Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-D10

Gene

HOXD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi266 – 325HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP28358

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10
Alternative name(s):
Homeobox protein Hox-4D
Homeobox protein Hox-4E
Gene namesi
Name:HOXD10
Synonyms:HOX4D, HOX4E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000128710.5
HGNCiHGNC:5133 HOXD10
MIMi142984 gene+phenotype
neXtProtiNX_P28358

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Vertical talus, congenital (CVT)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare malformation characterized by vertical orientation of the talus with a rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity with familial occurrence.
See also OMIM:192950
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022582319M → K in CVT; also in Charcot-Marie-Tooth disease-like foot deformities. 1 PublicationCorresponds to variant dbSNP:rs104893634EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3236
MalaCardsiHOXD10
MIMi142984 gene+phenotype
192950 phenotype
OpenTargetsiENSG00000128710
Orphaneti295203 Congenital vertical talus, bilateral
295201 Congenital vertical talus, unilateral
PharmGKBiPA29407

Polymorphism and mutation databases

BioMutaiHOXD10
DMDMi143811403

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002261 – 340Homeobox protein Hox-D10Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei238PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP28358
MaxQBiP28358
PaxDbiP28358
PeptideAtlasiP28358
PRIDEiP28358
ProteomicsDBi54481

PTM databases

iPTMnetiP28358
PhosphoSitePlusiP28358

Expressioni

Tissue specificityi

Strongly expressed in the adult male and female urogenital tracts.

Developmental stagei

Expressed in the developing limb buds.

Gene expression databases

BgeeiENSG00000128710 Expressed in 96 organ(s), highest expression level in metanephros
CleanExiHS_HOXD10
GenevisibleiP28358 HS

Organism-specific databases

HPAiHPA065871

Interactioni

Protein-protein interaction databases

BioGridi109476, 5 interactors
IntActiP28358, 1 interactor
STRINGi9606.ENSP00000249501

Structurei

3D structure databases

ProteinModelPortaliP28358
SMRiP28358
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiP28358
KOiK09295
OMAiWTDPSRS
OrthoDBiEOG091G0LON
PhylomeDBiP28358
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28358-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT
60 70 80 90 100
CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT
110 120 130 140 150
CSFTTNIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG
160 170 180 190 200
YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK
210 220 230 240 250
MNEPVSGQEP TKVSQVESPE AKGGLPEERS CLAEVSVSSP EVQEKESKEE
260 270 280 290 300
IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS
310 320 330 340
KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS
Length:340
Mass (Da):38,411
Last modified:April 3, 2007 - v2
Checksum:iFA6DB8C9DD97D7C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150G → R in CAA42017 (PubMed:1756725).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022582319M → K in CVT; also in Charcot-Marie-Tooth disease-like foot deformities. 1 PublicationCorresponds to variant dbSNP:rs104893634EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59373 mRNA Translation: CAA42017.1
BC069619 mRNA Translation: AAH69619.1
BC074760 mRNA Translation: AAH74760.1
CCDSiCCDS2266.1
PIRiA42008
S18650
RefSeqiNP_002139.2, NM_002148.3
UniGeneiHs.123070

Genome annotation databases

EnsembliENST00000249501; ENSP00000249501; ENSG00000128710
GeneIDi3236
KEGGihsa:3236
UCSCiuc002ukj.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59373 mRNA Translation: CAA42017.1
BC069619 mRNA Translation: AAH69619.1
BC074760 mRNA Translation: AAH74760.1
CCDSiCCDS2266.1
PIRiA42008
S18650
RefSeqiNP_002139.2, NM_002148.3
UniGeneiHs.123070

3D structure databases

ProteinModelPortaliP28358
SMRiP28358
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109476, 5 interactors
IntActiP28358, 1 interactor
STRINGi9606.ENSP00000249501

PTM databases

iPTMnetiP28358
PhosphoSitePlusiP28358

Polymorphism and mutation databases

BioMutaiHOXD10
DMDMi143811403

Proteomic databases

EPDiP28358
MaxQBiP28358
PaxDbiP28358
PeptideAtlasiP28358
PRIDEiP28358
ProteomicsDBi54481

Protocols and materials databases

DNASUi3236
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249501; ENSP00000249501; ENSG00000128710
GeneIDi3236
KEGGihsa:3236
UCSCiuc002ukj.4 human

Organism-specific databases

CTDi3236
DisGeNETi3236
EuPathDBiHostDB:ENSG00000128710.5
GeneCardsiHOXD10
HGNCiHGNC:5133 HOXD10
HPAiHPA065871
MalaCardsiHOXD10
MIMi142984 gene+phenotype
192950 phenotype
neXtProtiNX_P28358
OpenTargetsiENSG00000128710
Orphaneti295203 Congenital vertical talus, bilateral
295201 Congenital vertical talus, unilateral
PharmGKBiPA29407
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231182
HOVERGENiHBG052934
InParanoidiP28358
KOiK09295
OMAiWTDPSRS
OrthoDBiEOG091G0LON
PhylomeDBiP28358
TreeFamiTF317819

Enzyme and pathway databases

SIGNORiP28358

Miscellaneous databases

GeneWikiiHOXD10
GenomeRNAii3236
PROiPR:P28358
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000128710 Expressed in 96 organ(s), highest expression level in metanephros
CleanExiHS_HOXD10
GenevisibleiP28358 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD10_HUMAN
AccessioniPrimary (citable) accession number: P28358
Secondary accession number(s): Q6NT10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again