CD1B

Functionⁱ

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.2 Publications

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.

GO - Molecular functionⁱ

endogenous lipid antigen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
exogenous lipid antigen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipopeptide binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: UniProtKB-KW
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of T cell mediated cytotoxicity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell surface glycoprotein CD1b Alternative name(s): CD_antigen: CD1b
Gene namesⁱ	Name:CD1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158485.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1635 CD1B
MIMⁱ	188360 gene
neXtProtⁱ	NX_P29016

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	18 – 303	ExtracellularSequence analysisAdd BLAST	286
Transmembraneⁱ	304 – 324	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	325 – 333	CytoplasmicSequence analysis	9

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	329 – 330	YQ → AA: Strongly reduced internalization and trafficking to endosomes. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	910
Open Targets More...OpenTargetsⁱ	ENSG00000158485
PharmGKBⁱ	PA26194

Polymorphism and mutation databases

BioMutaⁱ	CD1B
DMDMⁱ	115962

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_0000014579	18 – 333	T-cell surface glycoprotein CD1bAdd BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	120 ↔ 184	Combined sources3 Publications
Glycosylationⁱ	146	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	149 ↔ 163	Combined sources3 Publications
Disulfide bondⁱ	224 ↔ 279	Combined sources3 Publications
Glycosylationⁱ	258	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P29016
PaxDbⁱ	P29016
PeptideAtlas More...PeptideAtlasⁱ	P29016
PRIDEⁱ	P29016
ProteomicsDBⁱ	54511 54512 [P29016-2]

PTM databases

iPTMnetⁱ	P29016
PhosphoSitePlusⁱ	P29016

Expressionⁱ

Tissue specificityⁱ

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

Bgeeⁱ	ENSG00000158485 Expressed in 35 organ(s), highest expression level in thymus
CleanExⁱ	HS_CD1B
ExpressionAtlasⁱ	P29016 baseline and differential
Genevisibleⁱ	P29016 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021824

HPAⁱ

HPA021824

Interactionⁱ

Subunit structureⁱ

Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
B2M	P61769	3	EBI-1033762,EBI-714718

With

Entry

#Exp.

IntAct

Notes

B2M

P61769

3

EBI-1033762,EBI-714718

Protein-protein interaction databases

BioGridⁱ	107348, 54 interactors
IntActⁱ	P29016, 1 interactor
Molecular INTeraction database More...MINTⁱ	P29016
STRINGⁱ	9606.ENSP00000357150

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 38	Combined sources	12
Beta strandⁱ	41 – 50	Combined sources	10
Beta strandⁱ	53 – 59	Combined sources	7
Turnⁱ	60 – 63	Combined sources	4
Beta strandⁱ	64 – 67	Combined sources	4
Turnⁱ	70 – 75	Combined sources	6
Helixⁱ	78 – 102	Combined sources	25
Turnⁱ	103 – 107	Combined sources	5
Beta strandⁱ	110 – 122	Combined sources	13
Beta strandⁱ	128 – 136	Combined sources	9
Beta strandⁱ	139 – 145	Combined sources	7
Beta strandⁱ	148 – 151	Combined sources	4
Helixⁱ	153 – 155	Combined sources	3
Helixⁱ	156 – 166	Combined sources	11
Helixⁱ	172 – 181	Combined sources	10
Helixⁱ	183 – 194	Combined sources	12
Helixⁱ	196 – 199	Combined sources	4
Beta strandⁱ	206 – 211	Combined sources	6
Beta strandⁱ	219 – 232	Combined sources	14
Beta strandⁱ	235 – 240	Combined sources	6
Beta strandⁱ	254 – 256	Combined sources	3
Turnⁱ	257 – 259	Combined sources	3
Beta strandⁱ	260 – 270	Combined sources	11
Helixⁱ	271 – 273	Combined sources	3
Beta strandⁱ	277 – 282	Combined sources	6
Helixⁱ	284 – 286	Combined sources	3
Beta strandⁱ	291 – 294	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P29016
SMRⁱ	P29016
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P29016

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	185 – 295	Ig-likeAdd BLAST		111

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	329 – 332	Internalization signal		4

Keywords - Domainⁱ

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410JACG Eukaryota ENOG41113WA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00480000042665
HOGENOMⁱ	HOG000111666
HOVERGENⁱ	HBG004453
InParanoidⁱ	P29016
KEGG Orthology (KO) More...KOⁱ	K06448
OMAⁱ	NWTWYLR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H36
PhylomeDBⁱ	P29016
TreeFamⁱ	TF336723

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF16497 MHC_I_3, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P29016-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL 
        60         70         80         90        100
DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ 
       110        120        130        140        150
DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV 
       160        170        180        190        200
PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ 
       210        220        230        240        250
RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL 
       260        270        280        290        300
GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS 
       310        320        330 
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP

Length:333

Mass (Da):36,939

Last modified:December 1, 1992 - v1

Checksum:ⁱ7D02B670D4DE8CC7

GO

Isoform 2 (identifier: P29016-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
242-296: Missing.

« Hide

        10         20         30         40         50
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL 
        60         70         80         90        100
DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ 
       110        120        130        140        150
DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV 
       160        170        180        190        200
PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ 
       210        220        230        240        250
RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GNPTSIGSIV 
       260        270 
LAIIVPSLLL LLCLALWYMR RRSYQNIP

Show »

Length:278

Mass (Da):30,740

Checksum:ⁱ087FD5FF65921339

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7C0I2	H7C0I2_HUMAN		T-cell surface glycoprotein CD1b T-cell surface glycoprotein CD1b	CD1B	246	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016911	242 – 296	Missing in isoform 2. CuratedAdd BLAST		55

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22173 M22172 Genomic DNA Translation: AAA51940.1 M28826 mRNA Translation: AAA51939.1 AL121986 Genomic DNA No translation available. BC069481 mRNA Translation: AAH69481.1 BC074747 mRNA Translation: AAH74747.1 BC104216 mRNA Translation: AAI04217.1 BC104217 mRNA Translation: AAI04218.1 M14665 Genomic DNA Translation: AAA51936.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1176.1 [P29016-1]
PIRⁱ	B39957 HLHUCB
NCBI Reference Sequences More...RefSeqⁱ	NP_001755.1, NM_001764.2 [P29016-1] XP_011508421.1, XM_011510119.2 [P29016-2]
UniGeneⁱ	Hs.1310

Genome annotation databases

Ensemblⁱ	ENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1]
GeneIDⁱ	910
KEGGⁱ	hsa:910
UCSC genome browser More...UCSCⁱ	uc001frx.4 human [P29016-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P29016	cDNA FLJ58995, highly similar to T-cell surface glycoprotein CD1b		HUMAN		327	UniRef100_P29016
Thymocyte antigen CD1b (Fragment)		HUMAN		91

Protein	Similar proteins		Species	Score	Length	Source
P29016	T-cell surface glycoprotein CD1b		AOTNA		333	UniRef90_P29016
cDNA FLJ58995, highly similar to T-cell surface glycoprotein CD1b		HUMAN		327
CD1b		MACMU		333
Uncharacterized protein		MACFA		333
Uncharacterized protein		COLAP		333
+19
P29016-2	T-cell surface glycoprotein CD1b (Fragment)		HUMAN		246	UniRef90_P29016-2
CD1B isoform 1 (Fragment)		PANTR		245
CD1B isoform 1 (Fragment)		PONAB		245
UPI0000E1ED03		PANTR		278

Protein	Similar proteins		Species	Score	Length	Source
P29016	T-cell surface glycoprotein CD1b		AOTNA		333	UniRef50_P29016
cDNA FLJ58995, highly similar to T-cell surface glycoprotein CD1b		HUMAN		327
Uncharacterized protein		CERAT		333
Uncharacterized protein		MANLE		333
Uncharacterized protein		MACFA		333
+33
P29016-2	T-cell surface glycoprotein CD1b (Fragment)		HUMAN		246	UniRef50_P29016-2
CD1B isoform 1 (Fragment)		PANTR		245
CD1B isoform 1 (Fragment)		PONAB		245
T-cell surface glycoprotein CD1b		MYOBR		344
T-cell surface glycoprotein CD1b-1 isoform X2		Florida manatee		277
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22173 M22172 Genomic DNA Translation: AAA51940.1 M28826 mRNA Translation: AAA51939.1 AL121986 Genomic DNA No translation available. BC069481 mRNA Translation: AAH69481.1 BC074747 mRNA Translation: AAH74747.1 BC104216 mRNA Translation: AAI04217.1 BC104217 mRNA Translation: AAI04218.1 M14665 Genomic DNA Translation: AAA51936.1
CCDSⁱ	CCDS1176.1 [P29016-1]
PIRⁱ	B39957 HLHUCB
RefSeqⁱ	NP_001755.1, NM_001764.2 [P29016-1] XP_011508421.1, XM_011510119.2 [P29016-2]
UniGeneⁱ	Hs.1310

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GZP	X-ray	2.80	A	18-295	[»]
	1GZQ	X-ray	2.26	A	18-295	[»]
	1UQS	X-ray	3.10	A	18-295	[»]
	2H26	X-ray	1.80	A	19-298	[»]
	3OV6	X-ray	2.50	A	166-295	[»]
	3T8X	X-ray	1.90	A/C	19-298	[»]
	4ONO	X-ray	2.70	A	201-295	[»]
	5C9J	X-ray	2.40	A	203-295	[»]
	5L2J	X-ray	1.65	A	20-296	[»]
	5L2K	X-ray	3.20	A	20-296	[»]
	5WKE	X-ray	1.69	A	20-296	[»]
	5WKG	X-ray	2.06	A	20-296	[»]
	5WKI	X-ray	2.75	A	20-296	[»]
	5WL1	X-ray	1.38	A	20-296	[»]
ProteinModelPortalⁱ	P29016
SMRⁱ	P29016
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107348, 54 interactors
IntActⁱ	P29016, 1 interactor
MINTⁱ	P29016
STRINGⁱ	9606.ENSP00000357150

PTM databases

iPTMnetⁱ	P29016
PhosphoSitePlusⁱ	P29016

Polymorphism and mutation databases

BioMutaⁱ	CD1B
DMDMⁱ	115962

Proteomic databases

MaxQBⁱ	P29016
PaxDbⁱ	P29016
PeptideAtlasⁱ	P29016
PRIDEⁱ	P29016
ProteomicsDBⁱ	54511 54512 [P29016-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	910
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1]
GeneIDⁱ	910
KEGGⁱ	hsa:910
UCSCⁱ	uc001frx.4 human [P29016-1]

Organism-specific databases

CTDⁱ	910
DisGeNETⁱ	910
EuPathDBⁱ	HostDB:ENSG00000158485.10
GeneCardsⁱ	CD1B
HGNCⁱ	HGNC:1635 CD1B
HPAⁱ	HPA021824
MIMⁱ	188360 gene
neXtProtⁱ	NX_P29016
OpenTargetsⁱ	ENSG00000158485
PharmGKBⁱ	PA26194
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410JACG Eukaryota ENOG41113WA LUCA
GeneTreeⁱ	ENSGT00480000042665
HOGENOMⁱ	HOG000111666
HOVERGENⁱ	HBG004453
InParanoidⁱ	P29016
KOⁱ	K06448
OMAⁱ	NWTWYLR
OrthoDBⁱ	EOG091G0H36
PhylomeDBⁱ	P29016
TreeFamⁱ	TF336723

Enzyme and pathway databases

Reactomeⁱ	R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Reactomeⁱ

R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

EvolutionaryTraceⁱ	P29016
GenomeRNAiⁱ	910
Protein Ontology More...PROⁱ	PR:P29016
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000158485 Expressed in 35 organ(s), highest expression level in thymus
CleanExⁱ	HS_CD1B
ExpressionAtlasⁱ	P29016 baseline and differential
Genevisibleⁱ	P29016 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF16497 MHC_I_3, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD1B_HUMAN
Accessionⁱ	P29016Primary (citable) accession number: P29016 Secondary accession number(s): Q5TDK9, Q5TDL0, Q9UMM2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P29016 (CD1B_HUMAN)

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T-cell surface glycoprotein CD1b

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endosome

Plasma membrane

Endosome

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ