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Entry version 199 (13 Nov 2019)
Sequence version 2 (23 Nov 2004)
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Protein

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Gene

CD38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ATP inhibits the hydrolyzing activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1191 Publication1
Active sitei2011 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Receptor, Transferase
LigandNAD, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS00103-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.4.99.20 2681
3.2.2.5 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196807 Nicotinate metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P28907

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC:3.2.2.6)
Alternative name(s):
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20)
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
Short name:
ADPRC 1
Cyclic ADP-ribose hydrolase 1
Short name:
cADPr hydrolase 1
T10
CD_antigen: CD38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1667 CD38

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107270 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28907

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini43 – 300ExtracellularSequence analysisAdd BLAST258

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119C → K: Loss of cADPr hydrolase activity. 1 Publication1
Mutagenesisi119C → R, E or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication1
Mutagenesisi160C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication1
Mutagenesisi173C → A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication1
Mutagenesisi201C → D, K or A: Loss of cADPr hydrolase and ADP-ribosyl cyclase activity. 1 Publication1
Mutagenesisi201C → E: Loss of cADPr hydrolase activity. 1 Publication1

Keywords - Diseasei

Diabetes mellitus

Organism-specific databases

DisGeNET

More...
DisGeNETi
952

Open Targets

More...
OpenTargetsi
ENSG00000004468

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26214

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P28907

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4660

Drug and drug target database

More...
DrugBanki
DB09331 Daratumumab

DrugCentral

More...
DrugCentrali
P28907

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2766

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD38

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55977782

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440661 – 300ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi67 ↔ 821 Publication
Disulfide bondi99 ↔ 1801 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi160 ↔ 1731 Publication
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi219N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi254 ↔ 2751 Publication
Disulfide bondi287 ↔ 2961 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P28907

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P28907

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P28907

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28907

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28907

PeptideAtlas

More...
PeptideAtlasi
P28907

PRoteomics IDEntifications database

More...
PRIDEi
P28907

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54507 [P28907-1]
54508 [P28907-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
997

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28907

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28907

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P28907

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000004468 Expressed in 143 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P28907 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P28907 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002493
CAB025255
HPA022132
HPA052381

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107390, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226279

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P28907

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P28907

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P28907

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADP-ribosyl cyclase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH8E Eukaryota
ENOG4111W33 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017291

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293141

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P28907

KEGG Orthology (KO)

More...
KOi
K01242

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMNYQSC

Database of Orthologous Groups

More...
OrthoDBi
1460460at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P28907

TreeFam database of animal gene trees

More...
TreeFami
TF332530

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04759 Rib_hydrolase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003193 ADP-ribosyl_cyclase
IPR033567 CD38

The PANTHER Classification System

More...
PANTHERi
PTHR10912 PTHR10912, 1 hit
PTHR10912:SF5 PTHR10912:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P28907-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANCEFSPVS GDKPCCRLSR RAQLCLGVSI LVLILVVVLA VVVPRWRQQW
60 70 80 90 100
SGPGTTKRFP ETVLARCVKY TEIHPEMRHV DCQSVWDAFK GAFISKHPCN
110 120 130 140 150
ITEEDYQPLM KLGTQTVPCN KILLWSRIKD LAHQFTQVQR DMFTLEDTLL
160 170 180 190 200
GYLADDLTWC GEFNTSKINY QSCPDWRKDC SNNPVSVFWK TVSRRFAEAA
210 220 230 240 250
CDVVHVMLNG SRSKIFDKNS TFGSVEVHNL QPEKVQTLEA WVIHGGREDS
260 270 280 290 300
RDLCQDPTIK ELESIISKRN IQFSCKNIYR PDKFLQCVKN PEDSSCTSEI
Length:300
Mass (Da):34,328
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47BBE38C3DE3E6AA
GO
Isoform 2 (identifier: P28907-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-122: I → K
     123-300: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:122
Mass (Da):13,788
Checksum:i06312C3A52C6ED5C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y950H0Y950_HUMAN
ADP-ribosyl cyclase/cyclic ADP-ribo...
CD38
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49Q → T in AAA68482 (PubMed:2319135).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_001323140R → W Seems to contribute to the development of type II diabetes; 50% reduction in activity. 1 PublicationCorresponds to variant dbSNP:rs1800561Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_000707122I → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_000708123 – 300Missing in isoform 2. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34461 mRNA Translation: AAA68482.1
D84276 mRNA Translation: BAA18964.1
D84277 mRNA Translation: BAA18965.1
D84284 Genomic DNA Translation: BAA18966.1
BC007964 mRNA Translation: AAH07964.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3417.1 [P28907-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43521

NCBI Reference Sequences

More...
RefSeqi
NP_001766.2, NM_001775.3 [P28907-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000226279; ENSP00000226279; ENSG00000004468 [P28907-1]
ENST00000502843; ENSP00000427277; ENSG00000004468 [P28907-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:952

UCSC genome browser

More...
UCSCi
uc003gol.2 human [P28907-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD38 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34461 mRNA Translation: AAA68482.1
D84276 mRNA Translation: BAA18964.1
D84277 mRNA Translation: BAA18965.1
D84284 Genomic DNA Translation: BAA18966.1
BC007964 mRNA Translation: AAH07964.1
CCDSiCCDS3417.1 [P28907-1]
PIRiA43521
RefSeqiNP_001766.2, NM_001775.3 [P28907-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YH3X-ray1.91A/B45-300[»]
1ZVMX-ray2.20A/B/C/D45-300[»]
2EF1X-ray2.40A/B45-300[»]
2HCTX-ray1.95A/B45-300[»]
2I65X-ray1.90A/B45-300[»]
2I66X-ray1.70A/B45-300[»]
2I67X-ray1.71A/B45-300[»]
2O3QX-ray1.98A/B45-300[»]
2O3RX-ray1.75A/B45-300[»]
2O3SX-ray1.50A/B45-300[»]
2O3TX-ray1.68A/B45-300[»]
2O3UX-ray2.11A/B45-300[»]
2PGJX-ray1.71A/B45-300[»]
2PGLX-ray1.76A/B45-300[»]
3DZFX-ray2.01A/B/C/D/E/F45-300[»]
3DZGX-ray1.65A/B45-300[»]
3DZHX-ray1.60A/B45-300[»]
3DZIX-ray1.73A/B45-300[»]
3DZJX-ray1.90A/B45-300[»]
3DZKX-ray1.81A/B45-300[»]
3F6YX-ray1.45A45-300[»]
3I9MX-ray1.75A/B45-300[»]
3I9NX-ray2.01A/B45-300[»]
3OFSX-ray2.20A/B/C/D/E/F46-300[»]
3RAJX-ray3.04A46-300[»]
3ROKX-ray1.65A/B45-296[»]
3ROMX-ray2.04A/B45-296[»]
3ROPX-ray1.94A/B45-296[»]
3ROQX-ray2.10A/B45-296[»]
3U4HX-ray1.88A/B45-300[»]
3U4IX-ray2.12A/B45-300[»]
4CMHX-ray1.53A45-300[»]
4F45X-ray2.10A/B46-300[»]
4F46X-ray1.69A/B46-300[»]
4OGWX-ray2.05A46-300[»]
4TMFX-ray2.05A/B50-300[»]
4XJSX-ray2.80A46-300[»]
4XJTX-ray2.60A46-300[»]
5F1KX-ray2.30A/B45-300[»]
5F1OX-ray2.20A46-300[»]
5F21X-ray1.90A46-300[»]
6EDRX-ray2.40A/B45-300[»]
SMRiP28907
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107390, 6 interactors
STRINGi9606.ENSP00000226279

Chemistry databases

BindingDBiP28907
ChEMBLiCHEMBL4660
DrugBankiDB09331 Daratumumab
DrugCentraliP28907
GuidetoPHARMACOLOGYi2766

PTM databases

GlyConnecti997
iPTMnetiP28907
PhosphoSitePlusiP28907
SwissPalmiP28907

Polymorphism and mutation databases

BioMutaiCD38
DMDMi55977782

Proteomic databases

EPDiP28907
jPOSTiP28907
MassIVEiP28907
MaxQBiP28907
PaxDbiP28907
PeptideAtlasiP28907
PRIDEiP28907
ProteomicsDBi54507 [P28907-1]
54508 [P28907-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P28907

The DNASU plasmid repository

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DNASUi
952

Genome annotation databases

EnsembliENST00000226279; ENSP00000226279; ENSG00000004468 [P28907-1]
ENST00000502843; ENSP00000427277; ENSG00000004468 [P28907-2]
GeneIDi952
KEGGihsa:952
UCSCiuc003gol.2 human [P28907-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
952
DisGeNETi952

GeneCards: human genes, protein and diseases

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GeneCardsi
CD38
HGNCiHGNC:1667 CD38
HPAiCAB002493
CAB025255
HPA022132
HPA052381
MIMi107270 gene
neXtProtiNX_P28907
OpenTargetsiENSG00000004468
PharmGKBiPA26214

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH8E Eukaryota
ENOG4111W33 LUCA
GeneTreeiENSGT00390000017291
HOGENOMiHOG000293141
InParanoidiP28907
KOiK01242
OMAiEMNYQSC
OrthoDBi1460460at2759
PhylomeDBiP28907
TreeFamiTF332530

Enzyme and pathway databases

BioCyciMetaCyc:HS00103-MONOMER
BRENDAi2.4.99.20 2681
3.2.2.5 2681
ReactomeiR-HSA-196807 Nicotinate metabolism
SABIO-RKiP28907

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD38 human
EvolutionaryTraceiP28907

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD38

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
952
PharosiP28907

Protein Ontology

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PROi
PR:P28907

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000004468 Expressed in 143 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiP28907 baseline and differential
GenevisibleiP28907 HS

Family and domain databases

CDDicd04759 Rib_hydrolase, 1 hit
InterProiView protein in InterPro
IPR003193 ADP-ribosyl_cyclase
IPR033567 CD38
PANTHERiPTHR10912 PTHR10912, 1 hit
PTHR10912:SF5 PTHR10912:SF5, 1 hit
PfamiView protein in Pfam
PF02267 Rib_hydrolayse, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD38_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28907
Secondary accession number(s): O00121, O00122, Q96HY4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 23, 2004
Last modified: November 13, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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