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Entry version 182 (08 May 2019)
Sequence version 4 (13 Jul 2010)
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Protein

Meprin A subunit alpha

Gene

Mep1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by metal ion chelators EDTA and 1,10-phenanthroline, bradykinin analogs, cysteine, CONA65, and several hydroxamate compounds, particularly tyrosine hydroxamate. Not inhibited by 3,4-dichloroisocourmarin, soybean trypsin inhibitor, or the cysteine proteinase inhibitors iodoacetic acid and E-64.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=29.6 µM for GRP3 Publications
  2. KM=67.2 µM for PTH 12-343 Publications
  3. KM=111 µM for secretin3 Publications
  4. KM=30.6 µM for substance P3 Publications
  5. KM=156 µM for LHRH3 Publications
  6. KM=22.3 µM for alpha-MSH3 Publications
  7. KM=101 µM for bradykinin3 Publications
  8. KM=290 µM for Arg-Pro-Pro-Gly-Npa-Ser-Pro-Phe-Arg3 Publications
  9. KM=331 µM for Arg-Pro-Pro-Gly-Npa-Ala-Pro-Phe-Arg3 Publications
  10. KM=174 µM for Arg-Pro-Pro-Gly-Npa-Arg-Pro-Phe-Arg3 Publications
  11. KM=226 µM for Arg-Pro-Pro-Gly-Npa-Phe-Pro-Phe-Arg3 Publications
  12. KM=182 µM for Arg-Pro-Pro-Gly-Npa-Lys-Pro-Phe-Arg3 Publications
  13. KM=339 µM for Arg-Pro-Pro-Gly-Npa-Glu-Pro-Phe-Arg3 Publications
  14. KM=366 µM for 2ABz-Arg-Pro-Gly-Phe-Ser-Pro-Npa-Arg3 Publications
  15. KM=296 µM for 2ABz-Arg-Pro-Ile-Phe-Ser-Pro-Npa-Arg3 Publications
  16. KM=183 µM for 2ABz-Arg-Hyp-Gly-Phe-Ser-Pro-Npa-Arg3 Publications
  17. KM=220 µM for 2ABz-Arg-Gly-Pro-Phe-Ser-Pro-Npa-Arg3 Publications
  18. KM=1380 µM for 2ABz-Arg-Pro-Gly-Ala-Ser-Pro-Npa-Arg3 Publications
  19. KM=1220 µM for 2ABz-Arg-Pro-Gly-Glu-Ser-Pro-Npa-Arg3 Publications
  20. KM=402 µM for 2ABz-Arg-Pro-Gly-Lys-Ser-Pro-Npa-Arg3 Publications
  21. KM=2460 µM for 2ABz-Arg-Pro-Gly-Leu-Ser-Pro-Npa-Arg3 Publications

    Temperature dependencei

    The half-life at 58 degrees Celsius is 50 minutes.3 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi154Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei155PROSITE-ProRule annotation1
    Metal bindingi158Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
    Metal bindingi164Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • metalloendopeptidase activity Source: GO_Central
    • zinc ion binding Source: InterPro

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.24.18 3474

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P28825

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M12.002

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Meprin A subunit alpha (EC:3.4.24.18)
    Alternative name(s):
    Endopeptidase-2
    MEP-1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Mep1a
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:96963 Mep1a

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini65 – 713ExtracellularSequence analysisAdd BLAST649
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei714 – 741HelicalSequence analysisAdd BLAST28
    Topological domaini742 – 747CytoplasmicSequence analysis6

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi139N → Q: Increased susceptibility to heat-inactivation. Forms homodimers and oligomers; when associated with Q-221. Inactive, impaired ability to form homodimers or oligomers; when associated with Q-257 or Q-221 and Q-257. 1 Publication1
    Mutagenesisi141S → A: Impaired ability to form homodimers or oligomers; when associated with A-259. 1 Publication1
    Mutagenesisi221N → Q: Increased susceptibility to heat-inactivation. Forms homodimers and oligomers; when associated with Q-139 or Q-257. Inactive, impaired ability to form homodimers or oligomers; when associated with Q-139 and Q-257. 1 Publication1
    Mutagenesisi257N → Q: Increased susceptibility to heat-inactivation. Forms homodimers and oligomers; when associated with Q-221. Inactive, impaired ability to form homodimers or oligomers; when associated with Q-139 or Q-139 and Q-221. 1 Publication1
    Mutagenesisi259T → A: Impaired ability to form homodimers or oligomers; when associated with A-141. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002887921 – 643 PublicationsAdd BLAST44
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002888065 – 747Meprin A subunit alphaAdd BLAST683

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi28N-linked (GlcNAc...) asparagine1 Publication1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 258PROSITE-ProRule annotation
    Disulfide bondi127 ↔ 146PROSITE-ProRule annotation
    Glycosylationi139N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi221N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi257N-linked (GlcNAc...) asparagine1 Publication1
    Disulfide bondi268 ↔ 430PROSITE-ProRule annotation
    Disulfide bondi276InterchainPROSITE-ProRule annotation
    Disulfide bondi307InterchainPROSITE-ProRule annotation
    Glycosylationi317N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi413N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi439N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi533N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi540N-linked (GlcNAc...) asparagine1 Publication1
    Disulfide bondi675 ↔ 686PROSITE-ProRule annotation
    Disulfide bondi680 ↔ 695PROSITE-ProRule annotation
    Disulfide bondi697 ↔ 710PROSITE-ProRule annotation

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated; contains GlcNAc, galactose, mannose and a small amount of fucose.2 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei601Not glycosylated1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P28825

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P28825

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P28825

    PeptideAtlas

    More...
    PeptideAtlasi
    P28825

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P28825

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P28825

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P28825

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Kidney, intestinal brush borders and salivary ducts.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000023914 Expressed in 56 organ(s), highest expression level in adult mammalian kidney

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P28825 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P28825 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer consisting of disulfide-linked alpha subunits, homooligomer consisting of disulfide-linked alpha subunit homodimers, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers. Genetic factors determine which oligomer(s) will be formed (strain-specific). Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity.3 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    201396, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P28825, 3 interactors

    Molecular INTeraction database

    More...
    MINTi
    P28825

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000024707

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P28825

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 259Peptidase M12APROSITE-ProRule annotationAdd BLAST195
    Domaini263 – 432MAMPROSITE-ProRule annotationAdd BLAST170
    Domaini433 – 594MATHPROSITE-ProRule annotationAdd BLAST162
    Domaini671 – 711EGF-likePROSITE-ProRule annotationAdd BLAST41

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3714 Eukaryota
    ENOG410ZPX7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000183111

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000043106

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P28825

    KEGG Orthology (KO)

    More...
    KOi
    K01395

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MHYAPFS

    Database of Orthologous Groups

    More...
    OrthoDBi
    241999at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P28825

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315280

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06263 MAM, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.210.10, 1 hit
    3.40.390.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013320 ConA-like_dom_sf
    IPR000742 EGF-like_dom
    IPR000998 MAM_dom
    IPR002083 MATH/TRAF_dom
    IPR008294 Meprin
    IPR034301 Meprin_alpha
    IPR024079 MetalloPept_cat_dom_sf
    IPR001506 Peptidase_M12A
    IPR006026 Peptidase_Metallo
    IPR008974 TRAF-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10127:SF824 PTHR10127:SF824, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01400 Astacin, 1 hit
    PF00008 EGF, 1 hit
    PF00629 MAM, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF001196 Meprin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00480 ASTACIN
    PR00020 MAMDOMAIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00137 MAM, 1 hit
    SM00061 MATH, 1 hit
    SM00235 ZnMc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49599 SSF49599, 1 hit
    SSF49899 SSF49899, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51864 ASTACIN, 1 hit
    PS50026 EGF_3, 1 hit
    PS00740 MAM_1, 1 hit
    PS50060 MAM_2, 1 hit
    PS50144 MATH, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    P28825-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLWIQPACLL SLIFSAHIAA VSIKHLLNGS DHDTDVGEQK DIFEINLAAG
    60 70 80 90 100
    LNLFQGDILL PRTRNAMRDP SSRWKLPIPY ILADNLELNA KGAILHAFEM
    110 120 130 140 150
    FRLKSCVDFK PYEGESSYII FQKLSGCWSM IGDQQVGQNI SIGEGCDFKA
    160 170 180 190 200
    TIEHEILHAL GFFHEQSRTD RDDYVNIWWD QIITDYEHNF NTYDDNTITD
    210 220 230 240 250
    LNTPYDYESL MHYGPFSFNK NESIPTITTK IPEFNTIIGQ LPDFSAIDLI
    260 270 280 290 300
    RLNRMYNCTA THTLLDHCDF EKTNVCGMIQ GTRDDADWAH GDSSQPEQVD
    310 320 330 340 350
    HTLVGQCKGA GYFMFFNTSL GARGEAALLE SRILYPKRKQ QCLQFFYKMT
    360 370 380 390 400
    GSPADRFEVW VRRDDNAGKV RQLAKIQTFQ GDSDHNWKIA HVTLNEEKKF
    410 420 430 440 450
    RYVFLGTKGD PGNSSGGIYL DDITLTETPC PAGVWTIRNI SQILENTVKG
    460 470 480 490 500
    DKLVSPRFYN SEGYGVGVTL YPNGRITSNS GFLGLTFHLY SGDNDAILEW
    510 520 530 540 550
    PVENRQAIMT ILDQEADTRN RMSLTLMFTT SKNQTSSAIN GSVIWDRPSK
    560 570 580 590 600
    VGVYDKDCDC FRSLDWGWGQ AISHQLLKRR NFLKGDSLII FVDFKDLTHL
    610 620 630 640 650
    NRTEVPASAR STMPRGLLLQ GQESPALGES SRKAMLEESL PSSLGQRHPS
    660 670 680 690 700
    RQKRSVENTG PMEDHNWPQY FRDPCDPNPC QNEGTCVNVK GMASCRCVSG
    710 720 730 740
    HAFFYAGERC QAMHVHGSLL GLLIGCIAGL IFLTFVTFST TNGKLRQ
    Length:747
    Mass (Da):84,231
    Last modified:July 13, 2010 - v4
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A1A268043559953
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0R4J043A0A0R4J043_MOUSE
    Meprin A subunit
    Mep1a
    760Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA75354 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
    The sequence AAH15258 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti482F → L in AAA75354 (PubMed:1374387).Curated1
    Sequence conflicti533N → I AA sequence (PubMed:1894622).Curated1
    Sequence conflicti540N → S AA sequence (PubMed:1894622).Curated1
    Sequence conflicti545W → T AA sequence (PubMed:1894622).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M74897 mRNA Translation: AAA75354.1 Different initiation.
    CT010585 Genomic DNA No translation available.
    BC015258 mRNA Translation: AAH15258.1 Different initiation.
    U62765 Genomic DNA Translation: AAC53194.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A40195

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_032611.2, NM_008585.2
    XP_006523814.1, XM_006523751.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000117137; ENSMUSP00000113838; ENSMUSG00000023914

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    17287

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:17287

    UCSC genome browser

    More...
    UCSCi
    uc008cpc.1 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M74897 mRNA Translation: AAA75354.1 Different initiation.
    CT010585 Genomic DNA No translation available.
    BC015258 mRNA Translation: AAH15258.1 Different initiation.
    U62765 Genomic DNA Translation: AAC53194.1
    PIRiA40195
    RefSeqiNP_032611.2, NM_008585.2
    XP_006523814.1, XM_006523751.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1IAFmodel-A65-261[»]
    SMRiP28825
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi201396, 2 interactors
    IntActiP28825, 3 interactors
    MINTiP28825
    STRINGi10090.ENSMUSP00000024707

    Protein family/group databases

    MEROPSiM12.002

    PTM databases

    iPTMnetiP28825
    PhosphoSitePlusiP28825

    Proteomic databases

    jPOSTiP28825
    MaxQBiP28825
    PaxDbiP28825
    PeptideAtlasiP28825
    PRIDEiP28825

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000117137; ENSMUSP00000113838; ENSMUSG00000023914
    GeneIDi17287
    KEGGimmu:17287
    UCSCiuc008cpc.1 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    4224
    MGIiMGI:96963 Mep1a

    Phylogenomic databases

    eggNOGiKOG3714 Eukaryota
    ENOG410ZPX7 LUCA
    GeneTreeiENSGT00950000183111
    HOGENOMiHOG000043106
    InParanoidiP28825
    KOiK01395
    OMAiMHYAPFS
    OrthoDBi241999at2759
    PhylomeDBiP28825
    TreeFamiTF315280

    Enzyme and pathway databases

    BRENDAi3.4.24.18 3474
    SABIO-RKiP28825

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Mep1a mouse

    Protein Ontology

    More...
    PROi
    PR:P28825

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000023914 Expressed in 56 organ(s), highest expression level in adult mammalian kidney
    ExpressionAtlasiP28825 baseline and differential
    GenevisibleiP28825 MM

    Family and domain databases

    CDDicd06263 MAM, 1 hit
    Gene3Di2.60.210.10, 1 hit
    3.40.390.10, 1 hit
    InterProiView protein in InterPro
    IPR013320 ConA-like_dom_sf
    IPR000742 EGF-like_dom
    IPR000998 MAM_dom
    IPR002083 MATH/TRAF_dom
    IPR008294 Meprin
    IPR034301 Meprin_alpha
    IPR024079 MetalloPept_cat_dom_sf
    IPR001506 Peptidase_M12A
    IPR006026 Peptidase_Metallo
    IPR008974 TRAF-like
    PANTHERiPTHR10127:SF824 PTHR10127:SF824, 1 hit
    PfamiView protein in Pfam
    PF01400 Astacin, 1 hit
    PF00008 EGF, 1 hit
    PF00629 MAM, 1 hit
    PIRSFiPIRSF001196 Meprin, 1 hit
    PRINTSiPR00480 ASTACIN
    PR00020 MAMDOMAIN
    SMARTiView protein in SMART
    SM00137 MAM, 1 hit
    SM00061 MATH, 1 hit
    SM00235 ZnMc, 1 hit
    SUPFAMiSSF49599 SSF49599, 1 hit
    SSF49899 SSF49899, 1 hit
    PROSITEiView protein in PROSITE
    PS51864 ASTACIN, 1 hit
    PS50026 EGF_3, 1 hit
    PS00740 MAM_1, 1 hit
    PS50060 MAM_2, 1 hit
    PS50144 MATH, 1 hit
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMEP1A_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28825
    Secondary accession number(s): B0V2P9, Q91WH9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 13, 2010
    Last modified: May 8, 2019
    This is version 182 of the entry and version 4 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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