UniProtKB - P28482 (MK01_HUMAN)
Mitogen-activated protein kinase 1
MAPK1
Functioni
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).
4 PublicationsBy similarity26 PublicationsActs as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
1 PublicationCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 54 | 4-(2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl)-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide; inhibitorCombined sources1 Publication | 1 | |
Binding sitei | 54 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 108 | 4-(2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl)-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide; inhibitor; via amide nitrogen and carbonyl oxygenCombined sources1 Publication | 1 | |
Active sitei | 149 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 167 | 4-(2-[(2-chlorophenyl)amino]-5-methylpyrimidin-4-yl)-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide; inhibitorCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 31 – 39 | ATPPROSITE-ProRule annotation | 9 | |
DNA bindingi | 259 – 277 | Add BLAST | 19 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- MAP kinase activity Source: GO_Central
- MAP kinase kinase activity Source: Ensembl
- phosphatase binding Source: UniProtKB
- phosphotyrosine residue binding Source: Ensembl
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: ProtInc
- B cell receptor signaling pathway Source: Ensembl
- Bergmann glial cell differentiation Source: Ensembl
- cardiac neural crest cell development involved in heart development Source: Ensembl
- caveolin-mediated endocytosis Source: UniProtKB
- cell cycle Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: GO_Central
- cellular response to amino acid starvation Source: CAFA
- cellular response to cadmium ion Source: CAFA
- cellular response to DNA damage stimulus Source: Ensembl
- cellular response to dopamine Source: CAFA
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
- cellular response to reactive oxygen species Source: CAFA
- cellular response to tumor necrosis factor Source: Ensembl
- chemical synaptic transmission Source: ProtInc
- chemotaxis Source: ProtInc
- cytosine metabolic process Source: Ensembl
- ERBB signaling pathway Source: UniProtKB
- ERK1 and ERK2 cascade Source: UniProtKB
- face development Source: Ensembl
- intracellular signal transduction Source: GO_Central
- labyrinthine layer blood vessel development Source: Ensembl
- learning or memory Source: ARUK-UCL
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- long-term synaptic potentiation Source: Ensembl
- lung morphogenesis Source: Ensembl
- mammary gland epithelial cell proliferation Source: Ensembl
- negative regulation of cell differentiation Source: Ensembl
- outer ear morphogenesis Source: Ensembl
- peptidyl-serine phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of gene expression Source: CAFA
- positive regulation of macrophage chemotaxis Source: ARUK-UCL
- positive regulation of macrophage proliferation Source: ARUK-UCL
- positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of telomerase activity Source: BHF-UCL
- positive regulation of telomere capping Source: BHF-UCL
- positive regulation of telomere maintenance via telomerase Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of cellular pH Source: Ensembl
- regulation of cytoskeleton organization Source: UniProtKB
- regulation of early endosome to late endosome transport Source: UniProtKB
- regulation of Golgi inheritance Source: UniProtKB
- regulation of ossification Source: Ensembl
- regulation of protein stability Source: UniProtKB
- regulation of stress-activated MAPK cascade Source: UniProtKB
- response to epidermal growth factor Source: UniProtKB
- response to exogenous dsRNA Source: Ensembl
- response to nicotine Source: ARUK-UCL
- signal transduction Source: ProtInc
- stress-activated MAPK cascade Source: CAFA
- T cell receptor signaling pathway Source: Ensembl
- thymus development Source: Ensembl
- thyroid gland development Source: Ensembl
- trachea formation Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Kinase, Repressor, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | P28482 |
Reactomei | R-HSA-111995, phospho-PLA2 pathway R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-1181150, Signaling by NODAL R-HSA-1295596, Spry regulation of FGF signaling R-HSA-1502540, Signaling by Activin R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170968, Frs2-mediated activation R-HSA-198753, ERK/MAPK targets R-HSA-202670, ERKs are inactivated R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585, Oncogene Induced Senescence R-HSA-2871796, FCERI mediated MAPK activation R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-437239, Recycling pathway of L1 R-HSA-444257, RSK activation R-HSA-445144, Signal transduction by L1 R-HSA-450341, Activation of the AP-1 family of transcription factors R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5674499, Negative feedback regulation of MAPK pathway R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-74749, Signal attenuation R-HSA-879415, Advanced glycosylation endproduct receptor signaling R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-8939211, ESR-mediated signaling R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9627069, Regulation of the apoptosome activity R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9635465, Suppression of apoptosis R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9652169, Signaling by MAP2K mutants R-HSA-9652817, Signaling by MAPK mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer R-HSA-982772, Growth hormone receptor signaling |
SABIO-RKi | P28482 |
SignaLinki | P28482 |
SIGNORi | P28482 |
Protein family/group databases
MoonDBi | P28482, Predicted |
MoonProti | P28482 |
Names & Taxonomyi
Protein namesi | Recommended name: Mitogen-activated protein kinase 1 (EC:2.7.11.24)Short name: MAP kinase 1 Short name: MAPK 1 Alternative name(s): ERT1 Extracellular signal-regulated kinase 2 Short name: ERK-2 MAP kinase isoform p42 Short name: p42-MAPK Mitogen-activated protein kinase 2 Short name: MAP kinase 2 Short name: MAPK 2 |
Gene namesi | Name:MAPK1 Synonyms:ERK2, PRKM1, PRKM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6871, MAPK1 |
MIMi | 176948, gene |
neXtProti | NX_P28482 |
VEuPathDBi | HostDB:ENSG00000100030 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- spindle By similarity
- centrosome
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- caveola By similarity
- focal adhesion By similarity
Note: Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB
- microtubule organizing center Source: UniProtKB-SubCell
- mitotic spindle Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Endosome
- early endosome Source: UniProtKB
- late endosome Source: UniProtKB
Extracellular region or secreted
- extracellular region Source: Reactome
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Lysosome
- azurophil granule lumen Source: Reactome
Mitochondrion
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- caveola Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- focal adhesion Source: UniProtKB
- pseudopodium Source: Ensembl
- synapse Source: GOC
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Noonan syndrome 13 (NS13)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085093 | 74 | I → N in NS13; results in increased MAPK signaling; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085094 | 80 | H → Y in NS13; results in increased MAPK signaling; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085095 | 174 | A → V in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085096 | 318 | D → G in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085097 | 318 | D → N in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085098 | 322 | E → Q in NS13. 1 Publication | 1 | |
Natural variantiVAR_085099 | 323 | P → R in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | K → R: Does not inhibit interaction with MAP2K1. 1 Publication | 1 | |
Mutagenesisi | 176 – 179 | Missing : Inhibits homodimerization and interaction with TPR. 1 Publication | 4 | |
Mutagenesisi | 185 | T → A: Inhibits interaction with TPR; when associated with A-187. 1 Publication | 1 | |
Mutagenesisi | 187 | Y → A: Inhibits interaction with TPR; when associated with A-185. 1 Publication | 1 | |
Mutagenesisi | 234 | L → A: Inhibits interaction with TPR. 1 Publication | 1 | |
Mutagenesisi | 318 | D → A: Loss of dephosphorylation by PTPRJ. 2 Publications | 1 | |
Mutagenesisi | 318 | D → N: Inhibits interaction with MAP2K1 but not with TPR; when associated with N-321. 2 Publications | 1 | |
Mutagenesisi | 321 | D → N: Inhibits interaction with MAP2K1 but not with TPR; when associated with N-318. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 5594 |
MalaCardsi | MAPK1 |
MIMi | 619087, phenotype |
OpenTargetsi | ENSG00000100030 |
Orphaneti | 261330, Distal 22q11.2 microdeletion syndrome |
PharmGKBi | PA30616 |
Miscellaneous databases
Pharosi | P28482, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4040 |
DrugBanki | DB07905, (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione DB07788, (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE DB07264, (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE DB08521, 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine DB07794, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE DB08513, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID DB00945, Acetylsalicylic acid DB01169, Arsenic trioxide DB01064, Isoprenaline DB01017, Minocycline DB06877, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE DB02116, Olomoucine DB06641, Perifosine DB02482, Phosphonothreonine DB02733, Purvalanol DB04338, SB220025 DB06195, Seliciclib DB11120, Turpentine DB13930, Ulixertinib |
DrugCentrali | P28482 |
GuidetoPHARMACOLOGYi | 1495 |
Genetic variation databases
BioMutai | MAPK1 |
DMDMi | 119554 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000186247 | 2 – 360 | Mitogen-activated protein kinase 1Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 29 | Phosphoserine; by SGK11 Publication | 1 | |
Modified residuei | 185 | Phosphothreonine; by MAP2K1 and MAP2K2Combined sources | 1 | |
Modified residuei | 187 | Phosphotyrosine; by MAP2K1 and MAP2K2Combined sources2 Publications | 1 | |
Modified residuei | 190 | Phosphothreonine; by autocatalysis1 Publication | 1 | |
Modified residuei | 246 | Phosphoserine1 Publication | 1 | |
Modified residuei | 248 | Phosphoserine1 Publication | 1 | |
Modified residuei | 284 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1352 CPTAC-1353 CPTAC-1354 CPTAC-1541 CPTAC-870 CPTAC-871 |
EPDi | P28482 |
jPOSTi | P28482 |
MassIVEi | P28482 |
MaxQBi | P28482 |
PaxDbi | P28482 |
PeptideAtlasi | P28482 |
PRIDEi | P28482 |
ProteomicsDBi | 1826 54488 [P28482-1] |
2D gel databases
OGPi | P28482 |
PTM databases
iPTMneti | P28482 |
MetOSitei | P28482 |
PhosphoSitePlusi | P28482 |
SwissPalmi | P28482 |
Expressioni
Gene expression databases
Bgeei | ENSG00000100030, Expressed in putamen and 251 other tissues |
ExpressionAtlasi | P28482, baseline and differential |
Genevisiblei | P28482, HS |
Organism-specific databases
HPAi | ENSG00000100030, Low tissue specificity |
Interactioni
Subunit structurei
Binds both upstream activators and downstream substrates in multimolecular complexes. This interaction inhibits its tyrosine-kinase activity.
Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, NISCH, SGK1, and isoform 1 of NEK2.
Interacts (via phosphorylated form) with TPR (via C-terminal region and phosphorylated form); the interaction requires dimerization of MAPK1/ERK2 and increases following EGF stimulation (PubMed:18794356).
Interacts with MAP2K1 (PubMed:32721402).
Interacts with DUSP6 (PubMed:9596579, PubMed:32721402).
Interacts (phosphorylated form) with CAV2 ('Tyr-19'-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation.
Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity).
Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4).
Interacts with STYX.
Interacts with CDK2AP2.
Interacts with CAVIN4 (By similarity).
Interacts with DUSP7; the interaction enhances DUSP7 phosphatase activity (PubMed:9788880).
Interacts with GIT1; this interaction is necessary for MAPK1 localization to focal adhesions (By similarity).
Interacts with ZNF263 (PubMed:32051553).
By similarity24 Publications(Microbial infection) Interacts with HIV-1 Nef through its SH3 domain.
1 PublicationBinary interactionsi
P28482
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphatase binding Source: UniProtKB
- phosphotyrosine residue binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111580, 390 interactors |
CORUMi | P28482 |
DIPi | DIP-519N |
ELMi | P28482 |
IntActi | P28482, 153 interactors |
MINTi | P28482 |
STRINGi | 9606.ENSP00000215832 |
Chemistry databases
BindingDBi | P28482 |
Miscellaneous databases
RNActi | P28482, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P28482 |
SMRi | P28482 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28482 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 313 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 289 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 108 | Inhibitor-binding | 4 | |
Regioni | 153 – 154 | Inhibitor-binding | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 185 – 187 | TXY1 Publication | 3 | |
Motifi | 318 – 322 | Cytoplasmic retention motif1 Publication | 5 | |
Motifi | 327 – 333 | Nuclear translocation motif1 Publication | 7 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0660, Eukaryota |
GeneTreei | ENSGT00940000156771 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | P28482 |
OMAi | QAISNDH |
PhylomeDBi | P28482 |
TreeFami | TF105097 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008349, MAPK_ERK1/2 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01770, ERK1ERK2MAPK |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR
60 70 80 90 100
VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD
110 120 130 140 150
VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL
160 170 180 190 200
KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML
210 220 230 240 250
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE
260 270 280 290 300
DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK
310 320 330 340 350
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE
360
TARFQPGYRS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | R → Q in CAA77752 (PubMed:1319925).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_085093 | 74 | I → N in NS13; results in increased MAPK signaling; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085094 | 80 | H → Y in NS13; results in increased MAPK signaling; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085095 | 174 | A → V in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085096 | 318 | D → G in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085097 | 318 | D → N in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 | |
Natural variantiVAR_085098 | 322 | E → Q in NS13. 1 Publication | 1 | |
Natural variantiVAR_085099 | 323 | P → R in NS13; results in increased MAPK signaling; increased translocation to the nucleus; reduced interaction wth DUSP6; no effect on interaction with MAP2K1. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047815 | 242 – 285 | Missing in isoform 2. 1 PublicationAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84489 mRNA Translation: AAA58459.1 Z11694 mRNA Translation: CAA77752.1 Z11695 mRNA Translation: CAA77753.1 Different initiation. DQ399292 mRNA Translation: ABD60303.1 AP000553 Genomic DNA No translation available. AP000554 Genomic DNA No translation available. AP000555 Genomic DNA No translation available. BC017832 mRNA Translation: AAH17832.1 |
CCDSi | CCDS13795.1 [P28482-1] |
PIRi | JQ1400 |
RefSeqi | NP_002736.3, NM_002745.4 [P28482-1] NP_620407.1, NM_138957.3 [P28482-1] |
Genome annotation databases
Ensembli | ENST00000215832; ENSP00000215832; ENSG00000100030 ENST00000398822; ENSP00000381803; ENSG00000100030 ENST00000544786; ENSP00000440842; ENSG00000100030 [P28482-2] |
GeneIDi | 5594 |
KEGGi | hsa:5594 |
MANE-Selecti | ENST00000215832.11; ENSP00000215832.7; NM_002745.5; NP_002736.3 |
UCSCi | uc010gtk.2, human [P28482-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Extracellular signal-regulated kinase entry |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84489 mRNA Translation: AAA58459.1 Z11694 mRNA Translation: CAA77752.1 Z11695 mRNA Translation: CAA77753.1 Different initiation. DQ399292 mRNA Translation: ABD60303.1 AP000553 Genomic DNA No translation available. AP000554 Genomic DNA No translation available. AP000555 Genomic DNA No translation available. BC017832 mRNA Translation: AAH17832.1 |
CCDSi | CCDS13795.1 [P28482-1] |
PIRi | JQ1400 |
RefSeqi | NP_002736.3, NM_002745.4 [P28482-1] NP_620407.1, NM_138957.3 [P28482-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PME | X-ray | 2.00 | A | 1-360 | [»] | |
1TVO | X-ray | 2.50 | A | 1-360 | [»] | |
1WZY | X-ray | 2.50 | A | 1-360 | [»] | |
2OJG | X-ray | 2.00 | A | 2-360 | [»] | |
2OJI | X-ray | 2.60 | A | 2-360 | [»] | |
2OJJ | X-ray | 2.40 | A | 2-360 | [»] | |
2Y9Q | X-ray | 1.55 | A | 1-360 | [»] | |
3D42 | X-ray | 2.46 | B | 184-191 | [»] | |
3D44 | X-ray | 1.90 | B | 184-191 | [»] | |
3I5Z | X-ray | 2.20 | A | 1-360 | [»] | |
3I60 | X-ray | 2.50 | A | 1-360 | [»] | |
3SA0 | X-ray | 1.59 | A | 1-360 | [»] | |
3TEI | X-ray | 2.40 | A | 1-360 | [»] | |
3W55 | X-ray | 3.00 | A | 1-360 | [»] | |
4FMQ | X-ray | 2.10 | A | 1-360 | [»] | |
4FUX | X-ray | 2.20 | A | 1-360 | [»] | |
4FUY | X-ray | 2.00 | A | 1-360 | [»] | |
4FV0 | X-ray | 2.10 | A | 1-360 | [»] | |
4FV1 | X-ray | 1.99 | A | 1-360 | [»] | |
4FV2 | X-ray | 2.00 | A | 1-360 | [»] | |
4FV3 | X-ray | 2.20 | A | 1-360 | [»] | |
4FV4 | X-ray | 2.50 | A | 1-360 | [»] | |
4FV5 | X-ray | 2.40 | A | 1-360 | [»] | |
4FV6 | X-ray | 2.50 | A | 1-360 | [»] | |
4FV7 | X-ray | 1.90 | A | 1-360 | [»] | |
4FV8 | X-ray | 2.00 | A | 1-360 | [»] | |
4FV9 | X-ray | 2.11 | A | 1-360 | [»] | |
4G6N | X-ray | 2.00 | A | 1-360 | [»] | |
4G6O | X-ray | 2.20 | A | 1-360 | [»] | |
4H3P | X-ray | 2.30 | A/D | 1-360 | [»] | |
4H3Q | X-ray | 2.20 | A | 1-360 | [»] | |
4IZ5 | X-ray | 3.19 | A/B/C/D | 8-360 | [»] | |
4IZ7 | X-ray | 1.80 | A/C | 8-360 | [»] | |
4IZA | X-ray | 1.93 | A/C | 8-360 | [»] | |
4N0S | X-ray | 1.80 | A | 1-360 | [»] | |
4NIF | X-ray | 2.15 | B/E | 1-360 | [»] | |
4O6E | X-ray | 1.95 | A | 13-360 | [»] | |
4QP1 | X-ray | 2.70 | A/B | 1-360 | [»] | |
4QP2 | X-ray | 2.23 | A/B | 1-360 | [»] | |
4QP3 | X-ray | 2.60 | A/B | 1-360 | [»] | |
4QP4 | X-ray | 2.20 | A/B | 1-360 | [»] | |
4QP6 | X-ray | 3.10 | A/B | 1-360 | [»] | |
4QP7 | X-ray | 2.25 | A/B | 1-360 | [»] | |
4QP8 | X-ray | 2.45 | A/B | 1-360 | [»] | |
4QP9 | X-ray | 2.00 | A | 1-360 | [»] | |
4QPA | X-ray | 2.85 | A/B | 1-360 | [»] | |
4QTA | X-ray | 1.45 | A | 1-360 | [»] | |
4QTE | X-ray | 1.50 | A | 1-360 | [»] | |
4XJ0 | X-ray | 2.58 | A/B | 12-360 | [»] | |
4ZXT | X-ray | 2.00 | A | 1-360 | [»] | |
4ZZM | X-ray | 1.89 | A | 11-360 | [»] | |
4ZZN | X-ray | 1.33 | A | 11-360 | [»] | |
4ZZO | X-ray | 1.63 | A | 11-360 | [»] | |
5AX3 | X-ray | 2.98 | A | 1-360 | [»] | |
5BUE | X-ray | 2.40 | A | 2-360 | [»] | |
5BUI | X-ray | 2.12 | A | 2-360 | [»] | |
5BUJ | X-ray | 1.85 | A | 2-360 | [»] | |
5BVD | X-ray | 1.90 | A | 2-360 | [»] | |
5BVE | X-ray | 2.00 | A | 2-360 | [»] | |
5BVF | X-ray | 1.90 | A | 2-360 | [»] | |
5K4I | X-ray | 1.76 | A | 9-360 | [»] | |
5LCJ | X-ray | 1.78 | A | 1-360 | [»] | |
5LCK | X-ray | 1.89 | A | 1-360 | [»] | |
5NGU | X-ray | 2.74 | A | 1-360 | [»] | |
5NHF | X-ray | 2.14 | A | 1-360 | [»] | |
5NHH | X-ray | 1.94 | A | 1-360 | [»] | |
5NHJ | X-ray | 2.12 | A | 1-360 | [»] | |
5NHL | X-ray | 2.07 | A | 1-360 | [»] | |
5NHO | X-ray | 2.24 | A | 1-360 | [»] | |
5NHP | X-ray | 1.99 | A | 1-360 | [»] | |
5NHV | X-ray | 2.00 | A | 1-360 | [»] | |
5V60 | X-ray | 2.18 | A | 8-360 | [»] | |
5V61 | X-ray | 2.20 | A | 8-360 | [»] | |
5V62 | X-ray | 1.90 | A | 10-360 | [»] | |
5WP1 | X-ray | 1.40 | A | 4-360 | [»] | |
6D5Y | X-ray | 2.86 | A | 13-360 | [»] | |
6DMG | X-ray | 2.20 | A | 11-357 | [»] | |
6G54 | X-ray | 2.05 | A | 1-360 | [»] | |
6G8X | X-ray | 1.76 | A | 1-360 | [»] | |
6G91 | X-ray | 1.80 | A | 1-360 | [»] | |
6G92 | X-ray | 1.99 | A | 1-360 | [»] | |
6G93 | X-ray | 1.67 | A | 1-360 | [»] | |
6G97 | X-ray | 1.90 | A | 1-360 | [»] | |
6G9A | X-ray | 1.91 | A | 1-360 | [»] | |
6G9D | X-ray | 1.80 | A | 1-360 | [»] | |
6G9H | X-ray | 1.73 | A | 1-360 | [»] | |
6G9J | X-ray | 1.98 | A | 1-360 | [»] | |
6G9K | X-ray | 1.94 | A | 1-360 | [»] | |
6G9M | X-ray | 1.86 | A | 1-360 | [»] | |
6G9N | X-ray | 1.76 | A | 1-360 | [»] | |
6GDM | X-ray | 1.91 | A | 1-360 | [»] | |
6GDQ | X-ray | 1.86 | A | 1-360 | [»] | |
6GE0 | X-ray | 1.82 | A | 1-360 | [»] | |
6GJB | X-ray | 1.82 | A | 1-360 | [»] | |
6GJD | X-ray | 1.58 | A | 1-360 | [»] | |
6NBS | X-ray | 1.90 | A | 9-360 | [»] | |
6OPG | X-ray | 2.90 | A | 8-360 | [»] | |
6OPH | X-ray | 2.40 | A | 8-360 | [»] | |
6OPI | X-ray | 3.00 | A | 8-360 | [»] | |
6Q7K | X-ray | 1.84 | A | 1-360 | [»] | |
6Q7S | X-ray | 1.73 | A | 1-360 | [»] | |
6Q7T | X-ray | 1.60 | A | 1-360 | [»] | |
6QA1 | X-ray | 1.58 | A | 1-360 | [»] | |
6QA3 | X-ray | 1.57 | A | 1-360 | [»] | |
6QA4 | X-ray | 1.60 | A | 1-360 | [»] | |
6QAG | X-ray | 2.07 | A | 1-360 | [»] | |
6QAH | X-ray | 1.58 | A | 1-360 | [»] | |
6QAL | X-ray | 1.57 | A | 1-360 | [»] | |
6QAQ | X-ray | 1.58 | A | 1-360 | [»] | |
6QAW | X-ray | 1.84 | A | 1-360 | [»] | |
6RQ4 | X-ray | 1.96 | A | 1-360 | [»] | |
6SLG | X-ray | 1.33 | A | 1-360 | [»] | |
7AUV | X-ray | 1.76 | A | 1-360 | [»] | |
7NQQ | X-ray | 1.94 | A | 1-360 | [»] | |
7NQW | X-ray | 1.77 | A | 1-360 | [»] | |
7NR3 | X-ray | 1.90 | A | 1-360 | [»] | |
7NR5 | X-ray | 1.77 | A | 1-360 | [»] | |
7NR8 | X-ray | 1.63 | A | 1-360 | [»] | |
7NR9 | X-ray | 1.91 | A | 1-360 | [»] | |
BMRBi | P28482 | |||||
SMRi | P28482 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111580, 390 interactors |
CORUMi | P28482 |
DIPi | DIP-519N |
ELMi | P28482 |
IntActi | P28482, 153 interactors |
MINTi | P28482 |
STRINGi | 9606.ENSP00000215832 |
Chemistry databases
BindingDBi | P28482 |
ChEMBLi | CHEMBL4040 |
DrugBanki | DB07905, (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione DB07788, (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE DB07264, (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE DB08521, 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine DB07794, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE DB08513, [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID DB00945, Acetylsalicylic acid DB01169, Arsenic trioxide DB01064, Isoprenaline DB01017, Minocycline DB06877, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE DB07010, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE DB02116, Olomoucine DB06641, Perifosine DB02482, Phosphonothreonine DB02733, Purvalanol DB04338, SB220025 DB06195, Seliciclib DB11120, Turpentine DB13930, Ulixertinib |
DrugCentrali | P28482 |
GuidetoPHARMACOLOGYi | 1495 |
Protein family/group databases
MoonDBi | P28482, Predicted |
MoonProti | P28482 |
PTM databases
iPTMneti | P28482 |
MetOSitei | P28482 |
PhosphoSitePlusi | P28482 |
SwissPalmi | P28482 |
Genetic variation databases
BioMutai | MAPK1 |
DMDMi | 119554 |
2D gel databases
OGPi | P28482 |
Proteomic databases
CPTACi | CPTAC-1352 CPTAC-1353 CPTAC-1354 CPTAC-1541 CPTAC-870 CPTAC-871 |
EPDi | P28482 |
jPOSTi | P28482 |
MassIVEi | P28482 |
MaxQBi | P28482 |
PaxDbi | P28482 |
PeptideAtlasi | P28482 |
PRIDEi | P28482 |
ProteomicsDBi | 1826 54488 [P28482-1] |
Protocols and materials databases
Antibodypediai | 3785, 1835 antibodies from 54 providers |
CPTCi | P28482, 4 antibodies |
DNASUi | 5594 |
Genome annotation databases
Ensembli | ENST00000215832; ENSP00000215832; ENSG00000100030 ENST00000398822; ENSP00000381803; ENSG00000100030 ENST00000544786; ENSP00000440842; ENSG00000100030 [P28482-2] |
GeneIDi | 5594 |
KEGGi | hsa:5594 |
MANE-Selecti | ENST00000215832.11; ENSP00000215832.7; NM_002745.5; NP_002736.3 |
UCSCi | uc010gtk.2, human [P28482-1] |
Organism-specific databases
CTDi | 5594 |
DisGeNETi | 5594 |
GeneCardsi | MAPK1 |
HGNCi | HGNC:6871, MAPK1 |
HPAi | ENSG00000100030, Low tissue specificity |
MalaCardsi | MAPK1 |
MIMi | 176948, gene 619087, phenotype |
neXtProti | NX_P28482 |
OpenTargetsi | ENSG00000100030 |
Orphaneti | 261330, Distal 22q11.2 microdeletion syndrome |
PharmGKBi | PA30616 |
VEuPathDBi | HostDB:ENSG00000100030 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0660, Eukaryota |
GeneTreei | ENSGT00940000156771 |
HOGENOMi | CLU_000288_181_1_1 |
InParanoidi | P28482 |
OMAi | QAISNDH |
PhylomeDBi | P28482 |
TreeFami | TF105097 |
Enzyme and pathway databases
BRENDAi | 2.7.11.24, 2681 |
PathwayCommonsi | P28482 |
Reactomei | R-HSA-111995, phospho-PLA2 pathway R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-112411, MAPK1 (ERK2) activation R-HSA-1181150, Signaling by NODAL R-HSA-1295596, Spry regulation of FGF signaling R-HSA-1502540, Signaling by Activin R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170968, Frs2-mediated activation R-HSA-198753, ERK/MAPK targets R-HSA-202670, ERKs are inactivated R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2173796, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559585, Oncogene Induced Senescence R-HSA-2871796, FCERI mediated MAPK activation R-HSA-3371453, Regulation of HSF1-mediated heat shock response R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-437239, Recycling pathway of L1 R-HSA-444257, RSK activation R-HSA-445144, Signal transduction by L1 R-HSA-450341, Activation of the AP-1 family of transcription factors R-HSA-456926, Thrombin signalling through proteinase activated receptors (PARs) R-HSA-5654726, Negative regulation of FGFR1 signaling R-HSA-5654727, Negative regulation of FGFR2 signaling R-HSA-5654732, Negative regulation of FGFR3 signaling R-HSA-5654733, Negative regulation of FGFR4 signaling R-HSA-5663213, RHO GTPases Activate WASPs and WAVEs R-HSA-5668599, RHO GTPases Activate NADPH Oxidases R-HSA-5673001, RAF/MAP kinase cascade R-HSA-5674135, MAP2K and MAPK activation R-HSA-5674499, Negative feedback regulation of MAPK pathway R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-6798695, Neutrophil degranulation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-74749, Signal attenuation R-HSA-879415, Advanced glycosylation endproduct receptor signaling R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-8939211, ESR-mediated signaling R-HSA-8940973, RUNX2 regulates osteoblast differentiation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9627069, Regulation of the apoptosome activity R-HSA-9634635, Estrogen-stimulated signaling through PRKCZ R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling R-HSA-9635465, Suppression of apoptosis R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9652169, Signaling by MAP2K mutants R-HSA-9652817, Signaling by MAPK mutants R-HSA-9656223, Signaling by RAF1 mutants R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-9725371, Nuclear events stimulated by ALK signaling in cancer R-HSA-982772, Growth hormone receptor signaling |
SABIO-RKi | P28482 |
SignaLinki | P28482 |
SIGNORi | P28482 |
Miscellaneous databases
BioGRID-ORCSi | 5594, 138 hits in 1090 CRISPR screens |
ChiTaRSi | MAPK1, human |
EvolutionaryTracei | P28482 |
GeneWikii | MAPK1 |
GenomeRNAii | 5594 |
Pharosi | P28482, Tchem |
PROi | PR:P28482 |
RNActi | P28482, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100030, Expressed in putamen and 251 other tissues |
ExpressionAtlasi | P28482, baseline and differential |
Genevisiblei | P28482, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR003527, MAP_kinase_CS IPR008349, MAPK_ERK1/2 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PRINTSi | PR01770, ERK1ERK2MAPK |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351, MAPK, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MK01_HUMAN | |
Accessioni | P28482Primary (citable) accession number: P28482 Secondary accession number(s): A8CZ64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 240 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families