MSX1

Functionⁱ

Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.2 Publications

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	172 – 231	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
enhancer binding Source: Ensembl
p53 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15705871
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of meiosis Source: Ensembl
anterior/posterior pattern specification Source: Ensembl
BMP signaling pathway involved in heart development Source: Ensembl
bone morphogenesis Source: Ensembl
cartilage morphogenesis Source: Ensembl
cell morphogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 15705871
cellular response to nicotine Source: Ensembl
embryonic forelimb morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
embryonic nail plate morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11369996
epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
face morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
in utero embryonic development Source: Ensembl
mammary gland epithelium development Source: Ensembl
mesenchymal cell proliferation Source: Ensembl
midbrain development Source: Ensembl
middle ear morphogenesis Source: Ensembl
muscle organ development Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell growth
Source: BHF-UCL
Inferred from direct assayⁱ
- 15705871
negative regulation of cell proliferation Source: Ensembl
negative regulation of striated muscle cell differentiation Source: Ensembl
negative regulation of transcription regulatory region DNA binding Source: Ensembl
odontogenesis of dentin-containing tooth
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
pituitary gland development Source: Ensembl
positive regulation of BMP signaling pathway Source: Ensembl
positive regulation of DNA damage response, signal transduction by p53 class mediator
Source: BHF-UCL
Inferred by curatorⁱ
- 15705871
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
Source: BHF-UCL
Inferred from direct assayⁱ
- 15705871
positive regulation of mesenchymal cell apoptotic process Source: Ensembl
protein localization to nucleus
Source: BHF-UCL
Inferred from direct assayⁱ
- 15705871
protein stabilization
Source: BHF-UCL
Inferred from direct assayⁱ
- 15705871
regulation of odontogenesis Source: Ensembl
roof of mouth development Source: Ensembl
signal transduction involved in regulation of gene expression Source: Ensembl
stem cell differentiation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkⁱ	P28360
SIGNORⁱ	P28360

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein MSX-1 Alternative name(s): Homeobox protein Hox-7 Msh homeobox 1-like protein
Gene namesⁱ	Name:MSX1 Synonyms:HOX7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000163132.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7391 MSX1
MIMⁱ	142983 gene
neXtProtⁱ	NX_P28360

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Tooth agenesis, selective, 1 (STHAG1)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG1 can be associated with orofacial cleft in some patients.

Ectodermal dysplasia 3, Witkop type (ECTD3)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD3 is characterized by abnormalities largely limited largely to teeth (some of which are missing) and nails (which are poorly formed early in life, especially toenails). This condition is distinguished from anhidrotic ectodermal dysplasia by autosomal dominant inheritance and little involvement of hair and sweat glands. The teeth are not as severely affected.

Non-syndromic orofacial cleft 5 (OFC5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018391	84	E → V in OFC5; cleft palate only. 1 PublicationCorresponds to variant dbSNP:rs28928890EnsemblClinVar.	1
Natural variantⁱVAR_018392	97	G → D in OFC5; cleft palate only. 1 Publication	1
Natural variantⁱVAR_018393	120	V → G in OFC5; cleft palate only. 1 PublicationCorresponds to variant dbSNP:rs759548721Ensembl.	1
Natural variantⁱVAR_018394	122	G → E in OFC5; bilateral cleft palate. 1 PublicationCorresponds to variant dbSNP:rs28933081EnsemblClinVar.	1
Natural variantⁱVAR_018395	157	R → S in OFC5; unilateral cleft palate. 2 PublicationsCorresponds to variant dbSNP:rs150284621EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation, Ectodermal dysplasia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4487
MalaCards human disease database More...MalaCardsⁱ	MSX1
MIMⁱ	106600 phenotype 189500 phenotype 608874 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000163132
Orphanetⁱ	141291 Cleft lip and alveolus 199306 Cleft lip/palate 2228 Hypodontia-dysplasia of nails syndrome 199302 Isolated cleft lip 2227 NON RARE IN EUROPE: Hypodontia 99798 Oligodontia
PharmGKBⁱ	PA31196

Polymorphism and mutation databases

BioMutaⁱ	MSX1
DMDMⁱ	557952603

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000049086	1 – 303	Homeobox protein MSX-1Add BLAST		303

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	15	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linkⁱ	133	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationⁱ

Sumoylated by PIAS1, desumoylated by SENP1.By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28360
PaxDbⁱ	P28360
PeptideAtlas More...PeptideAtlasⁱ	P28360
PRIDEⁱ	P28360
ProteomicsDBⁱ	54482

PTM databases

iPTMnetⁱ	P28360
PhosphoSitePlusⁱ	P28360

Expressionⁱ

Tissue specificityⁱ

Expressed in the developing nail bed mesenchyme.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000163132 Expressed in 190 organ(s), highest expression level in endometrium
CleanExⁱ	HS_MSX1
Genevisibleⁱ	P28360 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB026198 HPA063895 HPA073604

HPAⁱ

CAB026198
HPA063895
HPA073604

Interactionⁱ

GO - Molecular functionⁱ

p53 binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15705871

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110593, 14 interactors
CORUMⁱ	P28360
IntActⁱ	P28360, 5 interactors
Molecular INTeraction database More...MINTⁱ	P28360
STRINGⁱ	9606.ENSP00000372170

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28360
SMRⁱ	P28360
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	35 – 42	Poly-Ala		8
Compositional biasⁱ	261 – 269	Poly-Ala		9

Sequence similaritiesⁱ

Belongs to the Msh homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0492 Eukaryota ENOG410YT2J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148979
HOGENOMⁱ	HOG000231922
HOVERGENⁱ	HBG005205
InParanoidⁱ	P28360
KEGG Orthology (KO) More...KOⁱ	K09341
OMAⁱ	VGDIMNM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P1V
PhylomeDBⁱ	P28360
TreeFamⁱ	TF350699

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28360-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAPAADMTSL PLGVKVEDSA FGKPAGGGAG QAPSAAAATA AAMGADEEGA 
        60         70         80         90        100
KPKVSPSLLP FSVEALMADH RKPGAKESAL APSEGVQAAG GSAQPLGVPP 
       110        120        130        140        150
GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKP ERTPWMQSPR 
       160        170        180        190        200
FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA 
       210        220        230        240        250
ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA 
       260        270        280        290        300
FGLSFPLGGP AAVAAAAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY 

HLT

Length:303

Mass (Da):31,496

Last modified:November 13, 2013 - v3

Checksum:ⁱ1B5F01B35920E64F

GO

Sequence cautionⁱ

The sequence AAA52683 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA58665 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH67353 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAL17870 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence ABK81117 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAF83325 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	28	G → D in BAF83325 (PubMed:14702039).Curated	1
Sequence conflictⁱ	45	A → T in AAA58665 (PubMed:1284527).Curated	1
Sequence conflictⁱ	97 – 99	GVP → ASR in AAA58665 (PubMed:1284527).Curated	3
Sequence conflictⁱ	146	M → T in BAF83325 (PubMed:14702039).Curated	1
Sequence conflictⁱ	222	N → S in BAF83325 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_015712	67	M → K in STHAG1. 1 PublicationCorresponds to variant dbSNP:rs121913130EnsemblClinVar.	1
Natural variantⁱVAR_018391	84	E → V in OFC5; cleft palate only. 1 PublicationCorresponds to variant dbSNP:rs28928890EnsemblClinVar.	1
Natural variantⁱVAR_018392	97	G → D in OFC5; cleft palate only. 1 Publication	1
Natural variantⁱVAR_018393	120	V → G in OFC5; cleft palate only. 1 PublicationCorresponds to variant dbSNP:rs759548721Ensembl.	1
Natural variantⁱVAR_018394	122	G → E in OFC5; bilateral cleft palate. 1 PublicationCorresponds to variant dbSNP:rs28933081EnsemblClinVar.	1
Natural variantⁱVAR_018395	157	R → S in OFC5; unilateral cleft palate. 2 PublicationsCorresponds to variant dbSNP:rs150284621EnsemblClinVar.	1
Natural variantⁱVAR_003754	202	R → P in STHAG1. 1 PublicationCorresponds to variant dbSNP:rs121913129EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M76732, M76731 Genomic DNA Translation: AAA58665.1 Different initiation. M97676 mRNA Translation: AAA52683.1 Different initiation. AF426432 Genomic DNA Translation: AAL17870.1 Different initiation. AK290636 mRNA Translation: BAF83325.1 Different initiation. AC092437 Genomic DNA No translation available. BC021285 mRNA Translation: AAH21285.4 BC067353 mRNA Translation: AAH67353.1 Different initiation. EF065625 Genomic DNA Translation: ABK81117.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3378.2
PIRⁱ	A40560 I54320
NCBI Reference Sequences More...RefSeqⁱ	NP_002439.2, NM_002448.3
UniGeneⁱ	Hs.424414

Genome annotation databases

Ensemblⁱ	ENST00000382723; ENSP00000372170; ENSG00000163132
GeneIDⁱ	4487
KEGGⁱ	hsa:4487
UCSC genome browser More...UCSCⁱ	uc003gif.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28360	Homeobox protein MSX-1		PANTR		303	UniRef100_P28360
MSX1 isoform 1		PONAB		303
Uncharacterized protein		PANPA		249
MSX1 isoform 1		PANTR		303
Msh homeobox 1		PONAB		261
+3

Protein	Similar proteins		Species	Score	Length	Source
P28360	Homeobox protein MSX-1	)	MOUSE		303	UniRef90_P13297
Homeobox protein MSX-1		BOVIN		303
Homeobox protein MSX-1		CALJA		303
Homeobox protein MSX-1		PANTR		303
Homeobox protein MSX-1		MACMU		303
+95

Protein	Similar proteins		Species	Score	Length	Source
P28360	Homeobox protein MSX-1	)	MOUSE		303	UniRef50_P13297
Homeobox protein MSX-1		PANTR		303
Homeobox protein MSX-1		CALJA		303
Homeobox protein MSX-1		BOVIN		303
Homeobox protein MSX-1		MACMU		303
+243

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M76732, M76731 Genomic DNA Translation: AAA58665.1 Different initiation. M97676 mRNA Translation: AAA52683.1 Different initiation. AF426432 Genomic DNA Translation: AAL17870.1 Different initiation. AK290636 mRNA Translation: BAF83325.1 Different initiation. AC092437 Genomic DNA No translation available. BC021285 mRNA Translation: AAH21285.4 BC067353 mRNA Translation: AAH67353.1 Different initiation. EF065625 Genomic DNA Translation: ABK81117.1 Different initiation.
CCDSⁱ	CCDS3378.2
PIRⁱ	A40560 I54320
RefSeqⁱ	NP_002439.2, NM_002448.3
UniGeneⁱ	Hs.424414

3D structure databases

ProteinModelPortalⁱ	P28360
SMRⁱ	P28360
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110593, 14 interactors
CORUMⁱ	P28360
IntActⁱ	P28360, 5 interactors
MINTⁱ	P28360
STRINGⁱ	9606.ENSP00000372170

PTM databases

iPTMnetⁱ	P28360
PhosphoSitePlusⁱ	P28360

Polymorphism and mutation databases

BioMutaⁱ	MSX1
DMDMⁱ	557952603

Proteomic databases

MaxQBⁱ	P28360
PaxDbⁱ	P28360
PeptideAtlasⁱ	P28360
PRIDEⁱ	P28360
ProteomicsDBⁱ	54482

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000382723; ENSP00000372170; ENSG00000163132
GeneIDⁱ	4487
KEGGⁱ	hsa:4487
UCSCⁱ	uc003gif.4 human

Organism-specific databases

CTDⁱ	4487
DisGeNETⁱ	4487
EuPathDBⁱ	HostDB:ENSG00000163132.6
GeneCardsⁱ	MSX1
HGNCⁱ	HGNC:7391 MSX1
HPAⁱ	CAB026198 HPA063895 HPA073604
MalaCardsⁱ	MSX1
MIMⁱ	106600 phenotype 142983 gene 189500 phenotype 608874 phenotype
neXtProtⁱ	NX_P28360
OpenTargetsⁱ	ENSG00000163132
Orphanetⁱ	141291 Cleft lip and alveolus 199306 Cleft lip/palate 2228 Hypodontia-dysplasia of nails syndrome 199302 Isolated cleft lip 2227 NON RARE IN EUROPE: Hypodontia 99798 Oligodontia
PharmGKBⁱ	PA31196
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0492 Eukaryota ENOG410YT2J LUCA
GeneTreeⁱ	ENSGT00920000148979
HOGENOMⁱ	HOG000231922
HOVERGENⁱ	HBG005205
InParanoidⁱ	P28360
KOⁱ	K09341
OMAⁱ	VGDIMNM
OrthoDBⁱ	EOG091G0P1V
PhylomeDBⁱ	P28360
TreeFamⁱ	TF350699

Enzyme and pathway databases

SignaLinkⁱ	P28360
SIGNORⁱ	P28360

Miscellaneous databases

ChiTaRSⁱ	MSX1 human
GeneWikiⁱ	MSX1
GenomeRNAiⁱ	4487
Protein Ontology More...PROⁱ	PR:P28360
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000163132 Expressed in 190 organ(s), highest expression level in endometrium
CleanExⁱ	HS_MSX1
Genevisibleⁱ	P28360 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MSX1_HUMAN
Accessionⁱ	P28360Primary (citable) accession number: P28360 Secondary accession number(s): A0SZU5, A8K3M1, Q96NY4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	November 13, 2013
	Last modified:	November 7, 2018
	This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28360 (MSX1_HUMAN)

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Homeobox protein MSX-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ