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Protein

Hematopoietic progenitor cell antigen CD34

Gene

CD34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: HGNC
  • sulfate binding Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P28906

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hematopoietic progenitor cell antigen CD34
Alternative name(s):
CD_antigen: CD34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000174059.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1662 CD34

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142230 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P28906

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 290ExtracellularSequence analysisAdd BLAST259
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 385CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
947

Open Targets

More...
OpenTargetsi
ENSG00000174059

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26211

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD34

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3183511

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 312 PublicationsAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002090032 – 385Hematopoietic progenitor cell antigen CD34Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei329PhosphotyrosineBy similarity1
Modified residuei339PhosphotyrosineBy similarity1
Modified residuei346PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly glycosylated.
Phosphorylated on serine residues by PKC.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P28906

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28906

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28906

PeptideAtlas

More...
PeptideAtlasi
P28906

PRoteomics IDEntifications database

More...
PRIDEi
P28906

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54505
54506 [P28906-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1305

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28906

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28906

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

On early hematopoietic progenitor cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174059 Expressed in 166 organ(s), highest expression level in esophagus

CleanEx database of gene expression profiles

More...
CleanExi
HS_CD34

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P28906 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P28906 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000018
HPA036722
HPA036723

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107385, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P28906, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310036

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P28906

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD34 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPJJ Eukaryota
ENOG410YPR6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008414

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003461

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P28906

KEGG Orthology (KO)

More...
KOi
K06474

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMPRGWT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0K1S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P28906

TreeFam database of animal gene trees

More...
TreeFami
TF335795

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008083 CD34
IPR013836 CD34/Podocalyxin

The PANTHER Classification System

More...
PANTHERi
PTHR16677 PTHR16677, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06365 CD34_antigen, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01700 CD34ANTIGEN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation.

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform CD34-F (identifier: P28906-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS
60 70 80 90 100
NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT
110 120 130 140 150
SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS
160 170 180 190 200
TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA
210 220 230 240 250
EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR
260 270 280 290 300
TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL
310 320 330 340 350
LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ
360 370 380
GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL
Length:385
Mass (Da):40,716
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC581A8FCFFE2BB3
GO
Isoform CD34-T (identifier: P28906-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-328: GEDP → ELEP
     329-385: Missing.

Show »
Length:328
Mass (Da):35,011
Checksum:i7FFBEBC98D4CC61D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JTA5Q5JTA5_HUMAN
Hematopoietic progenitor cell antig...
CD34
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA03181 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti187Q → E AA sequence (PubMed:2462139).Curated1
Sequence conflicti325 – 327GED → ELE (PubMed:7678811).Curated3
Sequence conflicti361E → K (PubMed:1370171).Curated1
Sequence conflicti361E → K (PubMed:1374051).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050774367A → S. Corresponds to variant dbSNP:rs28362497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004159325 – 328GEDP → ELEP in isoform CD34-T. 1 Publication4
Alternative sequenceiVSP_004160329 – 385Missing in isoform CD34-T. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M81104 mRNA Translation: AAA03181.1 Different initiation.
M81945
, M81938, M81939, M81940, M81941, M81942, M81943, M81944 Genomic DNA Translation: AAA03659.1
S53910 mRNA Translation: AAB25222.1
S53911 mRNA Translation: AAB25223.1
AF523361 mRNA Translation: AAM82157.1
AK291529 mRNA Translation: BAF84218.1
AL356275 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93459.1
BC039146 mRNA Translation: AAH39146.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31011.1 [P28906-1]
CCDS31012.1 [P28906-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A38078
I67604

NCBI Reference Sequences

More...
RefSeqi
NP_001020280.1, NM_001025109.1 [P28906-1]
NP_001764.1, NM_001773.2 [P28906-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.374990

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310833; ENSP00000310036; ENSG00000174059 [P28906-1]
ENST00000356522; ENSP00000348916; ENSG00000174059 [P28906-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:947

UCSC genome browser

More...
UCSCi
uc001hgw.2 human [P28906-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD34 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81104 mRNA Translation: AAA03181.1 Different initiation.
M81945
, M81938, M81939, M81940, M81941, M81942, M81943, M81944 Genomic DNA Translation: AAA03659.1
S53910 mRNA Translation: AAB25222.1
S53911 mRNA Translation: AAB25223.1
AF523361 mRNA Translation: AAM82157.1
AK291529 mRNA Translation: BAF84218.1
AL356275 Genomic DNA No translation available.
CH471100 Genomic DNA Translation: EAW93459.1
BC039146 mRNA Translation: AAH39146.2
CCDSiCCDS31011.1 [P28906-1]
CCDS31012.1 [P28906-2]
PIRiA38078
I67604
RefSeqiNP_001020280.1, NM_001025109.1 [P28906-1]
NP_001764.1, NM_001773.2 [P28906-2]
UniGeneiHs.374990

3D structure databases

ProteinModelPortaliP28906
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107385, 1 interactor
IntActiP28906, 2 interactors
STRINGi9606.ENSP00000310036

PTM databases

GlyConnecti1305
iPTMnetiP28906
PhosphoSitePlusiP28906

Polymorphism and mutation databases

BioMutaiCD34
DMDMi3183511

Proteomic databases

EPDiP28906
MaxQBiP28906
PaxDbiP28906
PeptideAtlasiP28906
PRIDEiP28906
ProteomicsDBi54505
54506 [P28906-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
947
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310833; ENSP00000310036; ENSG00000174059 [P28906-1]
ENST00000356522; ENSP00000348916; ENSG00000174059 [P28906-2]
GeneIDi947
KEGGihsa:947
UCSCiuc001hgw.2 human [P28906-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
947
DisGeNETi947
EuPathDBiHostDB:ENSG00000174059.16

GeneCards: human genes, protein and diseases

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GeneCardsi
CD34
HGNCiHGNC:1662 CD34
HPAiCAB000018
HPA036722
HPA036723
MIMi142230 gene
neXtProtiNX_P28906
OpenTargetsiENSG00000174059
PharmGKBiPA26211

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IPJJ Eukaryota
ENOG410YPR6 LUCA
GeneTreeiENSGT00390000008414
HOVERGENiHBG003461
InParanoidiP28906
KOiK06474
OMAiGMPRGWT
OrthoDBiEOG091G0K1S
PhylomeDBiP28906
TreeFamiTF335795

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiP28906

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD34 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD34

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
947

Protein Ontology

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PROi
PR:P28906

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174059 Expressed in 166 organ(s), highest expression level in esophagus
CleanExiHS_CD34
ExpressionAtlasiP28906 baseline and differential
GenevisibleiP28906 HS

Family and domain databases

InterProiView protein in InterPro
IPR008083 CD34
IPR013836 CD34/Podocalyxin
PANTHERiPTHR16677 PTHR16677, 1 hit
PfamiView protein in Pfam
PF06365 CD34_antigen, 1 hit
PRINTSiPR01700 CD34ANTIGEN

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD34_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28906
Secondary accession number(s): A8K664
, Q15970, Q15971, Q5JTA3, Q5JTA4, Q9UJB1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 15, 1998
Last modified: November 7, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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