UniProtKB - P28704 (RXRB_MOUSE)
Retinoic acid receptor RXR-beta
Rxrb
Functioni
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 192 – 257 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 192 – 212 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 228 – 252 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- nuclear receptor activity Source: MGI
- nuclear receptor coactivator activity Source: MGI
- protein-containing complex binding Source: MGI
- retinoic acid receptor binding Source: MGI
- retinoic acid-responsive element binding Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- steroid hormone receptor activity Source: InterPro
- thyroid hormone receptor binding Source: MGI
- transcription cis-regulatory region binding Source: UniProtKB
- vitamin D receptor binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- cardiac muscle cell proliferation Source: MGI
- cell differentiation Source: GO_Central
- cellular response to retinoic acid Source: UniProtKB
- in utero embryonic development Source: MGI
- maternal placenta development Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of myelination Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to retinoic acid Source: GO_Central
- retinoic acid receptor signaling pathway Source: GO_Central
- ventricular cardiac muscle cell differentiation Source: MGI
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid R-MMU-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-MMU-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: Retinoic acid receptor RXR-betaAlternative name(s): MHC class I regulatory element-binding protein H-2RIIBP Nuclear receptor subfamily 2 group B member 2 Retinoid X receptor beta |
Gene namesi | Name:Rxrb Synonyms:Nr2b2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98215, Rxrb |
VEuPathDBi | HostDB:ENSMUSG00000039656 |
Subcellular locationi
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4047 |
DrugCentrali | P28704 |
GuidetoPHARMACOLOGYi | 611 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053573 | 1 – 520 | Retinoic acid receptor RXR-betaAdd BLAST | 520 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
MaxQBi | P28704 |
PaxDbi | P28704 |
PeptideAtlasi | P28704 |
PRIDEi | P28704 |
ProteomicsDBi | 256850 [P28704-1] 256851 [P28704-2] |
PTM databases
iPTMneti | P28704 |
PhosphoSitePlusi | P28704 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000039656, Expressed in embryo and 331 other tissues |
ExpressionAtlasi | P28704, baseline and differential |
Genevisiblei | P28704, MM |
Interactioni
Subunit structurei
Homodimer (in vitro). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer.
Interacts with NR1H3 (By similarity).
Interacts with AKAP13 (PubMed:20139090).
By similarity1 PublicationGO - Molecular functioni
- retinoic acid receptor binding Source: MGI
- thyroid hormone receptor binding Source: MGI
- vitamin D receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203039, 2 interactors |
ComplexPortali | CPX-706, RXRbeta-LXRbeta nuclear hormone receptor complex CPX-717, RXRbeta-LXRalpha nuclear hormone receptor complex CPX-872, RXRbeta-VDR nuclear hormone receptor complex |
IntActi | P28704, 1 interactor |
STRINGi | 10090.ENSMUSP00000036585 |
Chemistry databases
BindingDBi | P28704 |
Miscellaneous databases
RNActi | P28704, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 283 – 516 | NR LBDPROSITE-ProRule annotationAdd BLAST | 234 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 191 | ModulatingBy similarityAdd BLAST | 191 | |
Regioni | 1 – 167 | DisorderedSequence analysisAdd BLAST | 167 | |
Regioni | 258 – 382 | HingeAdd BLAST | 125 | |
Regioni | 263 – 285 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 300 – 323 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 76 – 90 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 91 – 120 | Pro residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 128 – 142 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 143 – 157 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 263 – 279 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 192 – 212 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 228 – 252 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159208 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P28704 |
PhylomeDBi | P28704 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWATRPPFL PPRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA
60 70 80 90 100
AAGEQQALEP EPGEAGRDGM GDSGRDSRSP DSSSPNPLSQ GIRPSSPPGP
110 120 130 140 150
PLTPSAPPPP MPPPPLGSPF PVISSSMGSP GLPPPAPPGF SGPVSSPQIN
160 170 180 190 200
STVSLPGGGS GPPEDVKPPV LGVRGLHCPP PPGGPGAGKR LCAICGDRSS
210 220 230 240 250
GKHYGVYSCE GCKGFFKRTI RKDLTYSCRD NKDCTVDKRQ RNRCQYCRYQ
260 270 280 290 300
KCLATGMKRE AVQEERQRGK DKDGDGDGAG GAPEEMPVDR ILEAELAVEQ
310 320 330 340 350
KSDQGVEGPG ATGGGGSSPN DPVTNICQAA DKQLFTLVEW AKRIPHFSSL
360 370 380 390 400
PLDDQVILLR AGWNELLIAS FSHRSIDVRD GILLATGLHV HRNSAHSAGV
410 420 430 440 450
GAIFDRVLTE LVSKMRDMRM DKTELGCLRA IILFNPDAKG LSNPGEVEIL
460 470 480 490 500
REKVYASLET YCKQKYPEQQ GRFAKLLLRL PALRSIGLKC LEHLFFFKLI
510 520
GDTPIDTFLM EMLEAPHQLA
The sequence of this isoform differs from the canonical sequence as follows:
1-110: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ3TWJ1 | Q3TWJ1_MOUSE | Retinoic acid receptor RXR-beta | Rxrb | 524 | Annotation score: | ||
Q8VCR0 | Q8VCR0_MOUSE | Retinoic acid receptor RXR-beta | Rxrb | 414 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 73 – 75 | SGR → MGP in AAA40081 (PubMed:1310259).Curated | 3 | |
Sequence conflicti | 75 – 77 | RDS → EFP in AAA37772 (PubMed:2554307).Curated | 3 | |
Sequence conflicti | 433 | L → M in AAA40081 (PubMed:1310259).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003678 | 1 – 110 | Missing in isoform Short. CuratedAdd BLAST | 110 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D21831 Genomic DNA Translation: BAA04858.1 D21831 Genomic DNA Translation: BAA04859.1 AF100956 Genomic DNA Translation: AAC69904.1 BC049773 mRNA Translation: AAH49773.1 M84818 mRNA Translation: AAA40081.2 M26804 mRNA Translation: AAA37772.1 X66224 mRNA Translation: CAA46963.1 |
CCDSi | CCDS57068.1 [P28704-2] CCDS89073.1 [P28704-1] |
PIRi | A34418 D41727 I84718 S26669 |
RefSeqi | NP_001192145.1, NM_001205216.1 [P28704-2] NP_035436.1, NM_011306.4 [P28704-1] |
Genome annotation databases
Ensembli | ENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656 [P28704-2] ENSMUST00000174299; ENSMUSP00000133775; ENSMUSG00000039656 [P28704-1] |
GeneIDi | 20182 |
KEGGi | mmu:20182 |
UCSCi | uc008cax.2, mouse [P28704-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D21831 Genomic DNA Translation: BAA04858.1 D21831 Genomic DNA Translation: BAA04859.1 AF100956 Genomic DNA Translation: AAC69904.1 BC049773 mRNA Translation: AAH49773.1 M84818 mRNA Translation: AAA40081.2 M26804 mRNA Translation: AAA37772.1 X66224 mRNA Translation: CAA46963.1 |
CCDSi | CCDS57068.1 [P28704-2] CCDS89073.1 [P28704-1] |
PIRi | A34418 D41727 I84718 S26669 |
RefSeqi | NP_001192145.1, NM_001205216.1 [P28704-2] NP_035436.1, NM_011306.4 [P28704-1] |
3D structure databases
SMRi | P28704 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203039, 2 interactors |
ComplexPortali | CPX-706, RXRbeta-LXRbeta nuclear hormone receptor complex CPX-717, RXRbeta-LXRalpha nuclear hormone receptor complex CPX-872, RXRbeta-VDR nuclear hormone receptor complex |
IntActi | P28704, 1 interactor |
STRINGi | 10090.ENSMUSP00000036585 |
Chemistry databases
BindingDBi | P28704 |
ChEMBLi | CHEMBL4047 |
DrugCentrali | P28704 |
GuidetoPHARMACOLOGYi | 611 |
PTM databases
iPTMneti | P28704 |
PhosphoSitePlusi | P28704 |
Proteomic databases
MaxQBi | P28704 |
PaxDbi | P28704 |
PeptideAtlasi | P28704 |
PRIDEi | P28704 |
ProteomicsDBi | 256850 [P28704-1] 256851 [P28704-2] |
Protocols and materials databases
Antibodypediai | 28936, 338 antibodies from 43 providers |
DNASUi | 20182 |
Genome annotation databases
Ensembli | ENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656 [P28704-2] ENSMUST00000174299; ENSMUSP00000133775; ENSMUSG00000039656 [P28704-1] |
GeneIDi | 20182 |
KEGGi | mmu:20182 |
UCSCi | uc008cax.2, mouse [P28704-1] |
Organism-specific databases
CTDi | 6257 |
MGIi | MGI:98215, Rxrb |
VEuPathDBi | HostDB:ENSMUSG00000039656 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159208 |
HOGENOMi | CLU_007368_5_4_1 |
InParanoidi | P28704 |
PhylomeDBi | P28704 |
Enzyme and pathway databases
Reactomei | R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid R-MMU-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux R-MMU-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
Miscellaneous databases
BioGRID-ORCSi | 20182, 6 hits in 67 CRISPR screens |
ChiTaRSi | Rxrb, mouse |
PROi | PR:P28704 |
RNActi | P28704, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039656, Expressed in embryo and 331 other tissues |
ExpressionAtlasi | P28704, baseline and differential |
Genevisiblei | P28704, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RXRB_MOUSE | |
Accessioni | P28704Primary (citable) accession number: P28704 Secondary accession number(s): P33243 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families