CNTN2

Functionⁱ

Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).By similarity

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: AgBase
Inferred from physical interactionⁱ
- 7490283

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

neuron cell-cell adhesion
Source: AgBase
Inferred from direct assayⁱ
- 7490283
neuron projection development Source: InterPro
presynaptic membrane organization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Contactin-2 Alternative name(s): Axonin-1
Gene namesⁱ	Name:CNTN2
Organismⁱ	Gallus gallus (Chicken)
Taxonomic identifierⁱ	9031 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
Proteomesⁱ	UP000000539 Componentⁱ: Unplaced

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
PropeptideⁱPRO_0000014702	? – 1036	Removed in mature form
Signal peptideⁱ	1 – 23	Or 25Sequence analysisAdd BLAST	23
ChainⁱPRO_0000014701	24 – ?	Contactin-2

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	56 ↔ 106	Combined sources1 Publication
Glycosylationⁱ	71	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	150 ↔ 202	Combined sources1 Publication
Glycosylationⁱ	199	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	256 ↔ 301	Combined sources1 Publication
Disulfide bondⁱ	343 ↔ 390	Combined sources1 Publication
Glycosylationⁱ	456	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	472	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	493	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	520	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	770	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	900	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	914	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The N-terminus is blocked.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbⁱ	P28685

PaxDbⁱ

P28685

Interactionⁱ

GO - Molecular functionⁱ

cell adhesion molecule binding
Source: AgBase
Inferred from physical interactionⁱ
- 7490283

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000034589

STRINGⁱ

9031.ENSGALP00000034589

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 36	Combined sources	7
Beta strandⁱ	41 – 44	Combined sources	4
Beta strandⁱ	51 – 54	Combined sources	4
Beta strandⁱ	57 – 62	Combined sources	6
Beta strandⁱ	65 – 70	Combined sources	6
Beta strandⁱ	81 – 86	Combined sources	6
Beta strandⁱ	89 – 94	Combined sources	6
Helixⁱ	97 – 100	Combined sources	4
Beta strandⁱ	102 – 110	Combined sources	9
Beta strandⁱ	113 – 116	Combined sources	4
Beta strandⁱ	120 – 127	Combined sources	8
Beta strandⁱ	138 – 141	Combined sources	4
Beta strandⁱ	146 – 148	Combined sources	3
Beta strandⁱ	154 – 157	Combined sources	4
Beta strandⁱ	160 – 167	Combined sources	8
Beta strandⁱ	176 – 180	Combined sources	5
Turnⁱ	182 – 184	Combined sources	3
Beta strandⁱ	187 – 191	Combined sources	5
Helixⁱ	194 – 196	Combined sources	3
Beta strandⁱ	198 – 208	Combined sources	11
Beta strandⁱ	211 – 216	Combined sources	6
Beta strandⁱ	220 – 226	Combined sources	7
Beta strandⁱ	232 – 238	Combined sources	7
Beta strandⁱ	242 – 247	Combined sources	6
Beta strandⁱ	252 – 255	Combined sources	4
Beta strandⁱ	257 – 262	Combined sources	6
Beta strandⁱ	265 – 270	Combined sources	6
Beta strandⁱ	280 – 288	Combined sources	9
Helixⁱ	293 – 295	Combined sources	3
Beta strandⁱ	297 – 305	Combined sources	9
Beta strandⁱ	308 – 326	Combined sources	19
Beta strandⁱ	331 – 334	Combined sources	4
Beta strandⁱ	339 – 342	Combined sources	4
Beta strandⁱ	344 – 349	Combined sources	6
Beta strandⁱ	352 – 357	Combined sources	6
Beta strandⁱ	366 – 371	Combined sources	6
Beta strandⁱ	374 – 379	Combined sources	6
Helixⁱ	382 – 384	Combined sources	3
Beta strandⁱ	386 – 394	Combined sources	9
Beta strandⁱ	397 – 408	Combined sources	12

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CS6	X-ray	1.80	A	28-409	[»]
ProteinModelPortalⁱ	P28685
SMRⁱ	P28685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P28685

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	32 – 123	Ig-like C2-type 1Add BLAST	92
Domainⁱ	128 – 223	Ig-like C2-type 2Add BLAST	96
Domainⁱ	234 – 317	Ig-like C2-type 3Add BLAST	84
Domainⁱ	322 – 406	Ig-like C2-type 4Add BLAST	85
Domainⁱ	412 – 499	Ig-like C2-type 5Add BLAST	88
Domainⁱ	504 – 598	Ig-like C2-type 6Add BLAST	95
Domainⁱ	605 – 703	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	99
Domainⁱ	708 – 805	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	810 – 907	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	911 – 1003	Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST	93

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	599 – 608	HingeSequence analysis		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	601 – 607	Gly/Pro-rich		7

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. Contactin family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG3513 Eukaryota ENOG410XSVG LUCA
HOGENOMⁱ	HOG000059617
HOVERGENⁱ	HBG051047
InParanoidⁱ	P28685
KEGG Orthology (KO) More...KOⁱ	K06760
PhylomeDBⁱ	P28685

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 3 hits
Gene3Dⁱ	2.60.40.10, 10 hits
InterProⁱ	View protein in InterPro IPR032991 Contactin-2 IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2
PANTHERⁱ	PTHR43905:SF1 PTHR43905:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF07679 I-set, 2 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 4 hits SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 6 hits SSF49265 SSF49265, 3 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 4 hits PS50835 IG_LIKE, 6 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P28685-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGGTAAFICT SLAVIICVVW CQAQSGMRSY GPVFEEQPAH TLFPEGSAEE 
        60         70         80         90        100
KVTLTCRARA NPPATYRWKM NGTELKMGPD SRYRLVAGDL VISNPVKAKD 
       110        120        130        140        150
AGSYQCVATN ARGTVVSREA SLRFGFLQEF SAEERDPVKI TEGWGVMFTC 
       160        170        180        190        200
SPPPHYPALS YRWLLNEFPN FIPADGRRFV SQTTGNLYIA KTEASDLGNY 
       210        220        230        240        250
SCFATSHIDF ITKSVFSKFS QLSLAAEDAR QYAPSIKAKF PADTYALTGQ 
       260        270        280        290        300
MVTLECFAFG NPVPQIKWRK LDGSQTSKWL SSEPLLHIQN VDFEDEGTYE 
       310        320        330        340        350
CEAENIKGRD TYQGRIIIHA QPDWLDVITD TEADIGSDLR WSCVASGKPR 
       360        370        380        390        400
PAVRWLRDGQ PLASQNRIEV SGGELRFSKL VLEDSGMYQC VAENKHGTVY 
       410        420        430        440        450
ASAELTVQAL APDFRLNPVK RLIPAARSGK VIIPCQPRAA PKATVLWTKG 
       460        470        480        490        500
TELLTNSSRV TITADGTLIL QNISKSDEGK YTCFAENFMG KANSTGILSV 
       510        520        530        540        550
RDATKITLAP SSADINVGEN LTLQCHASHD PTMDLTFTWS LDDFPIDLDK 
       560        570        580        590        600
SEGHYRRASV KEAVGDLAIV NAQLKHSGRY TCTAQTVVDS TSESATLTVR 
       610        620        630        640        650
GPPGPPGGVV VRDIGDTTVQ LSWSRGFDNH SPIARYSIEA RTLLSNKWKQ 
       660        670        680        690        700
MRTNPVNIEG NAETAQVVNL IPWMDYEFRV LASNILGVGE PSLPSSKIRT 
       710        720        730        740        750
KEAAPTVAPS GLGGGGGAPN ELIINWTPTL RDYQNGDGFG YILSFRKKGT 
       760        770        780        790        800
QGWLTARVPH AESLHYVYRN ESIGPYTPFE VKIKAYNRKG EGPESLTAIV 
       810        820        830        840        850
YSAEEEPKVA PFRVTAKAVL SSEMDVSWEP VEQGDMTGVL LGYEIRYWKD 
       860        870        880        890        900
GDKEEAADRV RTAGLVTSAH VTGLNPNTKY HVSVRAYNRA GAGPPSPSTN 
       910        920        930        940        950
ITTTKPPPRR PPGNISWTLT GSTVTIKWDP VVAQADESAV TGYKMLYRQD 
       960        970        980        990       1000
SHSAPTLYLA SKSRIDIPVP EDFTHAFVQI RVTGPGGDGT PAEVHIVRNS 
      1010       1020       1030 
GTSMMVEDSV TRPVPHAAII TTNSLAMVAL IRYLEL

Length:1,036

Mass (Da):113,302

Last modified:December 1, 1992 - v1

Checksum:ⁱ08B80143BE779794

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63101 mRNA Translation: CAA44815.1 X79607 Genomic DNA No translation available.
PIRⁱ	S22383
NCBI Reference Sequences More...RefSeqⁱ	NP_001004395.1, NM_001004395.1
UniGeneⁱ	Gga.2766

Genome annotation databases

GeneIDⁱ	419825
KEGGⁱ	gga:419825

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P28685	UPI0000110DA5		CHICK		382
UPI000522737E		OPIHO		1105
UPI0004F011D5		MERNU		1045
Contactin 2		ANAPL		1044
Contactin 2		FICAL		1041
+86

Protein	Similar proteins		Species	Score	Length
P28685	Contactin-2	)	MOUSE		1040
UPI000A31A375		MUSCR		1040
UPI000A30BA24		MUSPA		1040
UPI00074FFFF8		GEKJA		1035
UPI000C87B8C3		PTEVA		1077
+213

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63101 mRNA Translation: CAA44815.1 X79607 Genomic DNA No translation available.
PIRⁱ	S22383
NCBI Reference Sequences More...RefSeqⁱ	NP_001004395.1, NM_001004395.1
UniGeneⁱ	Gga.2766

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CS6	X-ray	1.80	A	28-409	[»]
ProteinModelPortalⁱ	P28685
SMRⁱ	P28685
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9031.ENSGALP00000034589

STRINGⁱ

9031.ENSGALP00000034589

Proteomic databases

PaxDbⁱ	P28685

PaxDbⁱ

P28685

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	419825
KEGGⁱ	gga:419825

Organism-specific databases

CTDⁱ	6900

CTDⁱ

6900

Phylogenomic databases

eggNOGⁱ	KOG3513 Eukaryota ENOG410XSVG LUCA
HOGENOMⁱ	HOG000059617
HOVERGENⁱ	HBG051047
InParanoidⁱ	P28685
KEGG Orthology (KO) More...KOⁱ	K06760
PhylomeDBⁱ	P28685

Miscellaneous databases

EvolutionaryTraceⁱ	P28685
Protein Ontology More...PROⁱ	PR:P28685

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 3 hits
Gene3Dⁱ	2.60.40.10, 10 hits
InterProⁱ	View protein in InterPro IPR032991 Contactin-2 IPR003961 FN3_dom IPR036116 FN3_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2
PANTHERⁱ	PTHR43905:SF1 PTHR43905:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00041 fn3, 3 hits PF07679 I-set, 2 hits
SMARTⁱ	View protein in SMART SM00060 FN3, 4 hits SM00409 IG, 6 hits SM00408 IGc2, 5 hits
SUPFAMⁱ	SSF48726 SSF48726, 6 hits SSF49265 SSF49265, 3 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 4 hits PS50835 IG_LIKE, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CNTN2_CHICK
Accessionⁱ	P28685Primary (citable) accession number: P28685
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	December 20, 2017
	This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - P28685 (CNTN2_CHICK)

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Contactin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ