UniProtKB - P28359 (HXD10_MOUSE)
Protein
Homeobox protein Hox-D10
Gene
Hoxd10
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 266 – 325 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- adult locomotory behavior Source: MGI
- anterior/posterior pattern specification Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- forelimb morphogenesis Source: MGI
- hindlimb morphogenesis Source: MGI
- neuromuscular process Source: MGI
- peripheral nervous system neuron development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- proximal/distal pattern formation Source: MGI
- regulation of gene expression Source: MGI
- single fertilization Source: MGI
- skeletal muscle tissue development Source: MGI
- skeletal system development Source: MGI
- spinal cord motor neuron cell fate specification Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D10Alternative name(s): Homeobox protein Hox-4.5 Homeobox protein Hox-5.3 |
Gene namesi | Name:Hoxd10 Synonyms:Hox-4.5, Hoxd-10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96202, Hoxd10 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- cytoplasmic ribonucleoprotein granule Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200227 | 1 – 340 | Homeobox protein Hox-D10Add BLAST | 340 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 238 | PhosphoserineCombined sources | 1 | |
Modified residuei | 239 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P28359 |
MaxQBi | P28359 |
PaxDbi | P28359 |
PRIDEi | P28359 |
PTM databases
iPTMneti | P28359 |
PhosphoSitePlusi | P28359 |
Expressioni
Developmental stagei
Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000050368, Expressed in mesonephros and 84 other tissues |
Genevisiblei | P28359, MM |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 200392, 10 interactors |
IntActi | P28359, 2 interactors |
STRINGi | 10090.ENSMUSP00000062412 |
Miscellaneous databases
RNActi | P28359, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000158266 |
HOGENOMi | CLU_057871_0_0_1 |
InParanoidi | P28359 |
OMAi | MGMNVHS |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28359 |
TreeFami | TF317819 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28359-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT
60 70 80 90 100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT
110 120 130 140 150
CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG
160 170 180 190 200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK
210 220 230 240 250
MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE
260 270 280 290 300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
310 320 330 340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | G → A in CAA44541 (PubMed:1348690).Curated | 1 | |
Sequence conflicti | 189 | Q → E in CAA44541 (PubMed:1348690).Curated | 1 | |
Sequence conflicti | 207 | G → A in CAA44541 (PubMed:1348690).Curated | 1 | |
Sequence conflicti | 268 | K → E (PubMed:1348690).Curated | 1 | |
Sequence conflicti | 268 | K → E (PubMed:2569970).Curated | 1 | |
Sequence conflicti | 268 | K → E (PubMed:2569969).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62669 Genomic DNA Translation: CAA44541.1 BC013463 mRNA Translation: AAH13463.1 BC048690 mRNA Translation: AAH48690.1 X14715 Genomic DNA Translation: CAB57814.1 |
CCDSi | CCDS16141.1 |
PIRi | S20879 |
RefSeqi | NP_038582.2, NM_013554.5 |
Genome annotation databases
Ensembli | ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368 |
GeneIDi | 15430 |
KEGGi | mmu:15430 |
UCSCi | uc008kdx.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62669 Genomic DNA Translation: CAA44541.1 BC013463 mRNA Translation: AAH13463.1 BC048690 mRNA Translation: AAH48690.1 X14715 Genomic DNA Translation: CAB57814.1 |
CCDSi | CCDS16141.1 |
PIRi | S20879 |
RefSeqi | NP_038582.2, NM_013554.5 |
3D structure databases
SMRi | P28359 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200392, 10 interactors |
IntActi | P28359, 2 interactors |
STRINGi | 10090.ENSMUSP00000062412 |
PTM databases
iPTMneti | P28359 |
PhosphoSitePlusi | P28359 |
Proteomic databases
jPOSTi | P28359 |
MaxQBi | P28359 |
PaxDbi | P28359 |
PRIDEi | P28359 |
Protocols and materials databases
Antibodypediai | 33906, 296 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368 |
GeneIDi | 15430 |
KEGGi | mmu:15430 |
UCSCi | uc008kdx.3, mouse |
Organism-specific databases
CTDi | 3236 |
MGIi | MGI:96202, Hoxd10 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000158266 |
HOGENOMi | CLU_057871_0_0_1 |
InParanoidi | P28359 |
OMAi | MGMNVHS |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28359 |
TreeFami | TF317819 |
Miscellaneous databases
BioGRID-ORCSi | 15430, 1 hit in 17 CRISPR screens |
ChiTaRSi | Hoxd10, mouse |
PROi | PR:P28359 |
RNActi | P28359, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000050368, Expressed in mesonephros and 84 other tissues |
Genevisiblei | P28359, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD10_MOUSE | |
Accessioni | P28359Primary (citable) accession number: P28359 Secondary accession number(s): Q91WU9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | September 5, 2006 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families