Hoxd10

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	266 – 325	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 16672333
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 1756725
DNA-binding transcription factor activity
Source: MGI
Inferred from direct assayⁱ
- 1756725
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11432851
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11432851

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
anterior/posterior pattern specification
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
- 12869760
embryonic limb morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 12869760
embryonic skeletal system morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
forelimb morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
hindlimb morphogenesis
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
neuromuscular process
Source: MGI
Inferred from genetic interactionⁱ
- 18065432
peripheral nervous system neuron development
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11432851
proximal/distal pattern formation
Source: MGI
Inferred from genetic interactionⁱ
- 12869760
regulation of gene expression
Source: MGI
Inferred from genetic interactionⁱ
- 23760953
single fertilization
Source: MGI
Inferred from genetic interactionⁱ
- 23760953
skeletal muscle tissue development
Source: MGI
Inferred from genetic interactionⁱ
- 10642795
skeletal system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 9409668
spinal cord motor neuron cell fate specification
Source: MGI
Inferred from genetic interactionⁱ
- 18065432

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-D10 Alternative name(s): Homeobox protein Hox-4.5 Homeobox protein Hox-5.3
Gene namesⁱ	Name:Hoxd10 Synonyms:Hox-4.5, Hoxd-10
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:96202 Hoxd10

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200227	1 – 340	Homeobox protein Hox-D10Add BLAST		340

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	238	PhosphoserineCombined sources		1
Modified residueⁱ	239	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28359
PaxDbⁱ	P28359
PRIDEⁱ	P28359

PTM databases

iPTMnetⁱ	P28359
PhosphoSitePlusⁱ	P28359

Expressionⁱ

Developmental stageⁱ

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the second or third lumbar pre-vertebrae.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000050368 Expressed in 70 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXD10
Genevisibleⁱ	P28359 MM

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Gmnn	O88513	2	EBI-445929,EBI-445922
Tbx1	P70323	3	EBI-445929,EBI-13635846

Protein-protein interaction databases

BioGridⁱ	200392, 5 interactors
IntActⁱ	P28359, 2 interactors
STRINGⁱ	10090.ENSMUSP00000062412

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28359
SMRⁱ	P28359
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Abd-B homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231182
HOVERGENⁱ	HBG052934
InParanoidⁱ	P28359
KEGG Orthology (KO) More...KOⁱ	K09295
OMAⁱ	NPRGSAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	P28359
TreeFamⁱ	TF317819

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28359-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT 
        60         70         80         90        100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT 
       110        120        130        140        150
CSFTANIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG 
       160        170        180        190        200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK 
       210        220        230        240        250
MNESASGQEP TKVSQVESPE AKGGLPEDRS CLAEVSVSSP EVQEKESKEE 
       260        270        280        290        300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS 
       310        320        330        340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS

Length:340

Mass (Da):38,328

Last modified:September 5, 2006 - v2

Checksum:ⁱ974ABDB417F9F90D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	184	G → A in CAA44541 (PubMed:1348690).Curated	1
Sequence conflictⁱ	189	Q → E in CAA44541 (PubMed:1348690).Curated	1
Sequence conflictⁱ	207	G → A in CAA44541 (PubMed:1348690).Curated	1
Sequence conflictⁱ	268	K → E (PubMed:1348690).Curated	1
Sequence conflictⁱ	268	K → E (PubMed:2569970).Curated	1
Sequence conflictⁱ	268	K → E (PubMed:2569969).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62669 Genomic DNA Translation: CAA44541.1 BC013463 mRNA Translation: AAH13463.1 BC048690 mRNA Translation: AAH48690.1 X14715 Genomic DNA Translation: CAB57814.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16141.1
PIRⁱ	S20879
NCBI Reference Sequences More...RefSeqⁱ	NP_038582.2, NM_013554.5
UniGeneⁱ	Mm.24420

Genome annotation databases

Ensemblⁱ	ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368
GeneIDⁱ	15430
KEGGⁱ	mmu:15430
UCSC genome browser More...UCSCⁱ	uc008kdx.3 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28359	Homeobox protein Hox-D10		HUMAN		340	UniRef90_P28359
Homeobox protein Hox-D10		LAGLA		340
Homeobox protein Hox-D10		PANTR		340
Homeobox protein Hox-D10		SAGLB		340
homeobox protein Hox-D10		ODORO		410
+180

Protein	Similar proteins		Species	Score	Length	Source
P28359	Homeobox protein Hox-D10		LAGLA		340	UniRef50_P28359
Homeobox protein Hox-D10		SAGLB		340
Homeobox protein Hox-D10		HUMAN		340
Homeobox protein Hox-D10		PANTR		340
Homeobox D10		CANLF		410
+197

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62669 Genomic DNA Translation: CAA44541.1 BC013463 mRNA Translation: AAH13463.1 BC048690 mRNA Translation: AAH48690.1 X14715 Genomic DNA Translation: CAB57814.1
CCDSⁱ	CCDS16141.1
PIRⁱ	S20879
RefSeqⁱ	NP_038582.2, NM_013554.5
UniGeneⁱ	Mm.24420

3D structure databases

ProteinModelPortalⁱ	P28359
SMRⁱ	P28359
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200392, 5 interactors
IntActⁱ	P28359, 2 interactors
STRINGⁱ	10090.ENSMUSP00000062412

PTM databases

iPTMnetⁱ	P28359
PhosphoSitePlusⁱ	P28359

Proteomic databases

MaxQBⁱ	P28359
PaxDbⁱ	P28359
PRIDEⁱ	P28359

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000061745; ENSMUSP00000062412; ENSMUSG00000050368
GeneIDⁱ	15430
KEGGⁱ	mmu:15430
UCSCⁱ	uc008kdx.3 mouse

Organism-specific databases

CTDⁱ	3236
MGIⁱ	MGI:96202 Hoxd10

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231182
HOVERGENⁱ	HBG052934
InParanoidⁱ	P28359
KOⁱ	K09295
OMAⁱ	NPRGSAK
OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	P28359
TreeFamⁱ	TF317819

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P28359
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000050368 Expressed in 70 organ(s), highest expression level in mesonephros
CleanExⁱ	MM_HOXD10
Genevisibleⁱ	P28359 MM

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXD10_MOUSE
Accessionⁱ	P28359Primary (citable) accession number: P28359 Secondary accession number(s): Q91WU9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	September 5, 2006
	Last modified:	September 12, 2018
	This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28359 (HXD10_MOUSE)

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Homeobox protein Hox-D10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ