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Protein

Gingipain R1

Gene

rgpA

Organism
Porphyromonas gingivalis
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA (By similarity). Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).By similarityCurated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1.1 Publication EC:3.4.22.37

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Requires cysteine for activation and Ca2+ and/or Mg2+ for stabilization. It is stimulated by glycine-containing dipeptides. It is resistant to inhibition by proteinase inhibitors in human plasma.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi305Calcium 1By similarity1
Metal bindingi327Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi330Calcium 2By similarity1
Metal bindingi332Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi334Calcium 2By similarity1
Metal bindingi388Calcium 3By similarity1
Metal bindingi393Calcium 3; via pros nitrogenBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei438Proton donorBy similarity1
Active sitei471NucleophileBy similarity1
Metal bindingi476Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi485Calcium 1By similarity1
Metal bindingi519Calcium 3By similarity1
Metal bindingi520Calcium 4By similarity1
Metal bindingi523Calcium 4By similarity1
Metal bindingi529Calcium 4; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: UniProtKB
  • calcium ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processVirulence
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.37 756

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C25.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gingipain R1 (EC:3.4.22.371 Publication)
Alternative name(s):
Arg-gingipain
Gingipain 1
RGP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rgpA
Synonyms:rgp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPorphyromonas gingivalis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri837 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002653325 – 2272 PublicationsAdd BLAST203
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000026534228 – 991Gingipain R1Add BLAST764

Keywords - PTMi

Zymogen

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P28784

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P28784

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P28784

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG41061HS Bacteria
ENOG4112AJT LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10913 Peptidase_C25_N_gingipain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.3800, 1 hit
3.40.50.10390, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR001769 Gingipain
IPR039392 Gingipain_N
IPR029031 Gingipain_N_sf
IPR038490 Gingipain_propep_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR018832 Pept_C25_gingipain_C
IPR005536 Peptidase_C25_Ig-like_domain
IPR012600 Propeptide_C25

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10365 DUF2436, 1 hit
PF01364 Peptidase_C25, 1 hit
PF03785 Peptidase_C25_C, 1 hit
PF08126 Propeptide_C25, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52129 SSF52129, 1 hit
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P28784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNLNKFVSI ALCSSLLGGM AFAQQTELGR NPNVRLLEST QQSVTKVQFR
60 70 80 90 100
MDNLKFTEVQ TPKGMAQVPT YTEGVNLSEK GMPTLPILSR SLAVSDTREM
110 120 130 140 150
KVEVVSSKFI EKKNVLIAPS KGMIMRNEDP KKIPYVYGKS YSQNKFFPGE
160 170 180 190 200
IATLDDPFIL RDVRGQVVNF APLQYNPVTK TLRIYTEITV AVSETSEQGK
210 220 230 240 250
NILNKKGTFA GFEDTYKRMF MNYEPGRYTP VEEKQNGRMI VIVAKKYEGD
260 270 280 290 300
IKDFVDWKNQ RGLRTEVKVA EDIASPVTAN AIQQFVKQEY EKEGNDLTYV
310 320 330 340 350
LLVGDHKDIP AKITPGIKSD QVYGQIVGND HYNEVFIGRF SCESKEDLKT
360 370 380 390 400
QIDRTIHYER NITTEDKWLG QALCIASAEG GPSADNGESD IQHENVIANL
410 420 430 440 450
LTQYGYTKII KCYDPGVTPK NIIDAFNGGI SLVNYTGHGS ETAWGTSHFG
460 470 480 490 500
TTHVKQLTNS NQLPFIFDVA CVNGDFLFSM PCFAEALMRA QKDGKPTGTV
510 520 530 540 550
AIIASTINQS WASPMRGQDE MNEILCEKHP NNIKRTFGGV TMNGMFAMVE
560 570 580 590 600
KYKKDGEKML DTWTVFGDPS LLVRTLVPTK MQVTAPAQIN LTDASVNVSC
610 620 630 640 650
DYNGAIATIS ANGKMFGSAV VENGTATINL TGLTNESTLT LTVVGYNKET
660 670 680 690 700
VIKTINTNGE PNPYQPVSNL TATTQGQKVT LKWDAPSTKT NATTNTARSV
710 720 730 740 750
DGIRELVLLS VSDAPELLRS GQAEIVLEAH DVWNDGSGYQ ILLDADHDQY
760 770 780 790 800
GQVIPSDTHT LWPNCSVPAN LFAPFEYTVP ENADPSCSPT NMIMDGTASV
810 820 830 840 850
NIPAGTYDFA IAAPQANAKI WIAGQGPTKE DDYVFEAGKK YHFLMKKMGS
860 870 880 890 900
GDGTELTISE GGGSDYTYTV YRDGTKIKEG LTETTYRDAG MSAQSHEYCV
910 920 930 940 950
EVKYAAGVSP KVCVDYIPDG VADVTAQKPY TLTVVGKTIT VTCQGEAMIY
960 970 980 990
DMNGRRLAAG RNTVVYTAQG GYYAVMVVVD GKSYVEKLAV K
Length:991
Mass (Da):108,782
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03EE3F43CEBE2544
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti264 – 265RT → TK AA sequence (PubMed:1527017).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D26470 Genomic DNA Translation: BAA05484.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I40229

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26470 Genomic DNA Translation: BAA05484.1
PIRiI40229

3D structure databases

ProteinModelPortaliP28784
SMRiP28784
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC25.001

Proteomic databases

PRIDEiP28784

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG41061HS Bacteria
ENOG4112AJT LUCA

Enzyme and pathway databases

BRENDAi3.4.22.37 756

Family and domain databases

CDDicd10913 Peptidase_C25_N_gingipain, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.3800, 1 hit
3.40.50.10390, 1 hit
InterProiView protein in InterPro
IPR029030 Caspase-like_dom_sf
IPR001769 Gingipain
IPR039392 Gingipain_N
IPR029031 Gingipain_N_sf
IPR038490 Gingipain_propep_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR018832 Pept_C25_gingipain_C
IPR005536 Peptidase_C25_Ig-like_domain
IPR012600 Propeptide_C25
PfamiView protein in Pfam
PF10365 DUF2436, 1 hit
PF01364 Peptidase_C25, 1 hit
PF03785 Peptidase_C25_C, 1 hit
PF08126 Propeptide_C25, 1 hit
SUPFAMiSSF52129 SSF52129, 1 hit
SSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPG1_PORGN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28784
Secondary accession number(s): Q45168
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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