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Protein

DNA repair protein RAD14

Gene

RAD14

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleotide excision repair. Binds specifically to damaged DNA. Required for the incision step.

Miscellaneous

Present with 1030 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri191 – 216Add BLAST26

GO - Molecular functioni

  • damaged DNA binding Source: SGD
  • zinc ion binding Source: SGD

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32888-MONOMER
ReactomeiR-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-5696400 Dual Incision in GG-NER
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD14
Gene namesi
Name:RAD14
Ordered Locus Names:YMR201C
ORF Names:YM8325.02C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

SGDiS000004814 RAD14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207V → M in RAD14-2; loss of recognition of cyclobutane pyrimidine dimers. 1
Mutagenesisi216C → Y in RAD14-2; loss of recognition of cyclobutane pyrimidine dimers. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002086541 – 371DNA repair protein RAD14Add BLAST371

Proteomic databases

MaxQBiP28519
PaxDbiP28519
PRIDEiP28519

PTM databases

iPTMnetiP28519

Interactioni

Subunit structurei

Component of the nucleotide excision repair factor 1 (NEF1) complex consisting of RAD1, RAD10 and RAD14.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RAD1P067774EBI-14641,EBI-14752

Protein-protein interaction databases

BioGridi35379, 388 interactors
ComplexPortaliCPX-1708 Nucleotide-excision repair factor 1 complex
DIPiDIP-1896N
ELMiP28519
IntActiP28519, 10 interactors
MINTiP28519
STRINGi4932.YMR201C

Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP28519
SMRiP28519
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XPA family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri191 – 216Add BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000002721
HOGENOMiHOG000161510
InParanoidiP28519
KOiK10847
OMAiQVEEYAF
OrthoDBiEOG092C44LK

Family and domain databases

Gene3Di3.90.530.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR022658 XPA_CS
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS
PANTHERiPTHR10142 PTHR10142, 1 hit
PfamiView protein in Pfam
PF05181 XPA_C, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR00598 rad14, 1 hit
PROSITEiView protein in PROSITE
PS00752 XPA_1, 1 hit
PS00753 XPA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28519-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPEQKAKLE ANRKLAIERL RKRGILSSDQ LNRIESRNEP LKTRPLAVTS
60 70 80 90 100
GSNRDDNAAA AVHVPNHNGQ PSALANTNTN TTSLYGSGVV DGSKRDASVL
110 120 130 140 150
DKRPTDRIRP SIRKQDYIEY DFATMQNLNG GYINPKDKLP NSDFTDDQEF
160 170 180 190 200
ESEFGSKKQK TLQDWKKEQL ERKMLYENAP PPEHISKAPK CIECHINIEM
210 220 230 240 250
DPVLHDVFKL QVCKQCSKEH PEKYALLTKT ECKEDYFLTD PELNDEDLFH
260 270 280 290 300
RLEKPNPHSG TFARMQLFVR CEVEAFAFKK WGGEEGLDEE WQRREEGKAH
310 320 330 340 350
RREKKYEKKI KEMRLKTRAQ EYTNRLREKK HGKAHIHHFS DPVDGGIDED
360 370
GYQIQRRRCT DCGLETEEID I
Length:371
Mass (Da):43,038
Last modified:February 1, 1996 - v2
Checksum:iA90FA9CAA6F3EA52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64064 Genomic DNA Translation: CAA45420.1
Z48755 Genomic DNA Translation: CAA88642.1
BK006946 Genomic DNA Translation: DAA10100.1
PIRiS59442
RefSeqiNP_013928.1, NM_001182708.1

Genome annotation databases

EnsemblFungiiYMR201C; YMR201C; YMR201C
GeneIDi855241
KEGGisce:YMR201C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64064 Genomic DNA Translation: CAA45420.1
Z48755 Genomic DNA Translation: CAA88642.1
BK006946 Genomic DNA Translation: DAA10100.1
PIRiS59442
RefSeqiNP_013928.1, NM_001182708.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A39X-ray2.80A/B188-302[»]
5A3DX-ray1.80A/B188-302[»]
5G32X-ray2.20A/B188-306[»]
5G33X-ray2.40A/B188-306[»]
5G34X-ray1.90A/B188-306[»]
5G35X-ray2.00A/B188-306[»]
5LCLX-ray2.20A188-306[»]
B1-371[»]
5LCMX-ray1.90A/B188-306[»]
ProteinModelPortaliP28519
SMRiP28519
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35379, 388 interactors
ComplexPortaliCPX-1708 Nucleotide-excision repair factor 1 complex
DIPiDIP-1896N
ELMiP28519
IntActiP28519, 10 interactors
MINTiP28519
STRINGi4932.YMR201C

PTM databases

iPTMnetiP28519

Proteomic databases

MaxQBiP28519
PaxDbiP28519
PRIDEiP28519

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR201C; YMR201C; YMR201C
GeneIDi855241
KEGGisce:YMR201C

Organism-specific databases

SGDiS000004814 RAD14

Phylogenomic databases

GeneTreeiENSGT00390000002721
HOGENOMiHOG000161510
InParanoidiP28519
KOiK10847
OMAiQVEEYAF
OrthoDBiEOG092C44LK

Enzyme and pathway databases

BioCyciYEAST:G3O-32888-MONOMER
ReactomeiR-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-5696400 Dual Incision in GG-NER
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER

Miscellaneous databases

PROiPR:P28519

Family and domain databases

Gene3Di3.90.530.10, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000465 XPA
IPR022656 XPA_C
IPR022658 XPA_CS
IPR037129 XPA_sf
IPR022652 Znf_XPA_CS
PANTHERiPTHR10142 PTHR10142, 1 hit
PfamiView protein in Pfam
PF05181 XPA_C, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
TIGRFAMsiTIGR00598 rad14, 1 hit
PROSITEiView protein in PROSITE
PS00752 XPA_1, 1 hit
PS00753 XPA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAD14_YEAST
AccessioniPrimary (citable) accession number: P28519
Secondary accession number(s): D6W026
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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