UniProtKB - P28705 (RXRG_MOUSE)
Protein
Retinoic acid receptor RXR-gamma
Gene
Rxrg
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 139 – 204 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 139 – 159 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 175 – 199 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- identical protein binding Source: MGI
- nuclear receptor activity Source: MGI
- retinoic acid-responsive element binding Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: MGI
- regulation of myelination Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to retinoic acid Source: GO_Central
- retinoic acid receptor signaling pathway Source: MGI
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor RXR-gammaAlternative name(s): Nuclear receptor subfamily 2 group B member 3 Retinoid X receptor gamma |
Gene namesi | Name:Rxrg Synonyms:Nr2b3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98216, Rxrg |
Subcellular locationi
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
- RNA polymerase II transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Knockout mice exhibit memory deficits.1 Publication
Chemistry databases
ChEMBLi | CHEMBL4402 |
DrugCentrali | P28705 |
GuidetoPHARMACOLOGYi | 612 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053577 | 1 – 463 | Retinoic acid receptor RXR-gammaAdd BLAST | 463 |
Post-translational modificationi
Acetylated by EP300.By similarity
Proteomic databases
MaxQBi | P28705 |
PaxDbi | P28705 |
PRIDEi | P28705 |
PTM databases
iPTMneti | P28705 |
PhosphoSitePlusi | P28705 |
Expressioni
Developmental stagei
Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000015843, Expressed in retina and 233 other tissues |
Genevisiblei | P28705, MM |
Interactioni
Subunit structurei
Homodimer (By similarity). Heterodimer with a RAR molecule (By similarity). Binds DNA preferentially as a RAR/RXR heterodimer (By similarity).
Interacts with RARA (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203040, 12 interactors |
STRINGi | 10090.ENSMUSP00000015987 |
Chemistry databases
BindingDBi | P28705 |
Miscellaneous databases
RNActi | P28705, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 231 – 459 | NR LBDPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 138 | ModulatingBy similarityAdd BLAST | 138 | |
Regioni | 205 – 230 | HingeAdd BLAST | 26 |
Domaini
Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 139 – 159 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 175 – 199 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161269 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P28705 |
OrthoDBi | 912470at2759 |
PhylomeDBi | P28705 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P28705-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDS
460
FLMEMLETPL QIT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9Q9V9 | E9Q9V9_MOUSE | Retinoic acid receptor RXR-gamma | Rxrg | 340 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 341 | A → R in CAA46964 (PubMed:1312497).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84819 mRNA Translation: AAA40082.1 X66225 mRNA Translation: CAA46964.1 S62948 mRNA Translation: AAB27244.1 BC058401 mRNA Translation: AAH58401.1 |
CCDSi | CCDS15459.1 |
PIRi | B41727 S26670 |
RefSeqi | NP_001153203.1, NM_001159731.1 NP_033133.1, NM_009107.3 |
Genome annotation databases
Ensembli | ENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843 ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843 ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843 |
GeneIDi | 20183 |
KEGGi | mmu:20183 |
UCSCi | uc007dla.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84819 mRNA Translation: AAA40082.1 X66225 mRNA Translation: CAA46964.1 S62948 mRNA Translation: AAB27244.1 BC058401 mRNA Translation: AAH58401.1 |
CCDSi | CCDS15459.1 |
PIRi | B41727 S26670 |
RefSeqi | NP_001153203.1, NM_001159731.1 NP_033133.1, NM_009107.3 |
3D structure databases
SMRi | P28705 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203040, 12 interactors |
STRINGi | 10090.ENSMUSP00000015987 |
Chemistry databases
BindingDBi | P28705 |
ChEMBLi | CHEMBL4402 |
DrugCentrali | P28705 |
GuidetoPHARMACOLOGYi | 612 |
PTM databases
iPTMneti | P28705 |
PhosphoSitePlusi | P28705 |
Proteomic databases
MaxQBi | P28705 |
PaxDbi | P28705 |
PRIDEi | P28705 |
Protocols and materials databases
Antibodypediai | 3620, 389 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843 ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843 ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843 |
GeneIDi | 20183 |
KEGGi | mmu:20183 |
UCSCi | uc007dla.2, mouse |
Organism-specific databases
CTDi | 6258 |
MGIi | MGI:98216, Rxrg |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000161269 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P28705 |
OrthoDBi | 912470at2759 |
PhylomeDBi | P28705 |
TreeFami | TF352097 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Miscellaneous databases
BioGRID-ORCSi | 20183, 0 hits in 17 CRISPR screens |
PROi | PR:P28705 |
RNActi | P28705, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015843, Expressed in retina and 233 other tissues |
Genevisiblei | P28705, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RXRG_MOUSE | |
Accessioni | P28705Primary (citable) accession number: P28705 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 176 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families