Htr1d

Functionⁱ

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.2 Publications

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity Source: UniProtKB
neurotransmitter receptor activity Source: GO_Central
serotonin binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: UniProtKB
chemical synaptic transmission Source: InterPro
intestine smooth muscle contraction Source: Ensembl
regulation of behavior Source: InterPro
regulation of locomotion Source: InterPro
response to toxic substance Source: Ensembl
vasoconstriction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors R-RNO-418594 G alpha (i) signalling events

Reactomeⁱ

R-RNO-390666 Serotonin receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 1D Short name: 5-HT-1D Short name: 5-HT1D Alternative name(s): Serotonin receptor 1D
Gene namesⁱ	Name:Htr1d
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 5

Organism-specific databases

Rat genome database More...RGDⁱ	2847 Htr1d

RGDⁱ

2847 Htr1d

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 35	ExtracellularBy similarityAdd BLAST	35
Transmembraneⁱ	36 – 61	Helical; Name=1By similarityAdd BLAST	26
Topological domainⁱ	62 – 72	CytoplasmicBy similarityAdd BLAST	11
Transmembraneⁱ	73 – 95	Helical; Name=2By similarityAdd BLAST	23
Topological domainⁱ	96 – 109	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	110 – 131	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	132 – 151	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	152 – 173	Helical; Name=4By similarityAdd BLAST	22
Topological domainⁱ	174 – 191	ExtracellularBy similarityAdd BLAST	18
Transmembraneⁱ	192 – 214	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	215 – 299	CytoplasmicBy similarityAdd BLAST	85
Transmembraneⁱ	300 – 323	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	324 – 332	ExtracellularBy similarity	9
Transmembraneⁱ	333 – 357	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	358 – 374	CytoplasmicBy similarityAdd BLAST	17

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL5450
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	3

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068931	1 – 374	5-hydroxytryptamine receptor 1DAdd BLAST		374

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	5	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	17	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	108 ↔ 185	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P28565
PRIDEⁱ	P28565

PTM databases

PhosphoSitePlusⁱ	P28565

PhosphoSitePlusⁱ

P28565

Expressionⁱ

Tissue specificityⁱ

Detected in dorsal raphe.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000012038 Expressed in 3 organ(s), highest expression level in brain
Genevisibleⁱ	P28565 RN

Interactionⁱ

Subunit structureⁱ

Homodimer. Heterodimer with HTR1B (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000016047

STRINGⁱ

10116.ENSRNOP00000016047

Chemistry databases

BindingDBⁱ

P28565

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28565
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	111 – 120	Agonist bindingBy similarity		10
Regionⁱ	311 – 315	Agonist bindingBy similarity		5

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	132 – 134	DRY motif; important for ligand-induced conformation changesBy similarity		3
Motifⁱ	349 – 353	NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity		5

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P28565
KEGG Orthology (KO) More...KOⁱ	K04153
OMAⁱ	YGKRFTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P28565
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR000505 5HT1D_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF17 PTHR24247:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00514 5HT1DRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28565-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLPNQSLEG LPQEASNRSL NATGAWDPEV LQALRISLVV VLSIITLATV 
        60         70         80         90        100
LSNAFVLTTI LLTKKLHTPA NYLIGSLATT DLLVSILVMP ISIAYTTTRT 
       110        120        130        140        150
WNFGQILCDI WVSSDITCCT ASILHLCVIA LDRYWAITDA LEYSKRRTAG 
       160        170        180        190        200
HAAAMIAAVW AISICISIPP LFWRQATAHE EMSDCLVNTS QISYTIYSTC 
       210        220        230        240        250
GAFYIPSILL IILYGRIYVA ARSRILNPPS LYGKRFTTAQ LITGSAGSSL 
       260        270        280        290        300
CSLNPSLHES HTHTVGSPLF FNQVKIKLAD SILERKRISA ARERKATKTL 
       310        320        330        340        350
GIILGAFIIC WLPFFVVSLV LPICRDSCWI HPALFDFFTW LGYLNSLINP 
       360        370 
VIYTVFNEDF RQAFQRVVHF RKAS

Length:374

Mass (Da):41,540

Last modified:December 1, 1992 - v1

Checksum:ⁱ345CBD528317DA21

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89953 Genomic DNA Translation: AAA40614.1
PIRⁱ	I77467
NCBI Reference Sequences More...RefSeqⁱ	NP_036984.1, NM_012852.1 XP_008762430.1, XM_008764208.2 XP_017448642.1, XM_017593153.1 XP_017448643.1, XM_017593154.1 XP_017448644.1, XM_017593155.1 XP_017448645.1, XM_017593156.1 XP_017448646.1, XM_017593157.1 XP_017448647.1, XM_017593158.1
UniGeneⁱ	Rn.34834

Genome annotation databases

Ensemblⁱ	ENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038
GeneIDⁱ	25323
KEGGⁱ	rno:25323
UCSC genome browser More...UCSCⁱ	RGD:2847 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28565	5-hydroxytryptamine receptor 1D		HUMAN		377	UniRef90_P28221
5-hydroxytryptamine receptor 1D		RABIT		377
5-hydroxytryptamine receptor 1D		CAVPO		376
5-hydroxytryptamine receptor 1D		MOUSE		374
HTR1D (Fragment)		MACMU		102
+97

Protein	Similar proteins		Species	Score	Length	Source
P28565	5-hydroxytryptamine receptor 1D		HUMAN		377	UniRef50_P28221
5-hydroxytryptamine receptor 1D		RABIT		377
5-hydroxytryptamine receptor 1D		CAVPO		376
5-hydroxytryptamine receptor 1D		MOUSE		374
5-hydroxytryptamine receptor 1D		TAKRU		379
+327

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M89953 Genomic DNA Translation: AAA40614.1
PIRⁱ	I77467
RefSeqⁱ	NP_036984.1, NM_012852.1 XP_008762430.1, XM_008764208.2 XP_017448642.1, XM_017593153.1 XP_017448643.1, XM_017593154.1 XP_017448644.1, XM_017593155.1 XP_017448645.1, XM_017593156.1 XP_017448646.1, XM_017593157.1 XP_017448647.1, XM_017593158.1
UniGeneⁱ	Rn.34834

3D structure databases

ProteinModelPortalⁱ	P28565
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000016047

STRINGⁱ

10116.ENSRNOP00000016047

Chemistry databases

BindingDBⁱ	P28565
ChEMBLⁱ	CHEMBL5450
GuidetoPHARMACOLOGYⁱ	3

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P28565

PhosphoSitePlusⁱ

P28565

Proteomic databases

PaxDbⁱ	P28565
PRIDEⁱ	P28565

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000016046; ENSRNOP00000016047; ENSRNOG00000012038
GeneIDⁱ	25323
KEGGⁱ	rno:25323
UCSCⁱ	RGD:2847 rat

Organism-specific databases

CTDⁱ	3352
RGDⁱ	2847 Htr1d

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P28565
KOⁱ	K04153
OMAⁱ	YGKRFTT
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P28565
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors R-RNO-418594 G alpha (i) signalling events

Reactomeⁱ

R-RNO-390666 Serotonin receptors
R-RNO-418594 G alpha (i) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P28565

PROⁱ

PR:P28565

Gene expression databases

Bgeeⁱ	ENSRNOG00000012038 Expressed in 3 organ(s), highest expression level in brain
Genevisibleⁱ	P28565 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000505 5HT1D_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF17 PTHR24247:SF17, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00514 5HT1DRECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT1D_RAT
Accessionⁱ	P28565Primary (citable) accession number: P28565
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	December 1, 1992
	Last modified:	September 12, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28565 (5HT1D_RAT)

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5-hydroxytryptamine receptor 1D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ