UniProtKB - P28698 (MZF1_HUMAN)

BLAST

>sp|P28698|MZF1_HUMAN Myeloid zinc finger 1 OS=Homo sapiens OX=9606 GN=MZF1 PE=1 SV=3
MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAARLRFRCFRYEEATGPQE
ALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQARVQGQRPGSPEEAAALVD
GLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEPPTPEPGPKTPPRTMQESPLG
LQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQRCGTVLDQIFPHSKTGPEGPSWR
EHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPHLHVPWDLGMAGLSGQIQSPSREGG
FAHALLLPSDLRSEQDPTDEDPCRGVGPALITTRWRSPRGRSRGRPSTGGGVVRGGRCDV
CGKVFSQRSNLLRHQKIHTGERPFVCSECGRSFSRSSHLLRHQLTHTEERPFVCGDCGQG
FVRSARLEEHRRVHTGEQPFRCAECGQSFRQRSNLLQHQRIHGDPPGPGAKPPAPPGAPE
PPGPFPCSECRESFARRAVLLEHQAVHTGDKSFGCVECGERFGRRSVLLQHRRVHSGERP
FACAECGQSFRQRSNLTQHRRIHTGERPFACAECGKAFRQRPTLTQHLRVHTGEKPFACP
ECGQRFSQRLKLTRHQRTHTGEKPYHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQ
SFRQHANLTQHRRIHTGERPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQ
STKLIQHQRVHSAE

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History
Entry version 188 (10 Oct 2018)
Sequence version 3 (25 Nov 2008)
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Protein

Myeloid zinc finger 1

Gene

MZF1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development.2 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	356 – 378	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	485 – 507	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	513 – 535	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	541 – 563	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	569 – 591	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	597 – 619	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	625 – 647	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	653 – 675	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	681 – 703	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	709 – 731	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: ProtInc
Non-traceable author statementⁱ
- 1860835
metal ion binding Source: UniProtKB-KW
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16950398
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 7579328
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 7579328
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 7579328
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15541732

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 7579328
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 7579328
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15541732

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkⁱ	P28698
SIGNORⁱ	P28698

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myeloid zinc finger 1 Short name: MZF-1 Alternative name(s): Zinc finger and SCAN domain-containing protein 6 Zinc finger protein 42
Gene namesⁱ	Name:MZF1 Synonyms:MZF, ZNF42, ZSCAN6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099326.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13108 MZF1
MIMⁱ	194550 gene
neXtProtⁱ	NX_P28698

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7593
Open Targets More...OpenTargetsⁱ	ENSG00000099326
PharmGKBⁱ	PA37683

Polymorphism and mutation databases

BioMutaⁱ	MZF1
DMDMⁱ	215274121

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047375	1 – 734	Myeloid zinc finger 1Add BLAST		734

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	111	PhosphoserineCombined sources		1
Cross-linkⁱ	723	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28698
PaxDbⁱ	P28698
PeptideAtlas More...PeptideAtlasⁱ	P28698
PRIDEⁱ	P28698
ProteomicsDBⁱ	54492 54493 [P28698-2]

PTM databases

iPTMnetⁱ	P28698
PhosphoSitePlusⁱ	P28698

Expressionⁱ

Tissue specificityⁱ

Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts.1 Publication

Inductionⁱ

By retinoic acid.

Gene expression databases

Bgeeⁱ	ENSG00000099326 Expressed in 216 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_MZF1
ExpressionAtlasⁱ	P28698 baseline and differential
Genevisibleⁱ	P28698 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001757

HPAⁱ

HPA001757

Interactionⁱ

Subunit structureⁱ

Homodimer.1 Publication

GO - Molecular functionⁱ

protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 16950398

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113419, 16 interactors
IntActⁱ	P28698, 3 interactors
STRINGⁱ	9606.ENSP00000215057

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	40 – 48	Combined sources	9
Turnⁱ	54 – 56	Combined sources	3
Helixⁱ	58 – 73	Combined sources	16
Turnⁱ	75 – 77	Combined sources	3
Helixⁱ	80 – 95	Combined sources	16
Helixⁱ	98 – 107	Combined sources	10
Helixⁱ	112 – 122	Combined sources	11
Turnⁱ	123 – 127	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P28698
SMRⁱ	P28698
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P28698

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 125	SCAN boxPROSITE-ProRule annotationAdd BLAST		82

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	310 – 321	Asp/Glu-rich (acidic)Add BLAST		12
Compositional biasⁱ	463 – 484	Gly/Pro-richAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	356 – 378	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	384 – 406	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	412 – 434	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	440 – 462	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	485 – 507	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	513 – 535	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	541 – 563	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	569 – 591	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	597 – 619	C2H2-type 9PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	625 – 647	C2H2-type 10PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	653 – 675	C2H2-type 11PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	681 – 703	C2H2-type 12PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	709 – 731	C2H2-type 13PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111047
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG062666
InParanoidⁱ	P28698
KEGG Orthology (KO) More...KOⁱ	K09221
OMAⁱ	QPFRCAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P28698
TreeFamⁱ	TF337913

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform MZF1A (identifier: P28698-1) [UniParc]FASTA Add to basket

Also known as: MZF1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF 
        60         70         80         90        100
RYEEATGPQE ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI 
       110        120        130        140        150
QARVQGQRPG SPEEAAALVD GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS 
       160        170        180        190        200
SFQPLPETEP PTPEPGPKTP PRTMQESPLG LQVKEESEVT EDSDFLESGP 
       210        220        230        240        250
LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR EHPRALWHEE 
       260        270        280        290        300
AGGIFSPGFA LQLGSISAGP GSVSPHLHVP WDLGMAGLSG QIQSPSREGG 
       310        320        330        340        350
FAHALLLPSD LRSEQDPTDE DPCRGVGPAL ITTRWRSPRG RSRGRPSTGG 
       360        370        380        390        400
GVVRGGRCDV CGKVFSQRSN LLRHQKIHTG ERPFVCSECG RSFSRSSHLL 
       410        420        430        440        450
RHQLTHTEER PFVCGDCGQG FVRSARLEEH RRVHTGEQPF RCAECGQSFR 
       460        470        480        490        500
QRSNLLQHQR IHGDPPGPGA KPPAPPGAPE PPGPFPCSEC RESFARRAVL 
       510        520        530        540        550
LEHQAVHTGD KSFGCVECGE RFGRRSVLLQ HRRVHSGERP FACAECGQSF 
       560        570        580        590        600
RQRSNLTQHR RIHTGERPFA CAECGKAFRQ RPTLTQHLRV HTGEKPFACP 
       610        620        630        640        650
ECGQRFSQRL KLTRHQRTHT GEKPYHCGEC GLGFTQVSRL TEHQRIHTGE 
       660        670        680        690        700
RPFACPECGQ SFRQHANLTQ HRRIHTGERP YACPECGKAF RQRPTLTQHL 
       710        720        730 
RTHRREKPFA CQDCGRRFHQ STKLIQHQRV HSAE

Length:734

Mass (Da):82,055

Last modified:November 25, 2008 - v3

Checksum:ⁱB804766A0B008048

Isoform MZF1B-C (identifier: P28698-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-249: Missing.
250-257: EAGGIFSP → MNGPLVYA

« Hide

        10         20         30         40         50
MNGPLVYAGF ALQLGSISAG PGSVSPHLHV PWDLGMAGLS GQIQSPSREG 
        60         70         80         90        100
GFAHALLLPS DLRSEQDPTD EDPCRGVGPA LITTRWRSPR GRSRGRPSTG 
       110        120        130        140        150
GGVVRGGRCD VCGKVFSQRS NLLRHQKIHT GERPFVCSEC GRSFSRSSHL 
       160        170        180        190        200
LRHQLTHTEE RPFVCGDCGQ GFVRSARLEE HRRVHTGEQP FRCAECGQSF 
       210        220        230        240        250
RQRSNLLQHQ RIHGDPPGPG AKPPAPPGAP EPPGPFPCSE CRESFARRAV 
       260        270        280        290        300
LLEHQAVHTG DKSFGCVECG ERFGRRSVLL QHRRVHSGER PFACAECGQS 
       310        320        330        340        350
FRQRSNLTQH RRIHTGERPF ACAECGKAFR QRPTLTQHLR VHTGEKPFAC 
       360        370        380        390        400
PECGQRFSQR LKLTRHQRTH TGEKPYHCGE CGLGFTQVSR LTEHQRIHTG 
       410        420        430        440        450
ERPFACPECG QSFRQHANLT QHRRIHTGER PYACPECGKA FRQRPTLTQH 
       460        470        480 
LRTHRREKPF ACQDCGRRFH QSTKLIQHQR VHSAE

Show »

Length:485

Mass (Da):54,392

Checksum:ⁱ60243378A7B2B6F4

Isoform 3 (identifier: P28698-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-290: FALQLGSISAGPGSVSPHLHVPWDLGMAGLSG → AGAGAAPALGAGWLGAAVAMYVARCSANAATC
291-734: Missing.

« Hide

        10         20         30         40         50
MRPAVLGSPD RAPPEDEGPV MVKLEDSEEE GEAALWDPGP EAARLRFRCF 
        60         70         80         90        100
RYEEATGPQE ALAQLRELCR QWLRPEVRSK EQMLELLVLE QFLGALPPEI 
       110        120        130        140        150
QARVQGQRPG SPEEAAALVD GLRREPGGPR RWVTVQVQGQ EVLSEKMEPS 
       160        170        180        190        200
SFQPLPETEP PTPEPGPKTP PRTMQESPLG LQVKEESEVT EDSDFLESGP 
       210        220        230        240        250
LAATQESVPT LLPEEAQRCG TVLDQIFPHS KTGPEGPSWR EHPRALWHEE 
       260        270        280        290
AGGIFSPGAG AGAAPALGAG WLGAAVAMYV ARCSANAATC

Show »

Length:290

Mass (Da):31,460

Checksum:ⁱ28940B137E71394F

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0R1U5	M0R1U5_HUMAN	Myeloid zinc finger 1 Myeloid zinc finger 1	MZF1	259	Annotation score:
M0R2C0	M0R2C0_HUMAN	Myeloid zinc finger 1 Myeloid zinc finger 1	MZF1	63	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	304 – 305	AL → RV in AAA59898 (PubMed:1860835).Curated		2

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_047677	51	R → H2 PublicationsCorresponds to variant dbSNP:rs3752109Ensembl.	1
Natural variantⁱVAR_047678	103	R → H. Corresponds to variant dbSNP:rs3752110Ensembl.	1
Natural variantⁱVAR_047679	130	R → Q. Corresponds to variant dbSNP:rs3752111Ensembl.	1
Natural variantⁱVAR_014826	331	I → V. Corresponds to variant dbSNP:rs4756Ensembl.	1
Natural variantⁱVAR_047680	441	R → P. Corresponds to variant dbSNP:rs2229255Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_006889	1 – 249	Missing in isoform MZF1B-C. 1 PublicationAdd BLAST	249
Alternative sequenceⁱVSP_006890	250 – 257	EAGGIFSP → MNGPLVYA in isoform MZF1B-C. 1 Publication	8
Alternative sequenceⁱVSP_047013	259 – 290	FALQL…AGLSG → AGAGAAPALGAGWLGAAVAM YVARCSANAATC in isoform 3. 1 PublicationAdd BLAST	32
Alternative sequenceⁱVSP_047014	291 – 734	Missing in isoform 3. 1 PublicationAdd BLAST	444

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M58297 mRNA Translation: AAA59898.1 AF055077 mRNA Translation: AAD55809.1 AF055078 mRNA Translation: AAD55810.1 AF161886 Genomic DNA Translation: AAF80465.1 AF161886 Genomic DNA Translation: AAF80466.1 AC016629 Genomic DNA No translation available. AC016630 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72617.1 BC007777 mRNA Translation: AAH07777.1 BC053316 mRNA Translation: AAH53316.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12988.1 [P28698-1] CCDS59427.1 [P28698-3]
PIRⁱ	A40751
NCBI Reference Sequences More...RefSeqⁱ	NP_001253962.1, NM_001267033.1 [P28698-3] NP_003413.2, NM_003422.2 [P28698-1] NP_932172.1, NM_198055.1 [P28698-1]
UniGeneⁱ	Hs.399810 Hs.684624

Genome annotation databases

Ensemblⁱ	ENST00000215057; ENSP00000215057; ENSG00000099326 [P28698-1] ENST00000594234; ENSP00000469378; ENSG00000099326 [P28698-3] ENST00000599369; ENSP00000469493; ENSG00000099326 [P28698-1]
GeneIDⁱ	7593
KEGGⁱ	hsa:7593
UCSC genome browser More...UCSCⁱ	uc002qtn.4 human [P28698-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28698	Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_a		HUMAN		775	UniRef100_P28698
Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_c		HUMAN		734
UPI0000202DEB		HUMAN		450

Protein	Similar proteins		Species	Score	Length	Source
P28698	Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_a		HUMAN		775	UniRef90_P28698
Uncharacterized protein		PAPAN		775
Uncharacterized protein		MACNE		775
Myeloid zinc finger 1 isoform 1 (Fragment)		MACMU		336
Uncharacterized protein		PANPA		736
+44
P28698-2	myeloid zinc finger 1		TURTR		591	UniRef90_P28698-2
UPI0003C91BE0		TUPCH		478
P28698-3	Uncharacterized protein		COLAP		290	UniRef90_P28698-3
MZF1 isoform 2		PONAB		290
MZF1 isoform 2		PANTR		290
Uncharacterized protein		NOMLE		290
Myeloid zinc finger 1		HUMAN		259
+5

Protein	Similar proteins		Species	Score	Length	Source
P28698	Zinc finger protein 42 (Myeloid-specific retinoic acid-responsive), isoform CRA_a		HUMAN		775	UniRef50_P28698
Uncharacterized protein		MACNE		775
Myeloid zinc finger 1 isoform 1 (Fragment)		MACMU		336
Uncharacterized protein		PAPAN		775
Uncharacterized protein		PANPA		736
+154
P28698-2	myeloid zinc finger 1		TURTR		591	UniRef50_P28698-2
myeloid zinc finger 1 isoform X3		Enhydra lutris kenyoni		544
Myeloid zinc finger 1, isoform CRA_a		MOUSE		542
myeloid zinc finger 1		MESAU		472
Zinc finger protein		CRIGR		472
+19
P28698-3	MZF1 isoform 2		PANTR		290	UniRef50_P28698-3
MZF1 isoform 2		PONAB		290
Uncharacterized protein		COLAP		290
Uncharacterized protein		NOMLE		290
Myeloid zinc finger 1		HUMAN		259
+14

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M58297 mRNA Translation: AAA59898.1 AF055077 mRNA Translation: AAD55809.1 AF055078 mRNA Translation: AAD55810.1 AF161886 Genomic DNA Translation: AAF80465.1 AF161886 Genomic DNA Translation: AAF80466.1 AC016629 Genomic DNA No translation available. AC016630 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72617.1 BC007777 mRNA Translation: AAH07777.1 BC053316 mRNA Translation: AAH53316.1
CCDSⁱ	CCDS12988.1 [P28698-1] CCDS59427.1 [P28698-3]
PIRⁱ	A40751
RefSeqⁱ	NP_001253962.1, NM_001267033.1 [P28698-3] NP_003413.2, NM_003422.2 [P28698-1] NP_932172.1, NM_198055.1 [P28698-1]
UniGeneⁱ	Hs.399810 Hs.684624

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2FI2	NMR	-	A/B	37-128	[»]
ProteinModelPortalⁱ	P28698
SMRⁱ	P28698
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113419, 16 interactors
IntActⁱ	P28698, 3 interactors
STRINGⁱ	9606.ENSP00000215057

PTM databases

iPTMnetⁱ	P28698
PhosphoSitePlusⁱ	P28698

Polymorphism and mutation databases

BioMutaⁱ	MZF1
DMDMⁱ	215274121

Proteomic databases

MaxQBⁱ	P28698
PaxDbⁱ	P28698
PeptideAtlasⁱ	P28698
PRIDEⁱ	P28698
ProteomicsDBⁱ	54492 54493 [P28698-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7593
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000215057; ENSP00000215057; ENSG00000099326 [P28698-1] ENST00000594234; ENSP00000469378; ENSG00000099326 [P28698-3] ENST00000599369; ENSP00000469493; ENSG00000099326 [P28698-1]
GeneIDⁱ	7593
KEGGⁱ	hsa:7593
UCSCⁱ	uc002qtn.4 human [P28698-1]

Organism-specific databases

CTDⁱ	7593
DisGeNETⁱ	7593
EuPathDBⁱ	HostDB:ENSG00000099326.8
GeneCardsⁱ	MZF1
HGNCⁱ	HGNC:13108 MZF1
HPAⁱ	HPA001757
MIMⁱ	194550 gene
neXtProtⁱ	NX_P28698
OpenTargetsⁱ	ENSG00000099326
PharmGKBⁱ	PA37683
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00730000111047
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG062666
InParanoidⁱ	P28698
KOⁱ	K09221
OMAⁱ	QPFRCAE
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	P28698
TreeFamⁱ	TF337913

Enzyme and pathway databases

SignaLinkⁱ	P28698
SIGNORⁱ	P28698

Miscellaneous databases

EvolutionaryTraceⁱ	P28698
GeneWikiⁱ	MZF1
GenomeRNAiⁱ	7593
Protein Ontology More...PROⁱ	PR:P28698
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000099326 Expressed in 216 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_MZF1
ExpressionAtlasⁱ	P28698 baseline and differential
Genevisibleⁱ	P28698 HS

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 11 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 13 hits
SUPFAMⁱ	SSF57667 SSF57667, 7 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 13 hits PS50157 ZINC_FINGER_C2H2_2, 13 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MZF1_HUMAN
Accessionⁱ	P28698Primary (citable) accession number: P28698 Secondary accession number(s): M0QXU0 , Q7Z729, Q96I71, Q9NRY0, Q9UBW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	November 25, 2008
	Last modified:	October 10, 2018
	This is version 188 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - P28698 (MZF1_HUMAN)

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Myeloid zinc finger 1

MZF1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Zinc finger

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ