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Protein

Brain protein I3

Gene

Bri3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref. 4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity).By similarity1 Publication

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Brain protein I3
Gene namesi
Name:Bri3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1933174 Bri3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649241 – 125Brain protein I3Add BLAST125

Proteomic databases

PaxDbiP28662
PRIDEiP28662

PTM databases

PhosphoSitePlusiP28662

Expressioni

Tissue specificityi

High expression in cerebral cortex, and in cerebellar cortex.

Inductioni

Up-regulated during TNF-mediated inflammation and immunity.1 Publication

Gene expression databases

BgeeiENSMUSG00000047843 Expressed in 22 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_BRI3
ExpressionAtlasiP28662 baseline and differential
GenevisibleiP28662 MM

Interactioni

Subunit structurei

Interacts with BRI3BP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057263

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 43Poly-Pro7

Sequence similaritiesi

Belongs to the BRI3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4517 Eukaryota
ENOG41121JM LUCA
GeneTreeiENSGT00510000048486
HOGENOMiHOG000035090
HOVERGENiHBG104957
InParanoidiP28662
OMAiGTYAIIQ
OrthoDBiEOG091G18Q7
PhylomeDBiP28662
TreeFamiTF329242

Family and domain databases

InterProiView protein in InterPro
IPR019317 Brain_I3
PANTHERiPTHR13551 PTHR13551, 1 hit
PfamiView protein in Pfam
PF10164 DUF2367, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P28662-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHKPLLQER PPAYNLEAGQ GDYACGPHGY GAIPTAPPPP PYPYLVTGIP
60 70 80 90 100
TSHPRVYNIH SRTVTRYPAN SIVVVGGCPV CRVGVLEYCF TCLGIFLAIV
110 120
LFPFGFLCCF ALRKRRCPNC GAVFT
Length:125
Mass (Da):13,643
Last modified:May 30, 2000 - v2
Checksum:i45BBE06BC77AD936
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUB2E9PUB2_MOUSE
Brain protein I3
Bri3
121Annotation score:
Q8C7X8Q8C7X8_MOUSE
Brain protein I3
Bri3 mCG_17951
100Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119 – 125NCGAVFT → TVERSLLRGNSTPSFP in CAA43694 (PubMed:12106288).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106967 mRNA Translation: AAD05168.1
BC095955 mRNA Translation: AAH95955.1
X61454 mRNA Translation: CAA43694.1
CCDSiCCDS19848.1
PIRiS16868
RefSeqiNP_061242.3, NM_018772.4
UniGeneiMm.38011

Genome annotation databases

EnsembliENSMUST00000056578; ENSMUSP00000057263; ENSMUSG00000047843
GeneIDi55950
KEGGimmu:55950
UCSCiuc009alo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF106967 mRNA Translation: AAD05168.1
BC095955 mRNA Translation: AAH95955.1
X61454 mRNA Translation: CAA43694.1
CCDSiCCDS19848.1
PIRiS16868
RefSeqiNP_061242.3, NM_018772.4
UniGeneiMm.38011

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057263

PTM databases

PhosphoSitePlusiP28662

Proteomic databases

PaxDbiP28662
PRIDEiP28662

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056578; ENSMUSP00000057263; ENSMUSG00000047843
GeneIDi55950
KEGGimmu:55950
UCSCiuc009alo.2 mouse

Organism-specific databases

CTDi25798
MGIiMGI:1933174 Bri3

Phylogenomic databases

eggNOGiKOG4517 Eukaryota
ENOG41121JM LUCA
GeneTreeiENSGT00510000048486
HOGENOMiHOG000035090
HOVERGENiHBG104957
InParanoidiP28662
OMAiGTYAIIQ
OrthoDBiEOG091G18Q7
PhylomeDBiP28662
TreeFamiTF329242

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiBri3 mouse
PROiPR:P28662
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047843 Expressed in 22 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_BRI3
ExpressionAtlasiP28662 baseline and differential
GenevisibleiP28662 MM

Family and domain databases

InterProiView protein in InterPro
IPR019317 Brain_I3
PANTHERiPTHR13551 PTHR13551, 1 hit
PfamiView protein in Pfam
PF10164 DUF2367, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRI3_MOUSE
AccessioniPrimary (citable) accession number: P28662
Secondary accession number(s): Q501N3, Q9Z1S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: May 30, 2000
Last modified: September 12, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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