pma2

Functionⁱ

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H⁺-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityⁱ

ATP + H₂O + H⁺(In) = ADP + phosphate + H⁺(Out).

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	464	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	720	MagnesiumBy similarity	1
Metal bindingⁱ	724	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: PomBase
metal ion binding Source: UniProtKB-KW
proton-exporting ATPase activity, phosphorylative mechanism
Source: PomBase
Inferred from mutant phenotypeⁱ
- 1833395

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

proton export across plasma membrane Source: InterPro
proton transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of intracellular pH
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Hydrogen ion transport, Ion transport, Transport
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Plasma membrane ATPase 2 (EC:7.1.2.1) Alternative name(s): Proton pump 2
Gene namesⁱ	Name:pma2 ORF Names:SPCC1020.01c, SPCC1393.01
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome III

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC1020.01c
PomBaseⁱ	SPCC1020.01c pma2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 201	CytoplasmicSequence analysisAdd BLAST	201
Transmembraneⁱ	202 – 222	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	223 – 226	ExtracellularSequence analysis	4
Transmembraneⁱ	227 – 246	Helical; Name=2Sequence analysisAdd BLAST	20
Topological domainⁱ	247 – 377	CytoplasmicSequence analysisAdd BLAST	131
Transmembraneⁱ	378 – 399	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	400 – 410	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	411 – 433	Helical; Name=4Sequence analysisAdd BLAST	23
Topological domainⁱ	434 – 805	CytoplasmicSequence analysisAdd BLAST	372
Transmembraneⁱ	806 – 824	Helical; Name=5Sequence analysisAdd BLAST	19
Topological domainⁱ	825 – 840	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	841 – 860	Helical; Name=6Sequence analysisAdd BLAST	20
Topological domainⁱ	861 – 912	CytoplasmicSequence analysisAdd BLAST	52
Transmembraneⁱ	913 – 933	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	934 – 946	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	947 – 963	Helical; Name=8Sequence analysisAdd BLAST	17
Topological domainⁱ	964 – 1010	CytoplasmicSequence analysisAdd BLAST	47

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046270	1 – 1010	Plasma membrane ATPase 2Add BLAST		1010

Post-translational modificationⁱ

In addition to transient phosphorylation of the active site Asp residue, this protein, but not the product of the pma1 locus, is phosphorylated efficiently in isolated plasma membrane.

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28876
PaxDbⁱ	P28876
PRIDEⁱ	P28876

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	275585, 3 interactors
STRINGⁱ	4896.SPCC1020.01c.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	121 – 150	Asp/Glu-rich (acidic)Add BLAST		30

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000160005
InParanoidⁱ	P28876
KEGG Orthology (KO) More...KOⁱ	K01535
OMAⁱ	HPGDGIY
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0HLD
PhylomeDBⁱ	P28876

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28876-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQRNNGEGRP EGMHRISRFL HGNPFKNNAS PQDDSTTRTE VYEEGGVEDS 
        60         70         80         90        100
AVDYDNASGN AAPRLTAAPN THAQQANLQS GNTSITHETQ STSRGQEATT 
       110        120        130        140        150
SPSLSASHEK PARPQTGEGS DNEDEDEDID ALIEDLYSQD QEEEQVEEEE 
       160        170        180        190        200
SPGPAGAAKV VPEELLETDP KYGLTESEVE ERKKKYGLNQ MKEEKTNNIK 
       210        220        230        240        250
KFLSFFVGPI QFVMELAAAL AAGLRDWVDF GVICALLLLN ATVGFVQEYQ 
       260        270        280        290        300
AGSIVDELKK TMALKASVLR DGRVKEIEAS EIVPGDILHL DEGTICPADG 
       310        320        330        340        350
RLITKDCFLQ VDQSAITGES LAVDKHQNDT MYSSSTVKRG EAFMVVTATA 
       360        370        380        390        400
DSTFVGRAAS LVGAAGQSQG HFTEVLNGIG TILLVLVILT LLCIYTAAFY 
       410        420        430        440        450
RSVRLAALLE YTLAITIIGV PVGLPAVVTT TMAVGAAYLA KKKAIVQKLS 
       460        470        480        490        500
AIESLAGVEI LCSDKTGTLT KNRLSLGEPY CVEGVSPDDL MLTACLASSR 
       510        520        530        540        550
KKKGLDAIDK AFLKALRNYP KAKDQLSKYK VLDFHPFDPV SKKITAYVEA 
       560        570        580        590        600
PDGQRITCVK GAPLWVFKTV QDDHEVPEAI TDAYREQVND MASRGFRSLG 
       610        620        630        640        650
VARKADGKQW EILGIMPCSD PPRHDTARTI HEAIGLGLRI KMLTGDAVGI 
       660        670        680        690        700
AKETARQLGM GTNVYNAERL GLSGGGDMPG SEVNDFVEAA DGFAEVFPQH 
       710        720        730        740        750
KYAVVDILQQ RGYLVAMTGD GVNDAPSLKK ADAGIAVEGA SDAARSAADI 
       760        770        780        790        800
VFLAPGLSAI IDALKTSRQI FHRMYAYVVY RIALSLHLEI FLGLWLIIRN 
       810        820        830        840        850
QLLNLELIVF IAIFADVATL AIAYDNAPYA MKPVKWNLPR LWGLATIVGI 
       860        870        880        890        900
LLAIGTWIVN TTMIAQGQNR GIVQNFGVQD EVLFLQISLT ENWLIFITRC 
       910        920        930        940        950
SGPFWSSFPS WQLSGAVLVV DILATLFCIF GWFKGGHQTS IVAVIRIWMY 
       960        970        980        990       1000
SFGIFCLIAG VYYILSESSS FDRWMHGKHK ERGTTRKLED FVMQLQRTST 
      1010
HHEAEGKVTS

Length:1,010

Mass (Da):110,128

Last modified:December 1, 1992 - v1

Checksum:ⁱ2C629A45125B4DC3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60471 Genomic DNA Translation: AAA35325.1 CU329672 Genomic DNA Translation: CAA18989.1
PIRⁱ	A40945 PXZP2P
NCBI Reference Sequences More...RefSeqⁱ	NP_587959.2, NM_001022950.2

Genome annotation databases

EnsemblFungiⁱ	SPCC1020.01c.1; SPCC1020.01c.1:pep; SPCC1020.01c
GeneIDⁱ	2539012
KEGGⁱ	spo:SPCC1020.01c

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28876	Plasma membrane ATPase		Purpureocillium lilacinum		1010	UniRef50_P28876
Plasma membrane ATPase		BEABA		950
Plasma membrane ATPase		Cordyceps brongniartii RCEF 3172		980
Plasma membrane ATPase		Beauveria bassiana D1-5		980
Plasma membrane ATPase		Fusarium oxysporum f. sp. melonis 26406		802
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M60471 Genomic DNA Translation: AAA35325.1 CU329672 Genomic DNA Translation: CAA18989.1
PIRⁱ	A40945 PXZP2P
RefSeqⁱ	NP_587959.2, NM_001022950.2

3D structure databases

ProteinModelPortalⁱ	P28876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	275585, 3 interactors
STRINGⁱ	4896.SPCC1020.01c.1

Proteomic databases

MaxQBⁱ	P28876
PaxDbⁱ	P28876
PRIDEⁱ	P28876

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPCC1020.01c.1; SPCC1020.01c.1:pep; SPCC1020.01c
GeneIDⁱ	2539012
KEGGⁱ	spo:SPCC1020.01c

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC1020.01c
PomBaseⁱ	SPCC1020.01c pma2

Phylogenomic databases

HOGENOMⁱ	HOG000160005
InParanoidⁱ	P28876
KOⁱ	K01535
OMAⁱ	HPGDGIY
OrthoDBⁱ	EOG092C0HLD
PhylomeDBⁱ	P28876

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P28876

PROⁱ

PR:P28876

Family and domain databases

CDDⁱ	cd02076 P-type_ATPase_H, 1 hit
Gene3Dⁱ	3.40.1110.10, 1 hit
InterProⁱ	View protein in InterPro IPR004014 ATPase_P-typ_cation-transptr_N IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR006534 P-type_ATPase_IIIA IPR001757 P_typ_ATPase
Pfamⁱ	View protein in Pfam PF00690 Cation_ATPase_N, 1 hit
PRINTSⁱ	PR00120 HATPASE
SMARTⁱ	View protein in SMART SM00831 Cation_ATPase_N, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit SSF81653 SSF81653, 1 hit SSF81665 SSF81665, 1 hit
TIGRFAMsⁱ	TIGR01647 ATPase-IIIA_H, 1 hit TIGR01494 ATPase_P-type, 2 hits
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PMA2_SCHPO
Accessionⁱ	P28876Primary (citable) accession number: P28876
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

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UniParc

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Supporting data

UniProtKB - P28876 (PMA2_SCHPO)

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Plasma membrane ATPase 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ