UniProtKB - P28685 (CNTN2_CHICK)
Protein
Contactin-2
Gene
CNTN2
Organism
Gallus gallus (Chicken)
Status
Functioni
Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).By similarity
GO - Molecular functioni
- cell adhesion molecule binding Source: AgBase
GO - Biological processi
- neuron cell-cell adhesion Source: AgBase
- presynaptic membrane organization Source: UniProtKB
Keywordsi
Biological process | Cell adhesion |
Names & Taxonomyi
Protein namesi | Recommended name: Contactin-2Alternative name(s): Axonin-1 |
Gene namesi | Name:CNTN2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Note: Attached to the neuronal membrane by a GPI-anchor.
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Or 25Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000014701 | 24 – ? | Contactin-2 | ||
PropeptideiPRO_0000014702 | ? – 1036 | Removed in mature form |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 56 ↔ 106 | Combined sources1 Publication | ||
Glycosylationi | 71 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 150 ↔ 202 | Combined sources1 Publication | ||
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 256 ↔ 301 | Combined sources1 Publication | ||
Disulfide bondi | 343 ↔ 390 | Combined sources1 Publication | ||
Glycosylationi | 456 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 472 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 493 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 520 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 770 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 900 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 914 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
The N-terminus is blocked.
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
PaxDbi | P28685 |
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: AgBase
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000000926 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28685 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28685 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 123 | Ig-like C2-type 1Add BLAST | 92 | |
Domaini | 128 – 223 | Ig-like C2-type 2Add BLAST | 96 | |
Domaini | 234 – 317 | Ig-like C2-type 3Add BLAST | 84 | |
Domaini | 322 – 406 | Ig-like C2-type 4Add BLAST | 85 | |
Domaini | 412 – 499 | Ig-like C2-type 5Add BLAST | 88 | |
Domaini | 504 – 598 | Ig-like C2-type 6Add BLAST | 95 | |
Domaini | 605 – 703 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 708 – 805 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 810 – 907 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 911 – 1003 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 93 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 599 – 608 | HingeSequence analysis | 10 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 601 – 607 | Gly/Pro-rich | 7 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | KOG3513, Eukaryota |
InParanoidi | P28685 |
OrthoDBi | 655902at2759 |
PhylomeDBi | P28685 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P28685-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGTAAFICT SLAVIICVVW CQAQSGMRSY GPVFEEQPAH TLFPEGSAEE
60 70 80 90 100
KVTLTCRARA NPPATYRWKM NGTELKMGPD SRYRLVAGDL VISNPVKAKD
110 120 130 140 150
AGSYQCVATN ARGTVVSREA SLRFGFLQEF SAEERDPVKI TEGWGVMFTC
160 170 180 190 200
SPPPHYPALS YRWLLNEFPN FIPADGRRFV SQTTGNLYIA KTEASDLGNY
210 220 230 240 250
SCFATSHIDF ITKSVFSKFS QLSLAAEDAR QYAPSIKAKF PADTYALTGQ
260 270 280 290 300
MVTLECFAFG NPVPQIKWRK LDGSQTSKWL SSEPLLHIQN VDFEDEGTYE
310 320 330 340 350
CEAENIKGRD TYQGRIIIHA QPDWLDVITD TEADIGSDLR WSCVASGKPR
360 370 380 390 400
PAVRWLRDGQ PLASQNRIEV SGGELRFSKL VLEDSGMYQC VAENKHGTVY
410 420 430 440 450
ASAELTVQAL APDFRLNPVK RLIPAARSGK VIIPCQPRAA PKATVLWTKG
460 470 480 490 500
TELLTNSSRV TITADGTLIL QNISKSDEGK YTCFAENFMG KANSTGILSV
510 520 530 540 550
RDATKITLAP SSADINVGEN LTLQCHASHD PTMDLTFTWS LDDFPIDLDK
560 570 580 590 600
SEGHYRRASV KEAVGDLAIV NAQLKHSGRY TCTAQTVVDS TSESATLTVR
610 620 630 640 650
GPPGPPGGVV VRDIGDTTVQ LSWSRGFDNH SPIARYSIEA RTLLSNKWKQ
660 670 680 690 700
MRTNPVNIEG NAETAQVVNL IPWMDYEFRV LASNILGVGE PSLPSSKIRT
710 720 730 740 750
KEAAPTVAPS GLGGGGGAPN ELIINWTPTL RDYQNGDGFG YILSFRKKGT
760 770 780 790 800
QGWLTARVPH AESLHYVYRN ESIGPYTPFE VKIKAYNRKG EGPESLTAIV
810 820 830 840 850
YSAEEEPKVA PFRVTAKAVL SSEMDVSWEP VEQGDMTGVL LGYEIRYWKD
860 870 880 890 900
GDKEEAADRV RTAGLVTSAH VTGLNPNTKY HVSVRAYNRA GAGPPSPSTN
910 920 930 940 950
ITTTKPPPRR PPGNISWTLT GSTVTIKWDP VVAQADESAV TGYKMLYRQD
960 970 980 990 1000
SHSAPTLYLA SKSRIDIPVP EDFTHAFVQI RVTGPGGDGT PAEVHIVRNS
1010 1020 1030
GTSMMVEDSV TRPVPHAAII TTNSLAMVAL IRYLEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63101 mRNA Translation: CAA44815.1 X79607 Genomic DNA No translation available. |
PIRi | S22383 |
RefSeqi | NP_001004395.1, NM_001004395.1 |
Genome annotation databases
GeneIDi | 419825 |
KEGGi | gga:419825 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63101 mRNA Translation: CAA44815.1 X79607 Genomic DNA No translation available. |
PIRi | S22383 |
RefSeqi | NP_001004395.1, NM_001004395.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CS6 | X-ray | 1.80 | A | 28-409 | [»] | |
SMRi | P28685 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000000926 |
Proteomic databases
PaxDbi | P28685 |
Genome annotation databases
GeneIDi | 419825 |
KEGGi | gga:419825 |
Organism-specific databases
CTDi | 6900 |
Phylogenomic databases
eggNOGi | KOG3513, Eukaryota |
InParanoidi | P28685 |
OrthoDBi | 655902at2759 |
PhylomeDBi | P28685 |
Miscellaneous databases
EvolutionaryTracei | P28685 |
PROi | PR:P28685 |
Family and domain databases
CDDi | cd00063, FN3, 3 hits |
Gene3Di | 2.60.40.10, 10 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 3 hits PF07679, I-set, 2 hits |
SMARTi | View protein in SMART SM00060, FN3, 4 hits SM00409, IG, 6 hits SM00408, IGc2, 5 hits |
SUPFAMi | SSF48726, SSF48726, 6 hits SSF49265, SSF49265, 3 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits PS50835, IG_LIKE, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTN2_CHICK | |
Accessioni | P28685Primary (citable) accession number: P28685 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families