UniProtKB - P28876 (PMA2_SCHPO)
Protein
Plasma membrane ATPase 2
Gene
pma2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.
Catalytic activityi
- EC:7.1.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 464 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 720 | MagnesiumBy similarity | 1 | |
Metal bindingi | 724 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: PomBase
- metal ion binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: PomBase
GO - Biological processi
- proton export across plasma membrane Source: InterPro
- proton transmembrane transport Source: GO_Central
- regulation of intracellular pH Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pma2 ORF Names:SPCC1020.01c, SPCC1393.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPCC1020.01c, pma2 |
VEuPathDBi | FungiDB:SPCC1020.01c |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
- cell division site Source: PomBase
- cell tip Source: PomBase
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 201 | CytoplasmicSequence analysisAdd BLAST | 201 | |
Transmembranei | 202 – 222 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 223 – 226 | ExtracellularSequence analysis | 4 | |
Transmembranei | 227 – 246 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 247 – 377 | CytoplasmicSequence analysisAdd BLAST | 131 | |
Transmembranei | 378 – 399 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 400 – 410 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 411 – 433 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 434 – 805 | CytoplasmicSequence analysisAdd BLAST | 372 | |
Transmembranei | 806 – 824 | Helical; Name=5Sequence analysisAdd BLAST | 19 | |
Topological domaini | 825 – 840 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 841 – 860 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 861 – 912 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 913 – 933 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 934 – 946 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 947 – 963 | Helical; Name=8Sequence analysisAdd BLAST | 17 | |
Topological domaini | 964 – 1010 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046270 | 1 – 1010 | Plasma membrane ATPase 2Add BLAST | 1010 |
Post-translational modificationi
In addition to transient phosphorylation of the active site Asp residue, this protein, but not the product of the pma1 locus, is phosphorylated efficiently in isolated plasma membrane.
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P28876 |
PaxDbi | P28876 |
PRIDEi | P28876 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 275585, 6 interactors |
STRINGi | 4896.SPCC1020.01c.1 |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 121 – 150 | Asp/Glu-rich (acidic)Add BLAST | 30 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_0_1 |
InParanoidi | P28876 |
OMAi | APLWVFK |
PhylomeDBi | P28876 |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQRNNGEGRP EGMHRISRFL HGNPFKNNAS PQDDSTTRTE VYEEGGVEDS
60 70 80 90 100
AVDYDNASGN AAPRLTAAPN THAQQANLQS GNTSITHETQ STSRGQEATT
110 120 130 140 150
SPSLSASHEK PARPQTGEGS DNEDEDEDID ALIEDLYSQD QEEEQVEEEE
160 170 180 190 200
SPGPAGAAKV VPEELLETDP KYGLTESEVE ERKKKYGLNQ MKEEKTNNIK
210 220 230 240 250
KFLSFFVGPI QFVMELAAAL AAGLRDWVDF GVICALLLLN ATVGFVQEYQ
260 270 280 290 300
AGSIVDELKK TMALKASVLR DGRVKEIEAS EIVPGDILHL DEGTICPADG
310 320 330 340 350
RLITKDCFLQ VDQSAITGES LAVDKHQNDT MYSSSTVKRG EAFMVVTATA
360 370 380 390 400
DSTFVGRAAS LVGAAGQSQG HFTEVLNGIG TILLVLVILT LLCIYTAAFY
410 420 430 440 450
RSVRLAALLE YTLAITIIGV PVGLPAVVTT TMAVGAAYLA KKKAIVQKLS
460 470 480 490 500
AIESLAGVEI LCSDKTGTLT KNRLSLGEPY CVEGVSPDDL MLTACLASSR
510 520 530 540 550
KKKGLDAIDK AFLKALRNYP KAKDQLSKYK VLDFHPFDPV SKKITAYVEA
560 570 580 590 600
PDGQRITCVK GAPLWVFKTV QDDHEVPEAI TDAYREQVND MASRGFRSLG
610 620 630 640 650
VARKADGKQW EILGIMPCSD PPRHDTARTI HEAIGLGLRI KMLTGDAVGI
660 670 680 690 700
AKETARQLGM GTNVYNAERL GLSGGGDMPG SEVNDFVEAA DGFAEVFPQH
710 720 730 740 750
KYAVVDILQQ RGYLVAMTGD GVNDAPSLKK ADAGIAVEGA SDAARSAADI
760 770 780 790 800
VFLAPGLSAI IDALKTSRQI FHRMYAYVVY RIALSLHLEI FLGLWLIIRN
810 820 830 840 850
QLLNLELIVF IAIFADVATL AIAYDNAPYA MKPVKWNLPR LWGLATIVGI
860 870 880 890 900
LLAIGTWIVN TTMIAQGQNR GIVQNFGVQD EVLFLQISLT ENWLIFITRC
910 920 930 940 950
SGPFWSSFPS WQLSGAVLVV DILATLFCIF GWFKGGHQTS IVAVIRIWMY
960 970 980 990 1000
SFGIFCLIAG VYYILSESSS FDRWMHGKHK ERGTTRKLED FVMQLQRTST
1010
HHEAEGKVTS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60471 Genomic DNA Translation: AAA35325.1 CU329672 Genomic DNA Translation: CAA18989.1 |
PIRi | A40945, PXZP2P |
RefSeqi | NP_587959.2, NM_001022950.2 |
Genome annotation databases
EnsemblFungii | SPCC1020.01c.1; SPCC1020.01c.1:pep; SPCC1020.01c |
GeneIDi | 2539012 |
KEGGi | spo:SPCC1020.01c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60471 Genomic DNA Translation: AAA35325.1 CU329672 Genomic DNA Translation: CAA18989.1 |
PIRi | A40945, PXZP2P |
RefSeqi | NP_587959.2, NM_001022950.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 275585, 6 interactors |
STRINGi | 4896.SPCC1020.01c.1 |
Proteomic databases
MaxQBi | P28876 |
PaxDbi | P28876 |
PRIDEi | P28876 |
Genome annotation databases
EnsemblFungii | SPCC1020.01c.1; SPCC1020.01c.1:pep; SPCC1020.01c |
GeneIDi | 2539012 |
KEGGi | spo:SPCC1020.01c |
Organism-specific databases
PomBasei | SPCC1020.01c, pma2 |
VEuPathDBi | FungiDB:SPCC1020.01c |
Phylogenomic databases
eggNOGi | KOG0205, Eukaryota |
HOGENOMi | CLU_002360_6_0_1 |
InParanoidi | P28876 |
OMAi | APLWVFK |
PhylomeDBi | P28876 |
Miscellaneous databases
PROi | PR:P28876 |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PMA2_SCHPO | |
Accessioni | P28876Primary (citable) accession number: P28876 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names