UniProtKB - P28908 (TNR8_HUMAN)
Protein
Tumor necrosis factor receptor superfamily member 8
Gene
TNFRSF8
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).2 Publications
Miscellaneous
Most specific Hodgkin disease associated antigen.
GO - Molecular functioni
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- cellular response to mechanical stimulus Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of TRAIL production Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- signal transduction Source: ProtInc
- tumor necrosis factor-mediated signaling pathway Source: Reactome
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P28908 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P28908 |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 8ImportedAlternative name(s): CD30L receptor Ki-1 antigen Lymphocyte activation antigen CD30 CD_antigen: CD301 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11923, TNFRSF8 |
MIMi | 153243, gene |
neXtProti | NX_P28908 |
VEuPathDBi | HostDB:ENSG00000120949.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication1 Publication; Single-pass type I membrane protein Sequence analysis
Other locations
- Cytoplasm 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 385 | ExtracellularCuratedAdd BLAST | 367 | |
Transmembranei | 386 – 406 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 407 – 595 | CytoplasmicCuratedAdd BLAST | 189 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 943 |
OpenTargetsi | ENSG00000120949 |
PharmGKBi | PA36616 |
Miscellaneous databases
Pharosi | P28908, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2364161 |
DrugBanki | DB08870, Brentuximab vedotin DB06324, XmAb 2513 |
DrugCentrali | P28908 |
GuidetoPHARMACOLOGYi | 1877 |
Genetic variation databases
BioMutai | TNFRSF8 |
DMDMi | 115978 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Add BLAST | 18 | |
ChainiPRO_0000034573 | 19 – 595 | Tumor necrosis factor receptor superfamily member 8Add BLAST | 577 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 29 ↔ 44 | PROSITE-ProRule annotation | ||
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 45 ↔ 58 | PROSITE-ProRule annotation | ||
Disulfide bondi | 48 ↔ 65 | PROSITE-ProRule annotation | ||
Disulfide bondi | 69 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 84 ↔ 98 | PROSITE-ProRule annotation | ||
Disulfide bondi | 87 ↔ 106 | PROSITE-ProRule annotation | ||
Glycosylationi | 101 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 108 ↔ 122 | PROSITE-ProRule annotation | ||
Disulfide bondi | 131 ↔ 149 | PROSITE-ProRule annotation | ||
Disulfide bondi | 233 ↔ 240 | PROSITE-ProRule annotation | ||
Disulfide bondi | 244 ↔ 256 | PROSITE-ProRule annotation | ||
Disulfide bondi | 259 ↔ 273 | PROSITE-ProRule annotation | ||
Disulfide bondi | 262 ↔ 281 | PROSITE-ProRule annotation | ||
Glycosylationi | 276 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 283 ↔ 297 | PROSITE-ProRule annotation | ||
Disulfide bondi | 289 ↔ 300 | PROSITE-ProRule annotation | ||
Glycosylationi | 336 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 438 | PhosphoserineCombined sources | 1 | |
Modified residuei | 452 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).Curated1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P28908 |
jPOSTi | P28908 |
MassIVEi | P28908 |
MaxQBi | P28908 |
PaxDbi | P28908 |
PeptideAtlasi | P28908 |
PRIDEi | P28908 |
ProteomicsDBi | 12802 54509 [P28908-1] 54510 [P28908-2] |
PTM databases
GlyGeni | P28908, 6 sites |
iPTMneti | P28908 |
PhosphoSitePlusi | P28908 |
SwissPalmi | P28908 |
Expressioni
Tissue specificityi
Detected in alveolar macrophages (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000120949, Expressed in granulocyte and 105 other tissues |
ExpressionAtlasi | P28908, baseline and differential |
Genevisiblei | P28908, HS |
Organism-specific databases
HPAi | ENSG00000120949, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
5 PublicationsProtein-protein interaction databases
BioGRIDi | 107381, 30 interactors |
DIPi | DIP-2930N |
ELMi | P28908 |
IntActi | P28908, 23 interactors |
STRINGi | 9606.ENSP00000263932 |
Miscellaneous databases
RNActi | P28908, protein |
Structurei
3D structure databases
SMRi | P28908 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28908 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 28 – 66 | TNFR-Cys 1Add BLAST | 39 | |
Repeati | 68 – 106 | TNFR-Cys 2Add BLAST | 39 | |
Repeati | 107 – 150 | TNFR-Cys 3Add BLAST | 44 | |
Repeati | 205 – 241 | TNFR-Cys 4Add BLAST | 37 | |
Repeati | 243 – 281 | TNFR-Cys 5Add BLAST | 39 | |
Repeati | 282 – 325 | TNFR-Cys 6Add BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 347 – 377 | Pro/Ser/Thr-richAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the TNFR8 family.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SNQ9, Eukaryota |
GeneTreei | ENSGT00510000049215 |
HOGENOMi | CLU_043282_0_0_1 |
InParanoidi | P28908 |
OMAi | VEKMPCA |
PhylomeDBi | P28908 |
TreeFami | TF331157 |
Family and domain databases
CDDi | cd13409, TNFRSF8, 2 hits |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020416, TNFR_8 IPR034002, TNFRSF8_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01923, TNFACTORR8 |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P28908-1) [UniParc]FASTAAdd to basket
Also known as: Long
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM
60 70 80 90 100
GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW
110 120 130 140 150
NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE
160 170 180 190 200
PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL
210 220 230 240 250
AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL
260 270 280 290 300
DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC
310 320 330 340 350
VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP
360 370 380 390 400
TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG
410 420 430 440 450
SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG
460 470 480 490 500
ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL
510 520 530 540 550
PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE
560 570 580 590
ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RAG8 | D6RAG8_HUMAN | Tumor necrosis factor receptor supe... | TNFRSF8 | 55 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054213 | 273 | C → F. Corresponds to variant dbSNP:rs2230624Ensembl. | 1 | |
Natural variantiVAR_018753 | 273 | C → Y1 PublicationCorresponds to variant dbSNP:rs2230624Ensembl. | 1 | |
Natural variantiVAR_055257 | 297 | C → R1 PublicationCorresponds to variant dbSNP:rs1763642Ensembl. | 1 | |
Natural variantiVAR_055258 | 314 | P → S. Corresponds to variant dbSNP:rs2275170Ensembl. | 1 | |
Natural variantiVAR_018754 | 402 | S → G1 PublicationCorresponds to variant dbSNP:rs2230625Ensembl. | 1 | |
Natural variantiVAR_055259 | 466 | Q → R. Corresponds to variant dbSNP:rs35511003Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018900 | 1 – 463 | Missing in isoform 2. 2 PublicationsAdd BLAST | 463 | |
Alternative sequenceiVSP_055032 | 1 – 111 | Missing in isoform 3. 1 PublicationAdd BLAST | 111 | |
Alternative sequenceiVSP_055033 | 446 | Missing in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83554 mRNA Translation: AAA51947.1 S75768 mRNA Translation: AAD14188.1 D86042 mRNA Translation: BAA12973.1 AJ289159 Genomic DNA Translation: CAC16652.1 AY498860 Genomic DNA Translation: AAR32099.1 AL357835 Genomic DNA No translation available. BC063482 mRNA Translation: AAH63482.2 BC136400 mRNA Translation: AAI36401.1 |
CCDSi | CCDS144.1 [P28908-1] CCDS59989.1 [P28908-3] |
PIRi | A42086 |
RefSeqi | NP_001234.3, NM_001243.4 [P28908-1] NP_001268359.2, NM_001281430.2 [P28908-3] |
Genome annotation databases
Ensembli | ENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1] ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2] ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3] |
GeneIDi | 943 |
KEGGi | hsa:943 |
UCSCi | uc001atq.3, human [P28908-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M83554 mRNA Translation: AAA51947.1 S75768 mRNA Translation: AAD14188.1 D86042 mRNA Translation: BAA12973.1 AJ289159 Genomic DNA Translation: CAC16652.1 AY498860 Genomic DNA Translation: AAR32099.1 AL357835 Genomic DNA No translation available. BC063482 mRNA Translation: AAH63482.2 BC136400 mRNA Translation: AAI36401.1 |
CCDSi | CCDS144.1 [P28908-1] CCDS59989.1 [P28908-3] |
PIRi | A42086 |
RefSeqi | NP_001234.3, NM_001243.4 [P28908-1] NP_001268359.2, NM_001281430.2 [P28908-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1D01 | X-ray | 2.00 | G/H/I | 576-583 | [»] | |
SMRi | P28908 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107381, 30 interactors |
DIPi | DIP-2930N |
ELMi | P28908 |
IntActi | P28908, 23 interactors |
STRINGi | 9606.ENSP00000263932 |
Chemistry databases
ChEMBLi | CHEMBL2364161 |
DrugBanki | DB08870, Brentuximab vedotin DB06324, XmAb 2513 |
DrugCentrali | P28908 |
GuidetoPHARMACOLOGYi | 1877 |
PTM databases
GlyGeni | P28908, 6 sites |
iPTMneti | P28908 |
PhosphoSitePlusi | P28908 |
SwissPalmi | P28908 |
Genetic variation databases
BioMutai | TNFRSF8 |
DMDMi | 115978 |
Proteomic databases
EPDi | P28908 |
jPOSTi | P28908 |
MassIVEi | P28908 |
MaxQBi | P28908 |
PaxDbi | P28908 |
PeptideAtlasi | P28908 |
PRIDEi | P28908 |
ProteomicsDBi | 12802 54509 [P28908-1] 54510 [P28908-2] |
Protocols and materials databases
ABCDi | P28908, 20 sequenced antibodies |
Antibodypediai | 3659, 2250 antibodies |
Genome annotation databases
Ensembli | ENST00000263932; ENSP00000263932; ENSG00000120949 [P28908-1] ENST00000413146; ENSP00000398337; ENSG00000120949 [P28908-2] ENST00000417814; ENSP00000390650; ENSG00000120949 [P28908-3] |
GeneIDi | 943 |
KEGGi | hsa:943 |
UCSCi | uc001atq.3, human [P28908-1] |
Organism-specific databases
CTDi | 943 |
DisGeNETi | 943 |
GeneCardsi | TNFRSF8 |
HGNCi | HGNC:11923, TNFRSF8 |
HPAi | ENSG00000120949, Tissue enhanced (blood) |
MIMi | 153243, gene |
neXtProti | NX_P28908 |
OpenTargetsi | ENSG00000120949 |
PharmGKBi | PA36616 |
VEuPathDBi | HostDB:ENSG00000120949.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SNQ9, Eukaryota |
GeneTreei | ENSGT00510000049215 |
HOGENOMi | CLU_043282_0_0_1 |
InParanoidi | P28908 |
OMAi | VEKMPCA |
PhylomeDBi | P28908 |
TreeFami | TF331157 |
Enzyme and pathway databases
PathwayCommonsi | P28908 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P28908 |
Miscellaneous databases
BioGRID-ORCSi | 943, 17 hits in 873 CRISPR screens |
ChiTaRSi | TNFRSF8, human |
EvolutionaryTracei | P28908 |
GeneWikii | CD30 |
GenomeRNAii | 943 |
Pharosi | P28908, Tclin |
PROi | PR:P28908 |
RNActi | P28908, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120949, Expressed in granulocyte and 105 other tissues |
ExpressionAtlasi | P28908, baseline and differential |
Genevisiblei | P28908, HS |
Family and domain databases
CDDi | cd13409, TNFRSF8, 2 hits |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR020416, TNFR_8 IPR034002, TNFRSF8_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01923, TNFACTORR8 |
SMARTi | View protein in SMART SM00208, TNFR, 4 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 2 hits PS50050, TNFR_NGFR_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR8_HUMAN | |
Accessioni | P28908Primary (citable) accession number: P28908 Secondary accession number(s): B1AN79 Q6P4D9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families