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Protein

Uracil-DNA glycosylase

Gene

61

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei155Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Alternative name(s):
UNGUniRule annotation
Gene namesi
Name:61
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi
  • UP000001189 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761931 – 312Uracil-DNA glycosylaseAdd BLAST312

Structurei

3D structure databases

ProteinModelPortaliP28866
SMRiP28866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000E7

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P28866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSACDHETE ASHVNIPETT PEENGSNSST PTSEIGPACV VSPAPGETGA
60 70 80 90 100
PPPKRRRPCG LPQGVALINT SVSTHPLFTT SCQSSWEDVE REFNIAPSWR
110 120 130 140 150
PILEREMQQP YVRLLLNEYK LRCASEEVFP PKEDIFAWTR FSPPEKVRVV
160 170 180 190 200
IVGQDPYHAP GQAHGLAFSV RKGVPVPPSL RNIYSAVQKS YPSFRHPMHG
210 220 230 240 250
FLERWAEQGV LLINTTLTVA RGKPGSHATL GWHRLVRAVI DRLCTTSQGL
260 270 280 290 300
VFMLWGAHAQ KSCSPNRQHH LVLTYGHPSP LSRVNFRDCP HFLEANAYLT
310
KTGRKPVDWQ IE
Length:312
Mass (Da):34,778
Last modified:December 1, 1992 - v1
Checksum:i6C70A454FCD16E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA Translation: AAT67318.1
PIRiG36801 DGBEF3
RefSeqiYP_053105.1, NC_001491.2

Genome annotation databases

GeneIDi2948563
KEGGivg:2948563

Similar proteinsi

Entry informationi

Entry nameiUNG_EHV1B
AccessioniPrimary (citable) accession number: P28866
Secondary accession number(s): Q6S6U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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