UniProtKB - P29017 (CD1C_HUMAN)
Protein
T-cell surface glycoprotein CD1c
Gene
CD1C
Organism
Homo sapiens (Human)
Status
Functioni
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.4 Publications
Miscellaneous
During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.
GO - Molecular functioni
- endogenous lipid antigen binding Source: UniProtKB
- exogenous lipid antigen binding Source: UniProtKB
- glycolipid binding Source: UniProtKB
- lipopeptide binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
- positive regulation of T cell mediated cytotoxicity Source: GO_Central
- regulation of immune response Source: Reactome
- T cell activation involved in immune response Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Immunity |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P29017 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD1cAlternative name(s): CD_antigen: CD1c |
Gene namesi | Name:CD1C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158481.12 |
HGNCi | HGNC:1636, CD1C |
MIMi | 188340, gene |
neXtProti | NX_P29017 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Lysosome
- Lysosome 1 Publication
Endosome
- Endosome membrane 2 Publications; Single-pass type I membrane protein
Note: Subject to intracellular trafficking between the cell membrane and endosomes.2 Publications
Endosome
- endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 302 | ExtracellularSequence analysisAdd BLAST | 285 | |
Transmembranei | 303 – 323 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 324 – 333 | CytoplasmicSequence analysis | 10 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 911 |
OpenTargetsi | ENSG00000158481 |
PharmGKBi | PA26195 |
Miscellaneous databases
Pharosi | P29017, Tbio |
Polymorphism and mutation databases
BioMutai | CD1C |
DMDMi | 143811371 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000014580 | 18 – 333 | T-cell surface glycoprotein CD1cAdd BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 75 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 120 ↔ 185 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 225 ↔ 280 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P29017 |
MassIVEi | P29017 |
MaxQBi | P29017 |
PaxDbi | P29017 |
PeptideAtlasi | P29017 |
PRIDEi | P29017 |
ProteomicsDBi | 54513 |
PTM databases
GlyGeni | P29017, 5 sites |
iPTMneti | P29017 |
PhosphoSitePlusi | P29017 |
SwissPalmi | P29017 |
Expressioni
Tissue specificityi
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Gene expression databases
Bgeei | ENSG00000158481, Expressed in thymus and 155 other tissues |
ExpressionAtlasi | P29017, baseline and differential |
Genevisiblei | P29017, HS |
Organism-specific databases
HPAi | ENSG00000158481, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Heterodimer with B2M (beta-2-microglobulin).
1 PublicationProtein-protein interaction databases
IntActi | P29017, 2 interactors |
STRINGi | 9606.ENSP00000357152 |
Miscellaneous databases
RNActi | P29017, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P29017 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29017 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 206 – 296 | Ig-likeAdd BLAST | 91 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 329 – 332 | Internalization signal | 4 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
GeneTreei | ENSGT01010000222442 |
HOGENOMi | CLU_047501_9_2_1 |
InParanoidi | P29017 |
OMAi | FVNQSWA |
OrthoDBi | 827472at2759 |
PhylomeDBi | P29017 |
TreeFami | TF336723 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P29017-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL
60 70 80 90 100
DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ
110 120 130 140 150
DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV
160 170 180 190 200
PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV
210 220 230 240 250
HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK
260 270 280 290 300
HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF
310 320 330
SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y6Y6 | H0Y6Y6_HUMAN | T-cell surface glycoprotein CD1c | CD1C | 281 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 290 | Q → R in CAG33361 (Ref. 3) Curated | 1 | |
Sequence conflicti | 327 – 333 | CSYQDIL → W in AAA51942 (PubMed:2447586).Curated | 7 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031564 | 70 | N → T. Corresponds to variant dbSNP:rs3138100Ensembl. | 1 | |
Natural variantiVAR_031565 | 300 | F → S1 PublicationCorresponds to variant dbSNP:rs3138105EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22178 , M22174, M22175, M22176, M22177 Genomic DNA Translation: AAA51942.1 M28827 mRNA Translation: AAA51941.1 CR457080 mRNA Translation: CAG33361.1 AL121986 Genomic DNA No translation available. BC126465 mRNA Translation: AAI26466.1 BC126467 mRNA Translation: AAI26468.1 AF142667 Genomic DNA Translation: AAD37580.1 M14667 Genomic DNA Translation: AAA51938.1 |
CCDSi | CCDS1175.1 |
PIRi | C45801, HLHUCC |
RefSeqi | NP_001756.2, NM_001765.2 |
Genome annotation databases
Ensembli | ENST00000368170; ENSP00000357152; ENSG00000158481 |
GeneIDi | 911 |
KEGGi | hsa:911 |
UCSCi | uc001fru.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22178 , M22174, M22175, M22176, M22177 Genomic DNA Translation: AAA51942.1 M28827 mRNA Translation: AAA51941.1 CR457080 mRNA Translation: CAG33361.1 AL121986 Genomic DNA No translation available. BC126465 mRNA Translation: AAI26466.1 BC126467 mRNA Translation: AAI26468.1 AF142667 Genomic DNA Translation: AAD37580.1 M14667 Genomic DNA Translation: AAA51938.1 |
CCDSi | CCDS1175.1 |
PIRi | C45801, HLHUCC |
RefSeqi | NP_001756.2, NM_001765.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3OV6 | X-ray | 2.50 | A | 19-201 | [»] | |
4ONO | X-ray | 2.70 | A | 24-201 | [»] | |
5C9J | X-ray | 2.40 | A | 24-203 | [»] | |
6C09 | X-ray | 2.95 | A | 19-297 | [»] | |
6C15 | X-ray | 3.21 | A | 19-297 | [»] | |
SMRi | P29017 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P29017, 2 interactors |
STRINGi | 9606.ENSP00000357152 |
PTM databases
GlyGeni | P29017, 5 sites |
iPTMneti | P29017 |
PhosphoSitePlusi | P29017 |
SwissPalmi | P29017 |
Polymorphism and mutation databases
BioMutai | CD1C |
DMDMi | 143811371 |
Proteomic databases
jPOSTi | P29017 |
MassIVEi | P29017 |
MaxQBi | P29017 |
PaxDbi | P29017 |
PeptideAtlasi | P29017 |
PRIDEi | P29017 |
ProteomicsDBi | 54513 |
Protocols and materials databases
Antibodypediai | 20454, 684 antibodies |
DNASUi | 911 |
Genome annotation databases
Ensembli | ENST00000368170; ENSP00000357152; ENSG00000158481 |
GeneIDi | 911 |
KEGGi | hsa:911 |
UCSCi | uc001fru.4, human |
Organism-specific databases
CTDi | 911 |
DisGeNETi | 911 |
EuPathDBi | HostDB:ENSG00000158481.12 |
GeneCardsi | CD1C |
HGNCi | HGNC:1636, CD1C |
HPAi | ENSG00000158481, Group enriched (blood, lymphoid tissue) |
MIMi | 188340, gene |
neXtProti | NX_P29017 |
OpenTargetsi | ENSG00000158481 |
PharmGKBi | PA26195 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
GeneTreei | ENSGT01010000222442 |
HOGENOMi | CLU_047501_9_2_1 |
InParanoidi | P29017 |
OMAi | FVNQSWA |
OrthoDBi | 827472at2759 |
PhylomeDBi | P29017 |
TreeFami | TF336723 |
Enzyme and pathway databases
PathwayCommonsi | P29017 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 911, 3 hits in 839 CRISPR screens |
ChiTaRSi | CD1C, human |
EvolutionaryTracei | P29017 |
GenomeRNAii | 911 |
Pharosi | P29017, Tbio |
PROi | PR:P29017 |
RNActi | P29017, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158481, Expressed in thymus and 155 other tissues |
ExpressionAtlasi | P29017, baseline and differential |
Genevisiblei | P29017, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD1C_HUMAN | |
Accessioni | P29017Primary (citable) accession number: P29017 Secondary accession number(s): Q5TDJ7 Q9UN96 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries