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Entry version 129 (10 Apr 2019)
Sequence version 1 (01 Dec 1992)
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Protein

Aminodeoxychorismate synthase component 1

Gene

pabB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC.1 Publication

Miscellaneous

The catalytically active amino acid residue K274 of E.coli enzyme is missing and corresponds to A283 in B.subtilis. It is postulated that the enzymatic mechanism for the PABA biosynthesis in B.subtilis proceeds without covalent intermediate. First, ammonia is added at C2 of chorismate with concomitant loss of the C4 hydroxy group, yielding 2-amino-2-deoxyisochorismate (ADIC). The second step is the addition of a second molecule ammonia to C4 of ADIC with concomitant loss of the C2 amino group, yielding ADC. Both steps are catalyzed by ADCS (PubMed:19275258).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=380 µM for chorismate (with PabA and ammonia as the amino donor at pH 7.5)1 Publication
  2. KM=420 µM for chorismate (with PabA and glutamine as the amino donor at pH 7.5)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes 4-aminobenzoate from chorismate.
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. Aminodeoxychorismate/anthranilate synthase component 2 (pabA), Aminodeoxychorismate synthase component 1 (pabB)
    2. Aminodeoxychorismate lyase (pabC)
    This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobenzoate from chorismate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processFolate biosynthesis
    LigandMagnesium

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    BSUB:BSU00740-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.6.1.85 658

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00077;UER00149

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Aminodeoxychorismate synthase component 1 (EC:2.6.1.85)
    Short name:
    ADC synthase
    Short name:
    ADCS
    Alternative name(s):
    4-amino-4-deoxychorismate synthase component 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:pabB
    Synonyms:pab
    Ordered Locus Names:BSU00740
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi283A → I: Complete loss of aminodeoxychorismate synthase activity. 1 Publication1
    Mutagenesisi283A → K: Absence of covalent intermediate. 1 Publication1
    Mutagenesisi283A → V: Complete loss of aminodeoxychorismate synthase activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001541351 – 470Aminodeoxychorismate synthase component 1Add BLAST470

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P28820

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P28820

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer. Heterodimer consisting of two non-identical subunits: a glutamine amidotransferase subunit (PabA) and a aminodeoxychorismate synthase subunit (PabB).1 Publication

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    224308.BSU00740

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P28820

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P28820

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG4105CRQ Bacteria
    COG0147 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000025142

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P28820

    KEGG Orthology (KO)

    More...
    KOi
    K01665

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PHNRFDI

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P28820

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.60.120.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005801 ADC_synthase
    IPR019999 Anth_synth_I-like
    IPR006805 Anth_synth_I_N
    IPR015890 Chorismate_C

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04715 Anth_synt_I_N, 1 hit
    PF00425 Chorismate_bind, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00095 ANTSNTHASEI

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56322 SSF56322, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    P28820-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAQRRPAGKK IPFQKDSFLQ QFEKLAQSRK HHVLLESARG GRYSIAGLDP
    60 70 80 90 100
    IATVKGKDGI TTIKHGDEML FKEGDPLRAF HSWFKTLETE TNHEFPDFQG
    110 120 130 140 150
    GAIGFLSYDY ARYIENFKML SLDDLETPDI YFLVFDDIAV YDHQEESLWL
    160 170 180 190 200
    ITHVNGSDQE TADVKLSELE QMWLTELPAV TSREMKPETA GSFAAPFTED
    210 220 230 240 250
    GFSQAVEKIK QYIASGDVFQ VNLSIRQSQS LSVHPYQIYK TLREVNPSPY
    260 270 280 290 300
    MAYLETPDFQ IICGSPELLV SKKGKLLETR PIAGTRSRGK TNEEDEALAN
    310 320 330 340 350
    ELIHNEKERA EHVMLVDLER NDLGRVSRYG SVRVNEFMAI EKYSHVMHIV
    360 370 380 390 400
    SNVQGELQDG YDAVDIIHAV FPGGTITGAP KVRTMEIIEE LEPTRRGLYT
    410 420 430 440 450
    GSIGWFGYNH DLQFNIVIRT IYATGGQAFM QSGAGVVIDS VPKHEYKESF
    460 470
    KKAFAMQRAL ELSEEETKIR
    Length:470
    Mass (Da):53,251
    Last modified:December 1, 1992 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA7544C30689383E
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M34053 Genomic DNA Translation: AAA22694.1
    D26185 Genomic DNA Translation: BAA05309.1
    AL009126 Genomic DNA Translation: CAB11850.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A37854

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_387955.1, NC_000964.3
    WP_003242468.1, NZ_JNCM01000028.1

    Genome annotation databases

    Ensembl bacterial and archaeal genome annotation project

    More...
    EnsemblBacteriai
    CAB11850; CAB11850; BSU00740

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    936926

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    bsu:BSU00740

    Pathosystems Resource Integration Center (PATRIC)

    More...
    PATRICi
    fig|224308.179.peg.74

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M34053 Genomic DNA Translation: AAA22694.1
    D26185 Genomic DNA Translation: BAA05309.1
    AL009126 Genomic DNA Translation: CAB11850.1
    PIRiA37854
    RefSeqiNP_387955.1, NC_000964.3
    WP_003242468.1, NZ_JNCM01000028.1

    3D structure databases

    ProteinModelPortaliP28820
    SMRiP28820
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi224308.BSU00740

    Proteomic databases

    PaxDbiP28820
    PRIDEiP28820

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiCAB11850; CAB11850; BSU00740
    GeneIDi936926
    KEGGibsu:BSU00740
    PATRICifig|224308.179.peg.74

    Phylogenomic databases

    eggNOGiENOG4105CRQ Bacteria
    COG0147 LUCA
    HOGENOMiHOG000025142
    InParanoidiP28820
    KOiK01665
    OMAiPHNRFDI
    PhylomeDBiP28820

    Enzyme and pathway databases

    UniPathwayi
    UPA00077;UER00149

    BioCyciBSUB:BSU00740-MONOMER
    BRENDAi2.6.1.85 658

    Family and domain databases

    Gene3Di3.60.120.10, 1 hit
    InterProiView protein in InterPro
    IPR005801 ADC_synthase
    IPR019999 Anth_synth_I-like
    IPR006805 Anth_synth_I_N
    IPR015890 Chorismate_C
    PfamiView protein in Pfam
    PF04715 Anth_synt_I_N, 1 hit
    PF00425 Chorismate_bind, 1 hit
    PRINTSiPR00095 ANTSNTHASEI
    SUPFAMiSSF56322 SSF56322, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPABB_BACSU
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28820
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: April 10, 2019
    This is version 129 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
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