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Protein

Alpha-conotoxin S2

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Has no effect on the release of catecholamines evoked by nicotine.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin S2
Alternative name(s):
Alpha-conotoxin SII
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri3900 SII precursor
9 SII precursor
91 SII precursor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000003488922 – 501 PublicationAdd BLAST29
PeptideiPRO_000003489051 – 69Alpha-conotoxin S2Add BLAST19
PropeptideiPRO_000003489170 – 723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 681 Publication
Disulfide bondi53 ↔ 581 Publication
Disulfide bondi54 ↔ 641 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP28879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is II (CCC-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958 Conotoxin_a-typ
IPR018072 Conotoxin_a-typ_CS
PfamiView protein in Pfam
PF07365 Toxin_8, 1 hit
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFPSDRASDG RDDEAKDERS DMHESDRNGR
60 70
GCCCNPACGP NYGCGTSCSR TL
Length:72
Mass (Da):7,830
Last modified:September 5, 2006 - v3
Checksum:i521191749F4A94CF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23P → T no nucleotide entry (PubMed:10573284).Curated1
Sequence conflicti72L → I in AAN77902 (PubMed:14602116).Curated1

Mass spectrometryi

Molecular mass is 1790.3 Da from positions 51 - 69. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157497 mRNA Translation: AAN77902.1
PIRiA44379

Similar proteinsi

Entry informationi

Entry nameiCAS2_CONST
AccessioniPrimary (citable) accession number: P28879
Secondary accession number(s): Q8I6R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 5, 2006
Last modified: January 31, 2018
This is version 79 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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