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Protein

Aromatase

Gene

Cyp19a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = 17-beta-estradiol + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity
Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 4 H2O + 3 [oxidized NADPH--hemoprotein reductase].By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei309SubstrateBy similarity1
Binding sitei374Substrate; via amide nitrogenBy similarity1
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-193144 Estrogen biosynthesis
R-MMU-211976 Endogenous sterols

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14By similarity)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:Cyp19a1
Synonyms:Arom, Cyp19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88587 Cyp19a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519571 – 503AromataseAdd BLAST503

Proteomic databases

PaxDbiP28649
PRIDEiP28649

PTM databases

iPTMnetiP28649
PhosphoSitePlusiP28649

Expressioni

Gene expression databases

BgeeiENSMUSG00000032274 Expressed in 32 organ(s), highest expression level in tertiary ovarian follicle
ExpressionAtlasiP28649 baseline and differential
GenevisibleiP28649 MM

Interactioni

Protein-protein interaction databases

IntActiP28649, 1 interactor
STRINGi10090.ENSMUSP00000034811

Structurei

3D structure databases

ProteinModelPortaliP28649
SMRiP28649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00840000129915
HOGENOMiHOG000111912
HOVERGENiHBG050750
InParanoidiP28649
KOiK07434
OMAiMRRIMLD
OrthoDBiEOG091G056R
PhylomeDBiP28649
TreeFamiTF352039

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P28649-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLEMLNPMQ YNVTIMVPET VTVSAMPLLL IMGLLLLIWN CESSSSIPGP
60 70 80 90 100
GYCLGIGPLI SHGRFLWMGI GSACNYYNKM YGEFMRVWIS GEETLIISKS
110 120 130 140 150
SSMFHVMKHS HYISRFGSKR GLQCIGMHEN GIIFNNNPSL WRTIRPFFMK
160 170 180 190 200
ALTGPGLVRM VEVCVESIKQ HLDRLGEVTD TSGYVDVLTL MRHIMLDTSN
210 220 230 240 250
MLFLGIPLDE SAIVKKIQGY FNAWQALLIK PNIFFKISWL YRKYERSVKD
260 270 280 290 300
LKDEIAVLVE KKRHKVSTAE KLEDCMDFAT DLIFAERRGD LTKENVNQCI
310 320 330 340 350
LEMLIAAPDT MSVTLYFMLL LVAEYPEVEA AILKEIHTVV GDRDIKIEDI
360 370 380 390 400
QNLKVVENFI NESMRYQPVV DLVMRRALED DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHRLEYFPKP NEFTLENFEK NVPYRYFQPF GFGPRGCAGK YIAMVMMKVV
460 470 480 490 500
LVTLLRRFQV KTLQKRCIEN IPKKNDLSLH PNEDRHLVEI IFSPRNSDKY

LQQ
Length:503
Mass (Da):58,015
Last modified:December 1, 1992 - v1
Checksum:i737400389D1AEFF1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUD6A0A1L1SUD6_MOUSE
Aromatase
Cyp19a1
436Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA Translation: BAA00551.1
CCDSiCCDS23187.1
PIRiS13912
RefSeqiNP_001335100.1, NM_001348171.1
NP_001335101.1, NM_001348172.1
NP_001335102.1, NM_001348173.1
NP_031836.1, NM_007810.4
UniGeneiMm.478781
Mm.5199

Genome annotation databases

EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274
GeneIDi13075
KEGGimmu:13075
UCSCiuc009pmu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00659 mRNA Translation: BAA00551.1
CCDSiCCDS23187.1
PIRiS13912
RefSeqiNP_001335100.1, NM_001348171.1
NP_001335101.1, NM_001348172.1
NP_001335102.1, NM_001348173.1
NP_031836.1, NM_007810.4
UniGeneiMm.478781
Mm.5199

3D structure databases

ProteinModelPortaliP28649
SMRiP28649
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP28649, 1 interactor
STRINGi10090.ENSMUSP00000034811

PTM databases

iPTMnetiP28649
PhosphoSitePlusiP28649

Proteomic databases

PaxDbiP28649
PRIDEiP28649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034811; ENSMUSP00000034811; ENSMUSG00000032274
GeneIDi13075
KEGGimmu:13075
UCSCiuc009pmu.1 mouse

Organism-specific databases

CTDi1588
MGIiMGI:88587 Cyp19a1

Phylogenomic databases

eggNOGiKOG0157 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00840000129915
HOGENOMiHOG000111912
HOVERGENiHBG050750
InParanoidiP28649
KOiK07434
OMAiMRRIMLD
OrthoDBiEOG091G056R
PhylomeDBiP28649
TreeFamiTF352039

Enzyme and pathway databases

ReactomeiR-MMU-193144 Estrogen biosynthesis
R-MMU-211976 Endogenous sterols

Miscellaneous databases

ChiTaRSiCyp19a1 mouse
PROiPR:P28649
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032274 Expressed in 32 organ(s), highest expression level in tertiary ovarian follicle
ExpressionAtlasiP28649 baseline and differential
GenevisibleiP28649 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP19A_MOUSE
AccessioniPrimary (citable) accession number: P28649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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