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Protein

Omega-conotoxin SVIA

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). In vivo, this toxin is a potent paralytic toxic in lower vertebrate species, but it is much less effective in mammals.1 Publication

Caution

Thr-72 is not followed in the nucleotide sequence by the expected Gly residue required to produce amidation.Curated

GO - Molecular functioni

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin SVIA1 Publication
Alternative name(s):
SNX-1571 Publication
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri863 SVIA precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

On fish, this toxin causes paralysis and death on intramuscular injection at doses of approximately 20 pmol/g. It does not kill mice even at extremely high doses.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003492423 – 48CuratedAdd BLAST26
PeptideiPRO_000003492549 – 72Omega-conotoxin SVIA1 PublicationAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 63By similarity
Modified residuei554-hydroxyproline1 Publication1
Disulfide bondi56 ↔ 66By similarity
Disulfide bondi62 ↔ 71By similarity
Modified residuei72Threonine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiP28880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
IPR012321 Conotoxin_omega-typ_CS
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLTCVMIVA VLLLTACQLI TAEDSRGTQK HRTLRSTARR SKSESTTRCR
60 70
SSGSPCGVTS ICCGRCYRGK CT
Length:72
Mass (Da):7,830
Last modified:August 29, 2001 - v2
Checksum:i4A6A412E450469A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti51S → P in SVIA-1, SVIA-2 and SVIA-5. 1 Publication1
Natural varianti54S → P in SVIA-4. 1 Publication1
Natural varianti55P → S in SVIA-3. 1 Publication1
Natural varianti59T → A in SVIA-5. 1 Publication1
Natural varianti67Y → S in SVIA-2 and SVIA-5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146347 mRNA Translation: AAD31907.1
PIRiB44379

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146347 mRNA Translation: AAD31907.1
PIRiB44379

3D structure databases

SMRiP28880
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri863 SVIA precursor

Family and domain databases

InterProiView protein in InterPro
IPR004214 Conotoxin
IPR012321 Conotoxin_omega-typ_CS
PfamiView protein in Pfam
PF02950 Conotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60004 OMEGA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO16A_CONST
AccessioniPrimary (citable) accession number: P28880
Secondary accession number(s): Q9UB26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 29, 2001
Last modified: September 12, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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