UniProtKB - P28698 (MZF1_HUMAN)
Myeloid zinc finger 1
MZF1
Functioni
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 356 – 378 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 541 – 563 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 569 – 591 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 597 – 619 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 625 – 647 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 653 – 675 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 681 – 703 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 709 – 731 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- metal ion binding Source: UniProtKB-KW
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- transcription cis-regulatory region binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P28698 |
SignaLinki | P28698 |
SIGNORi | P28698 |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid zinc finger 1Short name: MZF-1 Alternative name(s): Zinc finger and SCAN domain-containing protein 6 Zinc finger protein 42 |
Gene namesi | Name:MZF1 Synonyms:MZF, ZNF42, ZSCAN6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13108, MZF1 |
MIMi | 194550, gene |
neXtProti | NX_P28698 |
VEuPathDBi | HostDB:ENSG00000099326 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 7593 |
OpenTargetsi | ENSG00000099326 |
PharmGKBi | PA37683 |
Miscellaneous databases
Pharosi | P28698, Tbio |
Genetic variation databases
BioMutai | MZF1 |
DMDMi | 215274121 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047375 | 1 – 734 | Myeloid zinc finger 1Add BLAST | 734 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 111 | PhosphoserineCombined sources | 1 | |
Cross-linki | 723 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P28698 |
MassIVEi | P28698 |
MaxQBi | P28698 |
PaxDbi | P28698 |
PeptideAtlasi | P28698 |
PRIDEi | P28698 |
ProteomicsDBi | 54492 [P28698-1] 54493 [P28698-2] |
PTM databases
iPTMneti | P28698 |
PhosphoSitePlusi | P28698 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000099326, Expressed in right uterine tube and 230 other tissues |
ExpressionAtlasi | P28698, baseline and differential |
Genevisiblei | P28698, HS |
Organism-specific databases
HPAi | ENSG00000099326, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113419, 29 interactors |
IntActi | P28698, 5 interactors |
STRINGi | 9606.ENSP00000215057 |
Miscellaneous databases
RNActi | P28698, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P28698 |
BMRBi | P28698 |
SMRi | P28698 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28698 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 125 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 82 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 144 – 196 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 459 – 485 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 154 – 172 | Pro residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 466 – 485 | Pro residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 356 – 378 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 384 – 406 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 412 – 434 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 440 – 462 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 485 – 507 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 513 – 535 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 541 – 563 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 569 – 591 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 597 – 619 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 625 – 647 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 653 – 675 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 681 – 703 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 709 – 731 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00950000182890 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P28698 |
OMAi | FCYEEAV |
PhylomeDBi | P28698 |
TreeFami | TF337913 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
DisProti | DP02096 |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF
60 70 80 90 100
RYEEATGPQE ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI
110 120 130 140 150
QARVQGQRPG SPEEAAALVD GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS
160 170 180 190 200
SFQPLPETEP PTPEPGPKTP PRTMQESPLG LQVKEESEVT EDSDFLESGP
210 220 230 240 250
LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR EHPRALWHEE
260 270 280 290 300
AGGIFSPGFA LQLGSISAGP GSVSPHLHVP WDLGMAGLSG QIQSPSREGG
310 320 330 340 350
FAHALLLPSD LRSEQDPTDE DPCRGVGPAL ITTRWRSPRG RSRGRPSTGG
360 370 380 390 400
GVVRGGRCDV CGKVFSQRSN LLRHQKIHTG ERPFVCSECG RSFSRSSHLL
410 420 430 440 450
RHQLTHTEER PFVCGDCGQG FVRSARLEEH RRVHTGEQPF RCAECGQSFR
460 470 480 490 500
QRSNLLQHQR IHGDPPGPGA KPPAPPGAPE PPGPFPCSEC RESFARRAVL
510 520 530 540 550
LEHQAVHTGD KSFGCVECGE RFGRRSVLLQ HRRVHSGERP FACAECGQSF
560 570 580 590 600
RQRSNLTQHR RIHTGERPFA CAECGKAFRQ RPTLTQHLRV HTGEKPFACP
610 620 630 640 650
ECGQRFSQRL KLTRHQRTHT GEKPYHCGEC GLGFTQVSRL TEHQRIHTGE
660 670 680 690 700
RPFACPECGQ SFRQHANLTQ HRRIHTGERP YACPECGKAF RQRPTLTQHL
710 720 730
RTHRREKPFA CQDCGRRFHQ STKLIQHQRV HSAE
The sequence of this isoform differs from the canonical sequence as follows:
1-249: Missing.
250-257: EAGGIFSP → MNGPLVYA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R1U5 | M0R1U5_HUMAN | Myeloid zinc finger 1 | MZF1 | 259 | Annotation score: | ||
M0R2C0 | M0R2C0_HUMAN | Myeloid zinc finger 1 | MZF1 | 63 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 304 – 305 | AL → RV in AAA59898 (PubMed:1860835).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047677 | 51 | R → H2 PublicationsCorresponds to variant dbSNP:rs3752109Ensembl. | 1 | |
Natural variantiVAR_047678 | 103 | R → H. Corresponds to variant dbSNP:rs3752110Ensembl. | 1 | |
Natural variantiVAR_047679 | 130 | R → Q. Corresponds to variant dbSNP:rs3752111Ensembl. | 1 | |
Natural variantiVAR_014826 | 331 | I → V. Corresponds to variant dbSNP:rs4756Ensembl. | 1 | |
Natural variantiVAR_047680 | 441 | R → P. Corresponds to variant dbSNP:rs2229255Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006889 | 1 – 249 | Missing in isoform MZF1B-C. 1 PublicationAdd BLAST | 249 | |
Alternative sequenceiVSP_006890 | 250 – 257 | EAGGIFSP → MNGPLVYA in isoform MZF1B-C. 1 Publication | 8 | |
Alternative sequenceiVSP_047013 | 259 – 290 | FALQL…AGLSG → AGAGAAPALGAGWLGAAVAM YVARCSANAATC in isoform 3. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_047014 | 291 – 734 | Missing in isoform 3. 1 PublicationAdd BLAST | 444 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58297 mRNA Translation: AAA59898.1 AF055077 mRNA Translation: AAD55809.1 AF055078 mRNA Translation: AAD55810.1 AF161886 Genomic DNA Translation: AAF80465.1 AF161886 Genomic DNA Translation: AAF80466.1 AC016629 Genomic DNA No translation available. AC016630 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72617.1 BC007777 mRNA Translation: AAH07777.1 BC053316 mRNA Translation: AAH53316.1 |
CCDSi | CCDS12988.1 [P28698-1] CCDS59427.1 [P28698-3] |
PIRi | A40751 |
RefSeqi | NP_001253962.1, NM_001267033.1 [P28698-3] NP_003413.2, NM_003422.2 [P28698-1] NP_932172.1, NM_198055.1 [P28698-1] |
Genome annotation databases
Ensembli | ENST00000215057.7; ENSP00000215057.1; ENSG00000099326.9 ENST00000594234.5; ENSP00000469378.1; ENSG00000099326.9 [P28698-3] ENST00000599369.5; ENSP00000469493.1; ENSG00000099326.9 |
GeneIDi | 7593 |
KEGGi | hsa:7593 |
MANE-Selecti | ENST00000215057.7; ENSP00000215057.1; NM_198055.2; NP_932172.1 |
UCSCi | uc002qtn.4, human [P28698-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58297 mRNA Translation: AAA59898.1 AF055077 mRNA Translation: AAD55809.1 AF055078 mRNA Translation: AAD55810.1 AF161886 Genomic DNA Translation: AAF80465.1 AF161886 Genomic DNA Translation: AAF80466.1 AC016629 Genomic DNA No translation available. AC016630 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72617.1 BC007777 mRNA Translation: AAH07777.1 BC053316 mRNA Translation: AAH53316.1 |
CCDSi | CCDS12988.1 [P28698-1] CCDS59427.1 [P28698-3] |
PIRi | A40751 |
RefSeqi | NP_001253962.1, NM_001267033.1 [P28698-3] NP_003413.2, NM_003422.2 [P28698-1] NP_932172.1, NM_198055.1 [P28698-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2FI2 | NMR | - | A/B | 37-128 | [»] | |
AlphaFoldDBi | P28698 | |||||
BMRBi | P28698 | |||||
SMRi | P28698 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113419, 29 interactors |
IntActi | P28698, 5 interactors |
STRINGi | 9606.ENSP00000215057 |
PTM databases
iPTMneti | P28698 |
PhosphoSitePlusi | P28698 |
Genetic variation databases
BioMutai | MZF1 |
DMDMi | 215274121 |
Proteomic databases
jPOSTi | P28698 |
MassIVEi | P28698 |
MaxQBi | P28698 |
PaxDbi | P28698 |
PeptideAtlasi | P28698 |
PRIDEi | P28698 |
ProteomicsDBi | 54492 [P28698-1] 54493 [P28698-2] |
Protocols and materials databases
ABCDi | P28698, 3 sequenced antibodies |
Antibodypediai | 914, 170 antibodies from 26 providers |
DNASUi | 7593 |
Genome annotation databases
Ensembli | ENST00000215057.7; ENSP00000215057.1; ENSG00000099326.9 ENST00000594234.5; ENSP00000469378.1; ENSG00000099326.9 [P28698-3] ENST00000599369.5; ENSP00000469493.1; ENSG00000099326.9 |
GeneIDi | 7593 |
KEGGi | hsa:7593 |
MANE-Selecti | ENST00000215057.7; ENSP00000215057.1; NM_198055.2; NP_932172.1 |
UCSCi | uc002qtn.4, human [P28698-1] |
Organism-specific databases
CTDi | 7593 |
DisGeNETi | 7593 |
GeneCardsi | MZF1 |
HGNCi | HGNC:13108, MZF1 |
HPAi | ENSG00000099326, Low tissue specificity |
MIMi | 194550, gene |
neXtProti | NX_P28698 |
OpenTargetsi | ENSG00000099326 |
PharmGKBi | PA37683 |
VEuPathDBi | HostDB:ENSG00000099326 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00950000182890 |
HOGENOMi | CLU_002678_49_8_1 |
InParanoidi | P28698 |
OMAi | FCYEEAV |
PhylomeDBi | P28698 |
TreeFami | TF337913 |
Enzyme and pathway databases
PathwayCommonsi | P28698 |
SignaLinki | P28698 |
SIGNORi | P28698 |
Miscellaneous databases
BioGRID-ORCSi | 7593, 96 hits in 1101 CRISPR screens |
ChiTaRSi | MZF1, human |
EvolutionaryTracei | P28698 |
GeneWikii | MZF1 |
GenomeRNAii | 7593 |
Pharosi | P28698, Tbio |
PROi | PR:P28698 |
RNActi | P28698, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000099326, Expressed in right uterine tube and 230 other tissues |
ExpressionAtlasi | P28698, baseline and differential |
Genevisiblei | P28698, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
DisProti | DP02096 |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 13 hits |
SUPFAMi | SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MZF1_HUMAN | |
Accessioni | P28698Primary (citable) accession number: P28698 Secondary accession number(s): M0QXU0 Q9UBW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 212 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families