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Protein

Plasma membrane ATPase 2

Gene

pma2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4644-aspartylphosphate intermediateBy similarity1
Metal bindingi720MagnesiumBy similarity1
Metal bindingi724MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • proton-exporting ATPase activity, phosphorylative mechanism Source: PomBase

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasma membrane ATPase 2 (EC:3.6.3.6)
Alternative name(s):
Proton pump 2
Gene namesi
Name:pma2
ORF Names:SPCC1020.01c, SPCC1393.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1020.01c
PomBaseiSPCC1020.01c pma2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 201CytoplasmicSequence analysisAdd BLAST201
Transmembranei202 – 222Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini223 – 226ExtracellularSequence analysis4
Transmembranei227 – 246Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini247 – 377CytoplasmicSequence analysisAdd BLAST131
Transmembranei378 – 399Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini400 – 410ExtracellularSequence analysisAdd BLAST11
Transmembranei411 – 433Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini434 – 805CytoplasmicSequence analysisAdd BLAST372
Transmembranei806 – 824Helical; Name=5Sequence analysisAdd BLAST19
Topological domaini825 – 840ExtracellularSequence analysisAdd BLAST16
Transmembranei841 – 860Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini861 – 912CytoplasmicSequence analysisAdd BLAST52
Transmembranei913 – 933Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini934 – 946ExtracellularSequence analysisAdd BLAST13
Transmembranei947 – 963Helical; Name=8Sequence analysisAdd BLAST17
Topological domaini964 – 1010CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462701 – 1010Plasma membrane ATPase 2Add BLAST1010

Post-translational modificationi

In addition to transient phosphorylation of the active site Asp residue, this protein, but not the product of the pma1 locus, is phosphorylated efficiently in isolated plasma membrane.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28876
PaxDbiP28876
PRIDEiP28876

Interactioni

Protein-protein interaction databases

BioGridi275585, 3 interactors
STRINGi4896.SPCC1020.01c.1

Structurei

3D structure databases

ProteinModelPortaliP28876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi121 – 150Asp/Glu-rich (acidic)Add BLAST30

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000160005
InParanoidiP28876
KOiK01535
OMAiQHRQYRD
OrthoDBiEOG092C0HLD
PhylomeDBiP28876

Family and domain databases

CDDicd02076 P-type_ATPase_H, 1 hit
Gene3Di3.40.1110.10, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR006534 P-type_ATPase_IIIA
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01647 ATPase-IIIA_H, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P28876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNNGEGRP EGMHRISRFL HGNPFKNNAS PQDDSTTRTE VYEEGGVEDS
60 70 80 90 100
AVDYDNASGN AAPRLTAAPN THAQQANLQS GNTSITHETQ STSRGQEATT
110 120 130 140 150
SPSLSASHEK PARPQTGEGS DNEDEDEDID ALIEDLYSQD QEEEQVEEEE
160 170 180 190 200
SPGPAGAAKV VPEELLETDP KYGLTESEVE ERKKKYGLNQ MKEEKTNNIK
210 220 230 240 250
KFLSFFVGPI QFVMELAAAL AAGLRDWVDF GVICALLLLN ATVGFVQEYQ
260 270 280 290 300
AGSIVDELKK TMALKASVLR DGRVKEIEAS EIVPGDILHL DEGTICPADG
310 320 330 340 350
RLITKDCFLQ VDQSAITGES LAVDKHQNDT MYSSSTVKRG EAFMVVTATA
360 370 380 390 400
DSTFVGRAAS LVGAAGQSQG HFTEVLNGIG TILLVLVILT LLCIYTAAFY
410 420 430 440 450
RSVRLAALLE YTLAITIIGV PVGLPAVVTT TMAVGAAYLA KKKAIVQKLS
460 470 480 490 500
AIESLAGVEI LCSDKTGTLT KNRLSLGEPY CVEGVSPDDL MLTACLASSR
510 520 530 540 550
KKKGLDAIDK AFLKALRNYP KAKDQLSKYK VLDFHPFDPV SKKITAYVEA
560 570 580 590 600
PDGQRITCVK GAPLWVFKTV QDDHEVPEAI TDAYREQVND MASRGFRSLG
610 620 630 640 650
VARKADGKQW EILGIMPCSD PPRHDTARTI HEAIGLGLRI KMLTGDAVGI
660 670 680 690 700
AKETARQLGM GTNVYNAERL GLSGGGDMPG SEVNDFVEAA DGFAEVFPQH
710 720 730 740 750
KYAVVDILQQ RGYLVAMTGD GVNDAPSLKK ADAGIAVEGA SDAARSAADI
760 770 780 790 800
VFLAPGLSAI IDALKTSRQI FHRMYAYVVY RIALSLHLEI FLGLWLIIRN
810 820 830 840 850
QLLNLELIVF IAIFADVATL AIAYDNAPYA MKPVKWNLPR LWGLATIVGI
860 870 880 890 900
LLAIGTWIVN TTMIAQGQNR GIVQNFGVQD EVLFLQISLT ENWLIFITRC
910 920 930 940 950
SGPFWSSFPS WQLSGAVLVV DILATLFCIF GWFKGGHQTS IVAVIRIWMY
960 970 980 990 1000
SFGIFCLIAG VYYILSESSS FDRWMHGKHK ERGTTRKLED FVMQLQRTST
1010
HHEAEGKVTS
Length:1,010
Mass (Da):110,128
Last modified:December 1, 1992 - v1
Checksum:i2C629A45125B4DC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60471 Genomic DNA Translation: AAA35325.1
CU329672 Genomic DNA Translation: CAA18989.1
PIRiA40945 PXZP2P
RefSeqiNP_587959.2, NM_001022950.2

Genome annotation databases

EnsemblFungiiSPCC1020.01c.1; SPCC1020.01c.1:pep; SPCC1020.01c
GeneIDi2539012
KEGGispo:SPCC1020.01c

Similar proteinsi

Entry informationi

Entry nameiPMA2_SCHPO
AccessioniPrimary (citable) accession number: P28876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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