UniProtKB - P28829 (BYR2_SCHPO)
Protein
Protein kinase byr2
Gene
byr2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 423 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 522 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 400 – 408 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase kinase kinase activity Source: PomBase
- protein kinase activity Source: GO_Central
GO - Biological processi
- induction of conjugation with cellular fusion Source: PomBase
- pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
- pheromone response MAPK cascade Source: PomBase
- regulation of ascospore formation Source: PomBase
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Conjugation, Sporulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.25, 5613 |
Reactomei | R-SPO-2559580, Oxidative Stress Induced Senescence |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase byr2 (EC:2.7.11.25)Alternative name(s): MAPK kinase kinase Short name: MAPKKK Protein kinase ste8 |
Gene namesi | Name:byr2 Synonyms:ste8 ORF Names:SPBC1D7.05, SPBC2F12.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPBC1D7.05 |
PomBasei | SPBC1D7.05, byr2 |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: PomBase
Other locations
- cell division site Source: PomBase
- cell tip Source: PomBase
- cytoplasm Source: PomBase
- division septum Source: PomBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085689 | 1 – 659 | Protein kinase byr2Add BLAST | 659 |
Proteomic databases
PaxDbi | P28829 |
PRIDEi | P28829 |
Interactioni
Binary interactionsi
P28829
With | #Exp. | IntAct |
---|---|---|
ras1 [P08647] | 2 | EBI-1032333,EBI-15585264 |
Protein-protein interaction databases
BioGRIDi | 277138, 51 interactors |
DIPi | DIP-136N |
IntActi | P28829, 4 interactors |
MINTi | P28829 |
STRINGi | 4896.SPBC1D7.05.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P28829 |
SMRi | P28829 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28829 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 67 | SAMPROSITE-ProRule annotationAdd BLAST | 64 | |
Domaini | 394 – 658 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 265 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
HOGENOMi | CLU_003051_2_0_1 |
InParanoidi | P28829 |
OMAi | RFIACNG |
PhylomeDBi | P28829 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR029458, Ras-bd_By2 IPR001660, SAM IPR013761, SAM/pointed_sf IPR008271, Ser/Thr_kinase_AS IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM01304, Ras_bdg_2, 1 hit SM00220, S_TKc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50105, SAM_DOMAIN, 1 hit |
i Sequence
Sequence statusi: Complete.
P28829-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEYYTSKEVA EWLKSIGLEK YIEQFSQNNI EGRHLNHLTL PLLKDLGIEN
60 70 80 90 100
TAKGKQFLKQ RDYLREFPRP CILRFIACNG QTRAVQSRGD YQKTLAIALK
110 120 130 140 150
KFSLEDASKF IVCVSQSSRI KLITEEEFKQ ICFNSSSPER DRLIIVPKEK
160 170 180 190 200
PCPSFEDLRR SWEIELAQPA ALSSQSSLSP KLSSVLPTST QKRSVRSNNA
210 220 230 240 250
KPFESYQRPP SELINSRISD FFPDHQPKLL EKTISNSLRR NLSIRTSQGH
260 270 280 290 300
NLGNFGQEIL PRSSRRARPS ELVCPLSSLR ISVAEDVNRL PRIDRGFDPP
310 320 330 340 350
LTVSSTQRIS RPPSLQKSIT MVGVEPLYQS NGNEKSSKYN VFSESAHGNH
360 370 380 390 400
QVLSFSPGSS PSFIEQPSPI SPTSTTSEDT NTLEEDTDDQ SIKWIRGALI
410 420 430 440 450
GSGSFGQVYL GMNASSGELM AVKQVILDSV SESKDRHAKL LDALAGEIAL
460 470 480 490 500
LQELSHEHIV QYLGSNLNSD HLNIFLEYVP GGSVAGLLTM YGSFEETLVK
510 520 530 540 550
NFIKQTLKGL EYLHSRGIVH RDIKGANILV DNKGKIKISD FGISKKLELN
560 570 580 590 600
STSTKTGGAR PSFQGSSFWM APEVVKQTMH TEKTDIWSLG CLVIEMLTSK
610 620 630 640 650
HPYPNCDQMQ AIFRIGENIL PEFPSNISSS AIDFLEKTFA IDCNLRPTAS
ELLSHPFVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74293 Genomic DNA Translation: AAA35289.1 X68851 Genomic DNA Translation: CAA48731.1 CU329671 Genomic DNA Translation: CAB10150.1 |
PIRi | A39723 |
RefSeqi | NP_595714.2, NM_001021611.3 |
Genome annotation databases
EnsemblFungii | SPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05 |
GeneIDi | 2540612 |
KEGGi | spo:SPBC1D7.05 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M74293 Genomic DNA Translation: AAA35289.1 X68851 Genomic DNA Translation: CAA48731.1 CU329671 Genomic DNA Translation: CAB10150.1 |
PIRi | A39723 |
RefSeqi | NP_595714.2, NM_001021611.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1I35 | NMR | - | A | 71-165 | [»] | |
1K8R | X-ray | 3.00 | B | 71-180 | [»] | |
BMRBi | P28829 | |||||
SMRi | P28829 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 277138, 51 interactors |
DIPi | DIP-136N |
IntActi | P28829, 4 interactors |
MINTi | P28829 |
STRINGi | 4896.SPBC1D7.05.1 |
Proteomic databases
PaxDbi | P28829 |
PRIDEi | P28829 |
Genome annotation databases
EnsemblFungii | SPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05 |
GeneIDi | 2540612 |
KEGGi | spo:SPBC1D7.05 |
Organism-specific databases
EuPathDBi | FungiDB:SPBC1D7.05 |
PomBasei | SPBC1D7.05, byr2 |
Phylogenomic databases
eggNOGi | KOG0198, Eukaryota |
HOGENOMi | CLU_003051_2_0_1 |
InParanoidi | P28829 |
OMAi | RFIACNG |
PhylomeDBi | P28829 |
Enzyme and pathway databases
BRENDAi | 2.7.11.25, 5613 |
Reactomei | R-SPO-2559580, Oxidative Stress Induced Senescence |
Miscellaneous databases
EvolutionaryTracei | P28829 |
PROi | PR:P28829 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR029458, Ras-bd_By2 IPR001660, SAM IPR013761, SAM/pointed_sf IPR008271, Ser/Thr_kinase_AS IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF07647, SAM_2, 1 hit |
SMARTi | View protein in SMART SM01304, Ras_bdg_2, 1 hit SM00220, S_TKc, 1 hit SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit SSF54236, SSF54236, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50105, SAM_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BYR2_SCHPO | |
Accessioni | P28829Primary (citable) accession number: P28829 Secondary accession number(s): Q7LGJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families