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UniProtKB - P28349 (NIT4_NEUCR)
Protein
Nitrogen assimilation transcription factor nit-4
Gene
nit-4
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Functioni
Pathway-specific regulatory gene of nitrate assimilation; it activates the transcription of the genes for nitrate and nitrite reductases.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 53 – 81 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- nitrate assimilation Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Nitrate assimilation, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Nitrogen assimilation transcription factor nit-4 |
Gene namesi | Name:nit-4 ORF Names:NCU08294 |
Organismi | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic identifieri | 367110 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:NCU08294 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114960 | 1 – 1090 | Nitrogen assimilation transcription factor nit-4Add BLAST | 1090 |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 145 – 176 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 666 – 689 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 773 – 798 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 825 – 875 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 936 – 999 | DisorderedSequence analysisAdd BLAST | 64 | |
Regioni | 1033 – 1053 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 145 – 166 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 784 – 798 | Polar residuesSequence analysisAdd BLAST | 15 |
Domaini
The glutamine-rich domain might function in activating gene expression.
Phylogenomic databases
HOGENOMi | CLU_007003_6_0_1 |
InParanoidi | P28349 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P28349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSDVQMMS SQDAPGSAGL APDNIASSLP SKKKSRRGAD PTNQKRRCVS
60 70 80 90 100
TACIACRRRK SKCDGALPSC AACASVYGTE CIYDPNSDHR RKGVYREKND
110 120 130 140 150
SMKAQNATLQ ILIEAILNAS EEDVIDIVRR IRTCDDLDEV AESIRRDEKN
160 170 180 190 200
ATATNDNDDS DEPTQPGRDD ATSQAVEGER DLARKMGELR IENGSVRFIG
210 220 230 240 250
GTSHLIYLSE PTDASEEPEL ETRLSTCDEN PITTWTEVTK NPQLIIHLVN
260 270 280 290 300
MYFNWHYPYF TTLSRSLFYR DFIKGKPAGQ PRSTVYCSSL LVNAMLALGC
310 320 330 340 350
HFTSVDGAFA VPGDSRTKGD HFFAEAKRLI VQNDEYEKPR LTTVQALALM
360 370 380 390 400
SVREAGCGRE AKGWVYSGMS FRMAQDIGLN LDIGSLDEKE VDARRITFWG
410 420 430 440 450
CFVFDKCWSN YLGRLPQLPK NTYNVPKYDV FPDEDAELWS PYTDAGFDQS
460 470 480 490 500
CKQPSRTRAI GLQLSKLCEI SSDLLLFFYH PSHIGRSSGK SAELKKLSEL
510 520 530 540 550
HRRLEDWRTE LPKEFEPKDG QLPNVILMHM FYHLQYIHLF RPFLKYTKEA
560 570 580 590 600
SPLEKVQPRR ICTTNANSIS KLMRLYKKLY NLRQICNIAV YMLHSACTIH
610 620 630 640 650
MLNLPEKTAR RDITHGVRQL EEMAEDWPCA RRTLGIISVL ARKWNVELPE
660 670 680 690 700
EAAIVLKRTD EKYGMFSTSE VPSPNRTAPS LAPSSPAPPY TPEASLLFST
710 720 730 740 750
TAAAVLEQQP YSPMTLYSHP TPPHLGPESI SDPGMSPNIV TFSDLPDPSA
760 770 780 790 800
PIIPQQQQNM QAISSLSQNN MLHQHHHHLQ NQHQPQQPHH NHMTYQQQQH
810 820 830 840 850
NLLTHPVSAS SMSMSDTLAT ITAWGIPTSS PGNNNNNNIV SQHPHHQKQP
860 870 880 890 900
QQQQQPQAQR YPTVGSVGTN TVKPPAAATQ TFTPAQLHAN NLATATRSTA
910 920 930 940 950
SNHKSVGRHV SPSSIYAIDG QDWYLKDGVT WQQGFQGWDL EGGGAGTATS
960 970 980 990 1000
TGGIGDGGGP TGGAGDSMAR LAPRGNIGGG GGGGGGSTGQ RQQQQQRQQQ
1010 1020 1030 1040 1050
QQQQQQQQQQ QQQQQQQQQQ QQQQEANMFA YHHGAERGGG GIESTGMGMT
1060 1070 1080 1090
TVGGGGGGFD PIGGSGLLDD LVGLDELGSL DGLGHLPGLD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | K → KP in AAA33602 (PubMed:1840634).Curated | 1 | |
Sequence conflicti | 276 – 277 | KP → NA in AAA33602 (PubMed:1840634).Curated | 2 | |
Sequence conflicti | 276 – 277 | KP → NA (PubMed:1531376).Curated | 2 | |
Sequence conflicti | 467 | L → S in AAA33602 (PubMed:1840634).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80368 Genomic DNA Translation: AAA33602.1 CM002239 Genomic DNA Translation: EAA33271.3 |
PIRi | A41696 |
RefSeqi | XP_962507.3, XM_957414.3 |
Genome annotation databases
EnsemblFungii | EAA33271; EAA33271; NCU08294 |
GeneIDi | 3878673 |
KEGGi | ncr:NCU08294 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M80368 Genomic DNA Translation: AAA33602.1 CM002239 Genomic DNA Translation: EAA33271.3 |
PIRi | A41696 |
RefSeqi | XP_962507.3, XM_957414.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 5141.EFNCRP00000008391 |
Genome annotation databases
EnsemblFungii | EAA33271; EAA33271; NCU08294 |
GeneIDi | 3878673 |
KEGGi | ncr:NCU08294 |
Organism-specific databases
VEuPathDBi | FungiDB:NCU08294 |
Phylogenomic databases
HOGENOMi | CLU_007003_6_0_1 |
InParanoidi | P28349 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NIT4_NEUCR | |
Accessioni | P28349Primary (citable) accession number: P28349 Secondary accession number(s): Q7RVG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | December 4, 2007 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |