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Entry version 76 (12 Aug 2020)
Sequence version 1 (01 Dec 1992)
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Protein

High-affinity potassium transport protein

Gene

TRK1

Organism
Saccharomyces uvarum (Yeast) (Saccharomyces bayanus var. uvarum)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is required for high-affinity potassium transport.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High-affinity potassium transport protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces uvarum (Yeast) (Saccharomyces bayanus var. uvarum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri230603 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 70HelicalSequence analysisAdd BLAST22
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei784 – 806HelicalSequence analysisAdd BLAST23
Transmembranei819 – 840HelicalSequence analysisAdd BLAST22
Transmembranei844 – 864HelicalSequence analysisAdd BLAST21
Transmembranei868 – 888HelicalSequence analysisAdd BLAST21
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Transmembranei929 – 949HelicalSequence analysisAdd BLAST21
Transmembranei977 – 997HelicalSequence analysisAdd BLAST21
Transmembranei1084 – 1104HelicalSequence analysisAdd BLAST21
Transmembranei1117 – 1137HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704601 – 1241High-affinity potassium transport proteinAdd BLAST1241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi223N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi227N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi660N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi691N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi925N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003445, Cat_transpt
IPR004773, K/Na_transp_Trk/HKT
IPR015958, Trk_fungi

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02386, TrkH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002450, K+_transpter_TRK, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00934, 2a38euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P28569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHIRGTMSRV PTLASFEVRY KKSFGHKFRD FIALCGHYCS PIKKYIFPNF
60 70 80 90 100
IAVHYFYTIV LTLITSILLY PVKNIRYIDA LFLAAGAVTQ GGLNTVDVNN
110 120 130 140 150
LTLYQQIILY IICCISTPIA VHSCLAFVRL YWFERYFDGI RDSSRLNFKM
160 170 180 190 200
RRTKTILERE LTARTMTKSK TGGTQRVSRP GKSDKRDDFQ EKLFNGEMVN
210 220 230 240 250
RDEQDSVHSS HNSRDSNSNA NTNSSNNNSI NHNGSSGSLD DYVREDKADE
260 270 280 290 300
VEKYHGNKSY SSVGSSSNTA TDENISQKLK PSSLRFDESQ NKRKRTGAPS
310 320 330 340 350
EKFAKRRGSR DITPEDMYRS IMMLQGEHEG TAEDEGPPLV IGSPTDGTRN
360 370 380 390 400
MDNGSESKSA PTMNESKIRI QDKGAKISLD QDSVLHSSNS SACTSDEDSL
410 420 430 440 450
PTNFGGTTPS LSAKPRESSS GPIAFTEGEN ADRKQGPSIQ FNITKPPRKA
460 470 480 490 500
SKSKRVSTMD DLNPRSIFPH QKKSSKGYIM KHLPKARRIR QQIKRRLSTG
510 520 530 540 550
SIDKNSSSDA LDRGLISGLN DDDDGNEGDN MEEYFADNES GDEDDRMQQS
560 570 580 590 600
EPQSGSELKL KQQQQHQLQQ NLHRMYKTKS FDDNRSKPVL MERSKTIDMA
610 620 630 640 650
EARDLNELAR TPDFQKMVYK NWKAHHRNKP NFKRRGWNGK MFEHGPYTSD
660 670 680 690 700
SDHNYQDNGN NSNSIVHYAE SILHRDNSHR NGSEDVSSDS NETTYPLNGN
710 720 730 740 750
NDHSQNDANG YPTYNDEEEG YYGLHFDSDY NLDPHHALSS NASKNYLSWQ
760 770 780 790 800
PTIGRNSNFL GLTRAQKDEL GGVEYRAIKL LCTILVVYYV GWHIVSFVML
810 820 830 840 850
VPWINLKKHY SDIVRSDGVS PTWWGFWTAM SAFNDLGLTL TPDSMMSFDK
860 870 880 890 900
AVYPLIVMIW FIIIGNTGFP ILLRCIIWIM FKLSPDLSQM RESLGFLLDH
910 920 930 940 950
PRRCFTLLFP KAATWWLLLT LVGLNFTDWI LFIILDFGST VVKSLSKGYR
960 970 980 990 1000
VLVGLFQSVS TRTAGFSVVD LSQLHPSIQV SYMLMMYVSV LPLAISIRRT
1010 1020 1030 1040 1050
NVYEEQSLGL YGEMGGKPED TDTEEDGDCD DEDDDNEEEE SHEGGSSQRG
1060 1070 1080 1090 1100
KSKKETKKKK KRKENENPNE ESTKSFIGAH LRRQLSFDLW FLFLGLFIIC
1110 1120 1130 1140 1150
ICERDKIKDI QRPNFNVFTI LFEIVSAYGT VGLSLGYPNT NQSFSRQLTT
1160 1170 1180 1190 1200
LSKLIIIAML IRGKNRGLPY SLDRAIILPS DRLEHIDHIE DLKLKRQART
1210 1220 1230 1240
DTDDPMTEHL KRSISDAKHR WDELKHKRSL SRSSKRSTKT N
Length:1,241
Mass (Da):141,226
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF5149E47EC00BCD2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57508 Genomic DNA Translation: AAA34661.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57508 Genomic DNA Translation: AAA34661.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR003445, Cat_transpt
IPR004773, K/Na_transp_Trk/HKT
IPR015958, Trk_fungi
PfamiView protein in Pfam
PF02386, TrkH, 1 hit
PIRSFiPIRSF002450, K+_transpter_TRK, 1 hit
TIGRFAMsiTIGR00934, 2a38euk, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRK1_SACUV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28569
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: August 12, 2020
This is version 76 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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