UniProtKB - P28908 (TNR8_HUMAN)

BLAST

>sp|P28908|TNR8_HUMAN Tumor necrosis factor receptor superfamily member 8 OS=Homo sapiens OX=9606 GN=TNFRSF8 PE=1 SV=1
MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ
RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN
SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT
PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC
RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC
VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA
SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL
HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL
ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL
AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

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History
Entry version 186 (12 Sep 2018)
Sequence version 1 (01 Dec 1992)
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Protein

Tumor necrosis factor receptor superfamily member 8

Gene

TNFRSF8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.

Miscellaneous

Most specific Hodgkin disease associated antigen.

GO - Molecular functionⁱ

nerve growth factor binding Source: GO_Central
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 1310894
tumor necrosis factor-activated receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway Source: GO_Central
axon guidance Source: GO_Central
cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
immune response Source: GO_Central
inflammatory response Source: GO_Central
negative regulation of cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10192335
negative regulation of neuron projection development Source: GO_Central
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16108830
positive regulation of TRAIL biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16108830
positive regulation of tumor necrosis factor biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16108830
response to lipopolysaccharide Source: GO_Central
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10192335
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	P28908

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 8Imported Alternative name(s): CD30L receptor Ki-1 antigen Lymphocyte activation antigen CD30 CD_antigen: CD301 Publication
Gene namesⁱ	Name:TNFRSF8Imported Synonyms:CD301 Publication, D1S166E
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120949.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11923 TNFRSF8
MIMⁱ	153243 gene
neXtProtⁱ	NX_P28908

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 379	ExtracellularSequence analysisAdd BLAST	361
Transmembraneⁱ	380 – 407	HelicalSequence analysisAdd BLAST	28
Topological domainⁱ	408 – 595	CytoplasmicSequence analysisAdd BLAST	188

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	943
Open Targets More...OpenTargetsⁱ	ENSG00000120949
PharmGKBⁱ	PA36616

Chemistry databases

ChEMBLⁱ	CHEMBL2364161
Drug and drug target database More...DrugBankⁱ	DB08870 Brentuximab vedotin

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF8
DMDMⁱ	115978

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Add BLAST		18
ChainⁱPRO_0000034573	19 – 595	Tumor necrosis factor receptor superfamily member 8Add BLAST		577

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 44	PROSITE-ProRule annotation
Disulfide bondⁱ	45 ↔ 58	PROSITE-ProRule annotation
Disulfide bondⁱ	48 ↔ 65	PROSITE-ProRule annotation
Disulfide bondⁱ	69 ↔ 81	PROSITE-ProRule annotation
Disulfide bondⁱ	84 ↔ 98	PROSITE-ProRule annotation
Disulfide bondⁱ	87 ↔ 106	PROSITE-ProRule annotation
Glycosylationⁱ	101	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	108 ↔ 122	PROSITE-ProRule annotation
Disulfide bondⁱ	131 ↔ 149	PROSITE-ProRule annotation
Disulfide bondⁱ	233 ↔ 240	PROSITE-ProRule annotation
Disulfide bondⁱ	244 ↔ 256	PROSITE-ProRule annotation
Disulfide bondⁱ	259 ↔ 273	PROSITE-ProRule annotation
Disulfide bondⁱ	262 ↔ 281	PROSITE-ProRule annotation
Glycosylationⁱ	276	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	283 ↔ 297	PROSITE-ProRule annotation
Disulfide bondⁱ	289 ↔ 300	PROSITE-ProRule annotation
Modified residueⁱ	438	PhosphoserineCombined sources	1
Modified residueⁱ	452	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on serine and tyrosine residues.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P28908
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28908
PaxDbⁱ	P28908
PeptideAtlas More...PeptideAtlasⁱ	P28908
PRIDEⁱ	P28908
ProteomicsDBⁱ	54509 54510 [P28908-2]

PTM databases

iPTMnetⁱ	P28908
PhosphoSitePlusⁱ	P28908
SwissPalmⁱ	P28908

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000120949 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TNFRSF8
ExpressionAtlasⁱ	P28908 baseline and differential
Genevisibleⁱ	P28908 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000016 HPA032081 HPA032082

HPAⁱ

CAB000016
HPA032081
HPA032082

Interactionⁱ

Subunit structureⁱ

Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.5 Publications

GO - Molecular functionⁱ

nerve growth factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107381, 30 interactors
Database of interacting proteins More...DIPⁱ	DIP-2930N
ELMⁱ	P28908
IntActⁱ	P28908, 3 interactors
STRINGⁱ	9606.ENSP00000263932

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28908
SMRⁱ	P28908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P28908

EvolutionaryTraceⁱ

P28908

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	28 – 66	TNFR-Cys 1Add BLAST	39
Repeatⁱ	68 – 106	TNFR-Cys 2Add BLAST	39
Repeatⁱ	107 – 150	TNFR-Cys 3Add BLAST	44
Repeatⁱ	205 – 241	TNFR-Cys 4Add BLAST	37
Repeatⁱ	243 – 281	TNFR-Cys 5Add BLAST	39
Repeatⁱ	282 – 325	TNFR-Cys 6Add BLAST	44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	347 – 377	Pro/Ser/Thr-richAdd BLAST		31

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZAX Eukaryota ENOG410YM0N LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049215
HOGENOMⁱ	HOG000220871
HOVERGENⁱ	HBG005054
InParanoidⁱ	P28908
KEGG Orthology (KO) More...KOⁱ	K05145
OMAⁱ	MFCATSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P28908
TreeFamⁱ	TF331157

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13409 TNFRSF8, 2 hits
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020416 TNFR_8 IPR034002 TNFRSF8_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01923 TNFACTORR8
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: P28908-1) [UniParc]FASTA Add to basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM 
        60         70         80         90        100
GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW 
       110        120        130        140        150
NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE 
       160        170        180        190        200
PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL 
       210        220        230        240        250
AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL 
       260        270        280        290        300
DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC 
       310        320        330        340        350
VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP 
       360        370        380        390        400
TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG 
       410        420        430        440        450
SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG 
       460        470        480        490        500
ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL 
       510        520        530        540        550
PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE 
       560        570        580        590 
ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK

Length:595

Mass (Da):63,747

Last modified:December 1, 1992 - v1

Checksum:ⁱ7A407CC78A6E0BC8

Isoform 2 (identifier: P28908-2) [UniParc]FASTA Add to basket

Also known as: Cytoplasmic, Short, C30V

The sequence of this isoform differs from the canonical sequence as follows:
1-463: Missing.

« Hide

        10         20         30         40         50
MSQPLMETCH SVGAAYLESL PLQDASPAGG PSSPRDLPEP RVSTEHTNNK 
        60         70         80         90        100
IEKIYIMKAD TVIVGTVKAE LPEGRGLAGP AEPELEEELE ADHTPHYPEQ 
       110        120        130 
ETEPPLGSCS DVMLSVEEEG KEDPLPTAAS GK

Show »

Length:132

Mass (Da):14,088

Checksum:ⁱ211648B504B6313F

Isoform 3 (identifier: P28908-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-111: Missing.
446-446: Missing.

« Hide

        10         20         30         40         50
MFCSTSAVNS CARCFFHSVC PAGMIVKFPG TAQKNTVCEP ASPGVSPACA 
        60         70         80         90        100
SPENCKEPSS GTIPQAKPTP VSPATSSAST MPVRGGTRLA QEAASKLTRA 
       110        120        130        140        150
PDSPSSVGRP SSDPGLSPTQ PCPEGSGDCR KQCEPDYYLD EAGRCTACVS 
       160        170        180        190        200
CSRDDLVEKT PCAWNSSRTC ECRPGMICAT SATNSCARCV PYPICAAETV 
       210        220        230        240        250
TKPQDMAEKD TTFEAPPLGT QPDCNPTPEN GEAPASTSPT QSLLVDSQAS 
       260        270        280        290        300
KTLPIPTSAP VALSSTGKPV LDAGPVLFWV ILVLVVVVGS SAFLLCHRRA 
       310        320        330        340        350
CRKRIRQKLH LCYPVQTSQP KLELVDSRPR RSSTLRSGAS VTEPVAEERG 
       360        370        380        390        400
LMSQPLMETC HSVGAAYLES LPLQDASPAG GPSSPRDLPE PRVSTEHTNN 
       410        420        430        440        450
KIEKIYIMKA DTVIVGTVKA ELPEGRGLAG PAEPELEEEL EADHTPHYPE 
       460        470        480 
QETEPPLGSC SDVMLSVEEE GKEDPLPTAA SGK

Show »

Length:483

Mass (Da):50,935

Checksum:ⁱ8EA95A0BEA6BD315

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	D6RAG8	D6RAG8_HUMAN		Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 8	TNFRSF8	55	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054213	273	C → F. Corresponds to variant dbSNP:rs2230624Ensembl.	1
Natural variantⁱVAR_018753	273	C → Y1 PublicationCorresponds to variant dbSNP:rs2230624Ensembl.	1
Natural variantⁱVAR_055257	297	C → R1 PublicationCorresponds to variant dbSNP:rs1763642Ensembl.	1
Natural variantⁱVAR_055258	314	P → S. Corresponds to variant dbSNP:rs2275170Ensembl.	1
Natural variantⁱVAR_018754	402	S → G1 PublicationCorresponds to variant dbSNP:rs2230625Ensembl.	1
Natural variantⁱVAR_055259	466	Q → R. Corresponds to variant dbSNP:rs35511003Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018900	1 – 463	Missing in isoform 2. 2 PublicationsAdd BLAST	463
Alternative sequenceⁱVSP_055032	1 – 111	Missing in isoform 3. 1 PublicationAdd BLAST	111
Alternative sequenceⁱVSP_055033	446	Missing in isoform 3. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83554 mRNA Translation: AAA51947.1 S75768 mRNA Translation: AAD14188.1 D86042 mRNA Translation: BAA12973.1 AJ289159 Genomic DNA Translation: CAC16652.1 AY498860 Genomic DNA Translation: AAR32099.1 AL357835 Genomic DNA No translation available. BC063482 mRNA Translation: AAH63482.2 BC136400 mRNA Translation: AAI36401.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS144.1 [P28908-1] CCDS59989.1 [P28908-3]
PIRⁱ	A42086
NCBI Reference Sequences More...RefSeqⁱ	NP_001234.3, NM_001243.4 [P28908-1] NP_001268359.2, NM_001281430.2 [P28908-3]
UniGeneⁱ	Hs.1314

Genome annotation databases

Ensemblⁱ	ENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1] ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2] ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3]
GeneIDⁱ	943
KEGGⁱ	hsa:943
UCSC genome browser More...UCSCⁱ	uc001atq.3 human [P28908-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28908	Isoform 2 of Tumor necrosis factor receptor superfamily member 8		HUMAN		132	UniRef100_P28908
TNFRSF8 protein (Fragment)		HUMAN		187
UPI0005D00583		HUMAN		484

Protein	Similar proteins		Species	Score	Length	Source
P28908	Isoform 2 of Tumor necrosis factor receptor superfamily member 8		HUMAN		132	UniRef90_P28908
TNFRSF8 isoform 7		PANTR		643
TNF receptor superfamily member 8		GORGO		608
TNF receptor superfamily member 8		PANPA		597
TNF receptor superfamily member 8		RHIRO		595
+44

Protein	Similar proteins		Species	Score	Length	Source
P28908	Isoform 2 of Tumor necrosis factor receptor superfamily member 8		HUMAN		132	UniRef50_P28908
TNFRSF8 isoform 7		PANTR		643
TNF receptor superfamily member 8		GORGO		608
TNF receptor superfamily member 8		PANPA		597
TNF receptor superfamily member 8		MACNE		595
+71

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83554 mRNA Translation: AAA51947.1 S75768 mRNA Translation: AAD14188.1 D86042 mRNA Translation: BAA12973.1 AJ289159 Genomic DNA Translation: CAC16652.1 AY498860 Genomic DNA Translation: AAR32099.1 AL357835 Genomic DNA No translation available. BC063482 mRNA Translation: AAH63482.2 BC136400 mRNA Translation: AAI36401.1
CCDSⁱ	CCDS144.1 [P28908-1] CCDS59989.1 [P28908-3]
PIRⁱ	A42086
RefSeqⁱ	NP_001234.3, NM_001243.4 [P28908-1] NP_001268359.2, NM_001281430.2 [P28908-3]
UniGeneⁱ	Hs.1314

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1D01	X-ray	2.00	G/H/I	576-583	[»]
ProteinModelPortalⁱ	P28908
SMRⁱ	P28908
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107381, 30 interactors
DIPⁱ	DIP-2930N
ELMⁱ	P28908
IntActⁱ	P28908, 3 interactors
STRINGⁱ	9606.ENSP00000263932

Chemistry databases

ChEMBLⁱ	CHEMBL2364161
DrugBankⁱ	DB08870 Brentuximab vedotin

PTM databases

iPTMnetⁱ	P28908
PhosphoSitePlusⁱ	P28908
SwissPalmⁱ	P28908

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF8
DMDMⁱ	115978

Proteomic databases

EPDⁱ	P28908
MaxQBⁱ	P28908
PaxDbⁱ	P28908
PeptideAtlasⁱ	P28908
PRIDEⁱ	P28908
ProteomicsDBⁱ	54509 54510 [P28908-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1] ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2] ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3]
GeneIDⁱ	943
KEGGⁱ	hsa:943
UCSCⁱ	uc001atq.3 human [P28908-1]

Organism-specific databases

CTDⁱ	943
DisGeNETⁱ	943
EuPathDBⁱ	HostDB:ENSG00000120949.14
GeneCardsⁱ	TNFRSF8
H-InvDBⁱ	HIX0200047
HGNCⁱ	HGNC:11923 TNFRSF8
HPAⁱ	CAB000016 HPA032081 HPA032082
MIMⁱ	153243 gene
neXtProtⁱ	NX_P28908
OpenTargetsⁱ	ENSG00000120949
PharmGKBⁱ	PA36616
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZAX Eukaryota ENOG410YM0N LUCA
GeneTreeⁱ	ENSGT00510000049215
HOGENOMⁱ	HOG000220871
HOVERGENⁱ	HBG005054
InParanoidⁱ	P28908
KOⁱ	K05145
OMAⁱ	MFCATSA
OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	P28908
TreeFamⁱ	TF331157

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SignaLinkⁱ	P28908

Miscellaneous databases

ChiTaRSⁱ	TNFRSF8 human
EvolutionaryTraceⁱ	P28908
GeneWikiⁱ	CD30
GenomeRNAiⁱ	943
Protein Ontology More...PROⁱ	PR:P28908
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120949 Expressed in 82 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_TNFRSF8
ExpressionAtlasⁱ	P28908 baseline and differential
Genevisibleⁱ	P28908 HS

Family and domain databases

CDDⁱ	cd13409 TNFRSF8, 2 hits
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR020416 TNFR_8 IPR034002 TNFRSF8_N
Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01923 TNFACTORR8
SMARTⁱ	View protein in SMART SM00208 TNFR, 4 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 2 hits PS50050 TNFR_NGFR_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNR8_HUMAN
Accessionⁱ	P28908Primary (citable) accession number: P28908 Secondary accession number(s): B1AN79 , B9EGD9, D3YTD8, Q6P4D9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	September 12, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28908 (TNR8_HUMAN)

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Tumor necrosis factor receptor superfamily member 8

TNFRSF8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ