HOXD9

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	285 – 344	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
anterior/posterior pattern specification Source: Ensembl
embryonic forelimb morphogenesis Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
hindlimb morphogenesis Source: Ensembl
mammary gland development Source: Ensembl
negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725
peripheral nervous system neuron development Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
proximal/distal pattern formation Source: Ensembl
single fertilization Source: Ensembl
skeletal muscle tissue development Source: Ensembl
transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P28356

SIGNORⁱ

P28356

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-D9 Alternative name(s): Homeobox protein Hox-4C Homeobox protein Hox-5.2
Gene namesⁱ	Name:HOXD9 Synonyms:HOX4C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000128709.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5140 HOXD9
MIMⁱ	142982 gene
neXtProtⁱ	NX_P28356

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3235
Open Targets More...OpenTargetsⁱ	ENSG00000128709
PharmGKBⁱ	PA29414

Polymorphism and mutation databases

BioMutaⁱ	HOXD9
DMDMⁱ	294862543

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200220	1 – 352	Homeobox protein Hox-D9Add BLAST		352

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	146	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P28356
PaxDbⁱ	P28356
PeptideAtlas More...PeptideAtlasⁱ	P28356
PRIDEⁱ	P28356
ProteomicsDBⁱ	54480

PTM databases

iPTMnetⁱ	P28356
PhosphoSitePlusⁱ	P28356

Expressionⁱ

Developmental stageⁱ

Expressed in the developing limb buds.

Gene expression databases

Bgeeⁱ	ENSG00000128709 Expressed in 101 organ(s), highest expression level in myometrium
CleanExⁱ	HS_HOXD9
Genevisibleⁱ	P28356 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA068683

HPAⁱ

HPA068683

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109475, 9 interactors
IntActⁱ	P28356, 3 interactors
STRINGⁱ	9606.ENSP00000249499

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P28356
SMRⁱ	P28356
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	125 – 159	Gly-richAdd BLAST	35
Compositional biasⁱ	131 – 140	Poly-Gly	10
Compositional biasⁱ	175 – 188	Ser/Thr-richAdd BLAST	14

Sequence similaritiesⁱ

Belongs to the Abd-B homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231180
HOVERGENⁱ	HBG016849
InParanoidⁱ	P28356
KEGG Orthology (KO) More...KOⁱ	K09294
OMAⁱ	GIYHPYV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	P28356
TreeFamⁱ	TF317819

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR006711 Hox9_activation_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF04617 Hox9_act, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P28356-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA 
        60         70         80         90        100
GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV 
       110        120        130        140        150
PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS 
       160        170        180        190        200
GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ 
       210        220        230        240        250
GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI 
       260        270        280        290        300
PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL 
       310        320        330        340        350
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK 

GD

Length:352

Mass (Da):36,495

Last modified:April 20, 2010 - v5

Checksum:ⁱECBFE68B48C0F532

GO

Sequence cautionⁱ

The sequence AAH44855 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA42016 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	144 – 156	GPSPG…PANGR → VPALAPAAQPTGC in AAH44855 (PubMed:15489334).CuratedAdd BLAST	13
Sequence conflictⁱ	219 – 224	AATGGT → GGDGGN in CAA42016 (PubMed:1756725).Curated	6
Sequence conflictⁱ	276	A → E in CAA42016 (PubMed:1756725).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031851	269	Missing 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59372 mRNA Translation: CAA42016.1 Different initiation. AC009336 Genomic DNA No translation available. BC044855 mRNA Translation: AAH44855.2 Different initiation. X15506 Genomic DNA Translation: CAA33528.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2267.2
PIRⁱ	S18649
NCBI Reference Sequences More...RefSeqⁱ	NP_055028.3, NM_014213.3
UniGeneⁱ	Hs.236646

Genome annotation databases

Ensemblⁱ	ENST00000249499; ENSP00000249499; ENSG00000128709
GeneIDⁱ	3235
KEGGⁱ	hsa:3235
UCSC genome browser More...UCSCⁱ	uc010zex.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P28356	Uncharacterized protein		PROCO		357	UniRef90_P28356
Homeobox D9		BOVIN		354
Homeobox D9		OTOGA		354
Homeobox D9		GORGO		354
Uncharacterized protein		CERAT		353
+38

Protein	Similar proteins		Species	Score	Length	Source
P28356	Homeobox protein Hox-D9		MOUSE		339	UniRef50_P28357
Homeobox protein Hox-D9		RAT		343
homeobox protein Hox-D9		MESAU		338
Homeobox protein		NEOLE		337
Homeobox protein		NOMLE		310
+120

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59372 mRNA Translation: CAA42016.1 Different initiation. AC009336 Genomic DNA No translation available. BC044855 mRNA Translation: AAH44855.2 Different initiation. X15506 Genomic DNA Translation: CAA33528.1
CCDSⁱ	CCDS2267.2
PIRⁱ	S18649
RefSeqⁱ	NP_055028.3, NM_014213.3
UniGeneⁱ	Hs.236646

3D structure databases

ProteinModelPortalⁱ	P28356
SMRⁱ	P28356
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109475, 9 interactors
IntActⁱ	P28356, 3 interactors
STRINGⁱ	9606.ENSP00000249499

PTM databases

iPTMnetⁱ	P28356
PhosphoSitePlusⁱ	P28356

Polymorphism and mutation databases

BioMutaⁱ	HOXD9
DMDMⁱ	294862543

Proteomic databases

MaxQBⁱ	P28356
PaxDbⁱ	P28356
PeptideAtlasⁱ	P28356
PRIDEⁱ	P28356
ProteomicsDBⁱ	54480

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000249499; ENSP00000249499; ENSG00000128709
GeneIDⁱ	3235
KEGGⁱ	hsa:3235
UCSCⁱ	uc010zex.3 human

Organism-specific databases

CTDⁱ	3235
DisGeNETⁱ	3235
EuPathDBⁱ	HostDB:ENSG00000128709.11
GeneCardsⁱ	HOXD9
HGNCⁱ	HGNC:5140 HOXD9
HPAⁱ	HPA068683
MIMⁱ	142982 gene
neXtProtⁱ	NX_P28356
OpenTargetsⁱ	ENSG00000128709
PharmGKBⁱ	PA29414
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0487 Eukaryota ENOG4111FJP LUCA
GeneTreeⁱ	ENSGT00910000143984
HOGENOMⁱ	HOG000231180
HOVERGENⁱ	HBG016849
InParanoidⁱ	P28356
KOⁱ	K09294
OMAⁱ	GIYHPYV
OrthoDBⁱ	EOG091G0LON
PhylomeDBⁱ	P28356
TreeFamⁱ	TF317819

Enzyme and pathway databases

SIGNORⁱ	P28356

SIGNORⁱ

P28356

Miscellaneous databases

GeneWikiⁱ	HOXD9
GenomeRNAiⁱ	3235
Protein Ontology More...PROⁱ	PR:P28356
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000128709 Expressed in 101 organ(s), highest expression level in myometrium
CleanExⁱ	HS_HOXD9
Genevisibleⁱ	P28356 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR006711 Hox9_activation_N
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF04617 Hox9_act, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXD9_HUMAN
Accessionⁱ	P28356Primary (citable) accession number: P28356 Secondary accession number(s): Q86ST1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
	Last sequence update:	April 20, 2010
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 5 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P28356 (HXD9_HUMAN)

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Homeobox protein Hox-D9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ