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Protein

Granulins

Gene

GRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • growth factor activity Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

  • neutrophil degranulation Source: Reactome
  • signal transduction Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

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SIGNORi
P28799

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Granulins
Alternative name(s):
Proepithelin
Short name:
PEPI
Cleaved into the following 9 chains:
Alternative name(s):
Glycoprotein of 88 Kda
Short name:
GP88
Short name:
Glycoprotein 88
Progranulin
Alternative name(s):
Granulin G
Alternative name(s):
Granulin F
Alternative name(s):
Granulin B
Alternative name(s):
Granulin A
Alternative name(s):
Granulin C
Alternative name(s):
Granulin D
Alternative name(s):
Granulin E
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000030582.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4601 GRN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
138945 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P28799

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ubiquitin-positive frontotemporal dementia (UP-FTD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionFrontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.
See also OMIM:607485
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0444519A → D in UP-FTD; no significant difference in the total mRNA between cases and controls; although the mutant protein is expressed it is not secreted and appears to be trapped within an intracellular compartment. 2 PublicationsCorresponds to variant dbSNP:rs63751243EnsemblClinVar.1
Ceroid lipofuscinosis, neuronal, 11 (CLN11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.
See also OMIM:614706

Keywords - Diseasei

Neurodegeneration, Neuronal ceroid lipofuscinosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
2896

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
GRN

MalaCards human disease database

More...
MalaCardsi
GRN
MIMi607485 phenotype
614706 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000030582

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
275864 Behavioral variant of frontotemporal dementia
314629 CLN11 disease
100070 Progressive non-fluent aphasia
100069 Semantic dementia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28998

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
77416865

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001269318 – 593AcrograninAdd BLAST576
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001269418 – ?47ParagranulinAdd BLAST30
PeptideiPRO_0000012695?58 – ?113Granulin-1Add BLAST56
PeptideiPRO_0000012696123 – 179Granulin-2Add BLAST57
PeptideiPRO_0000012697206 – 261Granulin-3Add BLAST56
PeptideiPRO_0000012698281 – 336Granulin-4Add BLAST56
PeptideiPRO_0000012699364 – 417Granulin-5Add BLAST54
PeptideiPRO_0000012700442 – ?496Granulin-6Add BLAST55
PeptideiPRO_0000012701?518 – ?573Granulin-7Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi126 ↔ 1391 Publication
Disulfide bondi133 ↔ 1491 Publication
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi284 ↔ 2961 Publication
Disulfide bondi290 ↔ 3061 Publication
Disulfide bondi297 ↔ 3141 Publication
Disulfide bondi307 ↔ 3211 Publication
Disulfide bondi315 ↔ 3281 Publication
Disulfide bondi322 ↔ 3351 Publication
Disulfide bondi366 ↔ 3781 Publication
Glycosylationi368N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi372 ↔ 3881 Publication
Disulfide bondi397 ↔ 4101 Publication
Disulfide bondi404 ↔ 4161 Publication
Glycosylationi530N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Granulins are disulfide bridged.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P28799

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P28799

MaxQB - The MaxQuant DataBase

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MaxQBi
P28799

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P28799

PeptideAtlas

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PeptideAtlasi
P28799

PRoteomics IDEntifications database

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PRIDEi
P28799

ProteomicsDB human proteome resource

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ProteomicsDBi
54499
54500 [P28799-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P28799-2 [P28799-2]
P28799-3 [P28799-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1290

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P28799

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P28799

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P28799

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000030582 Expressed in 235 organ(s), highest expression level in esophagus mucosa

CleanEx database of gene expression profiles

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CleanExi
HS_GRN

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P28799 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P28799 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB019394
HPA008763
HPA028747

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Acrogranin/Progranulin is secreted as a homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109153, 108 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P28799

Database of interacting proteins

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DIPi
DIP-41742N

Protein interaction database and analysis system

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IntActi
P28799, 106 interactors

Molecular INTeraction database

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MINTi
P28799

STRING: functional protein association networks

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STRINGi
9606.ENSP00000053867

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G26NMR-A281-311[»]
2JYENMR-A281-337[»]
2JYTNMR-A364-417[»]
2JYUNMR-A364-417[»]
2JYVNMR-A123-179[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P28799

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28799

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P28799

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the granulin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4296 Eukaryota
ENOG410XR6S LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00470000042293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000067856

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000845

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28799

Identification of Orthologs from Complete Genome Data

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OMAi
NAICCSD

Database of Orthologous Groups

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OrthoDBi
162721at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P28799

TreeFam database of animal gene trees

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TreeFami
TF319678

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.20.500, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000118 Granulin
IPR039036 Granulin_fam
IPR037277 Granulin_sf

The PANTHER Classification System

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PANTHERi
PTHR12274 PTHR12274, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF00396 Granulin, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00277 GRAN, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00799 GRANULINS, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28799-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP
60 70 80 90 100
TTLSRHLGGP CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP
110 120 130 140 150
RGFHCSADGR SCFQRSGNNS VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC
160 170 180 190 200
PMPQASCCED RVHCCPHGAF CDLVHTRCIT PTGTHPLAKK LPAQRTNRAV
210 220 230 240 250
ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC SDHLHCCPQD
260 270 280 290 300
TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ
310 320 330 340 350
SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA
360 370 380 390 400
HLSLPDPQAL KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH
410 420 430 440 450
QHCCPQGYTC VAEGQCQRGS EIVAGLEKMP ARRASLSHPR DIGCDQHTSC
460 470 480 490 500
PVGQTCCPSL GGSWACCQLP HAVCCEDRQH CCPAGYTCNV KARSCEKEVV
510 520 530 540 550
SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG WACCPYRQGV
560 570 580 590
CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL
Length:593
Mass (Da):63,544
Last modified:October 11, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E5947F1B4EDE619
GO
Isoform 2 (identifier: P28799-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-531: Missing.

Show »
Length:438
Mass (Da):46,991
Checksum:i558B72CBAF3B991F
GO
Isoform 3 (identifier: P28799-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: MWTLVSWVAL...QVDAHCSAGH → MAITAAHGAS...LPAVKTGCTA
     72-251: Missing.

Note: No experimental confirmation available.
Show »
Length:413
Mass (Da):44,132
Checksum:i0E3767A44BE314EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ05K7EQ05_HUMAN
Granulins
GRN
436Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKL3K7EKL3_HUMAN
Granulins
GRN
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPL0K7EPL0_HUMAN
Granulins
GRN
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMR1K7EMR1_HUMAN
Granulins
GRN
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJY4K7EJY4_HUMAN
Granulins
GRN
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EM89K7EM89_HUMAN
Granulins
GRN
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERM2K7ERM2_HUMAN
Granulins
GRN
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQK6K7EQK6_HUMAN
Granulins
GRN
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENI2K7ENI2_HUMAN
Granulins
GRN
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK92K7EK92_HUMAN
Granulins
GRN
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219S → H AA sequence (PubMed:2268320).Curated1
Sequence conflicti290C → S AA sequence (PubMed:8471426).Curated1
Sequence conflicti386W → H AA sequence (PubMed:2268320).Curated1
Sequence conflicti428K → E in BAD96242 (Ref. 8) Curated1
Sequence conflicti454Q → G in AAA58617 (PubMed:1542665).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0444519A → D in UP-FTD; no significant difference in the total mRNA between cases and controls; although the mutant protein is expressed it is not secreted and appears to be trapped within an intracellular compartment. 2 PublicationsCorresponds to variant dbSNP:rs63751243EnsemblClinVar.1
Natural variantiVAR_06462519R → W1 PublicationCorresponds to variant dbSNP:rs63750723EnsemblClinVar.1
Natural variantiVAR_06462655R → W1 Publication1
Natural variantiVAR_06462769A → T1 PublicationCorresponds to variant dbSNP:rs199944486Ensembl.1
Natural variantiVAR_064628119Missing 1 Publication1
Natural variantiVAR_064629120S → Y1 PublicationCorresponds to variant dbSNP:rs63750043EnsemblClinVar.1
Natural variantiVAR_064630182T → M1 PublicationCorresponds to variant dbSNP:rs63750479EnsemblClinVar.1
Natural variantiVAR_064631221C → S1 PublicationCorresponds to variant dbSNP:rs758322775Ensembl.1
Natural variantiVAR_064632275P → L1 PublicationCorresponds to variant dbSNP:rs529849967Ensembl.1
Natural variantiVAR_064633376D → N1 PublicationCorresponds to variant dbSNP:rs143030899Ensembl.1
Natural variantiVAR_064634398S → L1 PublicationCorresponds to variant dbSNP:rs148213321Ensembl.1
Natural variantiVAR_064635433R → Q1 PublicationCorresponds to variant dbSNP:rs114248177EnsemblClinVar.1
Natural variantiVAR_014830515G → A1 PublicationCorresponds to variant dbSNP:rs25647EnsemblClinVar.1
Natural variantiVAR_064636564R → H1 PublicationCorresponds to variant dbSNP:rs971443926Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0534721 – 71MWTLV…CSAGH → MAITAAHGASTAVQTGDPAS KDQVTTPWVPSSALIVSSNA RTSPRAVLWSMAPGGAAPCP RLPAVKTGCTA in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_05347372 – 251Missing in isoform 3. 1 PublicationAdd BLAST180
Alternative sequenceiVSP_001837377 – 531Missing in isoform 2. 2 PublicationsAdd BLAST155

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X62320 mRNA Translation: CAA44196.1
AF055008 mRNA Translation: AAC09359.1
M75161 mRNA Translation: AAA58617.1 Sequence problems.
AY124489 mRNA Translation: AAM94026.1
BT006844 mRNA Translation: AAP35490.1
AK023348 mRNA Translation: BAB14535.1
AK222522 mRNA Translation: BAD96242.1
CH471178 Genomic DNA Translation: EAW51599.1
CH471178 Genomic DNA Translation: EAW51600.1
BC000324 mRNA Translation: AAH00324.1
BC010577 mRNA Translation: AAH10577.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11483.1 [P28799-1]

Protein sequence database of the Protein Information Resource

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PIRi
JC1284 GYHU

NCBI Reference Sequences

More...
RefSeqi
NP_002078.1, NM_002087.3 [P28799-1]
XP_005257310.1, XM_005257253.1 [P28799-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.514220

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000053867; ENSP00000053867; ENSG00000030582 [P28799-1]
ENST00000639447; ENSP00000492014; ENSG00000030582 [P28799-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2896

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2896

UCSC genome browser

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UCSCi
uc002igp.2 human [P28799-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62320 mRNA Translation: CAA44196.1
AF055008 mRNA Translation: AAC09359.1
M75161 mRNA Translation: AAA58617.1 Sequence problems.
AY124489 mRNA Translation: AAM94026.1
BT006844 mRNA Translation: AAP35490.1
AK023348 mRNA Translation: BAB14535.1
AK222522 mRNA Translation: BAD96242.1
CH471178 Genomic DNA Translation: EAW51599.1
CH471178 Genomic DNA Translation: EAW51600.1
BC000324 mRNA Translation: AAH00324.1
BC010577 mRNA Translation: AAH10577.1
CCDSiCCDS11483.1 [P28799-1]
PIRiJC1284 GYHU
RefSeqiNP_002078.1, NM_002087.3 [P28799-1]
XP_005257310.1, XM_005257253.1 [P28799-1]
UniGeneiHs.514220

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G26NMR-A281-311[»]
2JYENMR-A281-337[»]
2JYTNMR-A364-417[»]
2JYUNMR-A364-417[»]
2JYVNMR-A123-179[»]
ProteinModelPortaliP28799
SMRiP28799
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109153, 108 interactors
CORUMiP28799
DIPiDIP-41742N
IntActiP28799, 106 interactors
MINTiP28799
STRINGi9606.ENSP00000053867

PTM databases

GlyConnecti1290
iPTMnetiP28799
PhosphoSitePlusiP28799

Polymorphism and mutation databases

BioMutaiGRN
DMDMi77416865

Proteomic databases

EPDiP28799
jPOSTiP28799
MaxQBiP28799
PaxDbiP28799
PeptideAtlasiP28799
PRIDEiP28799
ProteomicsDBi54499
54500 [P28799-2]
TopDownProteomicsiP28799-2 [P28799-2]
P28799-3 [P28799-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2896
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000053867; ENSP00000053867; ENSG00000030582 [P28799-1]
ENST00000639447; ENSP00000492014; ENSG00000030582 [P28799-2]
GeneIDi2896
KEGGihsa:2896
UCSCiuc002igp.2 human [P28799-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2896
DisGeNETi2896
EuPathDBiHostDB:ENSG00000030582.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GRN
GeneReviewsiGRN
HGNCiHGNC:4601 GRN
HPAiCAB019394
HPA008763
HPA028747
MalaCardsiGRN
MIMi138945 gene
607485 phenotype
614706 phenotype
neXtProtiNX_P28799
OpenTargetsiENSG00000030582
Orphaneti275864 Behavioral variant of frontotemporal dementia
314629 CLN11 disease
100070 Progressive non-fluent aphasia
100069 Semantic dementia
PharmGKBiPA28998

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4296 Eukaryota
ENOG410XR6S LUCA
GeneTreeiENSGT00470000042293
HOGENOMiHOG000067856
HOVERGENiHBG000845
InParanoidiP28799
OMAiNAICCSD
OrthoDBi162721at2759
PhylomeDBiP28799
TreeFamiTF319678

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
SIGNORiP28799

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GRN human
EvolutionaryTraceiP28799

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Granulin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2896
PMAP-CutDBiP28799

Protein Ontology

More...
PROi
PR:P28799

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000030582 Expressed in 235 organ(s), highest expression level in esophagus mucosa
CleanExiHS_GRN
ExpressionAtlasiP28799 baseline and differential
GenevisibleiP28799 HS

Family and domain databases

Gene3Di3.10.20.500, 7 hits
InterProiView protein in InterPro
IPR000118 Granulin
IPR039036 Granulin_fam
IPR037277 Granulin_sf
PANTHERiPTHR12274 PTHR12274, 2 hits
PfamiView protein in Pfam
PF00396 Granulin, 7 hits
SMARTiView protein in SMART
SM00277 GRAN, 7 hits
PROSITEiView protein in PROSITE
PS00799 GRANULINS, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28799
Secondary accession number(s): D3DX55
, P23781, P23782, P23783, P23784, Q53HQ8, Q53Y88, Q540U8, Q9BWE7, Q9H8S1, Q9UCH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 11, 2005
Last modified: January 16, 2019
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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