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Protein

Hirudin-2

Gene
N/A
Organism
Hirudo medicinalis (Medicinal leech)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI14.001

Names & Taxonomyi

Protein namesi
Recommended name:
Hirudin-2
Alternative name(s):
Hirudin II
OrganismiHirudo medicinalis (Medicinal leech)
Taxonomic identifieri6421 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataHirudineaArhynchobdellidaHirudiniformesHirudinidaeHirudo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei9843 Hir me Hirudin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956441 – 65Hirudin-2Add BLAST65

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6 ↔ 14By similarity
Disulfide bondi16 ↔ 28By similarity
Disulfide bondi22 ↔ 39By similarity
Glycosylationi45O-linked (GalNAc...) threonineBy similarity1
Modified residuei63SulfotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Structurei

Secondary structure

165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi61 – 63Combined sources3

3D structure databases

ProteinModelPortaliP28504
SMRiP28504
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28504

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 3Interaction with thrombin active siteBy similarity3
Regioni55 – 65Interaction with fibrinogen-binding exosite of thrombinBy similarityAdd BLAST11

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR011061 Hirudin/antistatin
IPR000429 Prot_inh_hirudin
PfamiView protein in Pfam
PF00713 Hirudin, 1 hit
PIRSFiPIRSF001640 Hirudin, 1 hit
PRINTSiPR00777 HIRUDIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004216 Prot_inh_hirudin, 1 hit
SUPFAMiSSF57262 SSF57262, 1 hit

Sequencei

Sequence statusi: Complete.

P28504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ITYTDCTESG QDLCLCEGSN VCGKGNKCIL GSNGEENQCV TGEGTPKPQS
60
HNDGDFEEIP EEYLQ
Length:65
Mass (Da):6,987
Last modified:December 1, 1992 - v1
Checksum:i757EEAE55EAEB27E
GO

Sequence databases

PIRiS05678

Similar proteinsi

Entry informationi

Entry nameiHIR2_HIRME
AccessioniPrimary (citable) accession number: P28504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 10, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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