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Protein

Grancalcin

Gene

GCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

Miscellaneous

This protein has been shown to bind calcium with high affinity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi65 – 7218
Calcium bindingi132 – 1432Add BLAST12
Calcium bindingi161 – 1723PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • calcium ion binding Source: UniProtKB
  • protein heterodimerization activity Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • membrane fusion Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • proteolysis Source: GO_Central

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Grancalcin
Gene namesi
Name:GCA
Synonyms:GCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115271.10
HGNCiHGNC:15990 GCA
MIMi607030 gene
neXtProtiNX_P28676

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25801
OpenTargetsiENSG00000115271
PharmGKBiPA28602

Polymorphism and mutation databases

BioMutaiGCA
DMDMi1170014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000737211 – 217GrancalcinAdd BLAST217

Proteomic databases

EPDiP28676
MaxQBiP28676
PaxDbiP28676
PeptideAtlasiP28676
PRIDEiP28676
ProteomicsDBi54491

PTM databases

iPTMnetiP28676
PhosphoSitePlusiP28676

Expressioni

Tissue specificityi

Detected in neutrophils and macrophages (at protein level). Highly expressed in bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000115271 Expressed in 220 organ(s), highest expression level in bone marrow
CleanExiHS_GCA
ExpressionAtlasiP28676 baseline and differential
GenevisibleiP28676 HS

Organism-specific databases

HPAiHPA035033
HPA035034

Interactioni

Subunit structurei

Homodimer. Interacts with SRI and LCP1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA8P433615EBI-947242,EBI-10182930

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117333, 21 interactors
CORUMiP28676
DIPiDIP-41437N
IntActiP28676, 15 interactors
STRINGi9606.ENSP00000394842

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28676
SMRiP28676
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28676

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 83EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini89 – 122EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini119 – 154EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini155 – 180EF-hand 4PROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiP28676
OMAiMWTYFTA
OrthoDBiEOG091G0ISY
PhylomeDBiP28676
TreeFamiTF314682

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P28676-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYPGYGGGF GNFSIQVPGM QMGQPVPETG PAILLDGYSG PAYSDTYSSA
60 70 80 90 100
GDSVYTYFSA VAGQDGEVDA EELQRCLTQS GINGTYSPFS LETCRIMIAM
110 120 130 140 150
LDRDHTGKMG FNAFKELWAA LNAWKENFMT VDQDGSGTVE HHELRQAIGL
160 170 180 190 200
MGYRLSPQTL TTIVKRYSKN GRIFFDDYVA CCVKLRALTD FFRKRDHLQQ
210
GSANFIYDDF LQGTMAI
Length:217
Mass (Da):24,010
Last modified:November 1, 1995 - v2
Checksum:i88CA4DDF835AFFE4
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXD5H7BXD5_HUMAN
Grancalcin
GCA
198Annotation score:
H7C2Z6H7C2Z6_HUMAN
Grancalcin
GCA
146Annotation score:
C9JWQ8C9JWQ8_HUMAN
Grancalcin
GCA
146Annotation score:
C9JIZ3C9JIZ3_HUMAN
Grancalcin
GCA
132Annotation score:
C9JV47C9JV47_HUMAN
Grancalcin
GCA
87Annotation score:

Sequence cautioni

The sequence BAD93005 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166R → D AA sequence (PubMed:1530588).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04865780S → A1 PublicationCorresponds to variant dbSNP:rs17783344Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81637 mRNA Translation: AAA58498.1
AK312349 mRNA Translation: BAG35270.1
AB209768 mRNA Translation: BAD93005.1 Different initiation.
AC010876 Genomic DNA Translation: AAX93138.1
CH471058 Genomic DNA Translation: EAX11350.1
BC005214 mRNA Translation: AAH05214.1
CCDSiCCDS2218.1
PIRiA42578
RefSeqiNP_036330.1, NM_012198.4
UniGeneiHs.377894

Genome annotation databases

EnsembliENST00000437150; ENSP00000394842; ENSG00000115271
GeneIDi25801
KEGGihsa:25801
UCSCiuc002ucg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81637 mRNA Translation: AAA58498.1
AK312349 mRNA Translation: BAG35270.1
AB209768 mRNA Translation: BAD93005.1 Different initiation.
AC010876 Genomic DNA Translation: AAX93138.1
CH471058 Genomic DNA Translation: EAX11350.1
BC005214 mRNA Translation: AAH05214.1
CCDSiCCDS2218.1
PIRiA42578
RefSeqiNP_036330.1, NM_012198.4
UniGeneiHs.377894

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F4OX-ray2.50A/B53-217[»]
1F4QX-ray1.90A/B53-217[»]
1K94X-ray1.70A/B53-217[»]
1K95X-ray1.90A53-217[»]
ProteinModelPortaliP28676
SMRiP28676
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117333, 21 interactors
CORUMiP28676
DIPiDIP-41437N
IntActiP28676, 15 interactors
STRINGi9606.ENSP00000394842

PTM databases

iPTMnetiP28676
PhosphoSitePlusiP28676

Polymorphism and mutation databases

BioMutaiGCA
DMDMi1170014

Proteomic databases

EPDiP28676
MaxQBiP28676
PaxDbiP28676
PeptideAtlasiP28676
PRIDEiP28676
ProteomicsDBi54491

Protocols and materials databases

DNASUi25801
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437150; ENSP00000394842; ENSG00000115271
GeneIDi25801
KEGGihsa:25801
UCSCiuc002ucg.4 human

Organism-specific databases

CTDi25801
DisGeNETi25801
EuPathDBiHostDB:ENSG00000115271.10
GeneCardsiGCA
HGNCiHGNC:15990 GCA
HPAiHPA035033
HPA035034
MIMi607030 gene
neXtProtiNX_P28676
OpenTargetsiENSG00000115271
PharmGKBiPA28602
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
ENOG410YKQK LUCA
GeneTreeiENSGT00620000087734
HOGENOMiHOG000231982
HOVERGENiHBG004492
InParanoidiP28676
OMAiMWTYFTA
OrthoDBiEOG091G0ISY
PhylomeDBiP28676
TreeFamiTF314682

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiGCA human
EvolutionaryTraceiP28676
GeneWikiiGCA_(gene)
GenomeRNAii25801
PROiPR:P28676
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115271 Expressed in 220 organ(s), highest expression level in bone marrow
CleanExiHS_GCA
ExpressionAtlasiP28676 baseline and differential
GenevisibleiP28676 HS

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGRAN_HUMAN
AccessioniPrimary (citable) accession number: P28676
Secondary accession number(s): B2R5X3, Q53TB5, Q59EP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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