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Protein

T-cell surface glycoprotein CD1b

Gene

CD1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.2 Publications

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.

GO - Molecular functioni

  • endogenous lipid antigen binding Source: GO_Central
  • exogenous lipid antigen binding Source: GO_Central
  • lipopeptide binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1b
Alternative name(s):
CD_antigen: CD1b
Gene namesi
Name:CD1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158485.10
HGNCiHGNC:1635 CD1B
MIMi188360 gene
neXtProtiNX_P29016

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 303ExtracellularSequence analysisAdd BLAST286
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 333CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi329 – 330YQ → AA: Strongly reduced internalization and trafficking to endosomes. 1 Publication2

Organism-specific databases

DisGeNETi910
OpenTargetsiENSG00000158485
PharmGKBiPA26194

Polymorphism and mutation databases

BioMutaiCD1B
DMDMi115962

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001457918 – 333T-cell surface glycoprotein CD1bAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi75N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi120 ↔ 184Combined sources3 Publications
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 163Combined sources3 Publications
Disulfide bondi224 ↔ 279Combined sources3 Publications
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP29016
PaxDbiP29016
PeptideAtlasiP29016
PRIDEiP29016
ProteomicsDBi54511
54512 [P29016-2]

PTM databases

iPTMnetiP29016
PhosphoSitePlusiP29016

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Gene expression databases

BgeeiENSG00000158485 Expressed in 35 organ(s), highest expression level in thymus
CleanExiHS_CD1B
ExpressionAtlasiP29016 baseline and differential
GenevisibleiP29016 HS

Organism-specific databases

HPAiHPA021824

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2MP617693EBI-1033762,EBI-714718

Protein-protein interaction databases

BioGridi107348, 54 interactors
IntActiP29016, 1 interactor
MINTiP29016
STRINGi9606.ENSP00000357150

Structurei

Secondary structure

1333
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP29016
SMRiP29016
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29016

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 295Ig-likeAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi329 – 332Internalization signal4

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP29016
KOiK06448
OMAiNWTWYLR
OrthoDBiEOG091G0H36
PhylomeDBiP29016
TreeFamiTF336723

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P29016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL
60 70 80 90 100
DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ
110 120 130 140 150
DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV
160 170 180 190 200
PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ
210 220 230 240 250
RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL
260 270 280 290 300
GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS
310 320 330
IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP
Length:333
Mass (Da):36,939
Last modified:December 1, 1992 - v1
Checksum:i7D02B670D4DE8CC7
GO
Isoform 2 (identifier: P29016-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-296: Missing.

Show »
Length:278
Mass (Da):30,740
Checksum:i087FD5FF65921339
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0I2H7C0I2_HUMAN
T-cell surface glycoprotein CD1b
CD1B
246Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016911242 – 296Missing in isoform 2. CuratedAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22173
, M22168, M22169, M22170, M22171, M22172 Genomic DNA Translation: AAA51940.1
M28826 mRNA Translation: AAA51939.1
AL121986 Genomic DNA No translation available.
BC069481 mRNA Translation: AAH69481.1
BC074747 mRNA Translation: AAH74747.1
BC104216 mRNA Translation: AAI04217.1
BC104217 mRNA Translation: AAI04218.1
M14665 Genomic DNA Translation: AAA51936.1
CCDSiCCDS1176.1 [P29016-1]
PIRiB39957 HLHUCB
RefSeqiNP_001755.1, NM_001764.2 [P29016-1]
XP_011508421.1, XM_011510119.2 [P29016-2]
UniGeneiHs.1310

Genome annotation databases

EnsembliENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1]
GeneIDi910
KEGGihsa:910
UCSCiuc001frx.4 human [P29016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22173
, M22168, M22169, M22170, M22171, M22172 Genomic DNA Translation: AAA51940.1
M28826 mRNA Translation: AAA51939.1
AL121986 Genomic DNA No translation available.
BC069481 mRNA Translation: AAH69481.1
BC074747 mRNA Translation: AAH74747.1
BC104216 mRNA Translation: AAI04217.1
BC104217 mRNA Translation: AAI04218.1
M14665 Genomic DNA Translation: AAA51936.1
CCDSiCCDS1176.1 [P29016-1]
PIRiB39957 HLHUCB
RefSeqiNP_001755.1, NM_001764.2 [P29016-1]
XP_011508421.1, XM_011510119.2 [P29016-2]
UniGeneiHs.1310

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GZPX-ray2.80A18-295[»]
1GZQX-ray2.26A18-295[»]
1UQSX-ray3.10A18-295[»]
2H26X-ray1.80A19-298[»]
3OV6X-ray2.50A166-295[»]
3T8XX-ray1.90A/C19-298[»]
4ONOX-ray2.70A201-295[»]
5C9JX-ray2.40A203-295[»]
5L2JX-ray1.65A20-296[»]
5L2KX-ray3.20A20-296[»]
5WKEX-ray1.69A20-296[»]
5WKGX-ray2.06A20-296[»]
5WKIX-ray2.75A20-296[»]
5WL1X-ray1.38A20-296[»]
ProteinModelPortaliP29016
SMRiP29016
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107348, 54 interactors
IntActiP29016, 1 interactor
MINTiP29016
STRINGi9606.ENSP00000357150

PTM databases

iPTMnetiP29016
PhosphoSitePlusiP29016

Polymorphism and mutation databases

BioMutaiCD1B
DMDMi115962

Proteomic databases

MaxQBiP29016
PaxDbiP29016
PeptideAtlasiP29016
PRIDEiP29016
ProteomicsDBi54511
54512 [P29016-2]

Protocols and materials databases

DNASUi910
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368168; ENSP00000357150; ENSG00000158485 [P29016-1]
GeneIDi910
KEGGihsa:910
UCSCiuc001frx.4 human [P29016-1]

Organism-specific databases

CTDi910
DisGeNETi910
EuPathDBiHostDB:ENSG00000158485.10
GeneCardsiCD1B
HGNCiHGNC:1635 CD1B
HPAiHPA021824
MIMi188360 gene
neXtProtiNX_P29016
OpenTargetsiENSG00000158485
PharmGKBiPA26194
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP29016
KOiK06448
OMAiNWTWYLR
OrthoDBiEOG091G0H36
PhylomeDBiP29016
TreeFamiTF336723

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

EvolutionaryTraceiP29016
GenomeRNAii910
PROiPR:P29016
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158485 Expressed in 35 organ(s), highest expression level in thymus
CleanExiHS_CD1B
ExpressionAtlasiP29016 baseline and differential
GenevisibleiP29016 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD1B_HUMAN
AccessioniPrimary (citable) accession number: P29016
Secondary accession number(s): Q5TDK9, Q5TDL0, Q9UMM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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