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Protein

T-cell surface glycoprotein CD1c

Gene

CD1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.4 Publications

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1c
Alternative name(s):
CD_antigen: CD1c
Gene namesi
Name:CD1C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158481.12
HGNCiHGNC:1636 CD1C
MIMi188340 gene
neXtProtiNX_P29017

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 302ExtracellularSequence analysisAdd BLAST285
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 333CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi911
OpenTargetsiENSG00000158481
PharmGKBiPA26195

Polymorphism and mutation databases

BioMutaiCD1C
DMDMi143811371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001458018 – 333T-cell surface glycoprotein CD1cAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi120 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 280PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29017
PaxDbiP29017
PeptideAtlasiP29017
PRIDEiP29017
ProteomicsDBi54513

PTM databases

iPTMnetiP29017
PhosphoSitePlusiP29017
SwissPalmiP29017

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

BgeeiENSG00000158481 Expressed in 138 organ(s), highest expression level in thymus
CleanExiHS_CD1C
ExpressionAtlasiP29017 baseline and differential
GenevisibleiP29017 HS

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin).1 Publication

Protein-protein interaction databases

IntActiP29017, 2 interactors
STRINGi9606.ENSP00000357152

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29017
SMRiP29017
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29017

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 296Ig-likeAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Internalization signal4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP29017
KOiK06448
OMAiILYWGHH
OrthoDBiEOG091G0H36
PhylomeDBiP29017
TreeFamiTF336723

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL
60 70 80 90 100
DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ
110 120 130 140 150
DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV
160 170 180 190 200
PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV
210 220 230 240 250
HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK
260 270 280 290 300
HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF
310 320 330
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL
Length:333
Mass (Da):37,654
Last modified:April 3, 2007 - v2
Checksum:i8E4E057097E3E440
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6Y6H0Y6Y6_HUMAN
T-cell surface glycoprotein CD1c
CD1C
281Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290Q → R in CAG33361 (Ref. 3) Curated1
Sequence conflicti327 – 333CSYQDIL → W in AAA51942 (PubMed:2447586).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03156470N → T. Corresponds to variant dbSNP:rs3138100Ensembl.1
Natural variantiVAR_031565300F → S1 PublicationCorresponds to variant dbSNP:rs3138105Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA Translation: AAA51942.1
M28827 mRNA Translation: AAA51941.1
CR457080 mRNA Translation: CAG33361.1
AL121986 Genomic DNA No translation available.
BC126465 mRNA Translation: AAI26466.1
BC126467 mRNA Translation: AAI26468.1
AF142667 Genomic DNA Translation: AAD37580.1
M14667 Genomic DNA Translation: AAA51938.1
CCDSiCCDS1175.1
PIRiC45801 HLHUCC
RefSeqiNP_001756.2, NM_001765.2
UniGeneiHs.132448

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481
GeneIDi911
KEGGihsa:911
UCSCiuc001fru.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22178
, M22174, M22175, M22176, M22177 Genomic DNA Translation: AAA51942.1
M28827 mRNA Translation: AAA51941.1
CR457080 mRNA Translation: CAG33361.1
AL121986 Genomic DNA No translation available.
BC126465 mRNA Translation: AAI26466.1
BC126467 mRNA Translation: AAI26468.1
AF142667 Genomic DNA Translation: AAD37580.1
M14667 Genomic DNA Translation: AAA51938.1
CCDSiCCDS1175.1
PIRiC45801 HLHUCC
RefSeqiNP_001756.2, NM_001765.2
UniGeneiHs.132448

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OV6X-ray2.50A19-201[»]
4ONOX-ray2.70A24-201[»]
5C9JX-ray2.40A24-203[»]
6C09X-ray2.95A19-297[»]
6C15X-ray3.21A19-297[»]
ProteinModelPortaliP29017
SMRiP29017
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29017, 2 interactors
STRINGi9606.ENSP00000357152

PTM databases

iPTMnetiP29017
PhosphoSitePlusiP29017
SwissPalmiP29017

Polymorphism and mutation databases

BioMutaiCD1C
DMDMi143811371

Proteomic databases

MaxQBiP29017
PaxDbiP29017
PeptideAtlasiP29017
PRIDEiP29017
ProteomicsDBi54513

Protocols and materials databases

DNASUi911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368170; ENSP00000357152; ENSG00000158481
GeneIDi911
KEGGihsa:911
UCSCiuc001fru.4 human

Organism-specific databases

CTDi911
DisGeNETi911
EuPathDBiHostDB:ENSG00000158481.12
GeneCardsiCD1C
HGNCiHGNC:1636 CD1C
MIMi188340 gene
neXtProtiNX_P29017
OpenTargetsiENSG00000158481
PharmGKBiPA26195
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP29017
KOiK06448
OMAiILYWGHH
OrthoDBiEOG091G0H36
PhylomeDBiP29017
TreeFamiTF336723

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

ChiTaRSiCD1C human
EvolutionaryTraceiP29017
GenomeRNAii911
PROiPR:P29017
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158481 Expressed in 138 organ(s), highest expression level in thymus
CleanExiHS_CD1C
ExpressionAtlasiP29017 baseline and differential
GenevisibleiP29017 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD1C_HUMAN
AccessioniPrimary (citable) accession number: P29017
Secondary accession number(s): Q5TDJ7
, Q6IAS4, Q9UMM0, Q9UN96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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