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UniProtKB - P28523 (CSK2A_MAIZE)
Protein
Casein kinase II subunit alpha
Gene
ACK2
Organism
Zea mays (Maize)
Status
Functioni
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | ATP | 1 | |
Active sitei | 151 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 48 | ATP | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- peptidyl-serine phosphorylation Source: GO_Central
- peptidyl-threonine phosphorylation Source: GO_Central
- regulation of cell cycle Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 6752 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACK2 |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 30032 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Other locations
- protein kinase CK2 complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085901 | 1 – 332 | Casein kinase II subunit alphaAdd BLAST | 332 |
Proteomic databases
PaxDbi | P28523 |
Expressioni
Gene expression databases
ExpressionAtlasi | P28523, baseline and differential |
Genevisiblei | P28523, ZM |
Interactioni
Subunit structurei
Tetramer of two alpha and two beta chains (possible).
Protein-protein interaction databases
IntActi | P28523, 1 interactor |
STRINGi | 4577.GRMZM5G845755_P02 |
Chemistry databases
BindingDBi | P28523 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28523 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28523 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 319 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 286 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0668, Eukaryota |
HOGENOMi | CLU_000288_70_4_1 |
OMAi | RAYWDYD |
OrthoDBi | 1098380at2759 |
Family and domain databases
CDDi | cd14132, STKc_CK2_alpha, 1 hit |
InterProi | View protein in InterPro IPR045216, CK2_alpha IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24054, PTHR24054, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P28523-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKARVYADV NVLRPKEYWD YEALTVQWGE QDDYEVVRKV GRGKYSEVFE
60 70 80 90 100
GINVNNNEKC IIKILKPVKK KKIKREIKIL QNLCGGPNIV KLLDIVRDQH
110 120 130 140 150
SKTPSLIFEY VNNTDFKVLY PTLTDYDIRY YIYELLKALD YCHSQGIMHR
160 170 180 190 200
DVKPHNVMID HELRKLRLID WGLAEFYHPG KEYNVRVASR YFKGPELLVD
210 220 230 240 250
LQDYDYSLDM WSLGCMFAGM IFRKEPFFYG HDNHDQLVKI AKVLGTDGLN
260 270 280 290 300
VYLNKYRIEL DPQLEALVGR HSRKPWLKFM NADNQHLVSP EAIDFLDKLL
310 320 330
RYDHQERLTA LEAMTHPYFQ QVRAAENSRT RA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A804MX14 | A0A804MX14_MAIZE | Protein kinase domain-containing pr... | 542637 | 350 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61387 mRNA Translation: CAA43659.1 |
PIRi | S19726 |
RefSeqi | XP_008668648.1, XM_008670426.1 |
Genome annotation databases
EnsemblPlantsi | Zm00001eb118100_T001; Zm00001eb118100_P001; Zm00001eb118100 |
GeneIDi | 542637 |
Gramenei | Zm00001eb118100_T001; Zm00001eb118100_P001; Zm00001eb118100 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X61387 mRNA Translation: CAA43659.1 |
PIRi | S19726 |
RefSeqi | XP_008668648.1, XM_008670426.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DAW | X-ray | 2.20 | A | 2-328 | [»] | |
1DAY | X-ray | 2.20 | A | 2-328 | [»] | |
1DS5 | X-ray | 3.16 | A/B/C/D | 1-332 | [»] | |
1F0Q | X-ray | 2.63 | A | 1-332 | [»] | |
1J91 | X-ray | 2.22 | A/B | 1-332 | [»] | |
1JAM | X-ray | 2.18 | A | 1-332 | [»] | |
1LP4 | X-ray | 1.86 | A | 1-332 | [»] | |
1LPU | X-ray | 1.86 | A | 1-332 | [»] | |
1LR4 | X-ray | 2.00 | A | 1-332 | [»] | |
1M2P | X-ray | 2.00 | A | 2-326 | [»] | |
1M2Q | X-ray | 1.79 | A | 2-328 | [»] | |
1M2R | X-ray | 1.70 | A | 2-328 | [»] | |
1OM1 | X-ray | 1.68 | A | 1-332 | [»] | |
1ZOE | X-ray | 1.77 | A | 1-332 | [»] | |
1ZOG | X-ray | 2.30 | A | 1-332 | [»] | |
1ZOH | X-ray | 1.81 | A | 1-332 | [»] | |
2OXD | X-ray | 2.30 | A | 1-332 | [»] | |
2OXX | X-ray | 2.30 | A | 1-332 | [»] | |
2OXY | X-ray | 1.81 | A/B | 1-332 | [»] | |
2PVH | X-ray | 2.20 | A | 1-332 | [»] | |
2PVJ | X-ray | 1.70 | A | 1-332 | [»] | |
2PVK | X-ray | 1.90 | A | 1-332 | [»] | |
2PVL | X-ray | 1.90 | A | 1-332 | [»] | |
2PVM | X-ray | 2.00 | A | 1-332 | [»] | |
2PVN | X-ray | 2.00 | A | 1-332 | [»] | |
2QC6 | X-ray | 1.85 | A | 1-332 | [»] | |
3BE9 | X-ray | 2.00 | A | 1-332 | [»] | |
3FL5 | X-ray | 2.30 | A | 1-332 | [»] | |
3KXG | X-ray | 1.70 | A | 2-328 | [»] | |
3KXH | X-ray | 1.70 | A | 2-328 | [»] | |
3KXM | X-ray | 1.75 | A | 2-328 | [»] | |
3KXN | X-ray | 2.00 | A | 2-328 | [»] | |
3PVG | X-ray | 1.50 | A | 2-332 | [»] | |
3PWD | X-ray | 2.20 | A | 1-332 | [»] | |
3PZH | X-ray | 1.92 | A | 1-332 | [»] | |
4ANM | X-ray | 1.70 | A | 2-332 | [»] | |
4DGM | X-ray | 1.65 | A | 2-327 | [»] | |
4DGN | X-ray | 1.75 | A | 2-327 | [»] | |
4RLK | X-ray | 1.24 | A | 1-332 | [»] | |
5TS8 | X-ray | 1.45 | A | 1-332 | [»] | |
6QS5 | X-ray | 1.96 | A | 2-326 | [»] | |
SMRi | P28523 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P28523, 1 interactor |
STRINGi | 4577.GRMZM5G845755_P02 |
Chemistry databases
BindingDBi | P28523 |
ChEMBLi | CHEMBL4514 |
Proteomic databases
PaxDbi | P28523 |
Genome annotation databases
EnsemblPlantsi | Zm00001eb118100_T001; Zm00001eb118100_P001; Zm00001eb118100 |
GeneIDi | 542637 |
Gramenei | Zm00001eb118100_T001; Zm00001eb118100_P001; Zm00001eb118100 |
Organism-specific databases
MaizeGDBi | 30032 |
Phylogenomic databases
eggNOGi | KOG0668, Eukaryota |
HOGENOMi | CLU_000288_70_4_1 |
OMAi | RAYWDYD |
OrthoDBi | 1098380at2759 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 6752 |
Miscellaneous databases
EvolutionaryTracei | P28523 |
PROi | PR:P28523 |
Gene expression databases
ExpressionAtlasi | P28523, baseline and differential |
Genevisiblei | P28523, ZM |
Family and domain databases
CDDi | cd14132, STKc_CK2_alpha, 1 hit |
InterProi | View protein in InterPro IPR045216, CK2_alpha IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24054, PTHR24054, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSK2A_MAIZE | |
Accessioni | P28523Primary (citable) accession number: P28523 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families