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UniProtKB - P28887 (L_HRSVA)

Entry version 119 (23 Feb 2022)
Sequence version 1 (01 Dec 1992)
Previous versions | rss
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Human respiratory syncytial virus A (strain A2)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for RNA synthesis (replicase and transcriptase), cap addition, and cap methylation (PubMed:25010481, PubMed:31495574).

Performs also the polyadenylation of subgenomic mRNAs by a stuttering mechanism at a slipery stop site present at the end of viral genes (PubMed:8794332).

The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N) (Probable). The viral polymerase binds to the genomic RNA at two differents sites in the 3' leader promoter thereby initiating either genome replication or mRNA transcription (PubMed:29873775).

In the transcription mode, the polymerase performs the sequential transcription of all mRNAs using a termination-reinitiation mechanism responding to gene start and gene end signals (PubMed:8794332).

Some polymerase disengage from the template at each gene junction, resulting in a decreasing abundance of transcripts from the 3' to the 5' end of the genome (Probable). The first gene is the most transcribed, and the last the least transcribed (Probable). Needs as cofactors the phosphoprotein for processivity and the M2-1 anti-termination protein (PubMed:8552680, PubMed:31495574).

Polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides (PubMed:16189012, PubMed:8445369).

Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation (PubMed:33956914).

In the replication mode, the polymerase replicates the whole viral genome without recognizing the gene end transcriptional signals (PubMed:15681446).

The ability of the polymerase to override the gene end signals as it is producing the antigenome is probably due to replicative RNA becoming encapsidated with nucleoprotein as it is synthesized (PubMed:15681446).

By similarityCurated8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: For RNA-directed RNA polymerase activity. Mn2+ can stimulate de novo initiation but it is inefficient at supporting elongation of de novo initiated RNA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi700Magnesium; catalytic; for RNA-directed RNA polymerase1 Publication1
Metal bindingi811Magnesium; catalytic; for RNA-directed RNA polymerase1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1338Nucleophile; for GDP polyribonucleotidyltransferaseBy similarity1
Active sitei1831For mRNA (nucleoside-2'-O-)-methyltransferase 2By similarity1
Active sitei1936For mRNA (nucleoside-2'-O-)-methyltransferase 2By similarity1
Active sitei1973For mRNA (nucleoside-2'-O-)-methyltransferase 2By similarity1
Active sitei2004For mRNA (nucleoside-2'-O-)-methyltransferase 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Methyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.48, 17394

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.482 Publications)
GTP phosphohydrolase1 Publication (EC:3.6.1.-1 Publication)
GDP polyribonucleotidyltransferaseCurated (EC:2.7.7.881 Publication1 Publication)
Alternative name(s):
PRNTaseCurated
mRNA cap methyltransferaseCurated (EC:2.1.1.375By similarity)
Alternative name(s):
mRNA (guanine-N(7)-)-methyltransferaseBy similarity
Short name:
G-N7-MTaseBy similarity
mRNA (nucleoside-2'-O-)-methyltransferaseBy similarity
Short name:
N1-2'-O-MTaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman respiratory syncytial virus A (strain A2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11259 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Pneumoviridae › Orthopneumovirus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000181559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000181262 Componenti: Genome
  • UP000181145 Componenti: Genome
  • UP000134464 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi811D → A: Complete loss of RNA synthesis. 1 Publication1
Mutagenesisi812N → A: Complete loss of RNA synthesis. 1 Publication1
Mutagenesisi1261P → A: Inhibition of RNA synthesis. 1 Publication1
Mutagenesisi1262W → A: Inhibition of RNA synthesis. 1 Publication1
Mutagenesisi1274P → A: No effect on RNA synthesis. 1
Mutagenesisi1276Y → A: No effect on RNA synthesis. 1
Mutagenesisi1820R → A: Complete loss of methyltransferase activity. 1 Publication1
Mutagenesisi1855G → S: Complete loss of methyltransferase activity. 1 Publication1
Mutagenesisi1936D → A: About 90% loss of methyltransferase activity. 1 Publication1
Mutagenesisi1938E → A: Complete loss of methyltransferase activity. 1 Publication1
Mutagenesisi1998S → A: Complete loss of methyltransferase activity. 1 Publication1
Mutagenesisi2004E → A: Complete loss of methyltransferase activity. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4630897

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001427271 – 2165RNA-directed RNA polymerase LAdd BLAST2165

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the phosphoprotein (via C-terminus); the association of P and L forms the polymerase complex.

3 Publications

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P28887, 15 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28887

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini693 – 877RdRp catalyticPROSITE-ProRule annotationAdd BLAST185
Domaini1820 – 2008Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni968 – 1460GDP polyribonucleotidyltransferase1 PublicationAdd BLAST493
Regioni1853 – 1857Substrate binding for mRNA (nucleoside-2'-O-)-methyltransferase 2By similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains an RNA-dependent RNA polymerase (RdRp) domain, a polyribonucleotidyl transferase (PRNTase or capping) domain and a methyltransferase (MTase) domain.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the paramyxovirus L protein family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR016269, RNA-dir_pol_paramyxovirus

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000830, RNA_pol_ParamyxoV, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR04198, paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28887-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPIINGNSA NVYLTDSYLK GVISFSECNA LGSYIFNGPY LKNDYTNLIS 
        60         70         80         90        100
RQNPLIEHMN LKKLNITQSL ISKYHKGEIK LEEPTYFQSL LMTYKSMTSS 
       110        120        130        140        150
EQIATTNLLK KIIRRAIEIS DVKVYAILNK LGLKEKDKIK SNNGQDEDNS 
       160        170        180        190        200
VITTIIKDDI LSAVKDNQSH LKADKNHSTK QKDTIKTTLL KKLMCSMQHP 
       210        220        230        240        250
PSWLIHWFNL YTKLNNILTQ YRSNEVKNHG FTLIDNQTLS GFQFILNQYG 
       260        270        280        290        300
CIVYHKELKR ITVTTYNQFL TWKDISLSRL NVCLITWISN CLNTLNKSLG 
       310        320        330        340        350
LRCGFNNVIL TQLFLYGDCI LKLFHNEGFY IIKEVEGFIM SLILNITEED 
       360        370        380        390        400
QFRKRFYNSM LNNITDAANK AQKNLLSRVC HTLLDKTVSD NIINGRWIIL 
       410        420        430        440        450
LSKFLKLIKL AGDNNLNNLS ELYFLFRIFG HPMVDERQAM DAVKINCNET 
       460        470        480        490        500
KFYLLSSLSM LRGAFIYRII KGFVNNYNRW PTLRNAIVLP LRWLTYYKLN 
       510        520        530        540        550
TYPSLLELTE RDLIVLSGLR FYREFRLPKK VDLEMIINDK AISPPKNLIW 
       560        570        580        590        600
TSFPRNYMPS HIQNYIEHEK LKFSESDKSR RVLEYYLRDN KFNECDLYNC 
       610        620        630        640        650
VVNQSYLNNP NHVVSLTGKE RELSVGRMFA MQPGMFRQVQ ILAEKMIAEN 
       660        670        680        690        700
ILQFFPESLT RYGDLELQKI LELKAGISNK SNRYNDNYNN YISKCSIITD 
       710        720        730        740        750
LSKFNQAFRY ETSCICSDVL DELHGVQSLF SWLHLTIPHV TIICTYRHAP 
       760        770        780        790        800
PYIGDHIVDL NNVDEQSGLY RYHMGGIEGW CQKLWTIEAI SLLDLISLKG 
       810        820        830        840        850
KFSITALING DNQSIDISKP IRLMEGQTHA QADYLLALNS LKLLYKEYAG 
       860        870        880        890        900
IGHKLKGTET YISRDMQFMS KTIQHNGVYY PASIKKVLRV GPWINTILDD 
       910        920        930        940        950
FKVSLESIGS LTQELEYRGE SLLCSLIFRN VWLYNQIALQ LKNHALCNNK 
       960        970        980        990       1000
LYLDILKVLK HLKTFFNLDN IDTALTLYMN LPMLFGGGDP NLLYRSFYRR 
      1010       1020       1030       1040       1050
TPDFLTEAIV HSVFILSYYT NHDLKDKLQD LSDDRLNKFL TCIITFDKNP 
      1060       1070       1080       1090       1100
NAEFVTLMRD PQALGSERQA KITSEINRLA VTEVLSTAPN KIFSKSAQHY 
      1110       1120       1130       1140       1150
TTTEIDLNDI MQNIEPTYPH GLRVVYESLP FYKAEKIVNL ISGTKSITNI 
      1160       1170       1180       1190       1200
LEKTSAIDLT DIDRATEMMR KNITLLIRIL PLDCNRDKRE ILSMENLSIT 
      1210       1220       1230       1240       1250
ELSKYVRERS WSLSNIVGVT SPSIMYTMDI KYTTSTISSG IIIEKYNVNS 
      1260       1270       1280       1290       1300
LTRGERGPTK PWVGSSTQEK KTMPVYNRQV LTKKQRDQID LLAKLDWVYA 
      1310       1320       1330       1340       1350
SIDNKDEFME ELSIGTLGLT YEKAKKLFPQ YLSVNYLHRL TVSSRPCEFP 
      1360       1370       1380       1390       1400
ASIPAYRTTN YHFDTSPINR ILTEKYGDED IDIVFQNCIS FGLSLMSVVE 
      1410       1420       1430       1440       1450
QFTNVCPNRI ILIPKLNEIH LMKPPIFTGD VDIHKLKQVI QKQHMFLPDK 
      1460       1470       1480       1490       1500
ISLTQYVELF LSNKTLKSGS HVNSNLILAH KISDYFHNTY ILSTNLAGHW 
      1510       1520       1530       1540       1550
ILIIQLMKDS KGIFEKDWGE GYITDHMFIN LKVFFNAYKT YLLCFHKGYG 
      1560       1570       1580       1590       1600
KAKLECDMNT SDLLCVLELI DSSYWKSMSK VFLEQKVIKY ILSQDASLHR 
      1610       1620       1630       1640       1650
VKGCHSFKLW FLKRLNVAEF TVCPWVVNID YHPTHMKAIL TYIDLVRMGL 
      1660       1670       1680       1690       1700
INIDRIHIKN KHKFNDEFYT SNLFYINYNF SDNTHLLTKH IRIANSELEN 
      1710       1720       1730       1740       1750
NYNKLYHPTP ETLENILANP IKSNDKKTLN DYCIGKNVDS IMLPLLSNKK 
      1760       1770       1780       1790       1800
LIKSSAMIRT NYSKQDLYNL FPMVVIDRII DHSGNTAKSN QLYTTTSHQI 
      1810       1820       1830       1840       1850
SLVHNSTSLY CMLPWHHINR FNFVFSSTGC KISIEYILKD LKIKDPNCIA 
      1860       1870       1880       1890       1900
FIGEGAGNLL LRTVVELHPD IRYIYRSLKD CNDHSLPIEF LRLYNGHINI 
      1910       1920       1930       1940       1950
DYGENLTIPA TDATNNIHWS YLHIKFAEPI SLFVCDAELS VTVNWSKIII 
      1960       1970       1980       1990       2000
EWSKHVRKCK YCSSVNKCML IVKYHAQDDI DFKLDNITIL KTYVCLGSKL 
      2010       2020       2030       2040       2050
KGSEVYLVLT IGPANIFPVF NVVQNAKLIL SRTKNFIMPK KADKESIDAN 
      2060       2070       2080       2090       2100
IKSLIPFLCY PITKKGINTA LSKLKSVVSG DILSYSIAGR NEVFSNKLIN 
      2110       2120       2130       2140       2150
HKHMNILKWF NHVLNFRSTE LNYNHLYMVE STYPYLSELL NSLTTNELKK 
      2160 
LIKITGSLLY NFHNE
Length:2,165
Mass (Da):250,386
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A3DCA0805305197
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti17S → G. 1
Natural varianti319C → Y in strain: Cold-passage attenuated. 1
Natural varianti831Q → L. 1
Natural varianti1049N → D. 1
Natural varianti1183D → E. 1
Natural varianti1690H → Y in strain: Cold-passage attenuated. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M75730 Genomic RNA Translation: AAA47418.1
U27298 Genomic RNA Translation: AAA84898.1
U50362 Genomic RNA Translation: AAB86667.1
U50363 Genomic RNA Translation: AAB86679.1
U63644 Genomic RNA Translation: AAC55973.1
AF035006 Genomic RNA Translation: AAC14905.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40317, RRNZA2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75730 Genomic RNA Translation: AAA47418.1
U27298 Genomic RNA Translation: AAA84898.1
U50362 Genomic RNA Translation: AAB86667.1
U50363 Genomic RNA Translation: AAB86679.1
U63644 Genomic RNA Translation: AAC55973.1
AF035006 Genomic RNA Translation: AAC14905.1
PIRiA40317, RRNZA2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6PZKelectron microscopy3.20A1-2165[»]
6UENelectron microscopy3.67A1-1500[»]
SMRiP28887
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP28887, 15 interactors

Chemistry databases

ChEMBLiCHEMBL4630897

Enzyme and pathway databases

BRENDAi2.7.7.48, 17394

Family and domain databases

InterProiView protein in InterPro
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR016269, RNA-dir_pol_paramyxovirus
PfamiView protein in Pfam
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF000830, RNA_pol_ParamyxoV, 1 hit
TIGRFAMsiTIGR04198, paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_HRSVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28887
Secondary accession number(s): O41355
, O41356, P90197, Q82021
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 23, 2022
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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