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Protein

Beta-soluble NSF attachment protein

Gene

Napb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

GO - Molecular functioni

  • SNARE binding Source: MGI
  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
Brain protein I47
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:Napb
Synonyms:Snapb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104562 Napb

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190611 – 298Beta-soluble NSF attachment proteinAdd BLAST298

Proteomic databases

MaxQBiP28663
PaxDbiP28663
PeptideAtlasiP28663
PRIDEiP28663

PTM databases

iPTMnetiP28663
PhosphoSitePlusiP28663

Expressioni

Tissue specificityi

Cerebral cortex, cerebellar cortex, hippocampus, and dentate gyrus, weakly expressed in the putamen, the thalamus and the brain stem.1 Publication

Gene expression databases

BgeeiENSMUSG00000027438 Expressed in 233 organ(s), highest expression level in piriform cortex
ExpressionAtlasiP28663 baseline and differential
GenevisibleiP28663 MM

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201693, 3 interactors
IntActiP28663, 7 interactors
MINTiP28663
STRINGi10090.ENSMUSP00000028926

Structurei

3D structure databases

ProteinModelPortaliP28663
SMRiP28663
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586 Eukaryota
ENOG410XPQ6 LUCA
GeneTreeiENSGT00390000005826
HOGENOMiHOG000165015
HOVERGENiHBG001325
InParanoidiP28663
OMAiIAKNWSA
OrthoDBiEOG091G0KSY
PhylomeDBiP28663
TreeFamiTF316547

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
PRINTSiPR00448 NSFATTACHMNT
SUPFAMiSSF48452 SSF48452, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P28663-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:May 10, 2004 - v2
Checksum:i5B7BE0FB84BABD83
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHL2D6RHL2_MOUSE
Beta-soluble NSF attachment protein
Napb
115Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083184 mRNA Translation: BAC38798.1
BC038362 mRNA Translation: AAH38362.1
BC049874 mRNA Translation: AAH49874.1
X61455 mRNA Translation: CAA43695.1
CCDSiCCDS16842.1
PIRiS16869
RefSeqiNP_062606.1, NM_019632.3
UniGeneiMm.274308
Mm.391579

Genome annotation databases

EnsembliENSMUST00000028926; ENSMUSP00000028926; ENSMUSG00000027438
GeneIDi17957
KEGGimmu:17957
UCSCiuc008mti.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083184 mRNA Translation: BAC38798.1
BC038362 mRNA Translation: AAH38362.1
BC049874 mRNA Translation: AAH49874.1
X61455 mRNA Translation: CAA43695.1
CCDSiCCDS16842.1
PIRiS16869
RefSeqiNP_062606.1, NM_019632.3
UniGeneiMm.274308
Mm.391579

3D structure databases

ProteinModelPortaliP28663
SMRiP28663
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201693, 3 interactors
IntActiP28663, 7 interactors
MINTiP28663
STRINGi10090.ENSMUSP00000028926

PTM databases

iPTMnetiP28663
PhosphoSitePlusiP28663

Proteomic databases

MaxQBiP28663
PaxDbiP28663
PeptideAtlasiP28663
PRIDEiP28663

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028926; ENSMUSP00000028926; ENSMUSG00000027438
GeneIDi17957
KEGGimmu:17957
UCSCiuc008mti.1 mouse

Organism-specific databases

CTDi63908
MGIiMGI:104562 Napb

Phylogenomic databases

eggNOGiKOG1586 Eukaryota
ENOG410XPQ6 LUCA
GeneTreeiENSGT00390000005826
HOGENOMiHOG000165015
HOVERGENiHBG001325
InParanoidiP28663
OMAiIAKNWSA
OrthoDBiEOG091G0KSY
PhylomeDBiP28663
TreeFamiTF316547

Enzyme and pathway databases

ReactomeiR-MMU-204005 COPII-mediated vesicle transport
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-6811438 Intra-Golgi traffic
R-MMU-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

ChiTaRSiNapb mouse
PROiPR:P28663
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027438 Expressed in 233 organ(s), highest expression level in piriform cortex
ExpressionAtlasiP28663 baseline and differential
GenevisibleiP28663 MM

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
PRINTSiPR00448 NSFATTACHMNT
SUPFAMiSSF48452 SSF48452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNAB_MOUSE
AccessioniPrimary (citable) accession number: P28663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 10, 2004
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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