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UniProtKB - P28908 (TNR8_HUMAN)

Entry version 205 (07 Apr 2021)
Sequence version 1 (01 Dec 1992)
Previous versions | rss
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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

TNFRSF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).2 Publications

Miscellaneous

Most specific Hodgkin disease associated antigen.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P28908

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5669034, TNFs bind their physiological receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P28908

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 8Imported
Alternative name(s):
CD30L receptor
Ki-1 antigen
Lymphocyte activation antigen CD30
CD_antigen: CD301 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF8Imported
Synonyms:CD301 Publication, D1S166E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11923, TNFRSF8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		153243, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P28908

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000120949.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 385ExtracellularCuratedAdd BLAST367
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 595CytoplasmicCuratedAdd BLAST189

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		943

Open Targets

More...OpenTargetsi		ENSG00000120949

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36616

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P28908, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2364161

Drug and drug target database

More...DrugBanki		DB08870, Brentuximab vedotin
DB06324, XmAb 2513

DrugCentral

More...DrugCentrali		P28908

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1877

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNFRSF8

Domain mapping of disease mutations (DMDM)

More...DMDMi		115978

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Add BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003457319 – 595Tumor necrosis factor receptor superfamily member 8Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 44PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi45 ↔ 58PROSITE-ProRule annotation
Disulfide bondi48 ↔ 65PROSITE-ProRule annotation
Disulfide bondi69 ↔ 81PROSITE-ProRule annotation
Disulfide bondi84 ↔ 98PROSITE-ProRule annotation
Disulfide bondi87 ↔ 106PROSITE-ProRule annotation
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi108 ↔ 122PROSITE-ProRule annotation
Disulfide bondi131 ↔ 149PROSITE-ProRule annotation
Disulfide bondi233 ↔ 240PROSITE-ProRule annotation
Disulfide bondi244 ↔ 256PROSITE-ProRule annotation
Disulfide bondi259 ↔ 273PROSITE-ProRule annotation
Disulfide bondi262 ↔ 281PROSITE-ProRule annotation
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi283 ↔ 297PROSITE-ProRule annotation
Disulfide bondi289 ↔ 300PROSITE-ProRule annotation
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei438PhosphoserineCombined sources1
Modified residuei452PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).Curated1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P28908

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P28908

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P28908

MaxQB - The MaxQuant DataBase

More...MaxQBi		P28908

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28908

PeptideAtlas

More...PeptideAtlasi		P28908

PRoteomics IDEntifications database

More...PRIDEi		P28908

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12802
54509 [P28908-1]
54510 [P28908-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P28908, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28908

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28908

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P28908

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in alveolar macrophages (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120949, Expressed in granulocyte and 105 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P28908, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28908, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000120949, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.

5 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107381, 30 interactors

Database of interacting proteins

More...DIPi		DIP-2930N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P28908

Protein interaction database and analysis system

More...IntActi		P28908, 23 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263932

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P28908, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28908

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P28908

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 66TNFR-Cys 1Add BLAST39
Repeati68 – 106TNFR-Cys 2Add BLAST39
Repeati107 – 150TNFR-Cys 3Add BLAST44
Repeati205 – 241TNFR-Cys 4Add BLAST37
Repeati243 – 281TNFR-Cys 5Add BLAST39
Repeati282 – 325TNFR-Cys 6Add BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi347 – 377Pro/Ser/Thr-richAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TNFR8 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SNQ9, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000049215

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_043282_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28908

Identification of Orthologs from Complete Genome Data

More...OMAi		VEKMPCA

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28908

TreeFam database of animal gene trees

More...TreeFami		TF331157

Family and domain databases

Conserved Domains Database

More...CDDi		cd13409, TNFRSF8, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR020416, TNFR_8
IPR034002, TNFRSF8_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00020, TNFR_c6, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01923, TNFACTORR8

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00208, TNFR, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00652, TNFR_NGFR_1, 2 hits
PS50050, TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P28908-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM 
        60         70         80         90        100
GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW 
       110        120        130        140        150
NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE 
       160        170        180        190        200
PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL 
       210        220        230        240        250
AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL 
       260        270        280        290        300
DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC 
       310        320        330        340        350
VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP 
       360        370        380        390        400
TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG 
       410        420        430        440        450
SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG 
       460        470        480        490        500
ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL 
       510        520        530        540        550
PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE 
       560        570        580        590 
ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK
Length:595
Mass (Da):63,747
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A407CC78A6E0BC8
GO
Isoform 2 (identifier: P28908-2) [UniParc]FASTAAdd to basket
Also known as: Cytoplasmic, Short, C30V

The sequence of this isoform differs from the canonical sequence as follows:
     1-463: Missing.

Show »
Length:132
Mass (Da):14,088
Checksum:i211648B504B6313F
GO
Isoform 3 (identifier: P28908-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     446-446: Missing.

Show »
Length:483
Mass (Da):50,935
Checksum:i8EA95A0BEA6BD315
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RAG8D6RAG8_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF8
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054213273C → F. Corresponds to variant dbSNP:rs2230624Ensembl.1
Natural variantiVAR_018753273C → Y1 PublicationCorresponds to variant dbSNP:rs2230624Ensembl.1
Natural variantiVAR_055257297C → R1 PublicationCorresponds to variant dbSNP:rs1763642Ensembl.1
Natural variantiVAR_055258314P → S. Corresponds to variant dbSNP:rs2275170Ensembl.1
Natural variantiVAR_018754402S → G1 PublicationCorresponds to variant dbSNP:rs2230625Ensembl.1
Natural variantiVAR_055259466Q → R. Corresponds to variant dbSNP:rs35511003Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189001 – 463Missing in isoform 2. 2 PublicationsAdd BLAST463
Alternative sequenceiVSP_0550321 – 111Missing in isoform 3. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_055033446Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M83554 mRNA Translation: AAA51947.1
S75768 mRNA Translation: AAD14188.1
D86042 mRNA Translation: BAA12973.1
AJ289159 Genomic DNA Translation: CAC16652.1
AY498860 Genomic DNA Translation: AAR32099.1
AL357835 Genomic DNA No translation available.
BC063482 mRNA Translation: AAH63482.2
BC136400 mRNA Translation: AAI36401.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS144.1 [P28908-1]
CCDS59989.1 [P28908-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A42086

NCBI Reference Sequences

More...RefSeqi		NP_001234.3, NM_001243.4 [P28908-1]
NP_001268359.2, NM_001281430.2 [P28908-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1]
ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2]
ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:943

UCSC genome browser

More...UCSCi		uc001atq.3, human [P28908-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83554 mRNA Translation: AAA51947.1
S75768 mRNA Translation: AAD14188.1
D86042 mRNA Translation: BAA12973.1
AJ289159 Genomic DNA Translation: CAC16652.1
AY498860 Genomic DNA Translation: AAR32099.1
AL357835 Genomic DNA No translation available.
BC063482 mRNA Translation: AAH63482.2
BC136400 mRNA Translation: AAI36401.1
CCDSiCCDS144.1 [P28908-1]
CCDS59989.1 [P28908-3]
PIRiA42086
RefSeqiNP_001234.3, NM_001243.4 [P28908-1]
NP_001268359.2, NM_001281430.2 [P28908-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D01X-ray2.00G/H/I576-583[»]
SMRiP28908
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107381, 30 interactors
DIPiDIP-2930N
ELMiP28908
IntActiP28908, 23 interactors
STRINGi9606.ENSP00000263932

Chemistry databases

ChEMBLiCHEMBL2364161
DrugBankiDB08870, Brentuximab vedotin
DB06324, XmAb 2513
DrugCentraliP28908
GuidetoPHARMACOLOGYi1877

PTM databases

GlyGeniP28908, 6 sites
iPTMnetiP28908
PhosphoSitePlusiP28908
SwissPalmiP28908

Genetic variation databases

BioMutaiTNFRSF8
DMDMi115978

Proteomic databases

EPDiP28908
jPOSTiP28908
MassIVEiP28908
MaxQBiP28908
PaxDbiP28908
PeptideAtlasiP28908
PRIDEiP28908
ProteomicsDBi12802
54509 [P28908-1]
54510 [P28908-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P28908, 20 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3659, 2255 antibodies

Genome annotation databases

EnsembliENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1]
ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2]
ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3]
GeneIDi943
KEGGihsa:943
UCSCiuc001atq.3, human [P28908-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		943
DisGeNETi943

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNFRSF8
HGNCiHGNC:11923, TNFRSF8
HPAiENSG00000120949, Tissue enhanced (blood)
MIMi153243, gene
neXtProtiNX_P28908
OpenTargetsiENSG00000120949
PharmGKBiPA36616
VEuPathDBiHostDB:ENSG00000120949.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SNQ9, Eukaryota
GeneTreeiENSGT00510000049215
HOGENOMiCLU_043282_0_0_1
InParanoidiP28908
OMAiVEKMPCA
PhylomeDBiP28908
TreeFamiTF331157

Enzyme and pathway databases

PathwayCommonsiP28908
ReactomeiR-HSA-5669034, TNFs bind their physiological receptors
SignaLinkiP28908

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		943, 17 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNFRSF8, human
EvolutionaryTraceiP28908

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD30

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		943
PharosiP28908, Tclin

Protein Ontology

More...PROi		PR:P28908
RNActiP28908, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120949, Expressed in granulocyte and 105 other tissues
ExpressionAtlasiP28908, baseline and differential
GenevisibleiP28908, HS

Family and domain databases

CDDicd13409, TNFRSF8, 2 hits
InterProiView protein in InterPro
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR020416, TNFR_8
IPR034002, TNFRSF8_N
PfamiView protein in Pfam
PF00020, TNFR_c6, 1 hit
PRINTSiPR01923, TNFACTORR8
SMARTiView protein in SMART
SM00208, TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652, TNFR_NGFR_1, 2 hits
PS50050, TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28908
Secondary accession number(s): B1AN79
, B9EGD9, D3YTD8, Q6P4D9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 7, 2021
This is version 205 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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