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Protein

Ataxin-10

Gene

Atxn10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.By similarity

GO - Molecular functioni

GO - Biological processi

  • cilium assembly Source: MGI
  • nervous system development Source: MGI
  • neuron projection development Source: MGI
  • protein homotrimerization Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-10
Alternative name(s):
Brain protein E46
Spinocerebellar ataxia type 10 protein homolog
Gene namesi
Name:Atxn10
Synonyms:Sca10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1859293 Atxn10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647491 – 475Ataxin-10Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Omega-N-methylarginineCombined sources1
Modified residuei12PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiP28658
MaxQBiP28658
PaxDbiP28658
PeptideAtlasiP28658
PRIDEiP28658

PTM databases

iPTMnetiP28658
PhosphoSitePlusiP28658
SwissPalmiP28658

Expressioni

Tissue specificityi

In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000016541 Expressed in 292 organ(s), highest expression level in motor neuron
CleanExiMM_ATXN10
GenevisibleiP28658 MM

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with GNB2 (By similarity). Interacts with OGT. Interacts with IQCB1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Iqcb1Q8BP002EBI-4284019,EBI-4282243

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207574, 4 interactors
IntActiP28658, 3 interactors
MINTiP28658
STRINGi10090.ENSMUSP00000132450

Structurei

3D structure databases

ProteinModelPortaliP28658
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ataxin-10 family.Curated

Phylogenomic databases

eggNOGiKOG2676 Eukaryota
ENOG410YBUH LUCA
GeneTreeiENSGT00390000010377
HOGENOMiHOG000034224
HOVERGENiHBG050622
InParanoidiP28658
KOiK19323
OMAiDICAWES
OrthoDBiEOG091G05RO
PhylomeDBiP28658
TreeFamiTF323870

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019156 Ataxin-10_domain
PfamiView protein in Pfam
PF09759 Atx10homo_assoc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

P28658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV
60 70 80 90 100
LDILKKSTHA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN
110 120 130 140 150
SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEESQ
160 170 180 190 200
SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNAERM KDLEENLNIA
210 220 230 240 250
INVIEAHQKH PASEWPFLII SDHFLKSPEL VEAMYGKLSN QERITLLDIV
260 270 280 290 300
IAKLVGEEQL TKDDISIFVR HAELIANSFM DQCRNVLKLT SEPHTEDKEA
310 320 330 340 350
LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HEVGKESTNI
360 370 380 390 400
FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL
410 420 430 440 450
ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDVIAKME EQGLADASLL
460 470
KKMGFEIEKS GDKLILKSNN DIPPP
Length:475
Mass (Da):53,707
Last modified:October 18, 2001 - v2
Checksum:i273FDB6EDFE519C7
GO

Sequence cautioni

The sequence CAA43722 differs from that shown. Reason: Frameshift at position 409.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31A → V in CAA43722 (PubMed:12106288).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61506 mRNA Translation: CAA43722.1 Frameshift.
AK003530 mRNA Translation: BAB22840.1
AK047170 mRNA Translation: BAC32981.1
AK078459 mRNA Translation: BAC37285.1
AK153271 mRNA Translation: BAE31858.1
AK165941 mRNA Translation: BAE38473.1
AK170507 mRNA Translation: BAE41845.1
BC002285 mRNA Translation: AAH02285.1
BC016410 mRNA Translation: AAH16410.1
BC046802 mRNA Translation: AAH46802.1
CCDSiCCDS37170.1
PIRiS16416
RefSeqiNP_058539.2, NM_016843.3
UniGeneiMm.248906

Genome annotation databases

EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541
GeneIDi54138
KEGGimmu:54138
UCSCiuc007xdd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61506 mRNA Translation: CAA43722.1 Frameshift.
AK003530 mRNA Translation: BAB22840.1
AK047170 mRNA Translation: BAC32981.1
AK078459 mRNA Translation: BAC37285.1
AK153271 mRNA Translation: BAE31858.1
AK165941 mRNA Translation: BAE38473.1
AK170507 mRNA Translation: BAE41845.1
BC002285 mRNA Translation: AAH02285.1
BC016410 mRNA Translation: AAH16410.1
BC046802 mRNA Translation: AAH46802.1
CCDSiCCDS37170.1
PIRiS16416
RefSeqiNP_058539.2, NM_016843.3
UniGeneiMm.248906

3D structure databases

ProteinModelPortaliP28658
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207574, 4 interactors
IntActiP28658, 3 interactors
MINTiP28658
STRINGi10090.ENSMUSP00000132450

PTM databases

iPTMnetiP28658
PhosphoSitePlusiP28658
SwissPalmiP28658

Proteomic databases

EPDiP28658
MaxQBiP28658
PaxDbiP28658
PeptideAtlasiP28658
PRIDEiP28658

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163242; ENSMUSP00000132450; ENSMUSG00000016541
GeneIDi54138
KEGGimmu:54138
UCSCiuc007xdd.1 mouse

Organism-specific databases

CTDi25814
MGIiMGI:1859293 Atxn10

Phylogenomic databases

eggNOGiKOG2676 Eukaryota
ENOG410YBUH LUCA
GeneTreeiENSGT00390000010377
HOGENOMiHOG000034224
HOVERGENiHBG050622
InParanoidiP28658
KOiK19323
OMAiDICAWES
OrthoDBiEOG091G05RO
PhylomeDBiP28658
TreeFamiTF323870

Miscellaneous databases

PROiPR:P28658
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016541 Expressed in 292 organ(s), highest expression level in motor neuron
CleanExiMM_ATXN10
GenevisibleiP28658 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019156 Ataxin-10_domain
PfamiView protein in Pfam
PF09759 Atx10homo_assoc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiATX10_MOUSE
AccessioniPrimary (citable) accession number: P28658
Secondary accession number(s): Q543S3, Q99LP5, Q9D1I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 18, 2001
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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