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UniProtKB - P28347 (TEAD1_HUMAN)

Entry version 206 (07 Apr 2021)
Sequence version 2 (15 Jul 1998)
Previous versions | rss
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Protein

Transcriptional enhancer factor TEF-1

Gene

TEAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.2 Publications

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi28 – 104TEAPROSITE-ProRule annotationAdd BLAST77

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P28347

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P28347

SIGNOR Signaling Network Open Resource

More...SIGNORi		P28347

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-1
Alternative name(s):
NTEF-1
Protein GT-IIC
TEA domain family member 1
Short name:
TEAD-1
Transcription factor 13
Short name:
TCF-13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TEAD1
Synonyms:TCF13, TEF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11714, TEAD1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		189967, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P28347

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187079.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sveinsson chorioretinal atrophy (SCRA)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031530421Y → H in SCRA; loss of interaction with YAP1 and also activation by YAP1. 3 PublicationsCorresponds to variant dbSNP:rs11567847EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi421Y → A: Important loss of interaction with YAP1. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		7003

MalaCards human disease database

More...MalaCardsi		TEAD1
MIMi108985, phenotype

Open Targets

More...OpenTargetsi		ENSG00000187079

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		86813, Helicoid peripapillary chorioretinal degeneration

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36432

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P28347, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3334416

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TEAD1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3041733

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002059301 – 426Transcriptional enhancer factor TEF-1Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P28347

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P28347

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P28347

MaxQB - The MaxQuant DataBase

More...MaxQBi		P28347

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P28347

PeptideAtlas

More...PeptideAtlasi		P28347

PRoteomics IDEntifications database

More...PRIDEi		P28347

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54479 [P28347-1]
674

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P28347

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P28347

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P28347

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187079, Expressed in biceps brachii and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P28347, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P28347, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187079, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112862, 34 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-256, YAP1-TEAD1 complex

Database of interacting proteins

More...DIPi		DIP-34360N

Protein interaction database and analysis system

More...IntActi		P28347, 31 interactors

Molecular INTeraction database

More...MINTi		P28347

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000435233

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P28347

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P28347, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P28347

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P28347

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 426Transcriptional activationSequence analysisAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 204Pro-richAdd BLAST62
Compositional biasi306 – 328Ser/Thr/Tyr-richAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3841, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182956

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P28347

Database for complete collections of gene phylogenies

More...PhylomeDBi		P28347

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.1610, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00547

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000818, TEA/ATTS_dom
IPR038096, TEA/ATTS_sf
IPR016361, TEF_metazoa
IPR041086, YBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01285, TEA, 1 hit
PF17725, YBD, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002603, TEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00065, TEADOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00426, TEA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00554, TEA_1, 1 hit
PS51088, TEA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P28347-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY 
        60         70         80         90        100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR 
       110        120        130        140        150
KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF 
       160        170        180        190        200
PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPASAPA 
       210        220        230        240        250
PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS 
       260        270        280        290        300
DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD 
       310        320        330        340        350
DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV 
       360        370        380        390        400
YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL 
       410        420 
LCMACVFEVS NSEHGAQHHI YRLVKD
Length:426
Mass (Da):47,946
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFD8067F2770B3C7
GO
Isoform 2 (identifier: P28347-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.
     110-110: K → KVTSM
     234-291: Missing.

Show »
Length:357
Mass (Da):40,000
Checksum:i0CCACF105ABDFFD5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YE88H0YE88_HUMAN
Transcriptional enhancer factor TEF...
TEAD1
426Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEJ9H0YEJ9_HUMAN
Transcriptional enhancer factor TEF...
TEAD1
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKB7E9PKB7_HUMAN
Transcriptional enhancer factor TEF...
TEAD1
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCZ6H0YCZ6_HUMAN
Transcriptional enhancer factor TEF...
TEAD1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB00791 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031530421Y → H in SCRA; loss of interaction with YAP1 and also activation by YAP1. 3 PublicationsCorresponds to variant dbSNP:rs11567847EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0562751 – 15Missing in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_056276110K → KVTSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_056277234 – 291Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M63896 Genomic DNA Translation: AAB00791.1 Sequence problems.
AC013549 Genomic DNA No translation available.
AC084859 Genomic DNA No translation available.
AC107881 Genomic DNA No translation available.
BC115398 mRNA Translation: AAI15399.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7810.2 [P28347-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A40032

NCBI Reference Sequences

More...RefSeqi		NP_068780.2, NM_021961.5 [P28347-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334310; ENSP00000334754; ENSG00000187079 [P28347-2]
ENST00000527636; ENSP00000435233; ENSG00000187079 [P28347-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7003

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7003

UCSC genome browser

More...UCSCi		uc057zfn.1, human [P28347-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63896 Genomic DNA Translation: AAB00791.1 Sequence problems.
AC013549 Genomic DNA No translation available.
AC084859 Genomic DNA No translation available.
AC107881 Genomic DNA No translation available.
BC115398 mRNA Translation: AAI15399.1
CCDSiCCDS7810.2 [P28347-1]
PIRiA40032
RefSeqiNP_068780.2, NM_021961.5 [P28347-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HZDNMR-A28-104[»]
3KYSX-ray2.80A/C209-426[»]
4RE1X-ray2.20A/B209-426[»]
4Z8EX-ray2.09A/B/C28-104[»]
5NNXX-ray3.29A31-104[»]
6HILX-ray2.30A/B/C/D208-425[»]
6IM5X-ray1.70A/B210-426[»]
SMRiP28347
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112862, 34 interactors
ComplexPortaliCPX-256, YAP1-TEAD1 complex
DIPiDIP-34360N
IntActiP28347, 31 interactors
MINTiP28347
STRINGi9606.ENSP00000435233

Chemistry databases

BindingDBiP28347
ChEMBLiCHEMBL3334416

PTM databases

iPTMnetiP28347
PhosphoSitePlusiP28347
SwissPalmiP28347

Genetic variation databases

BioMutaiTEAD1
DMDMi3041733

Proteomic databases

EPDiP28347
jPOSTiP28347
MassIVEiP28347
MaxQBiP28347
PaxDbiP28347
PeptideAtlasiP28347
PRIDEiP28347
ProteomicsDBi54479 [P28347-1]
674

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11848, 249 antibodies

Genome annotation databases

EnsembliENST00000334310; ENSP00000334754; ENSG00000187079 [P28347-2]
ENST00000527636; ENSP00000435233; ENSG00000187079 [P28347-1]
GeneIDi7003
KEGGihsa:7003
UCSCiuc057zfn.1, human [P28347-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7003
DisGeNETi7003

GeneCards: human genes, protein and diseases

More...GeneCardsi		TEAD1
HGNCiHGNC:11714, TEAD1
HPAiENSG00000187079, Low tissue specificity
MalaCardsiTEAD1
MIMi108985, phenotype
189967, gene
neXtProtiNX_P28347
OpenTargetsiENSG00000187079
Orphaneti86813, Helicoid peripapillary chorioretinal degeneration
PharmGKBiPA36432
VEuPathDBiHostDB:ENSG00000187079.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3841, Eukaryota
GeneTreeiENSGT00950000182956
InParanoidiP28347
PhylomeDBiP28347

Enzyme and pathway databases

PathwayCommonsiP28347
ReactomeiR-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SignaLinkiP28347
SIGNORiP28347

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7003, 117 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TEAD1, human
EvolutionaryTraceiP28347

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TEAD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7003
PharosiP28347, Tbio

Protein Ontology

More...PROi		PR:P28347
RNActiP28347, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187079, Expressed in biceps brachii and 225 other tissues
ExpressionAtlasiP28347, baseline and differential
GenevisibleiP28347, HS

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
IDEALiIID00547
InterProiView protein in InterPro
IPR000818, TEA/ATTS_dom
IPR038096, TEA/ATTS_sf
IPR016361, TEF_metazoa
IPR041086, YBD
PfamiView protein in Pfam
PF01285, TEA, 1 hit
PF17725, YBD, 1 hit
PIRSFiPIRSF002603, TEF, 1 hit
PRINTSiPR00065, TEADOMAIN
SMARTiView protein in SMART
SM00426, TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554, TEA_1, 1 hit
PS51088, TEA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEAD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P28347
Secondary accession number(s): A4FUP2, E7EV65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 15, 1998
Last modified: April 7, 2021
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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