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Protein

Homeobox protein Hox-D9

Gene

Hoxd9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi272 – 331HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D9
Alternative name(s):
Homeobox protein Hox-4.4
Homeobox protein Hox-5.2
Gene namesi
Name:Hoxd9
Synonyms:Hox-4.4, Hoxd-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96210 Hoxd9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002211 – 339Homeobox protein Hox-D9Add BLAST339

Proteomic databases

MaxQBiP28357
PaxDbiP28357
PRIDEiP28357

PTM databases

PhosphoSitePlusiP28357

Expressioni

Developmental stagei

Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the first lumbar pre-vertebrae.1 Publication

Gene expression databases

BgeeiENSMUSG00000043342 Expressed in 167 organ(s), highest expression level in gonadal ridge
CleanExiMM_HOXD9
GenevisibleiP28357 MM

Interactioni

Protein-protein interaction databases

BioGridi200399, 3 interactors
STRINGi10090.ENSMUSP00000058490

Structurei

3D structure databases

ProteinModelPortaliP28357
SMRiP28357
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 140Gly-richAdd BLAST28
Compositional biasi119 – 131Poly-GlyAdd BLAST13
Compositional biasi163 – 176Ser/Thr-richAdd BLAST14

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP28357
KOiK09294
OMAiSGLYHPY
OrthoDBiEOG091G0LON
PhylomeDBiP28357
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28357-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAT
60 70 80 90 100
AEFASCSFAP KSSVFSASWS AVAAQPPAAA TMSGLYHPYV SPPPLAAAEP
110 120 130 140 150
GRYVRSWMEP LPGFPGGAGG GGGSGGGGGG GPGPVPSPGG PANGRHYGIK
160 170 180 190 200
PETGAAPAPA AASTSSSSST SSSSSSKRTE CSAARESQGS GGPEFPCNSF
210 220 230 240 250
LRDKAAAATG NGPGVGIGTG PGAVGSSEPS ACSDHPSPGC SLKEEEKQPP
260 270 280 290 300
QPPQQQLDPN NPAANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD
310 320 330
RRYEVARILN LTERQVKIWF QNRRMKMKKM SKEKCPKGD
Length:339
Mass (Da):34,992
Last modified:December 1, 1992 - v1
Checksum:i370DC47C6929F7E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62669 Genomic DNA Translation: CAA44542.1
AK134427 mRNA Translation: BAE22140.1
AK144746 mRNA Translation: BAE26045.1
AL928644 Genomic DNA Translation: CAM20529.1
BC019150 mRNA Translation: AAH19150.1
X14714 Genomic DNA Translation: CAB57813.1
CCDSiCCDS16142.1
PIRiS20880
RefSeqiNP_038583.1, NM_013555.4
UniGeneiMm.26544

Genome annotation databases

EnsembliENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342
GeneIDi15438
KEGGimmu:15438
UCSCiuc008kdz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62669 Genomic DNA Translation: CAA44542.1
AK134427 mRNA Translation: BAE22140.1
AK144746 mRNA Translation: BAE26045.1
AL928644 Genomic DNA Translation: CAM20529.1
BC019150 mRNA Translation: AAH19150.1
X14714 Genomic DNA Translation: CAB57813.1
CCDSiCCDS16142.1
PIRiS20880
RefSeqiNP_038583.1, NM_013555.4
UniGeneiMm.26544

3D structure databases

ProteinModelPortaliP28357
SMRiP28357
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200399, 3 interactors
STRINGi10090.ENSMUSP00000058490

PTM databases

PhosphoSitePlusiP28357

Proteomic databases

MaxQBiP28357
PaxDbiP28357
PRIDEiP28357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342
GeneIDi15438
KEGGimmu:15438
UCSCiuc008kdz.1 mouse

Organism-specific databases

CTDi3235
MGIiMGI:96210 Hoxd9

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP28357
KOiK09294
OMAiSGLYHPY
OrthoDBiEOG091G0LON
PhylomeDBiP28357
TreeFamiTF317819

Miscellaneous databases

PROiPR:P28357
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043342 Expressed in 167 organ(s), highest expression level in gonadal ridge
CleanExiMM_HOXD9
GenevisibleiP28357 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD9_MOUSE
AccessioniPrimary (citable) accession number: P28357
Secondary accession number(s): A2ASM9, Q3UMQ3, Q3UYS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 12, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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