 114152869 |
Proteomic databases
CPTACi | CPTAC-1453 |
EPDi | P29034 |
jPOSTi | P29034 |
MassIVEi | P29034 |
MaxQBi | P29034 |
PaxDbi | P29034 |
PeptideAtlasi | P29034 |
PRIDEi | P29034 |
ProteomicsDBi | 54515 |
Protocols and materials databases
Antibodypediai | 34127, 244 antibodies from 29 providers |
CPTCi | P29034, 3 antibodies |
DNASUi | 6273 |
Genome annotation databases
Ensembli | ENST00000368708; ENSP00000357697; ENSG00000196754 ENST00000368709; ENSP00000357698; ENSG00000196754 ENST00000368710; ENSP00000357699; ENSG00000196754 ENST00000487430; ENSP00000473260; ENSG00000196754 |
GeneIDi | 6273 |
KEGGi | hsa:6273 |
MANE-Selecti | ENST00000368708.9; ENSP00000357697.4; NM_005978.4; NP_005969.2 |
UCSCi | uc001fcb.4, human |
Organism-specific databases
CTDi | 6273 |
DisGeNETi | 6273 |
GeneCardsi | S100A2 |
HGNCi | HGNC:10492, S100A2 |
HPAi | ENSG00000196754, Tissue enhanced (esophagus, urinary bladder) |
MIMi | 176993, gene |
neXtProti | NX_P29034 |
OpenTargetsi | ENSG00000196754 |
PharmGKBi | PA34904 |
VEuPathDBi | HostDB:ENSG00000196754 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4AU, Eukaryota |
GeneTreei | ENSGT00940000163114 |
HOGENOMi | CLU_138624_2_0_1 |
InParanoidi | P29034 |
OMAi | ITVMCNE |
OrthoDBi | 1560865at2759 |
PhylomeDBi | P29034 |
TreeFami | TF332727 |
Enzyme and pathway databases
PathwayCommonsi | P29034 |
SignaLinki | P29034 |
Miscellaneous databases
BioGRID-ORCSi | 6273, 6 hits in 1033 CRISPR screens |
ChiTaRSi | S100A2, human |
EvolutionaryTracei | P29034 |
GeneWikii | S100A2 |
GenomeRNAii | 6273 |
Pharosi | P29034, Tbio |
PROi | PR:P29034 |
RNActi | P29034, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196754, Expressed in hair follicle and 162 other tissues |
ExpressionAtlasi | P29034, baseline and differential |
Genevisiblei | P29034, HS |
Family and domain databases
CDDi | cd00213, S-100, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034325, S-100_dom IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S10A2_HUMAN | |
Accessioni | P29034Primary (citable) accession number: P29034 Secondary accession number(s): O00266 Q9BU83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families