UniProtKB - P28635 (METQ_ECOLI)
Protein
D-methionine-binding lipoprotein MetQ
Gene
metQ
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.1 Publication
Miscellaneous
The MetNIQ system is also to be able to transport the toxic methionine analog alpha-methyl-methionine.
GO - Biological processi
- D-methionine transport Source: CACAO
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:METQ-MONOMER MetaCyc:METQ-MONOMER |
Protein family/group databases
TCDBi | 3.A.1.24.1, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: D-methionine-binding lipoprotein MetQ |
Gene namesi | Name:metQ Synonyms:yaeC Ordered Locus Names:b0197, JW0193 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated
Plasma Membrane
Other locations
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | PROSITE-ProRule annotationAdd BLAST | 22 | |
ChainiPRO_0000019739 | 23 – 271 | D-methionine-binding lipoprotein MetQAdd BLAST | 249 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 23 | N-palmitoyl cysteinePROSITE-ProRule annotation | 1 | |
Lipidationi | 23 | S-diacylglycerol cysteinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
jPOSTi | P28635 |
PaxDbi | P28635 |
PRIDEi | P28635 |
2D gel databases
SWISS-2DPAGEi | P28635 |
Interactioni
Binary interactionsi
P28635
With | #Exp. | IntAct |
---|---|---|
araG [P0AAF3] | 3 | EBI-1114713,EBI-559586 |
Protein-protein interaction databases
BioGRIDi | 4263377, 24 interactors 849293, 1 interactor |
ComplexPortali | CPX-2114, Methionine ABC transporter complex |
DIPi | DIP-11196N |
IntActi | P28635, 10 interactors |
STRINGi | 511145.b0197 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28635 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the NlpA lipoprotein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG1464, Bacteria |
HOGENOMi | CLU_067080_0_0_6 |
InParanoidi | P28635 |
PhylomeDBi | P28635 |
Family and domain databases
InterProi | View protein in InterPro IPR004872, Lipoprotein_NlpA |
PANTHERi | PTHR30429, PTHR30429, 1 hit |
Pfami | View protein in Pfam PF03180, Lipoprotein_9, 1 hit |
PIRSFi | PIRSF002854, MetQ, 1 hit |
TIGRFAMsi | TIGR00363, TIGR00363, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P28635-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFKFKTFAA VGALIGSLAL VGCGQDEKDP NHIKVGVIVG AEQQVAEVAQ
60 70 80 90 100
KVAKDKYGLD VELVTFNDYV LPNEALSKGD IDANAFQHKP YLDQQLKDRG
110 120 130 140 150
YKLVAVGNTF VYPIAGYSKK IKSLDELQDG SQVAVPNDPT NLGRSLLLLQ
160 170 180 190 200
KVGLIKLKDG VGLLPTVLDV VENPKNLKIV ELEAPQLPRS LDDAQIALAV
210 220 230 240 250
INTTYASQIG LTPAKDGIFV EDKESPYVNL IVTREDNKDA ENVKKFVQAY
260 270
QSDEVYEAAN KVFNGGAVKG W
Sequence cautioni
The sequence AAA24507 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 200 | V → L in AAA24507 (PubMed:1459951).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D15061 Genomic DNA Translation: BAA03657.1 U70214 Genomic DNA Translation: AAB08625.1 U00096 Genomic DNA Translation: AAC73308.1 AP009048 Genomic DNA Translation: BAA77874.1 L04474 Genomic DNA Translation: AAA24507.1 Frameshift. |
PIRi | E64744 |
RefSeqi | NP_414739.1, NC_000913.3 WP_000874226.1, NZ_SSZK01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC73308; AAC73308; b0197 BAA77874; BAA77874; BAA77874 |
GeneIDi | 58462110 944893 |
KEGGi | ecj:JW0193 eco:b0197 |
PATRICi | fig|1411691.4.peg.2081 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D15061 Genomic DNA Translation: BAA03657.1 U70214 Genomic DNA Translation: AAB08625.1 U00096 Genomic DNA Translation: AAC73308.1 AP009048 Genomic DNA Translation: BAA77874.1 L04474 Genomic DNA Translation: AAA24507.1 Frameshift. |
PIRi | E64744 |
RefSeqi | NP_414739.1, NC_000913.3 WP_000874226.1, NZ_SSZK01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4YAH | X-ray | 1.60 | X | 1-271 | [»] | |
6CVL | X-ray | 2.95 | E | 34-259 | [»] | |
SMRi | P28635 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4263377, 24 interactors 849293, 1 interactor |
ComplexPortali | CPX-2114, Methionine ABC transporter complex |
DIPi | DIP-11196N |
IntActi | P28635, 10 interactors |
STRINGi | 511145.b0197 |
Protein family/group databases
TCDBi | 3.A.1.24.1, the atp-binding cassette (abc) superfamily |
2D gel databases
SWISS-2DPAGEi | P28635 |
Proteomic databases
jPOSTi | P28635 |
PaxDbi | P28635 |
PRIDEi | P28635 |
Genome annotation databases
EnsemblBacteriai | AAC73308; AAC73308; b0197 BAA77874; BAA77874; BAA77874 |
GeneIDi | 58462110 944893 |
KEGGi | ecj:JW0193 eco:b0197 |
PATRICi | fig|1411691.4.peg.2081 |
Organism-specific databases
EchoBASEi | EB1467 |
Phylogenomic databases
eggNOGi | COG1464, Bacteria |
HOGENOMi | CLU_067080_0_0_6 |
InParanoidi | P28635 |
PhylomeDBi | P28635 |
Enzyme and pathway databases
BioCyci | EcoCyc:METQ-MONOMER MetaCyc:METQ-MONOMER |
Miscellaneous databases
PROi | PR:P28635 |
Family and domain databases
InterProi | View protein in InterPro IPR004872, Lipoprotein_NlpA |
PANTHERi | PTHR30429, PTHR30429, 1 hit |
Pfami | View protein in Pfam PF03180, Lipoprotein_9, 1 hit |
PIRSFi | PIRSF002854, MetQ, 1 hit |
TIGRFAMsi | TIGR00363, TIGR00363, 1 hit |
PROSITEi | View protein in PROSITE PS51257, PROKAR_LIPOPROTEIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | METQ_ECOLI | |
Accessioni | P28635Primary (citable) accession number: P28635 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families