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Protein

Gamma-aminobutyric acid receptor subunit rho-2

Gene

GABRR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • gamma-aminobutyric acid signaling pathway Source: Ensembl
  • signal transduction Source: ProtInc
  • visual perception Source: Ensembl

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-977442 GABA A (rho) receptor activation
SignaLinkiP28476

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit rho-2
Alternative name(s):
GABA(A) receptor subunit rho-2
GABA(C) receptor
Gene namesi
Name:GABRR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111886.10
HGNCiHGNC:4091 GABRR2
MIMi137162 gene
neXtProtiNX_P28476

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 260ExtracellularCuratedAdd BLAST240
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 443CytoplasmicCuratedAdd BLAST97
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2570
OpenTargetsiENSG00000111886
PharmGKBiPA28506

Chemistry databases

ChEMBLiCHEMBL2375
DrugBankiDB00546 Adinazolam
DB01558 Bromazepam
DB01594 Cinolazepam
DB01559 Clotiazepam
DB00829 Diazepam
DB01215 Estazolam
DB01567 Fludiazepam
DB00690 Flurazepam
DB00801 Halazepam
DB00683 Midazolam
DB01595 Nitrazepam
DB00842 Oxazepam
DB01588 Prazepam
DB01589 Quazepam
DB00231 Temazepam
DB00897 Triazolam

Polymorphism and mutation databases

DMDMi410516956

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000048821 – 465Gamma-aminobutyric acid receptor subunit rho-2Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 192By similarity
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP28476
PaxDbiP28476
PRIDEiP28476
ProteomicsDBi54487

PTM databases

iPTMnetiP28476
PhosphoSitePlusiP28476

Expressioni

Gene expression databases

BgeeiENSG00000111886
GenevisibleiP28476 HS

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000386029

Chemistry databases

BindingDBiP28476

Structurei

3D structure databases

ProteinModelPortaliP28476
SMRiP28476
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
InParanoidiP28476
KOiK05190
OMAiEKFPCMC
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008059 GABAAa_rho2_rcpt
IPR008057 GABAAa_rho_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01670 GABAARRHO
PR01672 GABAARRHO2
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: P28476-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYFTRLILF LFCLMVLVES RKPKRKRWTG QVEMPKPSHL YKKNLDVTKI
60 70 80 90 100
RKGKPQQLLR VDEHDFSMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM
110 120 130 140 150
TLYLRHYWKD ERLAFSSASN KSMTFDGRLV KKIWVPDVFF VHSKRSFTHD
160 170 180 190 200
TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA
210 220 230 240 250
YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR
260 270 280 290 300
LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVSLGITT
310 320 330 340 350
VLTMTTIITG VNASMPRVSY VKAVDIYLWV SFVFVFLSVL EYAAVNYLTT
360 370 380 390 400
VQERKERKLR EKFPCMCGML HSKTMMLDGS YSESEANSLA GYPRSHILTE
410 420 430 440 450
EERQDKIVVH LGLSGEANAA RKKGLLKGQT GFRIFQNTHA IDKYSRLIFP
460
ASYIFFNLIY WSVFS
Length:465
Mass (Da):54,151
Last modified:October 31, 2012 - v5
Checksum:i209700077636A395
GO
Isoform 2 (identifier: P28476-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVKPGGICSATGYWKAAFCLTDVHKM

Note: Isoform 2 could be translated from an upstream initiator ATG located in frame within the first coding exon. The probability of a signal peptide within this isoform is very low. No experimental confirmation available.
Show »
Length:490
Mass (Da):56,817
Checksum:i18F3AF79BD2D2B13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209Y → H in AAA52510 (PubMed:1315307).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0443731M → MVKPGGICSATGYWKAAFCL TDVHKM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86868 mRNA Translation: AAA52510.1
AL121833 Genomic DNA No translation available.
BC130352 mRNA Translation: AAI30353.1
BC130354 mRNA Translation: AAI30355.1
CCDSiCCDS5020.3 [P28476-1]
PIRiA38079
RefSeqiNP_002034.3, NM_002043.4 [P28476-1]
UniGeneiHs.379330
Hs.719891

Genome annotation databases

EnsembliENST00000402938; ENSP00000386029; ENSG00000111886 [P28476-1]
GeneIDi2570
KEGGihsa:2570
UCSCiuc003pnb.4 human [P28476-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiGBRR2_HUMAN
AccessioniPrimary (citable) accession number: P28476
Secondary accession number(s): A2BDE4, Q9H153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: October 31, 2012
Last modified: June 20, 2018
This is version 180 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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