UniProtKB - P28347 (TEAD1_HUMAN)
Protein
Transcriptional enhancer factor TEF-1
Gene
TEAD1
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.2 Publications
Caution
It is uncertain whether Met-1 or Met-16 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 104 | TEAPROSITE-ProRule annotationAdd BLAST | 77 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- DNA binding Source: ProtInc
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- embryonic organ development Source: GO_Central
- hippo signaling Source: UniProtKB
- nervous system development Source: Reactome
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: CAFA
- positive regulation of transcription by RNA polymerase II Source: CAFA
- protein-containing complex assembly Source: CAFA
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P28347 |
Reactomei | R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P28347 |
SIGNORi | P28347 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional enhancer factor TEF-1Alternative name(s): NTEF-1 Protein GT-IIC TEA domain family member 1 Short name: TEAD-1 Transcription factor 13 Short name: TCF-13 |
Gene namesi | Name:TEAD1 Synonyms:TCF13, TEF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11714, TEAD1 |
MIMi | 189967, gene |
neXtProti | NX_P28347 |
VEuPathDBi | HostDB:ENSG00000187079.14 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- TEAD-YAP complex Source: CAFA
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Sveinsson chorioretinal atrophy (SCRA)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCharacterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031530 | 421 | Y → H in SCRA; loss of interaction with YAP1 and also activation by YAP1. 3 PublicationsCorresponds to variant dbSNP:rs11567847EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 421 | Y → A: Important loss of interaction with YAP1. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7003 |
MalaCardsi | TEAD1 |
MIMi | 108985, phenotype |
OpenTargetsi | ENSG00000187079 |
Orphaneti | 86813, Helicoid peripapillary chorioretinal degeneration |
PharmGKBi | PA36432 |
Miscellaneous databases
Pharosi | P28347, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3334416 |
Genetic variation databases
BioMutai | TEAD1 |
DMDMi | 3041733 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205930 | 1 – 426 | Transcriptional enhancer factor TEF-1Add BLAST | 426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P28347 |
jPOSTi | P28347 |
MassIVEi | P28347 |
MaxQBi | P28347 |
PaxDbi | P28347 |
PeptideAtlasi | P28347 |
PRIDEi | P28347 |
ProteomicsDBi | 54479 [P28347-1] 674 |
PTM databases
iPTMneti | P28347 |
PhosphoSitePlusi | P28347 |
SwissPalmi | P28347 |
Expressioni
Tissue specificityi
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Gene expression databases
Bgeei | ENSG00000187079, Expressed in biceps brachii and 225 other tissues |
ExpressionAtlasi | P28347, baseline and differential |
Genevisiblei | P28347, HS |
Organism-specific databases
HPAi | ENSG00000187079, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with YAP1 and WWTR1/TAZ.
3 PublicationsBinary interactionsi
Hide detailsP28347
With | #Exp. | IntAct |
---|---|---|
YAP1 [P46937] | 10 | EBI-529156,EBI-1044059 |
vg [Q26366] from Drosophila melanogaster. | 3 | EBI-529156,EBI-162687 |
Isoform 2 [P28347-2]
Protein-protein interaction databases
BioGRIDi | 112862, 34 interactors |
ComplexPortali | CPX-256, YAP1-TEAD1 complex |
DIPi | DIP-34360N |
IntActi | P28347, 31 interactors |
MINTi | P28347 |
STRINGi | 9606.ENSP00000435233 |
Chemistry databases
BindingDBi | P28347 |
Miscellaneous databases
RNActi | P28347, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P28347 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P28347 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 167 – 426 | Transcriptional activationSequence analysisAdd BLAST | 260 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 143 – 204 | Pro-richAdd BLAST | 62 | |
Compositional biasi | 306 – 328 | Ser/Thr/Tyr-richAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG3841, Eukaryota |
GeneTreei | ENSGT00950000182956 |
InParanoidi | P28347 |
PhylomeDBi | P28347 |
Family and domain databases
Gene3Di | 1.10.10.1610, 1 hit |
IDEALi | IID00547 |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P28347-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY
60 70 80 90 100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR
110 120 130 140 150
KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF
160 170 180 190 200
PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPASAPA
210 220 230 240 250
PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS
260 270 280 290 300
DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD
310 320 330 340 350
DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV
360 370 380 390 400
YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL
410 420
LCMACVFEVS NSEHGAQHHI YRLVKD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YE88 | H0YE88_HUMAN | Transcriptional enhancer factor TEF... | TEAD1 | 426 | Annotation score: | ||
H0YEJ9 | H0YEJ9_HUMAN | Transcriptional enhancer factor TEF... | TEAD1 | 368 | Annotation score: | ||
E9PKB7 | E9PKB7_HUMAN | Transcriptional enhancer factor TEF... | TEAD1 | 330 | Annotation score: | ||
H0YCZ6 | H0YCZ6_HUMAN | Transcriptional enhancer factor TEF... | TEAD1 | 67 | Annotation score: |
Sequence cautioni
The sequence AAB00791 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATT isoleucine codon.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031530 | 421 | Y → H in SCRA; loss of interaction with YAP1 and also activation by YAP1. 3 PublicationsCorresponds to variant dbSNP:rs11567847EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056275 | 1 – 15 | Missing in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_056276 | 110 | K → KVTSM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_056277 | 234 – 291 | Missing in isoform 2. 1 PublicationAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63896 Genomic DNA Translation: AAB00791.1 Sequence problems. AC013549 Genomic DNA No translation available. AC084859 Genomic DNA No translation available. AC107881 Genomic DNA No translation available. BC115398 mRNA Translation: AAI15399.1 |
CCDSi | CCDS7810.2 [P28347-1] |
PIRi | A40032 |
RefSeqi | NP_068780.2, NM_021961.5 [P28347-1] |
Genome annotation databases
Ensembli | ENST00000334310; ENSP00000334754; ENSG00000187079 [P28347-2] ENST00000527636; ENSP00000435233; ENSG00000187079 [P28347-1] |
GeneIDi | 7003 |
KEGGi | hsa:7003 |
UCSCi | uc057zfn.1, human [P28347-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63896 Genomic DNA Translation: AAB00791.1 Sequence problems. AC013549 Genomic DNA No translation available. AC084859 Genomic DNA No translation available. AC107881 Genomic DNA No translation available. BC115398 mRNA Translation: AAI15399.1 |
CCDSi | CCDS7810.2 [P28347-1] |
PIRi | A40032 |
RefSeqi | NP_068780.2, NM_021961.5 [P28347-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HZD | NMR | - | A | 28-104 | [»] | |
3KYS | X-ray | 2.80 | A/C | 209-426 | [»] | |
4RE1 | X-ray | 2.20 | A/B | 209-426 | [»] | |
4Z8E | X-ray | 2.09 | A/B/C | 28-104 | [»] | |
5NNX | X-ray | 3.29 | A | 31-104 | [»] | |
6HIL | X-ray | 2.30 | A/B/C/D | 208-425 | [»] | |
6IM5 | X-ray | 1.70 | A/B | 210-426 | [»] | |
SMRi | P28347 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112862, 34 interactors |
ComplexPortali | CPX-256, YAP1-TEAD1 complex |
DIPi | DIP-34360N |
IntActi | P28347, 31 interactors |
MINTi | P28347 |
STRINGi | 9606.ENSP00000435233 |
Chemistry databases
BindingDBi | P28347 |
ChEMBLi | CHEMBL3334416 |
PTM databases
iPTMneti | P28347 |
PhosphoSitePlusi | P28347 |
SwissPalmi | P28347 |
Genetic variation databases
BioMutai | TEAD1 |
DMDMi | 3041733 |
Proteomic databases
EPDi | P28347 |
jPOSTi | P28347 |
MassIVEi | P28347 |
MaxQBi | P28347 |
PaxDbi | P28347 |
PeptideAtlasi | P28347 |
PRIDEi | P28347 |
ProteomicsDBi | 54479 [P28347-1] 674 |
Protocols and materials databases
Antibodypediai | 11848, 249 antibodies |
Genome annotation databases
Ensembli | ENST00000334310; ENSP00000334754; ENSG00000187079 [P28347-2] ENST00000527636; ENSP00000435233; ENSG00000187079 [P28347-1] |
GeneIDi | 7003 |
KEGGi | hsa:7003 |
UCSCi | uc057zfn.1, human [P28347-1] |
Organism-specific databases
CTDi | 7003 |
DisGeNETi | 7003 |
GeneCardsi | TEAD1 |
HGNCi | HGNC:11714, TEAD1 |
HPAi | ENSG00000187079, Low tissue specificity |
MalaCardsi | TEAD1 |
MIMi | 108985, phenotype 189967, gene |
neXtProti | NX_P28347 |
OpenTargetsi | ENSG00000187079 |
Orphaneti | 86813, Helicoid peripapillary chorioretinal degeneration |
PharmGKBi | PA36432 |
VEuPathDBi | HostDB:ENSG00000187079.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3841, Eukaryota |
GeneTreei | ENSGT00950000182956 |
InParanoidi | P28347 |
PhylomeDBi | P28347 |
Enzyme and pathway databases
PathwayCommonsi | P28347 |
Reactomei | R-HSA-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-HSA-8951671, RUNX3 regulates YAP1-mediated transcription R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | P28347 |
SIGNORi | P28347 |
Miscellaneous databases
BioGRID-ORCSi | 7003, 117 hits in 990 CRISPR screens |
ChiTaRSi | TEAD1, human |
EvolutionaryTracei | P28347 |
GeneWikii | TEAD1 |
GenomeRNAii | 7003 |
Pharosi | P28347, Tbio |
PROi | PR:P28347 |
RNActi | P28347, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187079, Expressed in biceps brachii and 225 other tissues |
ExpressionAtlasi | P28347, baseline and differential |
Genevisiblei | P28347, HS |
Family and domain databases
Gene3Di | 1.10.10.1610, 1 hit |
IDEALi | IID00547 |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEAD1_HUMAN | |
Accessioni | P28347Primary (citable) accession number: P28347 Secondary accession number(s): A4FUP2, E7EV65 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 1992 |
Last sequence update: | July 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references