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Protein

Protein Wnt-2

Gene

Wnt2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May function in gonadogenesis and limb development. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation.1 Publication

GO - Molecular functioni

  • frizzled binding Source: FlyBase
  • signaling receptor binding Source: FlyBase

GO - Biological processi

  • axon extension Source: FlyBase
  • canonical Wnt signaling pathway Source: FlyBase
  • cell fate commitment Source: GO_Central
  • muscle organ development Source: FlyBase
  • open tracheal system development Source: FlyBase
  • segment polarity determination Source: UniProtKB-KW
  • Wnt signaling pathway Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Segmentation polarity protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-3238698 WNT ligand biogenesis and trafficking
SignaLinkiP28465

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-2
Alternative name(s):
dWnt-2
Gene namesi
Name:Wnt2
Synonyms:Wnt-2
ORF Names:CG1916
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0004360 Wnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004147724 – 352Protein Wnt-2Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 76By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi115 ↔ 123By similarity
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi125 ↔ 148By similarity
Disulfide bondi196 ↔ 210By similarity
Disulfide bondi198 ↔ 205By similarity
Lipidationi202O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi297 ↔ 312By similarity
Disulfide bondi327 ↔ 342By similarity
Disulfide bondi329 ↔ 339By similarity
Disulfide bondi334 ↔ 335By similarity

Post-translational modificationi

Palmitoleoylated by porcupine. The lipid group functions as a sorting signal, targeting the ligand to polarized vesicles that transport Wnt2 to unique sites at the cell surface. Depalmitoleoylated by notum, leading to inhibit Wnt signaling pathway.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PaxDbiP28465
PRIDEiP28465

Expressioni

Tissue specificityi

Dynamic expression pattern during embryogenesis. Expression is predominantly segmented, with expression also seen in the limb primordia and presumptive gonads. In embryonic tracheal cells, expression is close to and dorsal to the tracheal placode.2 Publications

Gene expression databases

BgeeiFBgn0004360
ExpressionAtlasiP28465 baseline and differential
GenevisibleiP28465 DM

Interactioni

GO - Molecular functioni

  • frizzled binding Source: FlyBase
  • signaling receptor binding Source: FlyBase

Protein-protein interaction databases

BioGridi61806, 9 interactors
IntActiP28465, 5 interactors
STRINGi7227.FBpp0087596

Structurei

3D structure databases

ProteinModelPortaliP28465
SMRiP28465
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00760000118943
InParanoidiP28465
OrthoDBiEOG091G0OFF
PhylomeDBiP28465

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKIHNKLLI YILWIMEIRL VSSFTSVMLC GRIPGLTPGQ RNMCREMPDA
60 70 80 90 100
LIALGEGHQL GAQECQHQFR GHRWNCSEVW QRNVFAHVIP TASREAAYTY
110 120 130 140 150
AIASAGAAYA VTAACARGNI STCGCDVRHK ATPTGGGTPD EPWKWGGCSA
160 170 180 190 200
DVDFGMRYAR RFMDARELER DSRTLMNLHN NRAGRTLVKK MLRTDCKCHG
210 220 230 240 250
VSGSCVMKTC WKSLPPFRLV GDRLMLKYQK AKTVQAVKGK RGLRLVLSRK
260 270 280 290 300
KHAGTARAQK PVLDWPKRME LIYLEASPNY CERSLQTGSQ GTSGRTCQRT
310 320 330 340 350
GHGPQSCDLL CCGRGHNTQH IRRTTQCRCQ FRWCCEVKCD ECDESYEEFT

CK
Length:352
Mass (Da):39,763
Last modified:August 29, 2003 - v2
Checksum:iC021663DB4CAC5DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27V → A in CAA46001 (PubMed:1425336).Curated1
Sequence conflicti68Q → L in AAO24959 (Ref. 4) Curated1
Sequence conflicti110A → R in CAA46001 (PubMed:1425336).Curated1
Sequence conflicti226L → M in CAA46001 (PubMed:1425336).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64735 mRNA Translation: CAA46001.1
AE013599 Genomic DNA Translation: AAF58933.1
BT003204 mRNA Translation: AAO24959.1
PIRiS24559
RefSeqiNP_476810.1, NM_057462.5
UniGeneiDm.4787

Genome annotation databases

EnsemblMetazoaiFBtr0088512; FBpp0087596; FBgn0004360
GeneIDi35975
KEGGidme:Dmel_CG1916

Similar proteinsi

Entry informationi

Entry nameiWNT2_DROME
AccessioniPrimary (citable) accession number: P28465
Secondary accession number(s): Q86PC8, Q9V584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 29, 2003
Last modified: July 18, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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