UniProtKB - P29016 (CD1B_HUMAN)
Protein
T-cell surface glycoprotein CD1b
Gene
CD1B
Organism
Homo sapiens (Human)
Status
Functioni
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.2 Publications
Miscellaneous
During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.
GO - Molecular functioni
- endogenous lipid antigen binding Source: GO_Central
- exogenous lipid antigen binding Source: GO_Central
- lipopeptide binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
- antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
- positive regulation of T cell mediated cytotoxicity Source: GO_Central
- regulation of immune response Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P29016 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD1bAlternative name(s): CD_antigen: CD1b |
Gene namesi | Name:CD1B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158485.10 |
HGNCi | HGNC:1635, CD1B |
MIMi | 188360, gene |
neXtProti | NX_P29016 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein Sequence analysis
Lysosome
- Lysosome membrane 3 Publications; Single-pass type I membrane protein Sequence analysis
Endosome
- Endosome membrane 2 Publications; Single-pass type I membrane protein Sequence analysis
Note: Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.3 Publications
Endosome
- endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 303 | ExtracellularSequence analysisAdd BLAST | 286 | |
Transmembranei | 304 – 324 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 325 – 333 | CytoplasmicSequence analysis | 9 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 329 – 330 | YQ → AA: Strongly reduced internalization and trafficking to endosomes. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 910 |
OpenTargetsi | ENSG00000158485 |
PharmGKBi | PA26194 |
Miscellaneous databases
Pharosi | P29016, Tbio |
Polymorphism and mutation databases
BioMutai | CD1B |
DMDMi | 115962 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000014579 | 18 – 333 | T-cell surface glycoprotein CD1bAdd BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 75 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 120 ↔ 184 | Combined sources3 Publications | ||
Glycosylationi | 146 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 149 ↔ 163 | Combined sources3 Publications | ||
Disulfide bondi | 224 ↔ 279 | Combined sources3 Publications | ||
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P29016 |
MaxQBi | P29016 |
PaxDbi | P29016 |
PeptideAtlasi | P29016 |
PRIDEi | P29016 |
ProteomicsDBi | 54511 [P29016-1] 54512 [P29016-2] |
PTM databases
GlyGeni | P29016, 4 sites |
iPTMneti | P29016 |
PhosphoSitePlusi | P29016 |
Expressioni
Tissue specificityi
Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Gene expression databases
Bgeei | ENSG00000158485, Expressed in thymus and 70 other tissues |
ExpressionAtlasi | P29016, baseline and differential |
Genevisiblei | P29016, HS |
Organism-specific databases
HPAi | ENSG00000158485, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Heterodimer with B2M (beta-2-microglobulin).
Interacts with saposin C.
3 PublicationsBinary interactionsi
P29016
With | #Exp. | IntAct |
---|---|---|
B2M [P61769] | 4 | EBI-1033762,EBI-714718 |
Protein-protein interaction databases
BioGRIDi | 107348, 54 interactors |
IntActi | P29016, 34 interactors |
MINTi | P29016 |
STRINGi | 9606.ENSP00000357150 |
Miscellaneous databases
RNActi | P29016, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P29016 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P29016 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 185 – 295 | Ig-likeAdd BLAST | 111 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 329 – 332 | Internalization signal | 4 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
GeneTreei | ENSGT01010000222442 |
HOGENOMi | CLU_047501_9_2_1 |
InParanoidi | P29016 |
OMAi | FAGDFQI |
OrthoDBi | 827472at2759 |
PhylomeDBi | P29016 |
TreeFami | TF336723 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P29016-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL
60 70 80 90 100
DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ
110 120 130 140 150
DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV
160 170 180 190 200
PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ
210 220 230 240 250
RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL
260 270 280 290 300
GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS
310 320 330
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C0I2 | H7C0I2_HUMAN | T-cell surface glycoprotein CD1b | CD1B | 246 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016911 | 242 – 296 | Missing in isoform 2. CuratedAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22173 , M22168, M22169, M22170, M22171, M22172 Genomic DNA Translation: AAA51940.1 M28826 mRNA Translation: AAA51939.1 AL121986 Genomic DNA No translation available. BC069481 mRNA Translation: AAH69481.1 BC074747 mRNA Translation: AAH74747.1 BC104216 mRNA Translation: AAI04217.1 BC104217 mRNA Translation: AAI04218.1 M14665 Genomic DNA Translation: AAA51936.1 |
CCDSi | CCDS1176.1 [P29016-1] |
PIRi | B39957, HLHUCB |
RefSeqi | NP_001755.1, NM_001764.2 [P29016-1] XP_011508421.1, XM_011510119.2 [P29016-2] |
Genome annotation databases
Ensembli | ENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1] |
GeneIDi | 910 |
KEGGi | hsa:910 |
UCSCi | uc001frx.4, human [P29016-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22173 , M22168, M22169, M22170, M22171, M22172 Genomic DNA Translation: AAA51940.1 M28826 mRNA Translation: AAA51939.1 AL121986 Genomic DNA No translation available. BC069481 mRNA Translation: AAH69481.1 BC074747 mRNA Translation: AAH74747.1 BC104216 mRNA Translation: AAI04217.1 BC104217 mRNA Translation: AAI04218.1 M14665 Genomic DNA Translation: AAA51936.1 |
CCDSi | CCDS1176.1 [P29016-1] |
PIRi | B39957, HLHUCB |
RefSeqi | NP_001755.1, NM_001764.2 [P29016-1] XP_011508421.1, XM_011510119.2 [P29016-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GZP | X-ray | 2.80 | A | 18-295 | [»] | |
1GZQ | X-ray | 2.26 | A | 18-295 | [»] | |
1UQS | X-ray | 3.10 | A | 18-295 | [»] | |
2H26 | X-ray | 1.80 | A | 19-298 | [»] | |
3OV6 | X-ray | 2.50 | A | 166-295 | [»] | |
3T8X | X-ray | 1.90 | A/C | 19-298 | [»] | |
4ONO | X-ray | 2.70 | A | 201-295 | [»] | |
5C9J | X-ray | 2.40 | A | 203-295 | [»] | |
5L2J | X-ray | 1.65 | A | 20-296 | [»] | |
5L2K | X-ray | 3.20 | A | 20-296 | [»] | |
5WKE | X-ray | 1.69 | A | 20-296 | [»] | |
5WKG | X-ray | 2.06 | A | 20-296 | [»] | |
5WKI | X-ray | 2.75 | A | 20-296 | [»] | |
5WL1 | X-ray | 1.38 | A | 20-296 | [»] | |
6CUG | X-ray | 2.40 | A | 20-296 | [»] | |
6D64 | X-ray | 1.70 | A | 20-296 | [»] | |
SMRi | P29016 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107348, 54 interactors |
IntActi | P29016, 34 interactors |
MINTi | P29016 |
STRINGi | 9606.ENSP00000357150 |
PTM databases
GlyGeni | P29016, 4 sites |
iPTMneti | P29016 |
PhosphoSitePlusi | P29016 |
Polymorphism and mutation databases
BioMutai | CD1B |
DMDMi | 115962 |
Proteomic databases
MassIVEi | P29016 |
MaxQBi | P29016 |
PaxDbi | P29016 |
PeptideAtlasi | P29016 |
PRIDEi | P29016 |
ProteomicsDBi | 54511 [P29016-1] 54512 [P29016-2] |
Protocols and materials databases
ABCDi | P29016, 1 sequenced antibody |
Antibodypediai | 20455, 661 antibodies |
DNASUi | 910 |
Genome annotation databases
Ensembli | ENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1] |
GeneIDi | 910 |
KEGGi | hsa:910 |
UCSCi | uc001frx.4, human [P29016-1] |
Organism-specific databases
CTDi | 910 |
DisGeNETi | 910 |
EuPathDBi | HostDB:ENSG00000158485.10 |
GeneCardsi | CD1B |
HGNCi | HGNC:1635, CD1B |
HPAi | ENSG00000158485, Tissue enriched (lymphoid) |
MIMi | 188360, gene |
neXtProti | NX_P29016 |
OpenTargetsi | ENSG00000158485 |
PharmGKBi | PA26194 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SJH6, Eukaryota |
GeneTreei | ENSGT01010000222442 |
HOGENOMi | CLU_047501_9_2_1 |
InParanoidi | P29016 |
OMAi | FAGDFQI |
OrthoDBi | 827472at2759 |
PhylomeDBi | P29016 |
TreeFami | TF336723 |
Enzyme and pathway databases
PathwayCommonsi | P29016 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Miscellaneous databases
BioGRID-ORCSi | 910, 2 hits in 845 CRISPR screens |
EvolutionaryTracei | P29016 |
GenomeRNAii | 910 |
Pharosi | P29016, Tbio |
PROi | PR:P29016 |
RNActi | P29016, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158485, Expressed in thymus and 70 other tissues |
ExpressionAtlasi | P29016, baseline and differential |
Genevisiblei | P29016, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF16497, MHC_I_3, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD1B_HUMAN | |
Accessioni | P29016Primary (citable) accession number: P29016 Secondary accession number(s): Q5TDK9, Q5TDL0, Q9UMM2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries