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UniProtKB - P28599 (CH10_BACSU)
Protein
Co-chaperonin GroES
Gene
groES
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
UniRule annotationGO - Molecular functioni
- ATP binding Source: InterPro
- ATP hydrolysis activity Source: InterPro
- chaperone binding Source: GO_Central
- metal ion binding Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- chaperone cofactor-dependent protein refolding Source: GO_Central
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Enzyme and pathway databases
BioCyci | BSUB:BSU06020-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Co-chaperonin GroESUniRule annotationAlternative name(s): 10 kDa chaperoninUniRule annotation Chaperonin-10UniRule annotation Short name: Cpn10UniRule annotation |
Gene namesi | Name:groESUniRule annotation Synonyms:groSUniRule annotation, mopB Ordered Locus Names:BSU06020 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174698 | 1 – 94 | Co-chaperonin GroESAdd BLAST | 94 |
Proteomic databases
jPOSTi | P28599 |
PaxDbi | P28599 |
PRIDEi | P28599 |
Expressioni
Inductioni
By heat shock.
Interactioni
Subunit structurei
Heptamer of 7 subunits arranged in a ring.
Interacts with the chaperonin GroEL.
UniRule annotationGO - Molecular functioni
- chaperone binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 224308.BSU06020 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0234, Bacteria |
InParanoidi | P28599 |
OMAi | EVKYSGE |
PhylomeDBi | P28599 |
Family and domain databases
CDDi | cd00320, cpn10, 1 hit |
Gene3Di | 2.30.33.40, 1 hit |
HAMAPi | MF_00580, CH10, 1 hit |
InterProi | View protein in InterPro IPR020818, Chaperonin_GroES IPR037124, Chaperonin_GroES_sf IPR018369, Chaprnonin_Cpn10_CS IPR011032, GroES-like_sf |
PANTHERi | PTHR10772, PTHR10772, 1 hit |
Pfami | View protein in Pfam PF00166, Cpn10, 1 hit |
PRINTSi | PR00297, CHAPERONIN10 |
SMARTi | View protein in SMART SM00883, Cpn10, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit |
PROSITEi | View protein in PROSITE PS00681, CHAPERONINS_CPN10, 1 hit |
i Sequence
Sequence statusi: Complete.
P28599-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKPLGDRVV IELVESEEKT ASGIVLPDSA KEKPQEGKIV AAGSGRVLES
60 70 80 90
GERVALEVKE GDRIIFSKYA GTEVKYEGTE YLILRESDIL AVIG
Sequence cautioni
The sequence BAA19726 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84965 Genomic DNA Translation: AAA22530.1 M81132 Genomic DNA Translation: AAA22502.1 D10972 Genomic DNA Translation: BAA22518.1 D88802 Genomic DNA Translation: BAA19726.1 Different initiation. AB007637 Genomic DNA Translation: BAA22746.1 AL009126 Genomic DNA Translation: CAB12421.2 |
PIRi | A41884 |
RefSeqi | NP_388483.2, NC_000964.3 WP_003155970.1, NZ_JNCM01000032.1 |
Genome annotation databases
EnsemblBacteriai | CAB12421; CAB12421; BSU_06020 |
GeneIDi | 64302471 66327387 938006 |
KEGGi | bsu:BSU06020 |
PATRICi | fig|224308.179.peg.647 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84965 Genomic DNA Translation: AAA22530.1 M81132 Genomic DNA Translation: AAA22502.1 D10972 Genomic DNA Translation: BAA22518.1 D88802 Genomic DNA Translation: BAA19726.1 Different initiation. AB007637 Genomic DNA Translation: BAA22746.1 AL009126 Genomic DNA Translation: CAB12421.2 |
PIRi | A41884 |
RefSeqi | NP_388483.2, NC_000964.3 WP_003155970.1, NZ_JNCM01000032.1 |
3D structure databases
AlphaFoldDBi | P28599 |
SMRi | P28599 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU06020 |
Proteomic databases
jPOSTi | P28599 |
PaxDbi | P28599 |
PRIDEi | P28599 |
Genome annotation databases
EnsemblBacteriai | CAB12421; CAB12421; BSU_06020 |
GeneIDi | 64302471 66327387 938006 |
KEGGi | bsu:BSU06020 |
PATRICi | fig|224308.179.peg.647 |
Phylogenomic databases
eggNOGi | COG0234, Bacteria |
InParanoidi | P28599 |
OMAi | EVKYSGE |
PhylomeDBi | P28599 |
Enzyme and pathway databases
BioCyci | BSUB:BSU06020-MONOMER |
Miscellaneous databases
PROi | PR:P28599 |
Family and domain databases
CDDi | cd00320, cpn10, 1 hit |
Gene3Di | 2.30.33.40, 1 hit |
HAMAPi | MF_00580, CH10, 1 hit |
InterProi | View protein in InterPro IPR020818, Chaperonin_GroES IPR037124, Chaperonin_GroES_sf IPR018369, Chaprnonin_Cpn10_CS IPR011032, GroES-like_sf |
PANTHERi | PTHR10772, PTHR10772, 1 hit |
Pfami | View protein in Pfam PF00166, Cpn10, 1 hit |
PRINTSi | PR00297, CHAPERONIN10 |
SMARTi | View protein in SMART SM00883, Cpn10, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit |
PROSITEi | View protein in PROSITE PS00681, CHAPERONINS_CPN10, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CH10_BACSU | |
Accessioni | P28599Primary (citable) accession number: P28599 Secondary accession number(s): O08341 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | July 1, 1993 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families