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Entry version 148 (02 Jun 2021)
Sequence version 3 (03 Oct 2012)
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Protein

Actin-binding protein IPP

Gene

Ipp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in organizing the actin cytoskeleton.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-binding protein IPP
Alternative name(s):
Intracisternal A particle-promoted polypeptide
Short name:
IPP
Murine IAP-promoted placenta-expressed protein
Protein MIPP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ipp
Synonyms:Mipp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96581, Ipp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190761 – 584Actin-binding protein IPPAdd BLAST584

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P28575

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P28575

PRoteomics IDEntifications database

More...
PRIDEi
P28575

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
301661

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P28575

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P28575

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression seems confined to tissues derived from trophectoderm and primitive endoderm.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028696, Expressed in placenta and 243 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P28575, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200781, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000102088

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P28575, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P28575

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 104BTBPROSITE-ProRule annotationAdd BLAST68
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati296 – 343Kelch 1Add BLAST48
Repeati344 – 390Kelch 2Add BLAST47
Repeati391 – 437Kelch 3Add BLAST47
Repeati439 – 485Kelch 4Add BLAST47
Repeati487 – 533Kelch 5Add BLAST47
Repeati535 – 583Kelch 6Add BLAST49

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158629

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004253_14_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P28575

Identification of Orthologs from Complete Genome Data

More...
OMAi
IANCECY

Database of Orthologous Groups

More...
OrthoDBi
938011at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 1 hit
3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705, BACK
IPR017096, BTB-kelch_protein
IPR000210, BTB/POZ_dom
IPR030104, IPP
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011333, SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24412:SF35, PTHR24412:SF35, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 6 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037, Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 2 hits
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28575-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKEECPKAA DNSFSSDKHA QLILAQMNKM RSGQHFCDVQ LQVGKETFQV
60 70 80 90 100
HRLVLAASSP YFAALFTGGM KESSKDVVQI LGVEAGIFQL LLDFIYTGVV
110 120 130 140 150
NIAVTNVQEL IVAADMLQLT EVVNLCCDFL KGQIDPQNCI GLFQFSEQIA
160 170 180 190 200
CHDLLEFTEN YIHVHFLEVH TGEEFLGLTK DQLIKILRSE ELSIEDEYQV
210 220 230 240 250
FLAAMQWILK DLGKRRKHVV EVLDPVRFPL LPSQRLLKYI EGVSDFNLRV
260 270 280 290 300
ALQTLLKEYC EVCKSPKENK FCSFLQTSKV RPRKKARKYL YAVGGYTRLQ
310 320 330 340 350
GGRWSDSRAL SCVERFDTFS QYWTTVSSLH QARCGLGVAV VGGMVYAIGG
360 370 380 390 400
EKDSMIFDCT ECYDPVTKQW TTVASMNHPR CGLGVCVCYG AIYALGGWVG
410 420 430 440 450
AEIGNTIERF DPDENKWEVV GSMAVSRYYF GCCEMQGLIY AVGGISNEGL
460 470 480 490 500
ELRSFEVYDP LSKRWSPLPP MGTRRAYLGV AALNDCIYAI GGWNETQDAL
510 520 530 540 550
HTVEKYSFEE EKWVEVASMK VPRAGMCAVT VNGLLYVSGG RSSSHDFLAP
560 570 580
GTLDSVEVYN PHSDTWTEIG NMITSRCEGG VAVL
Length:584
Mass (Da):65,216
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE8CE11A53F7CFED
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK00278 differs from that shown. Reason: Frameshift.Curated
The sequence CAA41413 differs from that shown. Reason: Frameshift.Curated
The sequence CAA41414 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6 – 7CP → YA in AAK00278 (PubMed:11536049).Curated2
Sequence conflicti12N → S in AAK00278 (PubMed:11536049).Curated1
Sequence conflicti32S → T in AAK00278 (PubMed:11536049).Curated1
Sequence conflicti59S → K in AAK00278 (PubMed:11536049).Curated1
Sequence conflicti164 – 165VH → SI in AAK00278 (PubMed:11536049).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF285178 mRNA Translation: AAK00278.1 Frameshift.
AK131718 mRNA Translation: BAE20777.1
AL669953 Genomic DNA No translation available.
X58523 mRNA Translation: CAA41413.1 Frameshift.
X58524 Genomic DNA Translation: CAA41414.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38851.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S16442

NCBI Reference Sequences

More...
RefSeqi
NP_032415.2, NM_008389.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030461; ENSMUSP00000030461; ENSMUSG00000028696
ENSMUST00000106479; ENSMUSP00000102088; ENSMUSG00000028696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16351

UCSC genome browser

More...
UCSCi
uc008ugp.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF285178 mRNA Translation: AAK00278.1 Frameshift.
AK131718 mRNA Translation: BAE20777.1
AL669953 Genomic DNA No translation available.
X58523 mRNA Translation: CAA41413.1 Frameshift.
X58524 Genomic DNA Translation: CAA41414.1 Frameshift.
CCDSiCCDS38851.1
PIRiS16442
RefSeqiNP_032415.2, NM_008389.3

3D structure databases

SMRiP28575
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200781, 1 interactor
STRINGi10090.ENSMUSP00000102088

PTM databases

iPTMnetiP28575
PhosphoSitePlusiP28575

Proteomic databases

EPDiP28575
PaxDbiP28575
PRIDEiP28575
ProteomicsDBi301661

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32715, 65 antibodies

The DNASU plasmid repository

More...
DNASUi
16351

Genome annotation databases

EnsembliENSMUST00000030461; ENSMUSP00000030461; ENSMUSG00000028696
ENSMUST00000106479; ENSMUSP00000102088; ENSMUSG00000028696
GeneIDi16351
KEGGimmu:16351
UCSCiuc008ugp.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3652
MGIiMGI:96581, Ipp

Phylogenomic databases

eggNOGiKOG4441, Eukaryota
GeneTreeiENSGT00940000158629
HOGENOMiCLU_004253_14_1_1
InParanoidiP28575
OMAiIANCECY
OrthoDBi938011at2759
TreeFamiTF329218

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
16351, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ipp, mouse

Protein Ontology

More...
PROi
PR:P28575
RNActiP28575, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028696, Expressed in placenta and 243 other tissues
GenevisibleiP28575, MM

Family and domain databases

Gene3Di2.120.10.80, 1 hit
3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR011705, BACK
IPR017096, BTB-kelch_protein
IPR000210, BTB/POZ_dom
IPR030104, IPP
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011333, SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF35, PTHR24412:SF35, 1 hit
PfamiView protein in Pfam
PF07707, BACK, 1 hit
PF00651, BTB, 1 hit
PF01344, Kelch_1, 6 hits
PIRSFiPIRSF037037, Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875, BACK, 1 hit
SM00225, BTB, 1 hit
SM00612, Kelch, 6 hits
SUPFAMiSSF117281, SSF117281, 2 hits
SSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIPP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28575
Secondary accession number(s): Q3V2M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 3, 2012
Last modified: June 2, 2021
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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