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UniProtKB - P28796 (TNAA_PROVU)
Protein
Tryptophanase
Gene
tnaA
Organism
Proteus vulgaris
Status
Functioni
Catalytic activityi
- EC:4.1.99.1
Cofactori
: L-tryptophan degradation via pyruvate pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes indole and pyruvate from L-tryptophan. This subpathway is part of the pathway L-tryptophan degradation via pyruvate pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes indole and pyruvate from L-tryptophan, the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.
GO - Molecular functioni
- tryptophanase activity Source: UniProtKB-UniRule
Keywordsi
Molecular function | Lyase |
Biological process | Tryptophan catabolism |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 4.1.99.1, 5049 |
SABIO-RKi | P28796 |
UniPathwayi | UPA00332;UER00452 |
Names & Taxonomyi
Protein namesi | Recommended name: Tryptophanase (EC:4.1.99.1)Alternative name(s): L-tryptophan indole-lyase Short name: TNase |
Gene namesi | Name:tnaA |
Organismi | Proteus vulgaris |
Taxonomic identifieri | 585 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Morganellaceae › Proteus |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195619 | 1 – 467 | TryptophanaseAdd BLAST | 467 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 266 | N6-(pyridoxal phosphate)lysine | 1 |
Proteomic databases
PRIDEi | P28796 |
Interactioni
Subunit structurei
Homotetramer.
Protein-protein interaction databases
STRINGi | 585.DR95_2912 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28796 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28796 |
Family & Domainsi
Sequence similaritiesi
Belongs to the beta-eliminating lyase family.Curated
Phylogenomic databases
eggNOGi | COG3033, Bacteria |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00544, Tryptophanase, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR011166, Beta-eliminating_lyase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR013440, TNase IPR018176, Tryptophanase_CS |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit |
PIRSFi | PIRSF001386, Trpase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00853, BETA_ELIM_LYASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P28796-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKRIVEPFR IKMVEKIRVP SREEREAALK EAGYNPFLLP SSAVYIDLLT
60 70 80 90 100
DSGTNAMSDH QWAAMITGDE AYAGSRNYYD LKDKAKELFN YDYIIPAHQG
110 120 130 140 150
RGAENILFPV LLKYKQKEGK AKNPVFISNF HFDTTAAHVE LNGCKAINIV
160 170 180 190 200
TEKAFDSETY DDWKGDFDIK KLKENIAQHG ADNIVAIVST VTCNSAGGQP
210 220 230 240 250
VSMSNLKEVY EIAKQHGIFV VMDSARFCEN AYFIKARDPK YKNATIKEVI
260 270 280 290 300
FDMYKYADAL TMSAKKDPLL NIGGLVAIRD NEEIFTLARQ RCVPMEGFVT
310 320 330 340 350
YGGLAGRDMA AMVQGLEEGT EEEYLHYRIG QVKYLGDRLR EAGIPIQYPT
360 370 380 390 400
GGHAVFVDCK KLVPQIPGDQ FPAQAVINAL YLESGVRAVE IGSFLLGRDP
410 420 430 440 450
ATGEQKHADM EFMRLTIARR VYTNDHMDYI ADALIGLKEK FATLKGLEFE
460
YEPPVLRHFT ARLKPIE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93277 Genomic DNA Translation: AAA25664.1 |
PIRi | B44038 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M93277 Genomic DNA Translation: AAA25664.1 |
PIRi | B44038 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AX4 | X-ray | 2.10 | A/B/C/D | 1-467 | [»] | |
5W19 | X-ray | 2.10 | A/B/C/D | 1-467 | [»] | |
5W1B | X-ray | 2.00 | A/B/C/D | 1-467 | [»] | |
SMRi | P28796 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 585.DR95_2912 |
Proteomic databases
PRIDEi | P28796 |
Phylogenomic databases
eggNOGi | COG3033, Bacteria |
Enzyme and pathway databases
UniPathwayi | UPA00332;UER00452 |
BRENDAi | 4.1.99.1, 5049 |
SABIO-RKi | P28796 |
Miscellaneous databases
EvolutionaryTracei | P28796 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
HAMAPi | MF_00544, Tryptophanase, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR011166, Beta-eliminating_lyase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR013440, TNase IPR018176, Tryptophanase_CS |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit |
PIRSFi | PIRSF001386, Trpase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
PROSITEi | View protein in PROSITE PS00853, BETA_ELIM_LYASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TNAA_PROVU | |
Accessioni | P28796Primary (citable) accession number: P28796 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | September 29, 2021 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families