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Protein

Protein kinase byr2

Gene

byr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei423ATPPROSITE-ProRule annotation1
Active sitei522Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi400 – 408ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: PomBase
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processConjugation, Sporulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.25 5613
ReactomeiR-SPO-2559580 Oxidative Stress Induced Senescence

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase byr2 (EC:2.7.11.25)
Alternative name(s):
MAPK kinase kinase
Short name:
MAPKKK
Protein kinase ste8
Gene namesi
Name:byr2
Synonyms:ste8
ORF Names:SPBC1D7.05, SPBC2F12.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.05
PomBaseiSPBC1D7.05 byr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856891 – 659Protein kinase byr2Add BLAST659

Proteomic databases

PaxDbiP28829
PRIDEiP28829

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ras1P086472EBI-1032333,EBI-15585264

Protein-protein interaction databases

BioGridi277138, 42 interactors
DIPiDIP-136N
IntActiP28829, 2 interactors
MINTiP28829
STRINGi4896.SPBC1D7.05.1

Structurei

Secondary structure

1659
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28829
SMRiP28829
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28829

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 67SAMPROSITE-ProRule annotationAdd BLAST64
Domaini394 – 658Protein kinasePROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Phylogenomic databases

InParanoidiP28829
KOiK11228
OMAiRFIACNG
OrthoDBiEOG092C030N
PhylomeDBiP28829

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR029458 Ras-bd_By2
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF14847 Ras_bdg_2, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM01304 Ras_bdg_2, 1 hit
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P28829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEYYTSKEVA EWLKSIGLEK YIEQFSQNNI EGRHLNHLTL PLLKDLGIEN
60 70 80 90 100
TAKGKQFLKQ RDYLREFPRP CILRFIACNG QTRAVQSRGD YQKTLAIALK
110 120 130 140 150
KFSLEDASKF IVCVSQSSRI KLITEEEFKQ ICFNSSSPER DRLIIVPKEK
160 170 180 190 200
PCPSFEDLRR SWEIELAQPA ALSSQSSLSP KLSSVLPTST QKRSVRSNNA
210 220 230 240 250
KPFESYQRPP SELINSRISD FFPDHQPKLL EKTISNSLRR NLSIRTSQGH
260 270 280 290 300
NLGNFGQEIL PRSSRRARPS ELVCPLSSLR ISVAEDVNRL PRIDRGFDPP
310 320 330 340 350
LTVSSTQRIS RPPSLQKSIT MVGVEPLYQS NGNEKSSKYN VFSESAHGNH
360 370 380 390 400
QVLSFSPGSS PSFIEQPSPI SPTSTTSEDT NTLEEDTDDQ SIKWIRGALI
410 420 430 440 450
GSGSFGQVYL GMNASSGELM AVKQVILDSV SESKDRHAKL LDALAGEIAL
460 470 480 490 500
LQELSHEHIV QYLGSNLNSD HLNIFLEYVP GGSVAGLLTM YGSFEETLVK
510 520 530 540 550
NFIKQTLKGL EYLHSRGIVH RDIKGANILV DNKGKIKISD FGISKKLELN
560 570 580 590 600
STSTKTGGAR PSFQGSSFWM APEVVKQTMH TEKTDIWSLG CLVIEMLTSK
610 620 630 640 650
HPYPNCDQMQ AIFRIGENIL PEFPSNISSS AIDFLEKTFA IDCNLRPTAS

ELLSHPFVS
Length:659
Mass (Da):73,633
Last modified:December 1, 1992 - v1
Checksum:i18CD78F1D1FABBCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74293 Genomic DNA Translation: AAA35289.1
X68851 Genomic DNA Translation: CAA48731.1
CU329671 Genomic DNA Translation: CAB10150.1
PIRiA39723
RefSeqiNP_595714.2, NM_001021611.3

Genome annotation databases

EnsemblFungiiSPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05
GeneIDi2540612
KEGGispo:SPBC1D7.05

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74293 Genomic DNA Translation: AAA35289.1
X68851 Genomic DNA Translation: CAA48731.1
CU329671 Genomic DNA Translation: CAB10150.1
PIRiA39723
RefSeqiNP_595714.2, NM_001021611.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I35NMR-A71-165[»]
1K8RX-ray3.00B71-180[»]
ProteinModelPortaliP28829
SMRiP28829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277138, 42 interactors
DIPiDIP-136N
IntActiP28829, 2 interactors
MINTiP28829
STRINGi4896.SPBC1D7.05.1

Proteomic databases

PaxDbiP28829
PRIDEiP28829

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05
GeneIDi2540612
KEGGispo:SPBC1D7.05

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.05
PomBaseiSPBC1D7.05 byr2

Phylogenomic databases

InParanoidiP28829
KOiK11228
OMAiRFIACNG
OrthoDBiEOG092C030N
PhylomeDBiP28829

Enzyme and pathway databases

BRENDAi2.7.11.25 5613
ReactomeiR-SPO-2559580 Oxidative Stress Induced Senescence

Miscellaneous databases

EvolutionaryTraceiP28829
PROiPR:P28829

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR029458 Ras-bd_By2
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR008271 Ser/Thr_kinase_AS
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF14847 Ras_bdg_2, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM01304 Ras_bdg_2, 1 hit
SM00220 S_TKc, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF54236 SSF54236, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBYR2_SCHPO
AccessioniPrimary (citable) accession number: P28829
Secondary accession number(s): Q7LGJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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