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Protein

Septin-4

Gene

Sept4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei185GTPBy similarity1
Binding sitei211GTP; via amide nitrogenBy similarity1
Binding sitei348GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei363GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi151 – 158GTPBy similarity8
Nucleotide bindingi290 – 298GTPBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Differentiation, Spermatogenesis
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Septin-4
Alternative name(s):
Brain protein H5
Peanut-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sept4
Synonyms:Pnutl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1270156 Sept4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001735201 – 478Septin-4Add BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1
Modified residuei68PhosphoserineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei434PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28661

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P28661

PeptideAtlas

More...
PeptideAtlasi
P28661

PRoteomics IDEntifications database

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PRIDEi
P28661

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P28661

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P28661

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain. Abundant in areas of high cell density, particularly in the stria terminalis. Isoform 4 is predominantly expressed in embryonic mouse brain and dorsal root ganglion neurons.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed in embryos at 7 dpc. Isoform 4 predominantly expressed in the brain at 14 dpc and on postnatal day 1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000020486 Expressed in 282 organ(s), highest expression level in cerebellum

CleanEx database of gene expression profiles

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CleanExi
MM_SEPT4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P28661 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P28661 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with SEPT8 (By similarity). Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus (By similarity). Isoform 4 interacts with DPYSL5.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
202286, 5 interactors

Protein interaction database and analysis system

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IntActi
P28661, 3 interactors

Molecular INTeraction database

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MINTi
P28661

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000018544

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P28661

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28661

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 414Septin-type GPROSITE-ProRule annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni151 – 158G1 motifPROSITE-ProRule annotation8
Regioni208 – 211G3 motifPROSITE-ProRule annotation4
Regioni289 – 292G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili447 – 478Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2655 Eukaryota
COG5019 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157152

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG065093

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28661

KEGG Orthology (KO)

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KOi
K16943

Identification of Orthologs from Complete Genome Data

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OMAi
FSGNESC

Database of Orthologous Groups

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OrthoDBi
EOG091G07TS

Database for complete collections of gene phylogenies

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PhylomeDBi
P28661

TreeFam database of animal gene trees

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TreeFami
TF101079

Family and domain databases

Conserved Domains Database

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CDDi
cd01850 CDC_Septin, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR030643 Septin4

The PANTHER Classification System

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PANTHERi
PTHR18884:SF71 PTHR18884:SF71, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00735 Septin, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF006698 Septin, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51719 G_SEPTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28661-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDHSLGWQGN SVPEDGTEAG IKHFLEDSSD DAELSKFVKD FPGSEPYHSA
60 70 80 90 100
ESKTRVARPQ ILEPRPQSPD LCDDDVEFRG SLWPQPSDSQ QYFSAPAPLS
110 120 130 140 150
PSSRPRSPWG KLDPYDSSED DKEYVGFATL PNQVHRKSVK KGFDFTLMVA
160 170 180 190 200
GESGLGKSTL VNSLFLTDLY RDRKLLGAEE RIMQTVEITK HAVDIEEKGV
210 220 230 240 250
RLRLTIVDTP GFGDAVNNTE CWKPVAEYID QQFEQYFRDE SGLNRKNIQD
260 270 280 290 300
NRVHCCLYFI SPFGHGLRPL DVEFMKALHQ RVNIVPILAK ADTLTPPEVD
310 320 330 340 350
RKKCKIREEI EHFGIKIYQF PDCDSDEDED FKLQDQALKE SIPFAVIGSN
360 370 380 390 400
TVVEARGRRV RGRLYPWGIV EVENPGHCDF VKLRTMLVRT HMQDLKDVTR
410 420 430 440 450
ETHYENYRAQ CIQSMTRLVV KERNRNKLTR ESGTDFPIPA VPPGTDPETE
460 470
KLIREKDEEL RRMQEMLHKI QRQMKETH
Length:478
Mass (Da):54,936
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36655DE54A6C4908
GO
Isoform 2 (identifier: P28661-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDHSLGWQGNSVPEDGTEAG → M

Show »
Length:459
Mass (Da):52,998
Checksum:iB47573B04A6CCE67
GO
Isoform 3 (identifier: P28661-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     426-431: NKLTRE → KDRSRN
     432-478: Missing.

Note: No experimental confirmation available.
Show »
Length:431
Mass (Da):49,425
Checksum:i9768B713C998B739
GO
Isoform 4 (identifier: P28661-4) [UniParc]FASTAAdd to basket
Also known as: Mitochondrial septin, M-septin

The sequence of this isoform differs from the canonical sequence as follows:
     21-119: Missing.

Show »
Length:379
Mass (Da):43,789
Checksum:i4B31F40666EFD942
GO
Isoform 5 (identifier: P28661-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-118: Missing.
     119-119: E → M
     426-431: NKLTRE → KDRSRN
     432-478: Missing.

Note: No experimental confirmation available.
Show »
Length:313
Mass (Da):36,340
Checksum:iD69F63E697F5DB5D
GO
Isoform 6 (identifier: P28661-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDHSLGWQGNSVPEDGTEAG → M
     221-223: CWK → WYV
     224-478: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):22,983
Checksum:i1B5EC688E0025132
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5ND13Q5ND13_MOUSE
Septin-4
Sept4
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5ND09Q5ND09_MOUSE
Septin-4
Sept4
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5ND18Q5ND18_MOUSE
Septin-4
Sept4
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394D → N in BAE21934 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383071 – 118Missing in isoform 5. 1 PublicationAdd BLAST118
Alternative sequenceiVSP_0383081 – 20MDHSL…GTEAG → M in isoform 2 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_03830921 – 119Missing in isoform 4. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_038310119E → M in isoform 5. 1 Publication1
Alternative sequenceiVSP_038311221 – 223CWK → WYV in isoform 6. 1 Publication3
Alternative sequenceiVSP_038312224 – 478Missing in isoform 6. 1 PublicationAdd BLAST255
Alternative sequenceiVSP_038313426 – 431NKLTRE → KDRSRN in isoform 3 and isoform 5. 2 Publications6
Alternative sequenceiVSP_038314432 – 478Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X61452 mRNA Translation: CAA43692.1
AB078010 mRNA Translation: BAC55241.1
AK133933 mRNA Translation: BAE21934.1
AK135143 mRNA Translation: BAE22437.1
AK137299 mRNA Translation: BAE23298.1
AL596086 Genomic DNA Translation: CAI35128.2
AL596086 Genomic DNA Translation: CAI35129.1
AL596086 Genomic DNA Translation: CAI35132.1
AL596086 Genomic DNA Translation: CAI35133.1
AL596086 Genomic DNA Translation: CAI35134.1
CU406988 Genomic DNA Translation: CAQ52271.1
CU406988 Genomic DNA Translation: CAQ52272.1
CU406988 Genomic DNA Translation: CAQ52274.1
CU406988 Genomic DNA Translation: CAQ52275.1
CU406988 Genomic DNA Translation: CAQ52276.1
CH466556 Genomic DNA Translation: EDL15822.1
BC055101 mRNA Translation: AAH55101.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS25213.1 [P28661-1]
CCDS70275.1 [P28661-5]
CCDS70276.1 [P28661-3]
CCDS70277.1 [P28661-4]

Protein sequence database of the Protein Information Resource

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PIRi
S16867

NCBI Reference Sequences

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RefSeqi
NP_001271321.1, NM_001284392.1 [P28661-4]
NP_001271323.1, NM_001284394.1 [P28661-3]
NP_001271327.1, NM_001284398.1 [P28661-5]
NP_035259.1, NM_011129.2 [P28661-1]
XP_006532561.1, XM_006532498.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.2214

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000018544; ENSMUSP00000018544; ENSMUSG00000020486 [P28661-1]
ENSMUST00000063156; ENSMUSP00000060127; ENSMUSG00000020486 [P28661-4]
ENSMUST00000107960; ENSMUSP00000103594; ENSMUSG00000020486 [P28661-3]
ENSMUST00000107962; ENSMUSP00000103596; ENSMUSG00000020486 [P28661-2]
ENSMUST00000122067; ENSMUSP00000112960; ENSMUSG00000020486 [P28661-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
18952

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:18952

UCSC genome browser

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UCSCi
uc007kts.2 mouse [P28661-6]
uc007ktu.2 mouse [P28661-5]
uc007ktw.2 mouse [P28661-1]
uc007ktx.2 mouse [P28661-3]
uc007kty.2 mouse [P28661-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61452 mRNA Translation: CAA43692.1
AB078010 mRNA Translation: BAC55241.1
AK133933 mRNA Translation: BAE21934.1
AK135143 mRNA Translation: BAE22437.1
AK137299 mRNA Translation: BAE23298.1
AL596086 Genomic DNA Translation: CAI35128.2
AL596086 Genomic DNA Translation: CAI35129.1
AL596086 Genomic DNA Translation: CAI35132.1
AL596086 Genomic DNA Translation: CAI35133.1
AL596086 Genomic DNA Translation: CAI35134.1
CU406988 Genomic DNA Translation: CAQ52271.1
CU406988 Genomic DNA Translation: CAQ52272.1
CU406988 Genomic DNA Translation: CAQ52274.1
CU406988 Genomic DNA Translation: CAQ52275.1
CU406988 Genomic DNA Translation: CAQ52276.1
CH466556 Genomic DNA Translation: EDL15822.1
BC055101 mRNA Translation: AAH55101.1
CCDSiCCDS25213.1 [P28661-1]
CCDS70275.1 [P28661-5]
CCDS70276.1 [P28661-3]
CCDS70277.1 [P28661-4]
PIRiS16867
RefSeqiNP_001271321.1, NM_001284392.1 [P28661-4]
NP_001271323.1, NM_001284394.1 [P28661-3]
NP_001271327.1, NM_001284398.1 [P28661-5]
NP_035259.1, NM_011129.2 [P28661-1]
XP_006532561.1, XM_006532498.3
UniGeneiMm.2214

3D structure databases

ProteinModelPortaliP28661
SMRiP28661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202286, 5 interactors
IntActiP28661, 3 interactors
MINTiP28661
STRINGi10090.ENSMUSP00000018544

PTM databases

iPTMnetiP28661
PhosphoSitePlusiP28661

Proteomic databases

MaxQBiP28661
PaxDbiP28661
PeptideAtlasiP28661
PRIDEiP28661

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
18952
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018544; ENSMUSP00000018544; ENSMUSG00000020486 [P28661-1]
ENSMUST00000063156; ENSMUSP00000060127; ENSMUSG00000020486 [P28661-4]
ENSMUST00000107960; ENSMUSP00000103594; ENSMUSG00000020486 [P28661-3]
ENSMUST00000107962; ENSMUSP00000103596; ENSMUSG00000020486 [P28661-2]
ENSMUST00000122067; ENSMUSP00000112960; ENSMUSG00000020486 [P28661-5]
GeneIDi18952
KEGGimmu:18952
UCSCiuc007kts.2 mouse [P28661-6]
uc007ktu.2 mouse [P28661-5]
uc007ktw.2 mouse [P28661-1]
uc007ktx.2 mouse [P28661-3]
uc007kty.2 mouse [P28661-4]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5414
MGIiMGI:1270156 Sept4

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00940000157152
HOVERGENiHBG065093
InParanoidiP28661
KOiK16943
OMAiFSGNESC
OrthoDBiEOG091G07TS
PhylomeDBiP28661
TreeFamiTF101079

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sept4 mouse

Protein Ontology

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PROi
PR:P28661

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020486 Expressed in 282 organ(s), highest expression level in cerebellum
CleanExiMM_SEPT4
ExpressionAtlasiP28661 baseline and differential
GenevisibleiP28661 MM

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
IPR030643 Septin4
PANTHERiPTHR18884:SF71 PTHR18884:SF71, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEPT4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28661
Secondary accession number(s): B2KGM6
, Q3UVH1, Q3UZC3, Q5ND10, Q5ND15, Q5ND16, Q7TPM7, Q80VX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: December 5, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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