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Entry version 164 (08 May 2019)
Sequence version 2 (18 Oct 2001)
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Protein

CUGBP Elav-like family member 1

Gene

Celf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Promotes exclusion of exon 11 of the INSR pre-mRNA (By similarity). Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast (By similarity). Increases translation and controls the choice of translation initiation codon of CEBPB mRNA (By similarity). Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3 (By similarity). Mediates rapid cytoplasmic mRNA deadenylation (By similarity). Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation (By similarity). Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs) (By similarity). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity). Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA (By similarity). Binds to the 5'-region of CDKN1A and CEBPB mRNAs (By similarity). Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CUGBP Elav-like family member 1
Short name:
CELF-1
Alternative name(s):
50 kDa nuclear polyadenylated RNA-binding protein
Brain protein F41
Bruno-like protein 2
CUG triplet repeat RNA-binding protein 1
Short name:
CUG-BP1
CUG-BP- and ETR-3-like factor 1
Deadenylation factor CUG-BP
Deadenylation factor EDEN-BP
Embryo deadenylation element-binding protein homolog
Short name:
EDEN-BP homolog
RNA-binding protein BRUNOL-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Celf1
Synonyms:Brunol2, Cugbp, Cugbp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1342295 Celf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi302S → G: Reduces CDK4-mediated phosphorylation. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000815391 – 486CUGBP Elav-like family member 1Add BLAST486

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei4PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei179PhosphoserineBy similarity1
Modified residuei302Phosphoserine1 Publication1
Isoform 4 (identifier: P28659-4)
Modified residuei18PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylated by CDK4 on Ser-302. Its phosphorylation status increases in aging liver and is important for the formation of the EIF2 complex and activation of CEBPB mRNA translation. Hyperphosphorylated in the EIF2 complex. EGFR signaling regulates its phosphorylation status in epithelial cells.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P28659

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28659

PeptideAtlas

More...
PeptideAtlasi
P28659

PRoteomics IDEntifications database

More...
PRIDEi
P28659

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28659

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28659

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, uterus, diaphragm, lung, spleen, testis, mammary gland, adipose, eye and brain (at protein level). Strongly expressed in aging liver (at protein level). Expressed in lung, stomach, heart to very low levels (at protein level). Expressed in germ cells of the seminiferous tubules except in the central region that contains the elongated spermatids and spermatozoa (at protein level). Expressed in Leydig cells of the interstitial tissue (at protein level). Expressed in the heart, skeletal muscle, testis (from spermatogonia to round spermatids), spleen, lung, neocortex, cerebellar cortex, hippocampus and other areas, abundant in the putamen, and poorly expressed in the thalamus and in the brain stem.5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in heart, muscle, brain, liver, thigh, stomach and lung at 14 dpc (at protein level). Expressed from the two-cell to blastocyst stages. Expressed in tail region, somites, cephalic structures and limb buds at 10.5 dpc.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Its RNA-binding activity on CEBPB mRNA increases in response to EGF.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000005506 Expressed in 291 organ(s), highest expression level in lens of camera-type eye

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P28659 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P28659 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with polysomes (By similarity).

Interacts with HNRNPH1; the interaction in RNA-dependent.

Interacts with PARN (By similarity).

Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198980, 1 interactor

Protein interaction database and analysis system

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IntActi
P28659, 1 interactor

Molecular INTeraction database

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MINTi
P28659

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000070438

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P28659

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 99RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini108 – 188RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini401 – 479RRM 3PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi287 – 308Ser-richAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elements.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0146 Eukaryota
ENOG410XNTW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158970

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P28659

KEGG Orthology (KO)

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KOi
K13207

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRSWCEK

Database of Orthologous Groups

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OrthoDBi
1209165at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P28659

TreeFam database of animal gene trees

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TreeFami
TF314924

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P28659-1) [UniParc]FASTAAdd to basket
Also known as: LYLQ

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINILRD
60 70 80 90 100
RSQNPPQSKG CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE
110 120 130 140 150
KNNAVEDRKL FIGMISKKCT ENDIRVMFSS FGQIEECRIL RGPDGLSRGC
160 170 180 190 200
AFVTFTTRTM AQTAIKAMHQ AQTMEGCSSP MVVKFADTQK DKEQKRMAQQ
210 220 230 240 250
LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS SGNLNTLSSL
260 270 280 290 300
HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS
310 320 330 340 350
PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN
360 370 380 390 400
GTGSTMEALT QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG
410 420 430 440 450
ANLFIYHLPQ EFGDQDLLQM FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD
460 470 480
NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK NDSKPY
Length:486
Mass (Da):52,107
Last modified:October 18, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABB22D331A62B584
GO
Isoform 2 (identifier: P28659-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     231-234: Missing.

Show »
Length:482
Mass (Da):51,590
Checksum:i5419764243BC0587
GO
Isoform 3 (identifier: P28659-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     231-234: Missing.
     297-297: S → SA

Show »
Length:483
Mass (Da):51,661
Checksum:i88B57A65E75761F5
GO
Isoform 4 (identifier: P28659-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAAFKLDFLPEMMVDHCSLNSSPVSKKM

Note: Gene prediction based on similarity to human ortholog. No experimental confirmation available.Combined sources
Show »
Length:513
Mass (Da):55,116
Checksum:iE9CF94A90B3556D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0T5A0A0R4J0T5_MOUSE
CUG triplet repeat, RNA binding pro...
Celf1 Cugbp1, mCG_13484
487Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA43691 differs from that shown. Reason: Frameshift at position 367.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192K → E in BAB87831 (Ref. 7) Curated1
Sequence conflicti291L → P in AAF78957 (PubMed:11686919).Curated1
Sequence conflicti301P → T in AAF78957 (PubMed:11686919).Curated1
Sequence conflicti335G → R in AAF78957 (PubMed:11686919).Curated1
Sequence conflicti347G → A in AAF78957 (PubMed:11686919).Curated1
Sequence conflicti402N → Y in BAE33820 (PubMed:16141072).Curated1
Sequence conflicti466Q → R in BAE25504 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0267891M → MAAFKLDFLPEMMVDHCSLN SSPVSKKM in isoform 4. Curated1
Alternative sequenceiVSP_005786231 – 234Missing in isoform 2 and isoform 3. 2 Publications4
Alternative sequenceiVSP_005787297S → SA in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ007987 mRNA Translation: CAC20707.1
AF267535 mRNA Translation: AAF78957.1
AK135030 mRNA Translation: BAE22391.1
AK143698 mRNA Translation: BAE25504.1
AK014492 mRNA Translation: BAB29392.1
AK156725 mRNA Translation: BAE33820.1
AL672241 Genomic DNA No translation available.
BC021393 mRNA No translation available.
AF314172 mRNA Translation: AAK00297.1
AB050499 mRNA Translation: BAB87831.1
X61451 mRNA Translation: CAA43691.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS16420.1 [P28659-4]
CCDS16421.1 [P28659-1]

Protein sequence database of the Protein Information Resource

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PIRi
S16865

NCBI Reference Sequences

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RefSeqi
NP_001231820.1, NM_001244891.1 [P28659-1]
NP_001231832.1, NM_001244903.1 [P28659-1]
NP_059064.2, NM_017368.3 [P28659-4]
NP_941955.1, NM_198683.2 [P28659-1]
XP_006498727.1, XM_006498664.1
XP_006498728.1, XM_006498665.3
XP_006498732.1, XM_006498669.1 [P28659-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000005643; ENSMUSP00000005643; ENSMUSG00000005506 [P28659-4]
ENSMUST00000068747; ENSMUSP00000070438; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111448; ENSMUSP00000107075; ENSMUSG00000005506 [P28659-3]
ENSMUST00000111449; ENSMUSP00000107076; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111451; ENSMUSP00000107078; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111452; ENSMUSP00000107079; ENSMUSG00000005506 [P28659-4]
ENSMUST00000111455; ENSMUSP00000107082; ENSMUSG00000005506 [P28659-4]
ENSMUST00000177642; ENSMUSP00000136109; ENSMUSG00000005506 [P28659-1]
ENSMUST00000213174; ENSMUSP00000150227; ENSMUSG00000110883 [P28659-4]
ENSMUST00000213209; ENSMUSP00000149393; ENSMUSG00000110883 [P28659-4]
ENSMUST00000214114; ENSMUSP00000149473; ENSMUSG00000110883 [P28659-1]
ENSMUST00000214684; ENSMUSP00000150050; ENSMUSG00000110883 [P28659-1]
ENSMUST00000215738; ENSMUSP00000150186; ENSMUSG00000110883 [P28659-1]
ENSMUST00000215997; ENSMUSP00000149154; ENSMUSG00000110883 [P28659-4]
ENSMUST00000216171; ENSMUSP00000149376; ENSMUSG00000110883 [P28659-3]
ENSMUST00000217268; ENSMUSP00000150191; ENSMUSG00000110883 [P28659-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
13046

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:13046

UCSC genome browser

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UCSCi
uc008ktx.2 mouse [P28659-1]
uc008kua.2 mouse [P28659-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007987 mRNA Translation: CAC20707.1
AF267535 mRNA Translation: AAF78957.1
AK135030 mRNA Translation: BAE22391.1
AK143698 mRNA Translation: BAE25504.1
AK014492 mRNA Translation: BAB29392.1
AK156725 mRNA Translation: BAE33820.1
AL672241 Genomic DNA No translation available.
BC021393 mRNA No translation available.
AF314172 mRNA Translation: AAK00297.1
AB050499 mRNA Translation: BAB87831.1
X61451 mRNA Translation: CAA43691.1 Frameshift.
CCDSiCCDS16420.1 [P28659-4]
CCDS16421.1 [P28659-1]
PIRiS16865
RefSeqiNP_001231820.1, NM_001244891.1 [P28659-1]
NP_001231832.1, NM_001244903.1 [P28659-1]
NP_059064.2, NM_017368.3 [P28659-4]
NP_941955.1, NM_198683.2 [P28659-1]
XP_006498727.1, XM_006498664.1
XP_006498728.1, XM_006498665.3
XP_006498732.1, XM_006498669.1 [P28659-4]

3D structure databases

SMRiP28659
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198980, 1 interactor
IntActiP28659, 1 interactor
MINTiP28659
STRINGi10090.ENSMUSP00000070438

PTM databases

iPTMnetiP28659
PhosphoSitePlusiP28659

Proteomic databases

MaxQBiP28659
PaxDbiP28659
PeptideAtlasiP28659
PRIDEiP28659

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005643; ENSMUSP00000005643; ENSMUSG00000005506 [P28659-4]
ENSMUST00000068747; ENSMUSP00000070438; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111448; ENSMUSP00000107075; ENSMUSG00000005506 [P28659-3]
ENSMUST00000111449; ENSMUSP00000107076; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111451; ENSMUSP00000107078; ENSMUSG00000005506 [P28659-1]
ENSMUST00000111452; ENSMUSP00000107079; ENSMUSG00000005506 [P28659-4]
ENSMUST00000111455; ENSMUSP00000107082; ENSMUSG00000005506 [P28659-4]
ENSMUST00000177642; ENSMUSP00000136109; ENSMUSG00000005506 [P28659-1]
ENSMUST00000213174; ENSMUSP00000150227; ENSMUSG00000110883 [P28659-4]
ENSMUST00000213209; ENSMUSP00000149393; ENSMUSG00000110883 [P28659-4]
ENSMUST00000214114; ENSMUSP00000149473; ENSMUSG00000110883 [P28659-1]
ENSMUST00000214684; ENSMUSP00000150050; ENSMUSG00000110883 [P28659-1]
ENSMUST00000215738; ENSMUSP00000150186; ENSMUSG00000110883 [P28659-1]
ENSMUST00000215997; ENSMUSP00000149154; ENSMUSG00000110883 [P28659-4]
ENSMUST00000216171; ENSMUSP00000149376; ENSMUSG00000110883 [P28659-3]
ENSMUST00000217268; ENSMUSP00000150191; ENSMUSG00000110883 [P28659-1]
GeneIDi13046
KEGGimmu:13046
UCSCiuc008ktx.2 mouse [P28659-1]
uc008kua.2 mouse [P28659-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10658
MGIiMGI:1342295 Celf1

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
GeneTreeiENSGT00940000158970
InParanoidiP28659
KOiK13207
OMAiPRSWCEK
OrthoDBi1209165at2759
PhylomeDBiP28659
TreeFamiTF314924

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P28659

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000005506 Expressed in 291 organ(s), highest expression level in lens of camera-type eye
ExpressionAtlasiP28659 baseline and differential
GenevisibleiP28659 MM

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCELF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28659
Secondary accession number(s): A2AFW9
, A2AFX0, A2AFX1, A2AFX2, Q3U0N2, Q3UP93, Q3UY22, Q8R532, Q99PE1, Q9CXE5, Q9EPJ8, Q9JI37
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 18, 2001
Last modified: May 8, 2019
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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