UniProtKB - P28356 (HXD9_HUMAN)
Protein
Homeobox protein Hox-D9
Gene
HOXD9
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Caution
It is uncertain whether Met-1 or Met-11 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 285 – 344 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- anterior/posterior pattern specification Source: GO_Central
- embryonic forelimb morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: GO_Central
- hindlimb morphogenesis Source: Ensembl
- mammary gland development Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- peripheral nervous system neuron development Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- proximal/distal pattern formation Source: GO_Central
- single fertilization Source: Ensembl
- skeletal muscle tissue development Source: Ensembl
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P28356 |
SIGNORi | P28356 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D9Alternative name(s): Homeobox protein Hox-4C Homeobox protein Hox-5.2 |
Gene namesi | Name:HOXD9 Synonyms:HOX4C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5140, HOXD9 |
MIMi | 142982, gene |
neXtProti | NX_P28356 |
VEuPathDBi | HostDB:ENSG00000128709.11 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3235 |
OpenTargetsi | ENSG00000128709 |
PharmGKBi | PA29414 |
Miscellaneous databases
Pharosi | P28356, Tbio |
Genetic variation databases
BioMutai | HOXD9 |
DMDMi | 294862543 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200220 | 1 – 352 | Homeobox protein Hox-D9Add BLAST | 352 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 146 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P28356 |
MassIVEi | P28356 |
MaxQBi | P28356 |
PaxDbi | P28356 |
PeptideAtlasi | P28356 |
PRIDEi | P28356 |
ProteomicsDBi | 54480 |
PTM databases
iPTMneti | P28356 |
PhosphoSitePlusi | P28356 |
Expressioni
Developmental stagei
Expressed in the developing limb buds.
Gene expression databases
Bgeei | ENSG00000128709, Expressed in body of uterus and 121 other tissues |
Genevisiblei | P28356, HS |
Organism-specific databases
HPAi | ENSG00000128709, Tissue enhanced (endometrium) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109475, 10 interactors |
IntActi | P28356, 3 interactors |
STRINGi | 9606.ENSP00000249499 |
Miscellaneous databases
RNActi | P28356, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 125 – 159 | Gly-richAdd BLAST | 35 | |
Compositional biasi | 131 – 140 | Poly-Gly | 10 | |
Compositional biasi | 175 – 188 | Ser/Thr-richAdd BLAST | 14 |
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161503 |
InParanoidi | P28356 |
OMAi | PQGIYHP |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28356 |
TreeFami | TF317819 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28356-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGGSAGRLK MSSSGTLSNY YVDSLIGHEG DEVFAARFGP PGPGAQGRPA
60 70 80 90 100
GVADGPAATA AEFASCSFAP RSAVFSASWS AVPSQPPAAA AMSGLYHPYV
110 120 130 140 150
PPPPLAASAS EPGRYVRSWM EPLPGFPGGA GGGGGGGGGG PGRGPSPGPS
160 170 180 190 200
GPANGRHYGI KPETRAAPAP ATAASTTSSS STSLSSSSKR TECSVARESQ
210 220 230 240 250
GSSGPEFSCN SFLQEKAAAA TGGTGPGAGI GAATGTGGSS EPSACSDHPI
260 270 280 290 300
PGCSLKEEEK QHSQPQQQQL DPNNPAANWI HARSTRKKRC PYTKYQTLEL
310 320 330 340 350
EKEFLFNMYL TRDRRYEVAR ILNLTERQVK IWFQNRRMKM KKMSKEKCPK
GD
Sequence cautioni
The sequence AAH44855 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA42016 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 – 156 | GPSPG…PANGR → VPALAPAAQPTGC in AAH44855 (PubMed:15489334).CuratedAdd BLAST | 13 | |
Sequence conflicti | 219 – 224 | AATGGT → GGDGGN in CAA42016 (PubMed:1756725).Curated | 6 | |
Sequence conflicti | 276 | A → E in CAA42016 (PubMed:1756725).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031851 | 269 | Missing 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59372 mRNA Translation: CAA42016.1 Different initiation. AC009336 Genomic DNA No translation available. BC044855 mRNA Translation: AAH44855.2 Different initiation. X15506 Genomic DNA Translation: CAA33528.1 |
CCDSi | CCDS2267.2 |
PIRi | S18649 |
RefSeqi | NP_055028.3, NM_014213.3 |
Genome annotation databases
Ensembli | ENST00000249499; ENSP00000249499; ENSG00000128709 |
GeneIDi | 3235 |
KEGGi | hsa:3235 |
UCSCi | uc010zex.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59372 mRNA Translation: CAA42016.1 Different initiation. AC009336 Genomic DNA No translation available. BC044855 mRNA Translation: AAH44855.2 Different initiation. X15506 Genomic DNA Translation: CAA33528.1 |
CCDSi | CCDS2267.2 |
PIRi | S18649 |
RefSeqi | NP_055028.3, NM_014213.3 |
3D structure databases
BMRBi | P28356 |
SMRi | P28356 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109475, 10 interactors |
IntActi | P28356, 3 interactors |
STRINGi | 9606.ENSP00000249499 |
PTM databases
iPTMneti | P28356 |
PhosphoSitePlusi | P28356 |
Genetic variation databases
BioMutai | HOXD9 |
DMDMi | 294862543 |
Proteomic databases
jPOSTi | P28356 |
MassIVEi | P28356 |
MaxQBi | P28356 |
PaxDbi | P28356 |
PeptideAtlasi | P28356 |
PRIDEi | P28356 |
ProteomicsDBi | 54480 |
Protocols and materials databases
Antibodypediai | 33907, 189 antibodies |
Genome annotation databases
Ensembli | ENST00000249499; ENSP00000249499; ENSG00000128709 |
GeneIDi | 3235 |
KEGGi | hsa:3235 |
UCSCi | uc010zex.3, human |
Organism-specific databases
CTDi | 3235 |
DisGeNETi | 3235 |
GeneCardsi | HOXD9 |
HGNCi | HGNC:5140, HOXD9 |
HPAi | ENSG00000128709, Tissue enhanced (endometrium) |
MIMi | 142982, gene |
neXtProti | NX_P28356 |
OpenTargetsi | ENSG00000128709 |
PharmGKBi | PA29414 |
VEuPathDBi | HostDB:ENSG00000128709.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000161503 |
InParanoidi | P28356 |
OMAi | PQGIYHP |
OrthoDBi | 976319at2759 |
PhylomeDBi | P28356 |
TreeFami | TF317819 |
Enzyme and pathway databases
PathwayCommonsi | P28356 |
SIGNORi | P28356 |
Miscellaneous databases
BioGRID-ORCSi | 3235, 13 hits in 899 CRISPR screens |
GeneWikii | HOXD9 |
GenomeRNAii | 3235 |
Pharosi | P28356, Tbio |
PROi | PR:P28356 |
RNActi | P28356, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128709, Expressed in body of uterus and 121 other tissues |
Genevisiblei | P28356, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR006711, Hox9_activation_N |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF04617, Hox9_act, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD9_HUMAN | |
Accessioni | P28356Primary (citable) accession number: P28356 Secondary accession number(s): Q86ST1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | April 20, 2010 | |
Last modified: | February 10, 2021 | |
This is version 178 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families