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Protein

5-hydroxytryptamine receptor 1E

Gene

HTR1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.5 Publications

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • G protein-coupled serotonin receptor activity Source: MGI
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1E
Short name:
5-HT-1E
Short name:
5-HT1E
Alternative name(s):
S31
Serotonin receptor 1E
Gene namesi
Name:HTR1E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000168830.7
HGNCiHGNC:5291 HTR1E
MIMi182132 gene
neXtProtiNX_P28566

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22ExtracellularBy similarityAdd BLAST22
Transmembranei23 – 47Helical; Name=1By similarityAdd BLAST25
Topological domaini48 – 59CytoplasmicBy similarityAdd BLAST12
Transmembranei60 – 82Helical; Name=2By similarityAdd BLAST23
Topological domaini83 – 96ExtracellularBy similarityAdd BLAST14
Transmembranei97 – 118Helical; Name=3By similarityAdd BLAST22
Topological domaini119 – 138CytoplasmicBy similarityAdd BLAST20
Transmembranei139 – 159Helical; Name=4By similarityAdd BLAST21
Topological domaini160 – 179ExtracellularBy similarityAdd BLAST20
Transmembranei180 – 202Helical; Name=5By similarityAdd BLAST23
Topological domaini203 – 291CytoplasmicBy similarityAdd BLAST89
Transmembranei292 – 314Helical; Name=6By similarityAdd BLAST23
Topological domaini315 – 324ExtracellularBy similarity10
Transmembranei325 – 347Helical; Name=7By similarityAdd BLAST23
Topological domaini348 – 365CytoplasmicBy similarityAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3354
OpenTargetsiENSG00000168830
PharmGKBiPA29552

Chemistry databases

ChEMBLiCHEMBL2182
DrugBankiDB01238 Aripiprazole
DB00363 Clozapine
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB01221 Ketamine
DB00408 Loxapine
DB00247 Methysergide
DB00334 Olanzapine
DB01224 Quetiapine
DB13025 Tiapride
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi4

Polymorphism and mutation databases

BioMutaiHTR1E
DMDMi112822

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689331 – 3655-hydroxytryptamine receptor 1EAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 173PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28566
PRIDEiP28566
ProteomicsDBi54490

PTM databases

iPTMnetiP28566
PhosphoSitePlusiP28566

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiENSG00000168830 Expressed in 61 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_HTR1E
GenevisibleiP28566 HS

Organism-specific databases

HPAiHPA004931

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502223EBI-1043151,EBI-748397

Protein-protein interaction databases

BioGridi109586, 8 interactors
IntActiP28566, 1 interactor
STRINGi9606.ENSP00000307766

Chemistry databases

BindingDBiP28566

Structurei

3D structure databases

ProteinModelPortaliP28566
SMRiP28566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 107Agonist bindingBy similarity10
Regioni304 – 308Agonist bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi119 – 121DRY motif; important for ligand-induced conformation changesBy similarity3
Motifi340 – 344NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP28566
KOiK04153
OMAiPLSITYI
OrthoDBiEOG091G06VI
PhylomeDBiP28566
TreeFamiTF316350

Family and domain databases

CDDicd15335 7tmA_5-HT1E, 1 hit
InterProiView protein in InterPro
IPR027425 5HT1E_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF33 PTHR24247:SF33, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28566-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNITNCTTEA SMAIRPKTIT EKMLICMTLV VITTLTTLLN LAVIMAIGTT
60 70 80 90 100
KKLHQPANYL ICSLAVTDLL VAVLVMPLSI IYIVMDRWKL GYFLCEVWLS
110 120 130 140 150
VDMTCCTCSI LHLCVIALDR YWAITNAIEY ARKRTAKRAA LMILTVWTIS
160 170 180 190 200
IFISMPPLFW RSHRRLSPPP SQCTIQHDHV IYTIYSTLGA FYIPLTLILI
210 220 230 240 250
LYYRIYHAAK SLYQKRGSSR HLSNRSTDSQ NSFASCKLTQ TFCVSDFSTS
260 270 280 290 300
DPTTEFEKFH ASIRIPPFDN DLDHPGERQQ ISSTRERKAA RILGLILGAF
310 320 330 340 350
ILSWLPFFIK ELIVGLSIYT VSSEVADFLT WLGYVNSLIN PLLYTSFNED
360
FKLAFKKLIR CREHT
Length:365
Mass (Da):41,682
Last modified:December 1, 1992 - v1
Checksum:i4C31DD783A3F7483
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022061208A → T. Corresponds to variant dbSNP:rs3828741Ensembl.1
Natural variantiVAR_014165262S → F1 PublicationCorresponds to variant dbSNP:rs6303Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91467 mRNA Translation: AAA58353.1
Z11166 Genomic DNA Translation: CAA77558.1
M92826 Genomic DNA Translation: AAA58355.1
AF498980 mRNA Translation: AAM21127.1
AL157777 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48616.1
CH471051 Genomic DNA Translation: EAW48617.1
BC069751 mRNA Translation: AAH69751.1
AB041373 Genomic DNA Translation: BAA94458.1
CCDSiCCDS5006.1
PIRiS20579 A45260
RefSeqiNP_000856.1, NM_000865.2
XP_011534091.1, XM_011535789.2
UniGeneiHs.1611

Genome annotation databases

EnsembliENST00000305344; ENSP00000307766; ENSG00000168830
GeneIDi3354
KEGGihsa:3354
UCSCiuc003pli.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91467 mRNA Translation: AAA58353.1
Z11166 Genomic DNA Translation: CAA77558.1
M92826 Genomic DNA Translation: AAA58355.1
AF498980 mRNA Translation: AAM21127.1
AL157777 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48616.1
CH471051 Genomic DNA Translation: EAW48617.1
BC069751 mRNA Translation: AAH69751.1
AB041373 Genomic DNA Translation: BAA94458.1
CCDSiCCDS5006.1
PIRiS20579 A45260
RefSeqiNP_000856.1, NM_000865.2
XP_011534091.1, XM_011535789.2
UniGeneiHs.1611

3D structure databases

ProteinModelPortaliP28566
SMRiP28566
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109586, 8 interactors
IntActiP28566, 1 interactor
STRINGi9606.ENSP00000307766

Chemistry databases

BindingDBiP28566
ChEMBLiCHEMBL2182
DrugBankiDB01238 Aripiprazole
DB00363 Clozapine
DB00216 Eletriptan
DB01049 Ergoloid mesylate
DB01221 Ketamine
DB00408 Loxapine
DB00247 Methysergide
DB00334 Olanzapine
DB01224 Quetiapine
DB13025 Tiapride
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi4

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP28566
PhosphoSitePlusiP28566

Polymorphism and mutation databases

BioMutaiHTR1E
DMDMi112822

Proteomic databases

PaxDbiP28566
PRIDEiP28566
ProteomicsDBi54490

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305344; ENSP00000307766; ENSG00000168830
GeneIDi3354
KEGGihsa:3354
UCSCiuc003pli.4 human

Organism-specific databases

CTDi3354
DisGeNETi3354
EuPathDBiHostDB:ENSG00000168830.7
GeneCardsiHTR1E
HGNCiHGNC:5291 HTR1E
HPAiHPA004931
MIMi182132 gene
neXtProtiNX_P28566
OpenTargetsiENSG00000168830
PharmGKBiPA29552
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP28566
KOiK04153
OMAiPLSITYI
OrthoDBiEOG091G06VI
PhylomeDBiP28566
TreeFamiTF316350

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiHTR1E human
GeneWikii5-HT1E_receptor
GenomeRNAii3354
PROiPR:P28566
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168830 Expressed in 61 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_HTR1E
GenevisibleiP28566 HS

Family and domain databases

CDDicd15335 7tmA_5-HT1E, 1 hit
InterProiView protein in InterPro
IPR027425 5HT1E_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF33 PTHR24247:SF33, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT1E_HUMAN
AccessioniPrimary (citable) accession number: P28566
Secondary accession number(s): E1P503, Q9P1Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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