UniProtKB - P28357 (HXD9_MOUSE)
Protein
Homeobox protein Hox-D9
Gene
Hoxd9
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 272 – 331 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- adult locomotory behavior Source: MGI
- anterior/posterior pattern specification Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic skeletal system development Source: MGI
- embryonic skeletal system morphogenesis Source: MGI
- forelimb morphogenesis Source: MGI
- hindlimb morphogenesis Source: MGI
- mammary gland development Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- peripheral nervous system neuron development Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- proximal/distal pattern formation Source: MGI
- regulation of gene expression Source: MGI
- single fertilization Source: MGI
- skeletal muscle tissue development Source: MGI
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D9Alternative name(s): Homeobox protein Hox-4.4 Homeobox protein Hox-5.2 |
Gene namesi | Name:Hoxd9 Synonyms:Hox-4.4, Hoxd-9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96210, Hoxd9 |
Subcellular locationi
Nucleus
Nucleus
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200221 | 1 – 339 | Homeobox protein Hox-D9Add BLAST | 339 |
Proteomic databases
MaxQBi | P28357 |
PaxDbi | P28357 |
PRIDEi | P28357 |
PTM databases
PhosphoSitePlusi | P28357 |
Expressioni
Developmental stagei
Expressed in the developing limb buds. Expressed in the posterior-most regions of the fetus. Strongly expressed in 12.5 day old fetuses in both spinal cord and pre-vertebral column with an anterior boundary of expression lying at the level of the first lumbar pre-vertebrae.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000043342, Expressed in gonadal ridge and 185 other tissues |
Genevisiblei | P28357, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 200399, 3 interactors |
STRINGi | 10090.ENSMUSP00000058490 |
Miscellaneous databases
RNActi | P28357, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 113 – 140 | Gly-richAdd BLAST | 28 | |
Compositional biasi | 119 – 131 | Poly-GlyAdd BLAST | 13 | |
Compositional biasi | 163 – 176 | Ser/Thr-richAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161503 |
HOGENOMi | CLU_071854_0_0_1 |
InParanoidi | P28357 |
OMAi | PQGIYHP |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28357 |
TreeFami | TF317819 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28357-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGTQGRPA GVADGPAAAT
60 70 80 90 100
AEFASCSFAP KSSVFSASWS AVAAQPPAAA TMSGLYHPYV SPPPLAAAEP
110 120 130 140 150
GRYVRSWMEP LPGFPGGAGG GGGSGGGGGG GPGPVPSPGG PANGRHYGIK
160 170 180 190 200
PETGAAPAPA AASTSSSSST SSSSSSKRTE CSAARESQGS GGPEFPCNSF
210 220 230 240 250
LRDKAAAATG NGPGVGIGTG PGAVGSSEPS ACSDHPSPGC SLKEEEKQPP
260 270 280 290 300
QPPQQQLDPN NPAANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD
310 320 330
RRYEVARILN LTERQVKIWF QNRRMKMKKM SKEKCPKGD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62669 Genomic DNA Translation: CAA44542.1 AK134427 mRNA Translation: BAE22140.1 AK144746 mRNA Translation: BAE26045.1 AL928644 Genomic DNA No translation available. BC019150 mRNA Translation: AAH19150.1 X14714 Genomic DNA Translation: CAB57813.1 |
CCDSi | CCDS16142.1 |
PIRi | S20880 |
RefSeqi | NP_038583.1, NM_013555.4 |
Genome annotation databases
Ensembli | ENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342 |
GeneIDi | 15438 |
KEGGi | mmu:15438 |
UCSCi | uc008kdz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62669 Genomic DNA Translation: CAA44542.1 AK134427 mRNA Translation: BAE22140.1 AK144746 mRNA Translation: BAE26045.1 AL928644 Genomic DNA No translation available. BC019150 mRNA Translation: AAH19150.1 X14714 Genomic DNA Translation: CAB57813.1 |
CCDSi | CCDS16142.1 |
PIRi | S20880 |
RefSeqi | NP_038583.1, NM_013555.4 |
3D structure databases
BMRBi | P28357 |
SMRi | P28357 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200399, 3 interactors |
STRINGi | 10090.ENSMUSP00000058490 |
PTM databases
PhosphoSitePlusi | P28357 |
Proteomic databases
MaxQBi | P28357 |
PaxDbi | P28357 |
PRIDEi | P28357 |
Protocols and materials databases
Antibodypediai | 33907, 189 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000059272; ENSMUSP00000058490; ENSMUSG00000043342 |
GeneIDi | 15438 |
KEGGi | mmu:15438 |
UCSCi | uc008kdz.1, mouse |
Organism-specific databases
CTDi | 3235 |
MGIi | MGI:96210, Hoxd9 |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161503 |
HOGENOMi | CLU_071854_0_0_1 |
InParanoidi | P28357 |
OMAi | PQGIYHP |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28357 |
TreeFami | TF317819 |
Miscellaneous databases
BioGRID-ORCSi | 15438, 0 hits in 17 CRISPR screens |
ChiTaRSi | Hoxd9, mouse |
PROi | PR:P28357 |
RNActi | P28357, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043342, Expressed in gonadal ridge and 185 other tissues |
Genevisiblei | P28357, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD9_MOUSE | |
Accessioni | P28357Primary (citable) accession number: P28357 Secondary accession number(s): A2ASM9, Q3UMQ3, Q3UYS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries